The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Immunological Consequences of Intestinal Fungal Dysbiosis
Open accessAbstract
Compared to bacteria, the role of fungi within the intestinal microbiota is poorly understood. In this study we investigated whether the presence of a “healthy” fungal community in the gut is important for modulating immune function. Prolonged oral treatment of mice with antifungal drugs resulted in increased disease severity in acute and chronic models of colitis, and also exacerbated the development of allergic airway disease. Microbiota profiling revealed restructuring of fungal and bacterial communities. Specifically, representation of Candida spp. was reduced, while Aspergillus, Wallemia, and Epicoccum spp. were increased. Oral supplementation with a mixture of three fungi found to expand during antifungal treatment (Aspergillus amstelodami, Epicoccum nigrum, and Wallemia sebi) was sufficient to recapitulate the exacerbating effects of antifungal drugs on allergic airway disease. Taken together these results indicate that disruption of commensal fungal populations can influence local and peripheral immune responses and enhance relevant disease states.
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Citations
Cites
The impact of the gut microbiota on human health: an integrative view
Clemente, J. C., Ursell, L. K., Parfrey, L. W., & Knight, R. (2012) · Cell · doi:10.1016/j.cell.2012.01.035 · Cited by 3,710
The interplay between the intestinal microbiota and the brain
Collins, S. M., Surette, M., & Bercik, P. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2876 · Cited by 1,611 · cited 2×
“Microbial communities associated with mucosal surfaces of the body play essential roles in diverse biological processes ranging from digestion to behavior and are increasingly recognized as integral components of normal physiology (Clemente et al., 2012; Collins et al., 2012).”
BackgroundCharacterization of the oral fungal microbiome (mycobiome) in healthy individuals
Ghannoum, M. A., Jurevic, R. J., Mukherjee, P. K., Cui, F., Sikaroodi, M., Naqvi, A., & Gillevet, P. M. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1000713 · Cited by 1,150 · cited 1×
“These fungi are also consistently found at low levels in human stool samples by mycobiota sequencing (unpublished observations) and have been found in oral mycobiome studies (Dupuy et al., 2014; Ghannoum et al., 2010).”
BackgroundInteractions between commensal fungi and the C-type lectin receptor Dectin-1 influence colitis
Iliev, I. D., Funari, V. A., Taylor, K. D., Nguyen, Q., Reyes, C. N., Strom, S. P., Brown, J., Becker, C. A., Fleshner, P. R., Dubinsky, M., et al. (2012) · Science · doi:10.1126/science.1221789 · Cited by 1,073
Self-citationActivation of HIF-1α and LL-37 by commensal bacteria inhibits Candida albicans colonization
Fan, D., Coughlin, L. A., Neubauer, M. M., Kim, J., Kim, M. S., Zhan, X., Simms-Waldrip, T. R., Xie, Y., Hooper, L. V., & Koh, A. Y. (2015) · Nature Medicine · doi:10.1038/nm.3871 · Cited by 426 · cited 1×
“Fungal and bacterial populations occupy similar spaces in the gut and can influence each other (Erb Downward et al., 2013; Fan et al., 2015; Mason et al., 2012).”
BackgroundKim, Y.-G., Udayanga, K. G. S., Totsuka, N., Weinberg, J. B., Núñez, G., & Shibuya, A. (2014) · Cell Host & Microbe · doi:10.1016/j.chom.2013.12.010 · Cited by 366
Tang, C., Kamiya, T., Liu, Y., Kadoki, M., Kakuta, S., Oshima, K., Hattori, M., Takeshita, K., Kanai, T., Saijo, S., et al. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.07.003 · Cited by 285
Semic-Jusufagic, A., Belgrave, D., Pickles, A., Telcian, A. G., Bakhsoliani, E., Sykes, A., Simpson, A., Johnston, S. L., & Custovic, A. (2014) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(14)70096-7 · Cited by 95
Microbiome influences on allergy in mice and humans
Marsland, B. J., & Salami, O. (2015) · Current Opinion in Immunology · doi:10.1016/j.coi.2015.07.005 · Cited by 49
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Gut microbiota and IBD: causation or correlation?
