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Cellular Fatty Acid Metabolism and Cancer
Open accessAbstract
Cancer cells often have characteristic changes in metabolism. Cellular proliferation, a common feature of all cancers, requires fatty acids for synthesis of membranes and signaling molecules. Here, we provide a view of cancer cell metabolism from a lipid perspective, and we summarize evidence that limiting fatty acid availability can control cancer cell proliferation.
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“For example, expression of ACLY, a key enzyme in the shift from the TCA cycle to lipid formation that has been shown to cause lipid droplet accumulation42, is significantly higher in LDAM than in microglia without lipid droplets.”
From Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain (2020) · cites this paper as [42]
Experimental — accuracy not yet measuredIn the citing paper
“Fatty acid synthesis is an anabolic process that uses cytosolic citrate to produce acetyl-CoA73.”
From Glutamine reliance in cell metabolism (2020) · cites this paper as [73]
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“Next, mitochondrial citrate is transported across the inner mitochondrial membrane via a citrate carrier (CIC or SLC25A1) to support fatty acid synthesis for tumor progression in hypoxia73 (Fig. 4).”
From Glutamine reliance in cell metabolism (2020) · cites this paper as [73]
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“PHD3 is suppressed in cancers that rely on FAO, such as AML and prostate cancer, and elevated in cancers that rely on FAS such as breast and non-small-lung-cell cancer.55–57”
From The multifaceted contributions of mitochondria to cellular metabolism (2018) · cites this paper as [56]
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Cites
Warburg, O. (1956) · Science · doi:10.1126/science.123.3191.309 · Cited by 13,425
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver
Horton, J. D., Goldstein, J. L., & Brown, M. S. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15593 · Cited by 4,794
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver
Horton, J. D., Goldstein, J. L., & Brown, M. S. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215593 · Cited by 4,092
Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis
Menendez, J. A., & Lupu, R. (2007) · Nature Reviews Cancer · doi:10.1038/nrc2222 · Cited by 2,941
DeBerardinis, R. J., Mancuso, A., Daikhin, E., Nissim, I., Yudkoff, M., Wehrli, S., & Thompson, C. B. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709747104 · Cited by 2,622
Cancer cell metabolism: warburg and beyond
Hsu, P. P., & Sabatini, D. M. (2008) · Cell · doi:10.1016/j.cell.2008.08.021 · Cited by 2,452 · cited 1×
“A better understanding of these metabolic changes has prompted new approaches toward cancer therapy (reviewed in Hsu and Sabatini, 2008; Schulze and Harris, 2012).”
BackgroundATP-citrate lyase links cellular metabolism to histone acetylation
Wellen, K. E., Hatzivassiliou, G., Sachdeva, U. M., Bui, T. V., Cross, J. R., & Thompson, C. B. (2009) · Science · doi:10.1126/science.1164097 · Cited by 2,298
Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth
Nieman, K. M., Kenny, H. A., Penicka, C. V., Ladanyi, A., Buell-Gutbrod, R., Zillhardt, M. R., Romero, I. L., Carey, M. S., Mills, G. B., Hotamisligil, G. S., et al. (2011) · Nature Medicine · doi:10.1038/nm.2492 · Cited by 2,279
Wise, D. R., DeBerardinis, R. J., Mancuso, A., Sayed, N., Zhang, X.-Y., Pfeiffer, H. K., Nissim, I., Daikhin, E., Yudkoff, M., McMahon, S. B., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810199105 · Cited by 2,001
Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia
Metallo, C. M., Gameiro, P. A., Bell, E. L., Mattaini, K. R., Yang, J., Hiller, K., Jewell, C. M., Johnson, Z. R., Irvine, D. J., Guarente, L., et al. (2012) · Nature · doi:10.1038/nature10602 · Cited by 1,791
Cited by
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Items 901–1,000 of 1,000
Ye, J., Cai, S., Feng, Y., Li, J., Cai, Z., Deng, Y., Liu, R., Zhu, X., Lü, J., Zhuo, Y., et al. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01516-2 · Cited by 25
Lipid metabolism analysis in esophageal cancer and associated drug discovery
