Cited by 41Hypothalamic control of reproductive hormonesCircadian rhythm and melatoninReproductive Biology and Fertility

Integration of Circadian and Metabolic Control of Reproductive Function

Evans, Maggie C, Anderson, Greg M·2018·Endocrinology

Abstract

Optimal fertility in humans and animals relies on the availability of sufficient metabolic fuels, information about which is communicated to the brain via levels of the hormones leptin and insulin. The circadian clock system is also critical; this input is especially evident in the precise timing of the female-specific surge of GnRH and LH secretion that triggers ovulation the next day. Chronodisruption and metabolic imbalance can both impair reproductive activity, and these two disruptions exacerbate each other, such that they often occur simultaneously. Kisspeptin neurons located in the anteroventral periventricular nucleus of the hypothalamus are able to integrate both circadian and metabolic afferent inputs and use this information to modulate the timing and magnitude of the preovulatory GnRH/LH surge. In an environment in which exposure to high caloric diets and chronodisruptors such as artificial night lighting, shift work, and transmeridian travel have become the norm, the implications of these factors for couples struggling to conceive deserve closer attention and more public education.

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Crossref · 10.1210/en.2018-00691

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Authors
Evans, M. C., & Anderson, G. M.
Affiliations
University of Otago (NZ)
Corresponding author
Anderson, Greg M
Venue
Endocrinology
Published
2018-10-09
Volume
159
Issue
11
Pages
3661-3673
ISSN
  • 0013-7227 (ISSN-L)
  • 1945-7170
OpenAlex
W2898208092
Cited by
41
References
175
Citations by year
2026: 2 · 2025: 4 · 2024: 2 · 2023: 5 · 2022: 3 · 2021: 7 · 2020: 9 · 2019: 8
FWCI
0.91
Type
journal article
Language
en
Open access
closed
Locations
  • Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
Keywords
circadian clock, metabolic control, reproductive function, kisspeptin neurons, GnRH surge, luteinizing hormone surge, ovulation, leptin, insulin, circadian rhythm disruption, artificial night lighting, shift work, transmeridian travel, female fertility, hypothalamus
MeSH terms
Shift Work Schedule, Animals, Circadian Rhythm, Fertility, Humans, Hypothalamus, Anterior, Infertility, Insulin, Luteinizing Hormone, Gonadotropin-Releasing Hormone, Lighting, Neurons, Ovulation, Reproduction, Travel, Leptin, Kisspeptins

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