Ni, J., Wu, G. D., Albenberg, L., & Tomov, V. T. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.88 · Cited by 1,778
Microbiota: a key orchestrator of cancer therapy
Roy, S., & Trinchieri, G. (2017) · Nature Reviews Cancer · doi:10.1038/nrc.2017.13 · Cited by 883
Sartor, R. B., & Wu, G. D. (2017) · Gastroenterology · doi:10.1053/j.gastro.2016.10.012 · Cited by 808
The influence of the microbiome on respiratory health
Wypych, T. P., Wickramasinghe, L. C., & Marsland, B. J. (2019) · Nature Immunology · doi:10.1038/s41590-019-0451-9 · Cited by 611
Intestinal flora and disease mutually shape the regional immune system in the intestinal tract
Zhou, B., Yuan, Y., Zhang, S., Guo, C., Li, X., Li, G., Xiong, W., & Zeng, Z. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00575 · Cited by 396
Commensal Fungi in Health and Disease
Limon, J. J., Skalski, J. H., & Underhill, D. M. (2017) · Cell Host & Microbe · doi:10.1016/j.chom.2017.07.002 · Cited by 336
Self-citationHuang, Y. J., Marsland, B. J., Bunyavanich, S., O'Mahony, L., Leung, D. Y. M., Muraro, A., & Fleisher, T. A. (2017) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2017.02.007 · Cited by 330
Mucosal fungi promote gut barrier function and social behavior via Type 17 immunity
Leonardi, I., Gao, I. H., Lin, W.-Y., Allen, M., Li, X. V., Fiers, W. D., De Celie, M. B., Putzel, G. G., Yantiss, R. K., Johncilla, M., et al. (2022) · Cell · doi:10.1016/j.cell.2022.01.017 · Cited by 307
Self-citationCX3CR1 + mononuclear phagocytes control immunity to intestinal fungi
Leonardi, I., Li, X., Semon, A., Li, D., Doron, I., Putzel, G., Bar, A., Prieto, D., Rescigno, M., McGovern, D. P. B., et al. (2018) · Science · doi:10.1126/science.aao1503 · Cited by 289
Self-citationGut Mycobiota in Immunity and Inflammatory Disease
Li, X. V., Leonardi, I., & Iliev, I. D. (2019) · Immunity · doi:10.1016/j.immuni.2019.05.023 · Cited by 246
Self-citationGut microbiome modulates efficacy of immune checkpoint inhibitors
Yi, M., Yu, S., Qin, S., Liu, Q., Xu, H., Zhao, W., Chu, Q., & Wu, K. (2018) · Journal of Hematology & Oncology · doi:10.1186/s13045-018-0592-6 · Cited by 179
Vemuri, R., Shankar, E. M., Chieppa, M., Eri, R., & Kavanagh, K. (2020) · Microorganisms · doi:10.3390/microorganisms8040483 · Cited by 162
Lionakis, M. S., Iliev, I. D., & Hohl, T. M. (2017) · JCI Insight · doi:10.1172/jci.insight.93156 · Cited by 153
Self-citationMechanistic insight into the function of the microbiome in lung diseases
Ubags, N. D. J., & Marsland, B. J. (2017) · European Respiratory Journal · doi:10.1183/13993003.02467-2016 · Cited by 109
“ Candida Albicans Interactions With The Host: Crossing The Intestinal Epithelial Barrier”
Basmaciyan, L., Bon, F., Paradis, T., Lapaquette, P., & Dalle, F. (2019) · Tissue Barriers · doi:10.1080/21688370.2019.1612661 · Cited by 89
Mining the oral mycobiome: Methods, components, and meaning
Diaz, P. I., Hong, B.-Y., Dupuy, A. K., & Strausbaugh, L. D. (2017) · Virulence · doi:10.1080/21505594.2016.1252015 · Cited by 87
One population, multiple lifestyles: Commensalism and pathogenesis in the human mycobiome
Proctor, D. M., Drummond, R. A., Lionakis, M. S., & Segre, J. A. (2023) · Cell Host & Microbe · doi:10.1016/j.chom.2023.02.010 · Cited by 68
C-type lectin receptor-mediated immune recognition and response of the microbiota in the gut
Li, T.-H., Liu, L., Hou, Y.-Y., Shen, S.-N., & Wang, T.-T. (2019) · Gastroenterology Report · doi:10.1093/gastro/goz028 · Cited by 58
Zhang, I., Pletcher, S. D., Goldberg, A. N., Barker, B. M., & Cope, E. K. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.02477 · Cited by 51
A closer look at the mycobiome in Alzheimer’s disease: Fungal species, pathogenesis and transmission
Phuna, Z. X., & Madhavan, P. (2022) · European Journal of Neuroscience · doi:10.1111/ejn.15599 · Cited by 41
Metagenomic symphony of the intestinal ecosystem: How the composition affects the mind
Malan-Müller, S., Martín-Hernández, D., Caso, J. R., Matthijnssens, J., Rodríguez-Urrutia, A., Lowry, C. A., & Leza, J. C. (2025) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2024.09.033 · Cited by 24
Probiotics in inflammatory bowel disease: Does it work?
Silva, N. O. E., Brito, B. B. D., Silva, F. A. F. D., Santos, M. L. C., & Melo, F. F. D. (2020) · World Journal of Meta-Analysis · doi:10.13105/wjma.v8.i2.54 · Cited by 17
Tissue-resident memory T cells in antifungal immunity.
LeibundGut-Landmann, S. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.693055 · Cited by 10
Metadata
- Authors
- Wheeler, M. L., Limon, J. J., Bar, A. S., Leal, C. A., Gargus, M., Tang, J., Brown, J., Funari, V. A., Wang, H. L., Crother, T. R., Arditi, M., Underhill, D. M., & Iliev, I. D.
- Venue
- Cell Host & Microbe
- Publisher
- Elsevier BV
- Published
- 2016-06
- Volume
- 19
- Issue
- 6
- Pages
- 865-873
- ISSN
- 1931-3128 (ISSN-L)
- OpenAlex
- W2396765784
- Cited by
- 422
- References
- 9
- FWCI
- 19.26
- Type
- journal article
- Language
- en
- Open access
- bronze
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