The DOI matches its Crossref record; 81 of the 82 references it cites were found in a registry or an index.
Cellular Fatty Acid Metabolism and Cancer
Open accessAbstract
Cancer cells often have characteristic changes in metabolism. Cellular proliferation, a common feature of all cancers, requires fatty acids for synthesis of membranes and signaling molecules. Here, we provide a view of cancer cell metabolism from a lipid perspective, and we summarize evidence that limiting fatty acid availability can control cancer cell proliferation.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“For example, expression of ACLY, a key enzyme in the shift from the TCA cycle to lipid formation that has been shown to cause lipid droplet accumulation42, is significantly higher in LDAM than in microglia without lipid droplets.”
From Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain (2020) · cites this paper as [42]
Experimental — accuracy not yet measuredIn the citing paper
“Fatty acid synthesis is an anabolic process that uses cytosolic citrate to produce acetyl-CoA73.”
From Glutamine reliance in cell metabolism (2020) · cites this paper as [73]
In the citing paper
“Next, mitochondrial citrate is transported across the inner mitochondrial membrane via a citrate carrier (CIC or SLC25A1) to support fatty acid synthesis for tumor progression in hypoxia73 (Fig. 4).”
From Glutamine reliance in cell metabolism (2020) · cites this paper as [73]
In the citing paper
“PHD3 is suppressed in cancers that rely on FAO, such as AML and prostate cancer, and elevated in cancers that rely on FAS such as breast and non-small-lung-cell cancer.55–57”
From The multifaceted contributions of mitochondria to cellular metabolism (2018) · cites this paper as [56]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Warburg, O. (1956) · Science · doi:10.1126/science.123.3191.309 · Cited by 13,425
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver
Horton, J. D., Goldstein, J. L., & Brown, M. S. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15593 · Cited by 4,794
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver
Horton, J. D., Goldstein, J. L., & Brown, M. S. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215593 · Cited by 4,092
Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis
Menendez, J. A., & Lupu, R. (2007) · Nature Reviews Cancer · doi:10.1038/nrc2222 · Cited by 2,941
DeBerardinis, R. J., Mancuso, A., Daikhin, E., Nissim, I., Yudkoff, M., Wehrli, S., & Thompson, C. B. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709747104 · Cited by 2,622
Cancer cell metabolism: warburg and beyond
Hsu, P. P., & Sabatini, D. M. (2008) · Cell · doi:10.1016/j.cell.2008.08.021 · Cited by 2,452 · cited 1×
“A better understanding of these metabolic changes has prompted new approaches toward cancer therapy (reviewed in Hsu and Sabatini, 2008; Schulze and Harris, 2012).”
BackgroundATP-citrate lyase links cellular metabolism to histone acetylation
Wellen, K. E., Hatzivassiliou, G., Sachdeva, U. M., Bui, T. V., Cross, J. R., & Thompson, C. B. (2009) · Science · doi:10.1126/science.1164097 · Cited by 2,298
Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth
Nieman, K. M., Kenny, H. A., Penicka, C. V., Ladanyi, A., Buell-Gutbrod, R., Zillhardt, M. R., Romero, I. L., Carey, M. S., Mills, G. B., Hotamisligil, G. S., et al. (2011) · Nature Medicine · doi:10.1038/nm.2492 · Cited by 2,279
Wise, D. R., DeBerardinis, R. J., Mancuso, A., Sayed, N., Zhang, X.-Y., Pfeiffer, H. K., Nissim, I., Daikhin, E., Yudkoff, M., McMahon, S. B., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810199105 · Cited by 2,001
Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia
Metallo, C. M., Gameiro, P. A., Bell, E. L., Mattaini, K. R., Yang, J., Hiller, K., Jewell, C. M., Johnson, Z. R., Irvine, D. J., Guarente, L., et al. (2012) · Nature · doi:10.1038/nature10602 · Cited by 1,791
Cited by
Sorted by citations
Items 401–500 of 1,000
FoxA and LIPG endothelial lipase control the uptake of extracellular lipids for breast cancer growth
Slebe, F., Rojo, F., Vinaixa, M., Garcı́a-Rocha, M., Testoni, G., Guiu, M., Planet, E., Samino, S., Arenas, E. J., Beltran, A., et al. (2016) · Nature Communications · doi:10.1038/ncomms11199 · Cited by 64
Role of de novo cholesterol synthesis enzymes in cancer
Yang, J., Wang, L., & Jia, R. (2020) · Journal of Cancer · doi:10.7150/jca.38598 · Cited by 63
Sun, C., Liu, W., Geng, Y., & Wang, X. D. (2020) · Analytical Chemistry · doi:10.1021/acs.analchem.0c02303 · Cited by 64
Li, Z., Li, D., Choi, E. Y., Lapidus, R. G., Zhang, L., Huang, S. M., Shapiro, P., & Wang, H. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.783860 · Cited by 62
The Role of Lipid Metabolism in Gastric Cancer
Cui, M., Yi, X., Zhu, D., & Wu, J. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.916661 · Cited by 61
Metabolic Health, Mitochondrial Fitness, Physical Activity, and Cancer
Clemente‐Suárez, V. J., Martín-Rodríguez, A., Redondo-Flórez, L., Ruisoto, P., Navarro-Jiménez, E., Ramos‐Campo, D. J., & Tornero-Aguilera, J. F. (2023) · Cancers · doi:10.3390/cancers15030814 · Cited by 71
Abramczyk, H., & Brożek-Płuska, B. (2016) · Analytica Chimica Acta · doi:10.1016/j.aca.2015.12.038 · Cited by 62
Oncogene dependent requirement of fatty acid synthase in hepatocellular carcinoma
Che, L., Pilo, M. G., Cigliano, A., Latte, G., Simile, M. M., Ribback, S., Dombrowski, F., Evert, M., Chen, X., & Calvisi, D. F. (2017) · Cell Cycle · doi:10.1080/15384101.2017.1282586 · Cited by 62
Porto-Figueira, P., Pereira, J. A. M., & Câmara, J. S. (2018) · Analytica Chimica Acta · doi:10.1016/j.aca.2018.04.027 · Cited by 61
Cancer metabolism and intervention therapy
Zhao, H., & Li, Y. (2021) · Molecular Biomedicine · doi:10.1186/s43556-020-00012-1 · Cited by 67
Wang, H., Chen, Y., Liu, Y.-W., Li, Q., Luo, J., Wang, L., Chen, Y., Sang, C., Zhang, W., Ge, X., et al. (2021) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2021.12.010 · Cited by 61
Key Players in Choline Metabolic Reprograming in Triple-Negative Breast Cancer
Iorio, E., Caramujo, M.-J., Cecchetti, S., Spadaro, F., Carpinelli, G., Canese, R., & Podo, F. (2016) · Frontiers in Oncology · doi:10.3389/fonc.2016.00205 · Cited by 61
A Prodrug of Two Approved Drugs, Cisplatin and Chlorambucil, for Chemo War Against Cancer
Pathak, R., Wen, R. M., Kolishetti, N., & Dhar, S. (2017) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-16-0445 · Cited by 61
Bandyopadhyay, S., Li, J., Traer, E. A., Tyner, J. W., Zhou, A. W., Oh, S. T., & Cheng, J. (2017) · PLoS ONE · doi:10.1371/journal.pone.0179558 · Cited by 61