Jiao, R., Jiang, W. B., Xu, K., Luo, Q., Wang, L., & Zhao, C. (2023) · Journal of Pharmaceutical Analysis · doi:10.1016/j.jpha.2023.08.019 · Cited by 25
Translational control by mTOR-independent routes: how eIF6 organizes metabolism
Miluzio, A., Ricciardi, S., Manfrini, N., Alfieri, R. R., Oliveto, S., Brina, D., & Biffo, S. (2016) · Biochemical Society Transactions · doi:10.1042/bst20160179 · Cited by 24
Hepatoblastomas exhibit marked NNMT downregulation driven by promoter DNA hypermethylation
Rivas, M. P., Aguiar, T. F. M., Maschietto, M. C., Lemes, R. B., de Caires-Junior, L. C., Goulart, E., Telles-Silva, K. A., Novak, E. M., Cristófani, L. M., Filho, V. O., et al. (2020) · Tumor Biology · doi:10.1177/1010428320977124 · Cited by 24
Mou, L., Pu, Z., Luo, Y., Quan, R., So, Y., & Jiang, H. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1036562 · Cited by 23
Liu, H., Liu, Y., Zhou, Y., Chen, X., Pan, S., Zhou, Q., Ji, H., & Zhu, X. (2024) · Cell Death Discovery · doi:10.1038/s41420-024-01975-8 · Cited by 25
Novel strategies to overcome chemoresistance in human glioblastoma
Tang, Q., Ren, T., Bai, P., Wang, X., Zhao, L., Zhong, R., & Sun, G. (2024) · Biochemical Pharmacology · doi:10.1016/j.bcp.2024.116588 · Cited by 24
Shen, M., Tsai, Y., Zhu, R., Keng, P. C., Chen, Y., Chen, Y., & Lee, S. O. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2017.12.012 · Cited by 23
RetractedZhang, J., Zhou, Y., Yu, Z., Chen, A., Yu, Y., Wang, X., & Cao, X. (2019) · Bioscience Reports · doi:10.1042/bsr20190019 · Cited by 23
Jiang, Y., Tang, Y., Wang, S., Wu, J., Zhang, M., Pang, X., Wu, J., Chen, Y., Tang, Y., & Liang, X. (2019) · Cell Proliferation · doi:10.1111/cpr.12705 · Cited by 23
The fuel and engine: The roles of reprogrammed metabolism in metastasis of primary liver cancer
Zhu, W., Lü, M., Wang, X., Xu, Z., Gao, C., & Qin, L. (2020) · Genes & Diseases · doi:10.1016/j.gendis.2020.01.016 · Cited by 25
Biological roles of Yin Yang 2: Its implications in physiological and pathological events
Li, L., Li, Y., Meliala, I. T. S., Kasim, V., & Wu, S. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.15919 · Cited by 23
Role of Protein Kinase CK2 in Aberrant Lipid Metabolism in Cancer
Guerra, B., & Issinger, O. (2020) · Pharmaceuticals · doi:10.3390/ph13100292 · Cited by 25
Fan, Y., Li, X., Tian, L., & Wang, J. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.630905 · Cited by 23
Autophagy mediated lipid catabolism facilitates glioma progression to overcome bioenergetic crisis
Wang, C., Haas, M. A., Yeo, S. K., Paul, R., Yang, F., Vallabhapurapu, S., Qi, X., Plas, D. R., & Guan, J. (2021) · British Journal of Cancer · doi:10.1038/s41416-021-01294-0 · Cited by 23
Wang, W., Liu, Z., Chen, X., Lu, Y., Wang, B., Li, F., Lu, S., & Zhou, X. (2021) · DNA and Cell Biology · doi:10.1089/dna.2021.0370 · Cited by 23
Metabolic profiling analysis for clinical urine of colorectal cancer
Ning, W., Qiao, N., Zhang, X., Pei, D.-P., & Wang, W. (2021) · Asia-Pacific Journal of Clinical Oncology · doi:10.1111/ajco.13591 · Cited by 24
Yu, C., Niu, L., Luo, L., Li, T., Duan, L., He, Z., Zhao, Y. F., Zou, L., Wu, X., & Luo, C. (2021) · The Prostate · doi:10.1002/pros.24229 · Cited by 23
ACSL1 Inhibits ALV-J Replication by IFN-Ⅰ Signaling and PI3K/Akt Pathway
Zhang, Q., Xie, T., Mo, G., Zhang, Z., Lin, L., & Zhang, X. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.774323 · Cited by 23
DECR1 directly activates HSL to promote lipolysis in cervical cancer cells
Zhou, H., Zhang, J., Yan, Z., Qu, M., Zhang, G., Han, J., Wang, F., Sun, K., Wang, L., & Yang, X. (2021) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2021.159090 · Cited by 22
Wu, H., Cheng, H. D., Luo, S., Peng, C., Zhou, A., Chen, Z., Wu, H. W., & Li, Q. (2022) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2022.114654 · Cited by 23
Liu, T., Yu, J., Ge, C., Zhao, F., Chen, J., Miao, C., Jin, W., Zhou, Q., Qin, G., Lin, H., et al. (2022) · Cancer Letters · doi:10.1016/j.canlet.2022.215642 · Cited by 23
Mokhtari, K., Mahdevar, M., Hajipour, M., Esmaeili, M., Peymani, M., Mirzaei, S., Nasr‐Esfahani, M. H., Hashemi, M., Hushmandi, K., & Ghaedi, K. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113338 · Cited by 24
Lipids for CD8+ TILs: Beneficial or harmful?
