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Exercise alleviated intestinal damage and microbial disturbances in mice exposed to fluoride

Fu, Rong, Niu, Ruiyan, Zhao, Fangye, Wang, Jixiang, Cao, Qiqi, Yu, Yanghuan, Liu, Ci, Zhang, Ding, Sun, Zilong·2022·Chemosphere
DOI 10.1016/j.chemosphere.2021.132658
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Abstract

Gastrointestinal reaction is an important symptom of fluorosis and is associated with intestinal morphological and functional impairment. Regular moderate exercise may reduce the incidence of infection and contribute to the maintenance of intestinal mucosal function and immune homeostasis. In this study, the mice were randomly divided to four groups: control group (C, distilled water), exercise group (E, distilled water and treadmill exercise), fluoride group (F, 100 mg/L NaF), and exercise plus fluoride group (EF, 100 mg/L NaF and treadmill exercise). The treadmill exercise was performed as 5 m/min, 5 min; 10 or 12 m/min, 20 min; 5 m/min, 5 min, with 5 consecutive days per week. After 6 months, exercise alleviated the intestinal morphological structure damage and restored the villus height (VH) and VH/crypt depth (VH/CD) in the duodenum of fluoride-exposed mice. Exercise decreased the mRNA expressions of IL-1β, IL-6, TNF-α, TLR2 and NF-κB (p65) in fluoride-exposed mice, and restored the gene levels of Occludin and ZO-1 in the duodenum, as well as Occludin, ZO-1, and Claudin-1 in the colon. Although there were no significant differences in the Occludin and ZO-1 protein expressions between F and EF, two proteins in EF presented statistical homogeneousness when compared with the C. The 16S rDNA high-throughput sequencing found that exercise restored the variations in intestinal microbiota composition and the abundances of specific bacteria in fluoride-exposed mice, including in…

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Research works printed but not linked: 49

