Letter to the Editor: Is nutritional support effective in malnourished polymorbid medical inpatients?
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The Gressies et al. 2022 meta-analysis included trials exclusively conducted within the population of polymorbid patients using the exact same definition as used in this guideline.
“A meta-analysis by Gressies et al. conducted in 2022 that was an update and re-analysis of Gomes et al. included trials exclusively conducted within the population of polymorbid patients using the exact same definition as used in this guideline.”
From ESPEN guideline on nutritional support for polymorbid medical inpatients (2023) · cites this paper as [36]
The Gressies et al. analysis showed a significant reduction in mortality risk (OR 0.68; 95% CI 0.51 to 0.91).
“The analysis showed again a significant reduction in mortality risk (OR 0.68; 95% CI 0.51e0.91)(Fig. 1) and hospital readmissions (OR 0.64; 95% CI 0.45e0.90)proofing the effectiveness of nutritional”
From ESPEN guideline on nutritional support for polymorbid medical inpatients (2023) · cites this paper as [36]
The Gressies et al. analysis showed a significant reduction in hospital readmissions (OR 0.64; 95% CI 0.45 to 0.90).
“The analysis showed again a significant reduction in mortality risk (OR 0.68; 95% CI 0.51e0.91)(Fig. 1) and hospital readmissions (OR 0.64; 95% CI 0.45e0.90)proofing the effectiveness of nutritional”
From ESPEN guideline on nutritional support for polymorbid medical inpatients (2023) · cites this paper as [36]
There is strong evidence from large RCTs that polymorbid patients at risk for malnutrition benefit from nutritional support.
“There is strong evidence from large RCTs that polymorbid patients at risk for malnutrition benefit from nutritional support [36].”
From ESPEN guideline on nutritional support for polymorbid medical inpatients (2023) · cites this paper as [36]
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ESPEN guidelines on nutritional support for polymorbid internal medicine patients
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ESPEN guideline on nutritional support for polymorbid medical inpatients
Wunderle, C., Gomes, F., Schuetz, P., Stumpf, F., Austin, P., Ballesteros-Pomar, M. D., Cederholm, T., Fletcher, J., Laviano, A., Norman, K., et al. (2023) · Clinical Nutrition · doi:10.1016/j.clnu.2023.06.023 · Cited by 105 · see citing works
“…again a signi fi cant reduction in mortality risk (OR 0.68; 95% CI 0.51 e 0.91) (Fig.1) and hospital readmissions (OR 0.64; 95% CI 0.45 e 0.90) proo fi ng the effectiveness of nutritional support in this vulnerable patient group with complex combinations of diagnoses [36] ( Level of evidence 1 þþ ).”
InfluentialSelf-citationESPEN practical guideline: Nutritional support for polymorbid medical inpatients
Wunderle, C., Gomes, F., Schüetz, P., Stumpf, F., Austin, P. D., Ballesteros-Pomar, M. D., Cederholm, T., Fletcher, J. M., Laviano, A., Norman, K., et al. (2024) · Clinical Nutrition · doi:10.1016/j.clnu.2024.01.008 · Cited by 48 · see citing works
Self-citationWunderle, C., Martin, E., Wittig, A., Tribolet, P., Lutz, T. A., Köster-Hegmann, C., Stanga, Z. G., Müeller, B., & Schüetz, P. (2025) · Journal of Inflammation · doi:10.1186/s12950-025-00442-0 · Cited by 33 · see citing works
Enteral nutrition in hospitalized adults
Gramlich, L., & Guenter, P. (2025) · New England Journal of Medicine · doi:10.1056/nejmra2406954 · Cited by 30 · see citing works
Gómez, J. J. L., Bachiller, B. R., & de Luis, D. A. (2024) · Postgraduate Medicine · doi:10.1080/00325481.2024.2307869 · Cited by 5 · see citing works
- Authors
- Gressies, C., Kaegi-Braun, N., Gomes, F., & Schuetz, P.
- Affiliations
- Justus-Liebig-Universität Gießen (DE)
- Kantonsspital Aarau (CH)
- New York Academy of Sciences (US)
- Venue
- Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2023-01
- Volume
- 42
- Issue
- 1
- Pages
- 45-52
- ISSN
- 0261-5614 (ISSN-L)
- OpenAlex
- W4309341818
- Cited by
- 5
- References
- 23
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 1
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Forschungsrat des Kantonsspitals Aarau (1410.000.044)
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (PP00P3_150531/1)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Health Sciences › Medicine › Nephrology › Dialysis and Renal Disease Management
- Keywords
- nutritional support, malnutrition, multimorbidity, medical inpatients, mortality, clinical outcomes, guideline recommendations, health care costs
- MeSH terms
- Humans, Inpatients, Nutritional Status, Nutritional Support, Malnutrition
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