Wu, D., & Chen, Y. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1020422 · Cited by 24
Biological Role and Mechanism of Lipid Metabolism Reprogramming Related Gene ECHS1 in Cancer
Hu, T., Chen, X., Lu, S., Zeng, H., Guo, L., & Han, Y. (2022) · Technology in Cancer Research & Treatment · doi:10.1177/15330338221140655 · Cited by 24
The endocannabinoid system, a new gatekeeper in the pharmacology of human hepatocellular carcinoma
Ebrahimi, N., Far, N. P., Fakhr, S. S., Faghihkhorasani, F., Miraghel, S. A., Chaleshtori, S. R., Rezaei‐Tazangi, F., Beiranvand, S., Baziyar, P., Manavi, M. S., et al. (2023) · Environmental Research · doi:10.1016/j.envres.2023.115914 · Cited by 24
Choa, R., Panaroni, C., Bhatia, R., & Raje, N. S. (2023) · Blood Advances · doi:10.1182/bloodadvances.2023010822 · Cited by 23
Obesity does not promote tumorigenesis of localized patient-derived prostate cancer xenografts
Lo, J. C. Y., Clark, A. K., Ascui, N., Frydenberg, M., Risbridger, G. P., Taylor, R. A., & Watt, M. J. (2016) · Oncotarget · doi:10.18632/oncotarget.10258 · Cited by 23
Wei, Q., Mei, L., Yang, Y., Ma, H., Chen, H., Zhang, H., & Zhou, J. (2018) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2018.03.014 · Cited by 23
Fang, X. H., Sun, R. B., Hu, Y., Wang, H., Guo, Y., Yang, B., Pi, J., & Xu, Y. (2018) · Metallomics · doi:10.1039/c8mt00251g · Cited by 22
Ruidas, B., Chaudhury, S. S., Pal, K., Sarkar, P. K., & Mukhopadhyay, C. D. (2019) · Nanomedicine · doi:10.2217/nnm-2018-0187 · Cited by 23
Cannabinoid Signaling in Cancer
Das, S., Kaul, K., Mishra, S., Charan, M., & Ganju, R. K. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-21737-2_4 · Cited by 23
Identification of F5 as a Prognostic Biomarker in Patients with Gastric Cancer
Liu, Y., Liao, X., Qin, Y., Mo, X., & Luo, S. (2020) · BioMed Research International · doi:10.1155/2020/9280841 · Cited by 23
Cold-hearted: A case for cold stress in cancer risk
Bandyopadhayaya, S., Ford, B. M., & Mandal, C. C. (2020) · Journal of Thermal Biology · doi:10.1016/j.jtherbio.2020.102608 · Cited by 24
Glutaminase 1 inhibition reduces thymidine synthesis in NSCLC
Lee, J., Kang, J. H., Lee, S.-H., Lee, C. H., Son, J., & Kim, S. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.06.095 · Cited by 23
Panzilius, E., Holstein, F., Dehairs, J., Planque, M., von Toerne, C., Koenig, A.-C., Doll, S. G., Bannier-Hélaouët, M., Ganz, H. M., Hauck, S. M., et al. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/417949 · Cited by 24
Metabolic mechanisms of immunotherapy resistance
Cabezón‐Gutiérrez, L., Palka-Kotlowska, M., Custodio‐Cabello, S., Chacón-Ovejero, B., & Pacheco-Barcía, V. (2025) · Exploration of Targeted Anti-tumor Therapy · doi:10.37349/etat.2025.1002297 · Cited by 26
Halczy-Kowalik, L., Drozd, A., Stachowska, E., Drozd, R., Żabski, T., & Domagała, W. (2019) · PLoS ONE · doi:10.1371/journal.pone.0218246 · Cited by 22
Hsieh, C.-H., Cheung, C. H. Y., Liu, Y., Hou, C.-L., Hsu, C., Huang, C.-T., Yang, T., Chen, S., Chen, C., Hsu, W., et al. (2019) · Journal of Proteome Research · doi:10.1021/acs.jproteome.9b00245 · Cited by 22
Contribution of RAGE axis activation to the association between metabolic syndrome and cancer
