Cited by 191Infant Nutrition and HealthGut microbiota and healthProbiotics and Fermented Foods

Supplementation with a probiotic mixture accelerates gut microbiome maturation and reduces intestinal inflammation in extremely preterm infants

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Samara, Jumana, Moossavi, Shirin, Alshaikh, Belal, Ortega, Van A., Pettersen, Veronika Kuchařová, Ferdous, Tahsin, Hoops, Suzie L., Soraisham, Amuchou +10 more·2022·Cell Host & Microbe

Abstract

Probiotics are increasingly administered to premature infants to prevent necrotizing enterocolitis and neonatal sepsis. However, their effects on gut microbiome assembly and immunity are poorly understood. Using a randomized intervention trial in extremely premature infants, we tested the effects of a probiotic product containing four strains of Bifidobacterium species autochthonous to the infant gut and one Lacticaseibacillus strain on the compositional and functional trajectory of microbiome. Daily administration of the mixture accelerated the transition into a mature, term-like microbiome with higher stability and species interconnectivity. Besides infant age, Bifidobacterium strains and stool metabolites were the best predictors of microbiome maturation, and structural equation modeling confirmed probiotics as a major determinant for the trajectory of microbiome assembly. Bifidobacterium-driven microbiome maturation was also linked to an anti-inflammatory intestinal immune milieu. This demonstrates that Bifidobacterium strains are ecosystem engineers that lead to an acceleration of microbiome maturation and immunological consequences in extremely premature infants.

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Crossref · 10.1016/j.chom.2022.04.005

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Authors
Samara, J., Moossavi, S., Alshaikh, B., Ortega, V. A., Pettersen, V. K., Ferdous, T., Hoops, S. L., Soraisham, A., Vayalumkal, J., Dersch-Mills, D., Gerber, J. S., Mukhopadhyay, S., Puopolo, K., Tompkins, T. A., Knights, D., Walter, J., Amin, H., & Arrieta, M.-C.
Affiliations
  • University of Calgary (CA)
  • University of Minnesota (US)
  • Children's Hospital of Philadelphia (US)
  • Lallemand (Canada) (CA)
  • University College Cork (IE)
Corresponding author
Arrieta, Marie-Claire
Venue
Cell Host & Microbe
Publisher
Elsevier BV
Published
2022-05
Volume
30
Issue
5
Pages
696-711.e5
ISSN
1931-3128 (ISSN-L)
OpenAlex
W4280585986
Cited by
191
References
93
Citations by year
2026: 36 · 2025: 50 · 2024: 50 · 2023: 46 · 2022: 9
FWCI
23.89
Type
journal article
Language
en
Open access
Locations
  • Cell Host & Microbe (publishedVersion)
  • PubMed (publishedVersion)
  • NORA - Norwegian Open Research Archives (submittedVersion, other-oa)
Funders
  • Alberta Children's Hospital Research Institute
  • Cumming School of Medicine, University of Calgary
  • Canadian Institutes of Health Research
  • Science Foundation Ireland (19/RP/6853, APC/SFI/12/RC/2273_P2)
  • Mitacs
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Keywords
probiotics, extremely preterm infants, Bifidobacterium, Lacticaseibacillus, intestinal inflammation, necrotizing enterocolitis, neonatal sepsis, microbiome assembly, fecal metabolites, intestinal immunity, microbiome stability
MeSH terms
Gastrointestinal Microbiome, Bifidobacterium, Humans, Infant, Infant, Newborn, Inflammation, Ecosystem, Probiotics, Infant, Extremely Premature

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