  1. Amadeu de Oliveira, 2018, The effect of fluoride on the structure, function, and proteome of intestinal epithelia, Environ. Toxicol., 33, 1455, 10.1002/tox.22495 · DOI
  2. Al-Sadi, 2011, Occludin regulates macromolecule flux across the intestinal epithelial tight junction barrier, Am. J. Physiol. Gastrointest. Liver Physiol., 300, G1054, 10.1152/ajpgi.00055.2011 · DOI
  3. Burgueno, 2020, Epithelial Toll-like receptors and their role in gut homeostasis and disease, Nat. Rev. Gastroenterol. Hepatol., 17, 263, 10.1038/s41575-019-0261-4 · DOI
  4. Callahan, 2016, DADA2: high-resolution sample inference from Illumina amplicon data, Nat. Methods, 13, 581, 10.1038/nmeth.3869 · DOI · Paper page
  5. Cao, 2020, Intestinal fungal dysbiosis in mice induced by fluoride, Chemosphere, 245, 125617, 10.1016/j.chemosphere.2019.125617 · DOI
  6. Carmody, 2007, Nuclear factor-kappaB: activation and regulation during toll-like receptor signaling, Cell. Mol. Immunol., 4, 31
  7. Cario, 2007, Toll-like receptor 2 controls mucosal inflammation by regulating epithelial barrier function, Gastroenterology, 132, 1359, 10.1053/j.gastro.2007.02.056 · DOI · Paper page
  8. Chen, 2021, Ligustrum robustum (Roxb.) blume extract modulates gut microbiota and prevents metabolic syndrome in high-fat diet-fed mice, J. Ethnopharmacol., 268, 113695, 10.1016/j.jep.2020.113695 · DOI
  9. Coretti, 2017, The interplay between defensins and microbiota in Crohn's disease, Mediat. Inflamm., 8392523
  10. Coulombre, 1958, Intestinal development. I. Morphogenesis of the villi and musculature, J. Embryol. Exp. Morphol., 6, 403
  11. Daniele, 2017, Effects of exercise on depressive behavior and striatal levels of norepinephrine, serotonin and their metabolites in sleep-deprived mice, Behav. Brain Res., 332, 16, 10.1016/j.bbr.2017.05.062 · DOI
  12. Das, 1994, Toxic effects of chronic fluoride ingestion on the upper gastrointestinal tract, J. Clin. Gastroenterol., 18, 194, 10.1097/00004836-199404000-00004 · DOI
  13. Death, 2019, When less is more: a comparison of models to predict fluoride accumulation in free-ranging kangaroos, Sci. Total Environ., 660, 531, 10.1016/j.scitotenv.2018.12.203 · DOI
  14. Edmunds, 1996, Groundwater geochemistry and health: an overview, Geol. Soc. Spec. Publ., 113, 91, 10.1144/GSL.SP.1996.113.01.08 · DOI
  15. Fu, 2019, Fluoride-induced alteration in the diversity and composition of bacterial microbiota in mice colon, Biol. Trace Elem. Res., 196, 537, 10.1007/s12011-019-01942-w · DOI · Paper page
  16. Gallo, 2012, Epithelial antimicrobial defence of the skin and intestine, Nat. Rev. Immunol., 12, 503, 10.1038/nri3228 · DOI
  17. Gleeson, 2006, Exercise and toll-like receptors, Exerc. Immunol. Rev., 12, 34
  18. Godínez-Victoria, 2012, Effects on secretory IgA levels in small intestine of mice that underwent moderate exercise training followed by a bout of strenuous swimming exercise, Brain Behav. Immun., 26, 1300, 10.1016/j.bbi.2012.07.018 · DOI
  19. Guo, 2017, Effects of sodium fluoride on blood cellular and humoral immunity in mice, Oncotarget, 8, 85504, 10.18632/oncotarget.20198 · DOI
  20. Guo, 2019, Impaired intestinal barrier function in a mouse model of hyperuricemia, Mol. Med. Rep., 20, 3292
  21. Jagtap, 2012, Fluoride in drinking water and defluoridation of water, Chem. Rev., 112, 2454, 10.1021/cr2002855 · DOI
  22. Kahrstrom, 2016, Intestinal microbiota in health and disease, Nature, 535, 47, 10.1038/535047a · DOI
  23. Lee, 2015, Interleukin-23-independent IL-17 production regulates intestinal epithelial permeability, Immunity, 43, 727, 10.1016/j.immuni.2015.09.003 · DOI · Paper page
  24. Li, 2020, Self-recovery study of the adverse effects of fluoride on small intestine: involvement of pyroptosis induced inflammation, Sci. Total Environ., 742, 140533, 10.1016/j.scitotenv.2020.140533 · DOI
  25. Li, 2020, Alterations of the gut microbiome composition and lipid metabolic profile in radiation enteritis, Front. Cell. Infect. Microbiol., 10, 541178, 10.3389/fcimb.2020.541178 · DOI
  26. Liu, 2019, Intestinal barrier damage involved in intestinal microflora changes in fluoride-induced mice, Chemosphere, 234, 409, 10.1016/j.chemosphere.2019.06.080 · DOI · Paper page