Garay‐Sevilla, M. E., Gómez-Ojeda, A., González, I., Luévano‐Contreras, C., & Armando Rojas, R. (2021) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-020-04022-z · Cited by 22
Cornò, M. D., Varı́, R., Scazzocchio, B., Varano, B., Masella, R., & Conti, L. (2021) · Cells · doi:10.3390/cells10071738 · Cited by 22
Wang, M., Ye, Y., zhang, M.-J., Zhou, B., Wang, J., Song, Y., & Xia, W. (2021) · Clinical & Translational Oncology · doi:10.1007/s12094-021-02682-x · Cited by 22
Extracellular Vesicles in Cancer Metabolism: Implications for Cancer Diagnosis and Treatment
Zhang, Q., Yang, X., & Liu, H. (2021) · Technology in Cancer Research & Treatment · doi:10.1177/15330338211037821 · Cited by 22
Micallef, P., Wu, Y., Bauzá-Thorbrügge, M., Chanclón, B., Vujičić, M., Peris, E., Ek, C. J., & Asterholm, I. W. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111881 · Cited by 24
Targeting the metabolism of cancer stem cells by energy disruptor molecules
Dadgar, T., Ebrahimi, N., Gholipour, A. R., Akbari, M., Khani, L., Ahmadi, A., & Hamblin, M. R. (2021) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2021.103545 · Cited by 22
Type-2 diabetes mellitus-associated cancer risk: In pursuit of understanding the possible link
Vulichi, S. R., Runthala, A., Nagaraju, B., Kumar, R., Chunduri, V. R., Kapur, S., Chippada, A. R., & Sistla, D. S. M. (2022) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2022.102591 · Cited by 23
Huang, X., Sun, Y., Song, J., Huang, Y., Shi, H., Qian, A., Cao, Y., Zhou, Y., & Wang, Q. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1301452 · Cited by 22
Thomas, G., Brown, A. L., & Brown, J. M. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2014.01.004 · Cited by 22
Arlia‐Ciommo, A., Svistkova, V., Mohtashami, S., & Titorenko, V. I. (2015) · Oncotarget · doi:10.18632/oncotarget.6440 · Cited by 22
Activation of cellular metabolism during latent Kaposi's Sarcoma herpesvirus infection
Lagunoff, M. (2016) · Current Opinion in Virology · doi:10.1016/j.coviro.2016.06.012 · Cited by 22
Raman, V., Aryal, U. K., Hedrick, V., Mohallem, R., Fuentes, J. L., Stashenko, E. E., Levy, M., Levy, M. M., & Camarillo, I. G. (2018) · Journal of Proteome Research · doi:10.1021/acs.jproteome.8b00255 · Cited by 23
Diet-induced hepatic steatosis activates Ras to promote hepatocarcinogenesis via CPT1α
Xu, A., Wang, B., Fu, J., Qin, W., Yu, T., Yang, Z., Lu, Q., Chen, J., Chen, Y., & Wang, H. (2018) · Cancer Letters · doi:10.1016/j.canlet.2018.10.024 · Cited by 22
Blat, A., Wiercigroch, E., Smęda, M., Wislocka, A., Chłopicki, S., & Małek, K. (2019) · Journal of Biophotonics · doi:10.1002/jbio.201900067 · Cited by 22
Ismail, I. T., Fiehn, O., Elfert, A., Helal, M., Salama, I. A.-K., & El‐Said, H. (2020) · Cancers · doi:10.3390/cancers12020484 · Cited by 22
Wang, T., Wang, L., Wang, G., & Zhuang, Y. (2020) · Bioresources and Bioprocessing · doi:10.1186/s40643-020-00325-7 · Cited by 21
Buenger, E. W., & Reid, G. E. (2020) · European Journal of Mass Spectrometry · doi:10.1177/1469066720960341 · Cited by 22
Sholl, J., Mailing, L. J., & Wood, T. R. (2021) · mBio · doi:10.1128/mbio.00579-21 · Cited by 23
Mathan, S. V., & Singh, R. P. (2025) · Cancers · doi:10.3390/cancers17132100 · Cited by 24
