Adverse Childhood Experiences and Executive Function Difficulties in Children: A Systematic Review
Abstract
BACKGROUND The relationship between adverse childhood experiences (ACEs) and detrimental poor mental health outcomes has been increasingly explored within scientific literature since the original ACE study was published by Felitti et al. (1998). Given that deficits in executive functions (EF) are prominent in most forms of psychopathology across the lifespan, there is utility in considering how ACEs relate to EF outcomes. OBJECTIVE To consolidate the research to date on the relationship between ACEs and EF outcomes among child samples. METHODS A systematic review was conducted that included 16 scientific databases and 17 grey literatures. RESULTS Across 36 studies, many examined EF related to forms of maltreatment (e.g. abuse, neglect, and exposure to intimate partner violence) and found a strong relationship between maltreatment and EF deficits among children. Similarly, family member mental illness (maternal depression in particular) was associated with poor EF outcomes. The relationship between other ACEs and EF outcomes have not been uniquely examined, including intimate partner violence and family member incarceration. CONCLUSIONS This review acts as a preliminary step towards broader understanding of outcomes related to early childhood experiences through the consideration of EFs. Through documentation of such relationships, it is possible to consider how prevention and treatment approaches may be improved.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
General early adversity is linked to challenges with executive functioning, atypical behavioral development, and mental health concerns.
“Furthermore, general early adversity has been linked to challenges with executive functioning (Lund et al., 2020), atypical behavioral development (Domoff et al., 2021; Howard et al., 2020; Ross et al., 2020; Wilke et al., 2020), and mental health concerns (Atluri et al., 2018; Pham et al., 2021).”
From The relationship between spirituality and resilience and well-being: a study of 529 care leavers from 11 nations. (2023) · cites this paper as Lund et al., 2020
Cites
Felitti, V. J., Anda, R. F., Nordenberg, D., Williamson, D. F., Spitz, A. M., Edwards, V., Koss, M. P., & Marks, J. S. (1998) · American Journal of Preventive Medicine · doi:10.1016/s0749-3797(98)00017-8 · Cited by 18,943 · see citing works
Diamond, A. (2013) · Annual Review of Psychology · doi:10.1146/annurev-psych-113011-143750 · Cited by 13,268 · see citing works
Miller, G. E., Chen, E., & Zhou, E. S. (2007) · Psychological Bulletin · doi:10.1037/0033-2909.133.1.25 · Cited by 2,467 · see citing works
The link between childhood trauma and depression: insights from HPA axis studies in humans
Heim, C., Newport, D. J., Mletzko, T., Miller, A. H., & Nemeroff, C. B. (2008) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.03.008 · Cited by 1,704 · see citing works
McLaughlin, K. A., Sheridan, M. A., & Lambert, H. K. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.10.012 · Cited by 1,389 · see citing works
Diamond, A. (2002) · Principles of Frontal Lobe Function · doi:10.1093/acprof:oso/9780195134971.003.0029 · Cited by 1,248 · see citing works
Amygdala, medial prefrontal cortex, and hippocampal function in PTSD
SHIN, L. M., RAUCH, S. L., & PITMAN, R. K. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1364.007 · Cited by 1,203 · see citing works