Lipidomic study of cell lines reveals differences between breast cancer subtypes
Eiríksson, F. F., Nøhr, M. K., Costa, M., Böðvarsdóttir, S. K., Ogmundsdottir, H. M., & Þorsteinsdóttir, M. (2020) · PLoS ONE · doi:10.1371/journal.pone.0231289 · Cited by 61
Feider, C. L., Macias, L. A., Brodbelt, J. S., & Eberlin, L. S. (2020) · Analytical Chemistry · doi:10.1021/acs.analchem.0c00970 · Cited by 61
Hulse, M., Johnson, S. M., Boyle, S., Caruso, L. B., & Tempera, I. (2020) · Journal of Virology · doi:10.1128/jvi.01857-20 · Cited by 61
Biogenesis and Breakdown of Lipid Droplets in Pathological Conditions
Kaiser, C. M. F., Romano, P. S., Vanrell, M. C., Pocognoni, C. A., Jacob, J., Caruso, B., & Delgui, L. R. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.826248 · Cited by 63
Overview of Cancer Metabolism and Signaling Transduction
Chae, H., & Hong, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms24010012 · Cited by 66
Wu, C., Dong, S., Huang, R., & Chen, X. (2023) · Cancers · doi:10.3390/cancers15030726 · Cited by 60
Deng, B., Kong, W., Shen, X., Han, C. Q., Zhao, Z., Chen, S., Zhou, C., & Bae-Jump, V. L. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05084-z · Cited by 63
Santos, I. P., Caspers, P. J., Schut, T. C. B., van Doorn, R., Hegt, V. N., Koljenović, S., & Puppels, G. J. (2016) · Analytical Chemistry · doi:10.1021/acs.analchem.6b01592 · Cited by 60
Reenergizing T cell anti-tumor immunity by harnessing immunometabolic checkpoints and machineries
Ho, P., & Kaech, S. M. (2017) · Current Opinion in Immunology · doi:10.1016/j.coi.2017.04.003 · Cited by 62
Zhang, H., Gao, Y., Sun, J., Fan, S., Yao, X., Ran, X., Zheng, C., Huang, M., & Bi, H. (2017) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-017-0483-7 · Cited by 61
Metabolomics of Non-muscle Invasive Bladder Cancer: Biomarkers for Early Detection of Bladder Cancer
Cheng, X., Liu, X., Liu, X., Guo, Z., Sun, H., Zhang, M., Ji, Z., & Sun, W. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00494 · Cited by 60
Bueno, M. J., Jimenez-Renard, V., Samino, S., Capellades, J., Junza, A., López-Rodríguez, M. L., Garcı́a-Cárceles, J., López-Fabuel, I., Bolaños, J. P., Chandel, N. S., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-13028-1 · Cited by 57
Inhibitors of lipogenic enzymes as a potential therapy against cancer
Montesdeoca, N., López, M., Ariza, X., Herrero, L., & Makowski, K. (2020) · The FASEB Journal · doi:10.1096/fj.202000705r · Cited by 58
Metformin: A Dual-Role Player in Cancer Treatment and Prevention
Galal, M. A., Al-Rimawi, M., Hajeer, A., Dahman, H., Alouch, S. S., & Aljada, A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25074083 · Cited by 73
Targeting endothelial metabolism for anti-angiogenesis therapy: A pharmacological perspective
Missiaen, R., Morales-Rodriguez, F., Eelen, G., & Carmeliet, P. (2017) · Vascular Pharmacology · doi:10.1016/j.vph.2017.01.001 · Cited by 58
Close interactions between lncRNAs, lipid metabolism and ferroptosis in cancer
Huang, J., Wang, J., He, H., Huang, Z., Wu, S., Chen, C., Liu, W., Xie, L., Tao, Y., Li, C., et al. (2021) · International Journal of Biological Sciences · doi:10.7150/ijbs.66181 · Cited by 60
The roles and mechanisms of SREBP1 in cancer development and drug response