Baldassarri, M., Fallerini, C., Cetta, F., Ghisalberti, M., Bellan, C., Furini, S., Spiga, O., Crispino, S., Gotti, G., Ariani, F., et al. (2017) · Cancer Research and Treatment · doi:10.4143/crt.2017.125 · Cited by 21
Bringing naturally-occurring saturated fatty acids into biomedical research
Xue, K., Lv, S., & Zhu, C. (2021) · Journal of Materials Chemistry B · doi:10.1039/d1tb00843a · Cited by 21
Recent Updates of Natural and Synthetic URAT1 Inhibitors and Novel Screening Methods
Chen, Y., You, R., Wang, K., & Wang, Y. (2021) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2021/5738900 · Cited by 21
Bao, G., Li, S., Zhao, F., Wang, J., Liu, X., Hu, J., Shi, B., Wen, Y., Zhao, L., & Luo, Y. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.847077 · Cited by 21
Tõkés, A., Vári-Kakas, S., Kulka, J., & Törőcsik, B. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.850401 · Cited by 21
Rossi, T., Zamponi, R., Chirico, M., Pisanu, M. E., Iorio, E., Torricelli, F., Gugnoni, M., Ciarrocchi, A., & Pistoni, M. (2023) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-022-02571-3 · Cited by 21
Pu, X., Wu, Y., Ji, Q., Fu, S., Zuo, H., Chu, L., Tang, H., Wan, M., Wang, X., & Xu, M. (2023) · International Journal of Oncology · doi:10.3892/ijo.2023.5523 · Cited by 22
Emerging insights into mechanisms of trastuzumab resistance in HER2-positive cancers
Wu, X., Huang, S., He, W., & Song, M. L. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110602 · Cited by 23
ACSL1-Mediated Fatty Acid β-Oxidation Enhances Metastasis and Proliferation in Endometrial Cancer
Zhou, Y., Li, Y., Chen, G., Guo, X., Gao, X. C., Meng, J., Xu, Y., Zhou, N., Zhang, B., & Zhou, X. (2024) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2902066 · Cited by 21
Malatesti, N., Harej, A., Pavelić, S. K., Lončarić, M., Zorc, H., Wittine, K., Andjelković, U., & Josić, D. (2016) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2016.07.003 · Cited by 21
Wilkins, O. M., Titus, A., Gui, J., Eliot, M., Butler, R. A., Sturgis, E. M., Li, G., Kelsey, K. T., & Christensen, B. C. (2017) · Carcinogenesis · doi:10.1093/carcin/bgx056 · Cited by 21
Wang, X., Niu, J., Li, J., Shen, X., Shen, S., Straubinger, R. M., & Qu, J. (2018) · Molecular & Cellular Proteomics · doi:10.1074/mcp.ra117.000519 · Cited by 21
GScluster: network-weighted gene-set clustering analysis
Yoon, S., Kim, J., Kim, S., Baik, B., Chi, S.-M., Kim, S., & Nam, D. (2019) · BMC Genomics · doi:10.1186/s12864-019-5738-6 · Cited by 20
Specifically blocking the fatty acid synthesis to inhibit the malignant phenotype of bladder cancer
Li, A., Yao, L., Fang, Y., Yang, K., Jiang, W. H., Huang, W., & Cai, Z. (2019) · International Journal of Biological Sciences · doi:10.7150/ijbs.32518 · Cited by 21
Targeting Cancer Metabolism and Cell Cycle by Plant-Derived Compounds
Aydemir, E., Tecimel, D., Şahi̇n, F., & Deniz, A. A. H. (2019) · Advances in experimental medicine and biology · doi:10.1007/5584_2019_449 · Cited by 22
Cheng, T., Wang, Y., Lu, M., Zhan, X., Zhou, T., Li, B., & Zhan, X. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00854 · Cited by 21
Li, S., Liu, R., Pan, Q., Wang, G., Cheng, D., Yang, J., Chen, H., & Xu, G. (2020) · MedComm · doi:10.1002/mco2.15 · Cited by 21
Song, C., Liu, B., Jiang, S., Xiong, Y., Sun, C., Zhou, Q., Jiang, Z., Liu, B., & Zhang, H. (2020) · 3 Biotech · doi:10.1007/s13205-020-02519-4 · Cited by 21