Snyder, H. R., Miyake, A., & Hankin, B. L. (2015) · Frontiers in Psychology · doi:10.3389/fpsyg.2015.00328 · Cited by 946 · see citing works
Child maltreatment and the developing HPA axis
Tarullo, A. R., & Gunnar, M. R. (2006) · Hormones and Behavior · doi:10.1016/j.yhbeh.2006.06.010 · Cited by 737 · see citing works
Hair cortisol, stress exposure, and mental health in humans: A systematic review
Staufenbiel, S. M., Penninx, B. W. J. H., Spijker, A. T., Elzinga, B. M., & van Rossum, E. F. C. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.11.015 · Cited by 736 · see citing works
Childhood maltreatment, emotional dysregulation, and psychiatric comorbidities
Dvir, Y., Ford, J. D., Hill, M., & Frazier, J. A. (2014) · Harvard Review of Psychiatry · doi:10.1097/hrp.0000000000000014 · Cited by 698 · see citing works
Dimensions of early experience and neural development: deprivation and threat
Sheridan, M. A., & McLaughlin, K. A. (2014) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2014.09.001 · Cited by 697 · see citing works
Gioia, G. A., Isquith, P. K., Retzlaff, P. D., & Espy, K. A. (2002) · Child Neuropsychology · doi:10.1076/chin.8.4.249.13513 · Cited by 608 · see citing works
Asmundson, G. J. G., & Afifi, T. O. (2020) · Elsevier eBooks · doi:10.1016/c2017-0-03827-2 · Cited by 580 · see citing works
NIGG, J. T., WONG, M. M., MARTEL, M. M., JESTER, J. M., PUTTLER, L. I., GLASS, J. M., ADAMS, K. M., FITZGERALD, H. E., & ZUCKER, R. A. (2006) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/01.chi.0000199028.76452.a9 · Cited by 549 · see citing works
Neuropsychological Function in Children With Maltreatment-Related Posttraumatic Stress Disorder
Beers, S. R., & De Bellis, M. D. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.3.483 · Cited by 531 · see citing works
Kerker, B. D., Zhang, J., Nadeem, E., Stein, R. E. K., Hurlburt, M. S., Heneghan, A., Landsverk, J., & McCue Horwitz, S. (2015) · Academic Pediatrics · doi:10.1016/j.acap.2015.05.005 · Cited by 412 · see citing works
Executive function performance and trauma exposure in a community sample of children
DePrince, A. P., Weinzierl, K. M., & Combs, M. D. (2009) · Child Abuse & Neglect · doi:10.1016/j.chiabu.2008.08.002 · Cited by 370 · see citing works
Reduced Medial Prefrontal Cortex Volume in Adults Reporting Childhood Emotional Maltreatment
van Harmelen, A.-L., van Tol, M.-J., van der Wee, N. J. A., Veltman, D. J., Aleman, A., Spinhoven, P., van Buchem, M. A., Zitman, F. G., Penninx, B. W. J. H., & Elzinga, B. M. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.06.011 · Cited by 362 · see citing works
Neuropsychological findings in childhood neglect and their relationships to pediatric PTSD
Bellis, M. D. D., Hooper, S. R., Spratt, E. G., & Woolley, D. P. (2009) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617709990464 · Cited by 350 · see citing works
Frodl, T., Reinhold, E., Koutsouleris, N., Reiser, M., & Meisenzahl, E. M. (2010) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2010.01.006 · Cited by 323 · see citing works
Sheridan, M. A., Peverill, M., Finn, A. S., & McLaughlin, K. A. (2017) · Development and Psychopathology · doi:10.1017/s0954579417001390 · Cited by 276 · see citing works
Colvert, E., Rutter, M., Kreppner, J., Beckett, C., Castle, J., Groothues, C., Hawkins, A., Stevens, S., & Sonuga-Barke, E. J. S. (2008) · Journal of Abnormal Child Psychology · doi:10.1007/s10802-008-9232-x · Cited by 270 · see citing works
Alcohol abuse as a risk factor for and consequence of child abuse.