  27. Liu, 2017, Effects of TLR-2/NF-κB signaling pathway on the occurrence of degenerative knee osteoarthritis: an in vivo and in vitro study, Oncotarget, 8, 38602, 10.18632/oncotarget.16199 · DOI
  28. Martin, 2011, Physical activity benefits and risks on the gastrointestinal system, South. Med. J., 104, 831, 10.1097/SMJ.0b013e318236c263 · DOI
  29. Palladino, 2008, Localization of Toll-like receptors on epididymal epithelial cells and spermatozoa, Am. J. Reprod. Immunol., 60, 541, 10.1111/j.1600-0897.2008.00654.x · DOI
  30. Pengelly, 1965, Intestine villi, Br. Med. J., 1, 1331, 10.1136/bmj.1.5446.1331 · DOI
  31. Peters, 2001, Potential benefits and hazards of physical activity and exercise on the gastrointestinal tract, Gut, 48, 435, 10.1136/gut.48.3.435 · DOI
  32. Rooks, 2016, Gut microbiota, metabolites and host immunity, Nat. Rev. Immunol., 16, 341, 10.1038/nri.2016.42 · DOI · Paper page
  33. Saitou, 2000, Complex phenotype of mice lacking occludin, a component of tight junction strands, Mol. Biol. Cell, 11, 4131, 10.1091/mbc.11.12.4131 · DOI · Paper page
  34. Sharma, 2017, Fluoride: a review of pre-clinical and clinical studies, Environ. Toxicol. Pharmacol., 56, 297, 10.1016/j.etap.2017.10.008 · DOI
  35. Siegenbeek van Heukelom, 1986, Physiological aspects of absorption and secretion in intestine, Vet. Res. Commun., 10, 341, 10.1007/BF02214000 · DOI
  36. Sharma, 2009, Gastric discomforts from fluoride in drinking water in Sanganer Tehsil, Rajasthan, India, Fluoride, 42, 286
  37. Shin, 2006, Tight junctions and cell polarity, Annu. Rev. Cell Dev. Biol., 22, 207, 10.1146/annurev.cellbio.22.010305.104219 · DOI
  38. Susheela, 1993, Prevalence of endemic fluorosis with gastro-intestinal manifestations in people living in some North-Indian villages, Fluoride, 26, 97
  39. Suzuki, 2013, Regulation of intestinal epithelial permeability by tight junctions, Cell. Mol. Life Sci., 70, 631, 10.1007/s00018-012-1070-x · DOI
  40. Suzuki, 2019, Chronic inflammation as an immunological abnormality and effectiveness of exercise, Biomolecules, 9, 223, 10.3390/biom9060223 · DOI
  41. Turner, 2009, Intestinal mucosal barrier function in health and disease, Nat. Rev. Immunol., 9, 799, 10.1038/nri2653 · DOI · Paper page
  42. Volk, 2019, The Nlrp6 inflammasome is not required for baseline colonic inner mucus layer formation or function, J. Exp. Med., 216, 2602, 10.1084/jem.20190679 · DOI
  43. Wang, 2019, Effect of fluoride on small intestine morphology and serum cytokine contents in rats, Biol. Trace Elem. Res., 189, 511, 10.1007/s12011-018-1503-y · DOI
  44. Whitford, 1994, Intake and metabolism of fluoride, Adv. Dent. Res., 8, 5, 10.1177/08959374940080011001 · DOI
  45. Whitford, 1989, The metabolism and toxicity of fluoride, Monogr. Oral Sci., 13, 1, 10.1159/000417211 · DOI
  46. Xia, 2021, Polyphenol-rich vinegar extract regulates intestinal microbiota and immunity and prevents alcohol-induced inflammation in mice, Food Res. Int., 140, 110064, 10.1016/j.foodres.2020.110064 · DOI
  47. Yang, 2021, Combined use of bacillus subtilis yb-114,246 and bacillus licheniformis yb-214,245 improves body growth performance of Chinese Huainan partridge shank chickens by enhancing intestinal digestive profiles, Probiotics Antimicrob. Proteins, 13, 327, 10.1007/s12602-020-09691-2 · DOI
  48. Yu, 2012, Host-microbial interactions and regulation of intestinal epithelial barrier function: from physiology to pathology, World J. Gastrointest. Pathophysiol., 3, 27, 10.4291/wjgp.v3.i1.27 · DOI
  49. Zhao, 2018, The effects of treadmill exercise on autophagy in hippocampus of APP/PS1 transgenic mice, Neuroreport, 29, 819, 10.1097/WNR.0000000000001038 · DOI

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Metadata

Authors
Fu, R., Niu, R., Zhao, F., Wang, J., Cao, Q., Yu, Y., Liu, C., Zhang, D., & Sun, Z.
ORCID
Sun, Zilong
Venue
Chemosphere
Publisher
Elsevier BV
Published
2022-02
Volume
288
Pages
132658
ISSN
0045-6535
DOI
10.1016/j.chemosphere.2021.132658
Cited by
31
References
6
Language
en
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