Cited by 693Gut microbiota and healthMicrobial Community Ecology and PhysiologyGastrointestinal motility and disorders

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The Gut Microbiome: Connecting Spatial Organization to Function

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Tropini, Carolina, Earle, Kristen A., Huang, Kerwyn Casey, Sonnenburg, Justin L.·2017·Cell Host & Microbe

DOI 10.1016/j.chom.2017.03.010PMC PMC5576359

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Abstract

The first rudimentary evidence that the human body harbors a microbiota hinted at the complexity of host-associated microbial ecosystems. Now, almost 400 years later, a renaissance in the study of microbiota spatial organization, driven by coincident revolutions in imaging and sequencing technologies, is revealing functional relationships between biogeography and health, particularly in the vertebrate gut. In this Review, we present our current understanding of principles governing the localization of intestinal bacteria, and spatial relationships between bacteria and their hosts. We further discuss important emerging directions that will enable progressing from the inherently descriptive nature of localization and -omics technologies to provide functional, quantitative, and mechanistic insight into this complex ecosystem.

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Authors: Tropini, C., Earle, K. A., Huang, K. C., & Sonnenburg, J. L.
Affiliations: Stanford Medicine (US)
Stanford University (US)
Corresponding author: Huang, Kerwyn Casey
Sonnenburg, Justin L.
ORCID: Tropini, Carolina
Earle, Kristen A.
Huang, Kerwyn Casey
Sonnenburg, Justin L.
Venue: Cell Host & Microbe
Publisher: Elsevier BV
Published: 2017-04
Volume: 21
Issue: 4
Pages: 433-442
ISSN: 1931-3128 (ISSN-L)
DOI: 10.1016/j.chom.2017.03.010
PMC: PMC5576359
OpenAlex: W2606802599
Cited by: 685
References: 107
Citations by year: 2026: 71 · 2025: 86 · 2024: 79 · 2023: 80 · 2022: 84 · 2021: 99 · 2020: 84 · 2019: 54 · 2018: 36 · 2017: 11
FWCI: 4.76
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 376 d)
Locations: Cell Host & Microbe (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: NSF CAREER Award (MCB-1149328)
James S. McDonnell Studying Complex Systems Postdoctoral Fellowship (R01-DK101674, R01-DK085025)
National Institutes of Health NIDDK
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Physical Sciences › Environmental Science › Ecology › Microbial Community Ecology and Physiology
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords: gut microbiota, host-microbe interactions
MeSH terms: Gastrointestinal Microbiome, Animals, Bacteria, Humans, Ecosystem, Bacterial Physiological Phenomena, Gastrointestinal Tract, Microbiota

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The Gut Microbiome: Connecting Spatial Organization to Function

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