Widom, C. S., & Hiller-Sturmhöfel, S. (2001) · PubMed Central · Cited by 257 · see citing works
Hostinar, C. E., Stellern, S. A., Schaefer, C., Carlson, S. M., & Gunnar, M. R. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1121246109 · Cited by 234 · see citing works
Miller, A. B., Sheridan, M. A., Hanson, J. L., McLaughlin, K. A., Bates, J. E., Lansford, J. E., Pettit, G. S., & Dodge, K. A. (2018) · Journal of Abnormal Psychology · doi:10.1037/abn0000331 · Cited by 225 · see citing works
Neuroimaging Studies of Emotional Responses in PTSD
LIBERZON, I., & MARTIS, B. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1364.009 · Cited by 198 · see citing works
Childhood abuse and neglect and cognitive flexibility in adolescents
Spann, M. N., Mayes, L. C., Kalmar, J. H., Guiney, J., Womer, F. Y., Pittman, B. P., Mazure, C. M., Sinha, R., & Blumberg, H. P. (2011) · Child Neuropsychology · doi:10.1080/09297049.2011.595400 · Cited by 187 · see citing works
Carrion, V. G., Garrett, A., Menon, V., Weems, C. F., & Reiss, A. L. (2008) · Depression and Anxiety · doi:10.1002/da.20346 · Cited by 185 · see citing works
The traumatic stress response in child maltreatment and resultant neuropsychological effects
Wilson, K. R., Hansen, D. J., & Li, M. (2011) · Aggression and Violent Behavior · doi:10.1016/j.avb.2010.12.007 · Cited by 175 · see citing works
Using neuropsychological profiles to classify neglected children with or without physical abuse
Nolin, P., & Éthier, L. S. (2007) · Child Abuse & Neglect · doi:10.1016/j.chiabu.2006.12.009 · Cited by 151 · see citing works
Decreased Prefrontal Cortical Volume Associated with Increased Bedtime Cortisol in Traumatized Youth
Carrión, V. G., Weems, C. F., Richert, K., Hoffman, B. C., & Reiss, A. L. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.05.010 · Cited by 150 · see citing works
Does maternal depression predict young children’s executive function? - a 4-year Longitudinal Study.
Hughes, C., Roman, G., Hart, M. J., & Ensor, R. (2013) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12014 · Cited by 146 · see citing works
Early adversity and neural correlates of executive function: Implications for academic adjustment
McDermott, J. M., Westerlund, A., Zeanah, C. H., Nelson, C. A., & Fox, N. A. (2012) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2011.09.008 · Cited by 146 · see citing works
Adverse childhood experiences and chronic hypothalamic–pituitary–adrenal activity
Kalmakis, K. A., Meyer, J. S., Chiodo, L. M., & Leung, K. (2015) · Stress · doi:10.3109/10253890.2015.1023791 · Cited by 129 · see citing works
Cognitive impairment in school-aged children with early trauma
Bücker, J., Kapczinski, F. P., Post, R. M., Ceresér, K. M. M., Szobot, C. M., Yatham, L. N., Kapczinski, N. S., & Kauer‐Sant’Anna, M. (2012) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2011.12.006 · Cited by 122 · see citing works
Berthelsen, D. C., Hayes, N., White, S. L. J., & Williams, K. E. (2017) · Frontiers in Psychology · doi:10.3389/fpsyg.2017.00903 · Cited by 112 · see citing works
Neuropsychological Functioning in Children with Posttraumatic Stress Disorder
Samuelson, K. W., Krueger, C. E., Burnett, C., & Wilson, C. K. (2009) · Child Neuropsychology · doi:10.1080/09297040903190782 · Cited by 95 · see citing works
Wade, M., Fox, N. A., Zeanah, C. H., & Nelson, C. A. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1809145116 · Cited by 92 · see citing works
Child Abuse and Performance Task Assessments of Executive Functions in Boys
Mezzacappa, E., Kindlon, D., & Earls, F. J. (2001) · Journal of Child Psychology and Psychiatry · doi:10.1111/1469-7610.00803 · Cited by 91 · see citing works
Egeland, J., & Fallmyr, Ø. (2010) · Child Neuropsychology · doi:10.1080/09297041003601462 · Cited by 91 · see citing works
Maternal depressive symptoms, mother-child interactions, and children’s executive function.
