Targeting Metabolism for Cancer Therapy

Cites (292)

Items 201–281 of 281

1. Targetable Signaling Pathway Mutations Are Associated with Malignant Phenotype in <i>IDH</i> -Mutant Gliomas
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2. Catabolism of exogenous lactate reveals it as a legitimate metabolic substrate in breast cancer
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3. From methotrexate to pemetrexed and beyond. A review of the pharmacodynamic and clinical properties of antifolates
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4. New IDH1 mutant inhibitors for treatment of acute myeloid leukemia
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5. Global proteomic assessment of the classical protein-tyrosine phosphatome and “Redoxome”
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6. PHGDH defines a metabolic subtype in lung adenocarcinomas with poor prognosis
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7. The purine path to chemotherapy
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8. Targeted disruption of the mouse 3-phosphoglycerate dehydrogenase gene causes severe neurodevelopmental defects and results in embryonic lethality
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9. Targeting mitochondrial complex I using BAY 87-2243 reduces melanoma tumor growth
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10. Myc-Driven glycolysis is a therapeutic target in glioblastoma
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11. A randomised phase II study of pegylated arginine deiminase (ADI-PEG 20) in Asian advanced hepatocellular carcinoma patients
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12. Arginine Deprivation Inhibits the Warburg Effect and Upregulates Glutamine Anaplerosis and Serine Biosynthesis in ASS1-Deficient Cancers
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13. M2 isoform of pyruvate kinase is dispensable for tumor maintenance and growth
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14. Certain Metabolic and Pharmacologic Effects in Cancer Patients Given Infusions of 2-Deoxy-D-Glucose
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15. Untitled work
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16. Sensitivity to L-asparaginase is not associated with expression levels of asparagine synthetase in t(12;21)+ pediatric ALL
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17. Radioprotection of <i>IDH1</i> -Mutated Cancer Cells by the IDH1-Mutant Inhibitor AGI-5198
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18. Rational design of selective allosteric inhibitors of PHGDH and serine synthesis with anti-tumor activity
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19. Phase I/II study of pegylated arginine deiminase (ADI-PEG 20) in patients with advanced melanoma
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20. Role of mesenchymal stem cells in osteosarcoma and metabolic reprogramming of tumor cells
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21. Dicarbonyl proteome and genome damage in metabolic and vascular disease
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22. PTEN Regulates Glutamine Flux to Pyrimidine Synthesis and Sensitivity to Dihydroorotate Dehydrogenase Inhibition
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23. Serine deprivation enhances antineoplastic activity of biguanides
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24. Synthetic lethality of PARP and NAMPT inhibition in triple-negative breast cancer cells
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25. FASN Inhibition and Taxane Treatment Combine to Enhance Anti-tumor Efficacy in Diverse Xenograft Tumor Models through Disruption of Tubulin Palmitoylation and Microtubule Organization and FASN Inhibition-Mediated Effects on Oncogenic Signaling and Gene Expression
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26. Enzymic imbalance in serine metabolism in human colon carcinoma and rat sarcoma
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27. Collateral lethality: a new therapeutic strategy in oncology
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28. Dual Requirement of Walker Carcinosarcoma 256 in vitro for Asparagine and Glutamine
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29. Arginine deiminase resistance in melanoma cells is associated with metabolic reprogramming, glucose dependence, and glutamine addiction
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30. A Phase I Study of the First-in-Class Antimitochondrial Metabolism Agent, CPI-613, in Patients with Advanced Hematologic Malignancies
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31. Negative argininosuccinate synthetase expression in melanoma tumours may predict clinical benefit from arginine-depleting therapy with pegylated arginine deiminase
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32. CDA directs metabolism of epigenetic nucleosides revealing a therapeutic window in cancer
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33. Phenformin as prophylaxis and therapy in breast cancer xenografts
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34. Understanding the complex-I-ty of metformin action: limiting mitochondrial respiration to improve cancer therapy
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35. A Genome-Wide View of the <i>In vitro</i> Response to <scp>l</scp>-Asparaginase in Acute Lymphoblastic Leukemia
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36. Reversed argininosuccinate lyase activity in fumarate hydratase-deficient cancer cells
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37. Inactivation of <i>SDH</i> and <i>FH</i> cause loss of 5hmC and increased H3K9me3 in paraganglioma/pheochromocytoma and smooth muscle tumors
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38. A role for cytosolic fumarate hydratase in urea cycle metabolism and renal neoplasia
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39. A metabolic synthetic lethal strategy with arginine deprivation and chloroquine leads to cell death in ASS1-deficient sarcomas
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40. SF2312 is a natural phosphonate inhibitor of enolase
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41. Oncogenic properties of the endogenous fatty acid metabolism: molecular pathology of fatty acid synthase in cancer cells
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42. Phosphoinositide 3-kinase inhibitors induce DNA damage through nucleoside depletion
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43. AG-221, an Oral, Selective, First-in-Class, Potent Inhibitor of the IDH2 Mutant Metabolic Enzyme, Induces Durable Remissions in a Phase I Study in Patients with IDH2 Mutation Positive Advanced Hematologic Malignancies
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44. Targeting T Cell Immunometabolism for Cancer Immunotherapy; Understanding the Impact of the Tumor Microenvironment
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45. The modulation of serine metabolism in hepatoma 3924A during different phases of cellular proliferation in culture
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46. Phosphoglycerate dehydrogenase is dispensable for breast tumor maintenance and growth
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47. A phase II multicenter study of L-alanosine, a potent inhibitor of adenine biosynthesis, in patients with MTAP-deficient cancer
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48. Metabolic Response to Pegylated Arginine Deiminase in Mesothelioma With Promoter Methylation of Argininosuccinate Synthetase
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49. Up-regulation of asparagine synthetase expression is not linked to the clinical response L-asparaginase in pediatric acute lymphoblastic leukemia
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50. Selective Killing of Tumors Deficient in Methylthioadenosine Phosphorylase: A Novel Strategy
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51. Thymidine catabolism as a metabolic strategy for cancer survival
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52. Resistance to the anti-proliferative activity of recombinant arginine deiminase in cell culture correlates with the endogenous enzyme, argininosuccinate synthetase
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54. A Phase II Clinical Trial of CPI-613 in Patients with Relapsed or Refractory Small Cell Lung Carcinoma
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56. Methylthioadenosine phosphorylase cDNA transfection alters sensitivity to depletion of purine and methionine in A549 lung cancer cells.
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57. Inhibition of the Polyamine Synthesis Pathway Is Synthetically Lethal with Loss of Argininosuccinate Synthase 1
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58. Targeting Metabolic Changes in Cancer: Novel Therapeutic Approaches
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59. Inhibition of Nicotinamide Phosphoribosyltransferase (NAMPT), an Enzyme Essential for NAD+ Biosynthesis, Leads to Altered Carbohydrate Metabolism in Cancer Cells
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