Suzuki, H., Kohjima, M., Tanaka, M., Goya, T., Itoh, S., Yoshizumi, T., Mori, M., Tsuda, M., Takahashi, M., Kurokawa, M., et al. (2021) · Canadian Journal of Gastroenterology and Hepatology · doi:10.1155/2021/8813410 · Cited by 25
Iordanescu, G., Brendler, C. B., Crawford, S. E., Wyrwicz, A. M., Venkatasubramanian, P. N., & Doll, J. A. (2014) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.24824 · Cited by 21
Microbial Production of Fatty Acids
Ratledge, C., & Lippmeier, J. C. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809521-8.00006-4 · Cited by 21
da Silva, B. D. O., Alberici, L. C., Ramos, L. F., da Silva, C. M., da Silveira, M. B., Dechandt, C. R. P., Friedman, S. L., Sakane, K. K., Gonçalves, L. R., & Moraes, K. C. M. (2018) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2018.02.018 · Cited by 21
Xie, Q.-J., Zeng, Y., Zhang, X., & Yu, F. (2024) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-024-03748-9 · Cited by 24
Obesity Paradox in Cancer: A Complex Interplay Between Risk and Therapeutic Outcomes
Chen, T., Zhai, W., Song, J., Liu, W., Wu, Z., Yang, F., & Wang, L. (2025) · MedComm · doi:10.1002/mco2.70494 · Cited by 22
Qin, X., Tatsukawa, H., Hitomi, K., Shirakami, Y., Ishibashi, N., Shimizu, M., Moriwaki, H., & Kojima, S. (2016) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-15-0326 · Cited by 20
Liu, S., Xie, F., Xiang, X., Liu, S., Dong, S., Qu, K., & Lin, T. Y. (2017) · Oncotarget · doi:10.18632/oncotarget.22181 · Cited by 20
Murakami, S., Tanaka, H., Nakayama, T., Taniura, N., Miyake, T., Tani, M., Kushima, R., Yamamoto, G., Sugihara, H., & Mukaisho, K. (2020) · Cancer Science · doi:10.1111/cas.14749 · Cited by 21
Wang, Y., Chen, W., Li, K., Wu, G., Zhang, W., Ma, P., & Feng, S. (2021) · Bioscience Reports · doi:10.1042/bsr20211476 · Cited by 20
Tumor Microenvironment Acidity Triggers Lipid Accumulation in Liver Cancer via SCD1 Activation
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Metadata
- Authors
- Currie, E., Schulze, A., Zechner, R., Walther, T. C., & Farese, R. V.
- Affiliations
- University of California, San Francisco (US)
- Cancer Research UK (GB)
- University of Graz (AT)
- Yale University (US)
- Corresponding author
- Farese, Robert V.
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2013-08
- Volume
- 18
- Issue
- 2
- Pages
- 153-161
- ISSN
- 1550-4131 (ISSN-L)
- PMC
- PMC3742569
- OpenAlex
- W1980568044
- Cited by
- 2,123
- References
- 82
- Citations by year
- 2026: 118 · 2025: 221 · 2024: 228 · 2023: 221 · 2022: 266 · 2021: 204 · 2020: 193 · 2019: 177 · 2018: 139 · 2017: 122 · 2016: 115 · 2015: 72 · 2014: 41 · 2013: 1
- FWCI
- 6.32
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 370 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of General Medical Sciences (R01GM099844, R01GM097194)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK056084, P30DK063720, P30DK026743)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Keywords
- fatty acid metabolism, cancer metabolism, lipid metabolism, tumor cell proliferation, fatty acid availability, membrane lipid synthesis
- MeSH terms
- Energy Metabolism, Fatty Acids, Humans, Neoplasms, Cell Proliferation, Lipid Metabolism
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