Gueron‐Sela, N., The Family Life Project Key Investigators, Camerota, M., Willoughby, M. T., Vernon‐Feagans, L., & Cox, M. J. (2017) · Developmental Psychology · doi:10.1037/dev0000389 · Cited by 90 · see citing works
Maltreatment Is Associated With Specific Impairments in Executive Functions: A Pilot Study
Augusti, E., & Melinder, A. M. D. (2013) · Journal of Traumatic Stress · doi:10.1002/jts.21860 · Cited by 71 · see citing works
Bruce, J., Fisher, P. A., Graham, A. M., Moore, W. E., Peake, S. J., & Mannering, A. M. (2013) · Development and Psychopathology · doi:10.1017/s095457941300028x · Cited by 65 · see citing works
Childhood maltreatment and executive functions in adolescents.
Mothes, L., Kristensen, C., Grassi-Oliveira, R., Fonseca, R., Argimon, I. I. D. L., & Irigaray, T. Q. (2015) · Child and Adolescent Mental Health · doi:10.1111/camh.12068 · Cited by 59 · see citing works
Executive functioning: Developmental consequences on adolescents with histories of maltreatment
Kirke‐Smith, M., Henry, L. A., & Messer, D. J. (2014) · British Journal of Developmental Psychology · doi:10.1111/bjdp.12041 · Cited by 52 · see citing works
Executive functioning deficits and childhood trauma in juvenile violent offenders in China
Zou, Z., Meng, H., Ma, Z., Deng, W., Du, L., Wang, H., Chen, P., & Hu, H. (2012) · Psychiatry Research · doi:10.1016/j.psychres.2012.09.013 · Cited by 49 · see citing works
Wide-ranging cognitive deficits in adolescents following early life maltreatment.
Vasilevski, V., & Tucker, A. (2015) · Neuropsychology · doi:10.1037/neu0000215 · Cited by 48 · see citing works
Parental predictors of children's executive functioning from ages 6 to 10
Halse, M., Steinsbekk, S., Hammar, Å., Belsky, J., & Wichstrøm, L. (2019) · British Journal of Developmental Psychology · doi:10.1111/bjdp.12282 · Cited by 48 · see citing works
Grekin, E. R., Brennan, P. A., & Hammen, C. L. (2005) · Journal of Studies on Alcohol · doi:10.15288/jsa.2005.66.14 · Cited by 45 · see citing works
Parent-Reported Executive Functioning in Postinstitutionalized Children: A Follow-Up Study
Merz, E. C., McCall, R. B., & Groza, V. K. (2013) · Journal of Clinical Child & Adolescent Psychology · doi:10.1080/15374416.2013.764826 · Cited by 43 · see citing works
Cognitive Effects of Intravenous Hydrocortisone in Subjects with PTSD and Healthy Control Subjects
GROSSMAN, R., Yehuda, R., Golier, J. A., McEwen, B. S., Harvey, P. D., & Maria, N. S. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1364.032 · Cited by 40 · see citing works
Baker, C. E., & Kuhn, L. (2017) · Infant and Child Development · doi:10.1002/icd.2052 · Cited by 37 · see citing works
Hodgdon, H., Liebman, R. E., Martin, L., Suvak, M. K., Beserra, K., Rosenblum, W., & Spinazzola, J. (2018) · Journal of Traumatic Stress · doi:10.1002/jts.22267 · Cited by 32 · see citing works
Long-Term Cognitive Sequelae: Abused Children Without PTSD
Perna, R. B., & Kiefner, M. G. (2012) · Applied Neuropsychology Child · doi:10.1080/09084282.2011.595460 · Cited by 30 · see citing works
Wang, Y., & Dix, T. (2017) · Developmental Psychology · doi:10.1037/dev0000373 · Cited by 27 · see citing works
Executive functions and clinical symptoms in children exposed to maltreatment
Carvalho, J. C. N., Renner, A. M., Donat, J. C., de Moura, T. C., Fonseca, R. P., & Kristensen, C. H. (2018) · Applied Neuropsychology Child · doi:10.1080/21622965.2018.1497989 · Cited by 27 · see citing works
Institutionalization, Romanian Adoptions and Executive Functioning
Groza, V. K., Ryan, S. D., & Thomas, S. (2008) · Child and Adolescent Social Work Journal · doi:10.1007/s10560-008-0120-6 · Cited by 23 · see citing works
