Integration of Circadian and Metabolic Control of Reproductive Function
Abstract
Optimal fertility in humans and animals relies on the availability of sufficient metabolic fuels, information about which is communicated to the brain via levels of the hormones leptin and insulin. The circadian clock system is also critical; this input is especially evident in the precise timing of the female-specific surge of GnRH and LH secretion that triggers ovulation the next day. Chronodisruption and metabolic imbalance can both impair reproductive activity, and these two disruptions exacerbate each other, such that they often occur simultaneously. Kisspeptin neurons located in the anteroventral periventricular nucleus of the hypothalamus are able to integrate both circadian and metabolic afferent inputs and use this information to modulate the timing and magnitude of the preovulatory GnRH/LH surge. In an environment in which exposure to high caloric diets and chronodisruptors such as artificial night lighting, shift work, and transmeridian travel have become the norm, the implications of these factors for couples struggling to conceive deserve closer attention and more public education.
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Hyperinsulinemia can interfere with GnRH signaling, resulting in higher LH levels and more frequent and intense GnRH pulses.
“Hyperinsulinemia can interfere with the signaling of GnRH, resulting in higher levels of LH and more frequent and intense GnRH pulses [57].”
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Role of insulin in the neuroendocrine control of reproduction
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沖縄「基地…軍隊を許さない行動する女たちの会」にみる安全保障の再定義にむけた女性の主体的行動
秋林, こ. (2003) · 日本女子大学総合研究所紀要
Lord, R. A., Inglis, M. A., Juengel, J. L., & Anderson, G. M. (2025) · Endocrinology · doi:10.1210/endocr/bqaf058
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Beyond comfort: Basic environmental enrichment accelerates sexual development in mouse pups
Luque, E. M., Inés, C. V., Carlini, V. P., Torres, P. J., David, R. N., Ponzio, M. F., & Carolina, M. A. (2026) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2026.107918
- Authors
- Evans, M. C., & Anderson, G. M.
- Affiliations
- University of Otago (NZ)
- Corresponding author
- Anderson, Greg M
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 2018-10-09
- Volume
- 159
- Issue
- 11
- Pages
- 3661-3673
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W2898208092
- Cited by
- 41
- References
- 175
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 2 · 2023: 5 · 2022: 3 · 2021: 7 · 2020: 9 · 2019: 8
- FWCI
- 0.91
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Keywords
- circadian clock, metabolic control, reproductive function, kisspeptin neurons, GnRH surge, luteinizing hormone surge, ovulation, leptin, insulin, circadian rhythm disruption, artificial night lighting, shift work, transmeridian travel, female fertility, hypothalamus
- MeSH terms
- Shift Work Schedule, Animals, Circadian Rhythm, Fertility, Humans, Hypothalamus, Anterior, Infertility, Insulin, Luteinizing Hormone, Gonadotropin-Releasing Hormone, Lighting, Neurons, Ovulation, Reproduction, Travel, Leptin, Kisspeptins
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