The Effect of Maltreatment Type on Adolescent Executive Functioning and Inner Speech
Kirke‐Smith, M., Henry, L. A., & Messer, D. J. (2015) · Infant and Child Development · doi:10.1002/icd.1951 · Cited by 19 · see citing works
Nooner, K. B., Hooper, S. R., & Bellis, M. D. D. (2017) · Psychological Trauma Theory Research Practice and Policy · doi:10.1037/tra0000356 · Cited by 19 · see citing works
Martin, L. I., Kidd, M., & Seedat, S. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2018.09.009 · Cited by 16 · see citing works
Attentional and Executive Functions in Neglected Children
Nadeau, M.-É., & Nolin, P. (2013) · Journal of Child & Adolescent Trauma · doi:10.1080/19361521.2013.733794 · Cited by 13 · see citing works
Biedermann, S. V., Meliß, S., Simmons, C., Nöthling, J., Suliman, S., & Seedat, S. (2018) · Child Abuse & Neglect · doi:10.1016/j.chiabu.2018.04.003 · Cited by 10 · see citing works
Brief report: Executive functions in adolescent offspring of mothers with a history of depression
Wagner, C. A., Abramson, L. Y., & Alloy, L. B. (2015) · Journal of Adolescence · doi:10.1016/j.adolescence.2015.06.005 · Cited by 9 · see citing works
Bengwasan, P. D. (2018) · Child Abuse & Neglect · doi:10.1016/j.chiabu.2018.05.019 · Cited by 8 · see citing works
Parent depressive symptoms and offspring executive functioning
Craun, E. A., Lachance, K., Williams, C. L., & Wong, M. M.-H. (2018) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/13803395.2018.1504893 · Cited by 7 · see citing works
From the Archive: The Adverse Childhood Experiences Study
Boulton, M. L. (2019) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2019.02.012 · Cited by 2 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Cruz, D., Lichten, M., Berg, K., & George, P. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.800687 · Cited by 158 · see citing works
Howard, A. H., Roberts, M., Mitchell, T., & Wilke, N. G. (2023) · Adversity and Resilience Science · doi:10.1007/s42844-023-00088-y · Cited by 50 · see citing works
Allostasis, health, and development in Latin America
Migeot, J., Panesso, C., Duran-Aniotz, C., Ávila-Rincón, C., Ochoa, C., Huepe, D., Santamaría-García, H., Miranda, J. J., Escobar, M. J., Pina-Escudero, S., et al. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105697 · Cited by 25 · see citing works
- Authors
- Lund, J. I., Toombs, E., Radford, A., Boles, K., & Mushquash, C.
- Affiliations
- Lakehead University (CA)
- Thunder Bay Regional Health Sciences Centre (CA)
- Corresponding author
- Lund, Jessie I.
- Venue
- Child Abuse & Neglect
- Publisher
- Elsevier BV
- Published
- 2020-08
- Volume
- 106
- Pages
- 104485
- ISSN
- 0145-2134 (ISSN-L)
- OpenAlex
- W3023074219
- Semantic Scholar
- 70588ffb0eadf9c796c2b27687a5bbe7fdc3b8b9
- Cited by
- 211
- References
- 67
- Citations by year
- 2026: 37 · 2025: 66 · 2024: 48 · 2023: 23 · 2022: 18 · 2021: 15 · 2020: 2
- FWCI
- 1.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Child Abuse & Neglect (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Social Sciences › Safety Research › Child Welfare and Adoption
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Keywords
- adverse childhood experiences, executive function, child abuse, child neglect, intimate partner violence exposure, maternal depression, child mental health, early childhood experiences
- MeSH terms
- Intimate Partner Violence, Adverse Childhood Experiences, Adult, Mental Disorders, Child, Child Abuse, Child, Preschool, Family, Humans, Male, Executive Function
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review