He, Y., Qi, S., Chen, L., Zhu, J., Liang, L., Chen, X., Zhang, H., Zhuo, L., Zhao, S., Liu, S., et al. (2023) · Genes & Diseases · doi:10.1016/j.gendis.2023.04.022 · Cited by 58
Jiang, M., Huizenga, M. C. W., Wirt, J. L., Pálóczi, J., Amedi, A., van den Berg, R. J. B. H. N., Benz, J., Collin, L., Deng, H., Di, X., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-43606-3 · Cited by 63
del Solar, V., Lizardo, D. Y., Li, N., Hurst, J. J., Brais, C. J., & Atilla‐Gokcumen, G. E. (2015) · Chemistry & Biology · doi:10.1016/j.chembiol.2015.11.004 · Cited by 58
Zhu, W., Zhao, Y., Zhou, J., Wang, X., Pan, Q., Zhang, N., Wang, L., Wang, M., Zhan, D.-H., Liu, Z., et al. (2016) · Journal of Hematology & Oncology · doi:10.1186/s13045-016-0361-3 · Cited by 58
Lucarelli, G. T., Loizzo, D., Ferro, M., Rutigliano, M., Vartolomei, M. D., Cantiello, F., Buonerba, C., Lorenzo, G. D., Terracciano, D., COBELLI, O. D., et al. (2019) · Expert Review of Molecular Diagnostics · doi:10.1080/14737159.2019.1604223 · Cited by 58
Ma, Y., Zhang, X., Alsaidan, O. A., Yang, X., Sulejmani, E., Zha, J., Beharry, Z. M., Huang, H., Bartlett, M. G., Lewis, Z., et al. (2020) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-20-0379 · Cited by 58
Zhao, R., Li, F.-Q., Tian, L., Shang, D., Guo, Y., Zhang, J., & Liu, M. (2018) · Functional & Integrative Genomics · doi:10.1007/s10142-018-0631-y · Cited by 57
Exploiting metabolic vulnerabilities for personalized therapy in acute myeloid leukemia
Stuani, L., Sabatier, M., & Sarry, J. (2019) · BMC Biology · doi:10.1186/s12915-019-0670-4 · Cited by 66
The role and therapeutic implication of CPTs in fatty acid oxidation and cancers progression.
Wang, J., Xiang, H., Lu, Y., Wu, T., & Ji, G. (2021) · PubMed Central · Cited by 58
Targeting lipid metabolism for ferroptotic cancer therapy
Luo, M., Yan, J., Hu, X., Li, H., Li, H., Liu, Q., Chen, Y., & Zou, Z. (2022) · APOPTOSIS · doi:10.1007/s10495-022-01795-0 · Cited by 62
Kim, S., Yang, X., Li, Q., Wu, M., Costyn, L. J., Beharry, Z. M., Bartlett, M. G., & Cai, H. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.798827 · Cited by 57
Rapid discrimination of pediatric brain tumors by mass spectrometry imaging
Clark, A. R., Calligaris, D., Regan, M. S., Krummel, D. P., Agar, J. N., Kallay, L. M., MacDonald, T. J., Schniederjan, M., Santagata, S., Pomeroy, S. L., et al. (2018) · Journal of Neuro-Oncology · doi:10.1007/s11060-018-2978-2 · Cited by 57
Ayyagari, V. N., Wang, X., Díaz‐Sylvester, P., Groesch, K. A., & Brard, L. (2020) · PLoS ONE · doi:10.1371/journal.pone.0228024 · Cited by 57
Peng, J., Cai, D., Zeng, R., Zhang, C., Li, G., Chen, S., Yuan, X., & Peng, L. (2022) · Advanced Science · doi:10.1002/advs.202204711 · Cited by 56
Belkaid, A., Ouellette, R. J., & Surette, M. E. (2017) · Carcinogenesis · doi:10.1093/carcin/bgx020 · Cited by 56
TCSBN: a database of tissue and cancer specific biological networks
Lee, S., Zhang, C., Arif, M., Liu, Z., Benfeitas, R., Bidkhori, G., Deshmukh, S., Shobky, M. A., Lovrić, A., Borén, J., et al. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx994 · Cited by 58
Dessai, A. S., Domínguez, M. P., Chen, U.-I., Hasper, J., Prechtl, C., Yu, C. R., Katsuta, E., Dai, T., Zhu, B., Jung, S. Y., et al. (2020) · Cancer Research · doi:10.1158/0008-5472.can-20-1708 · Cited by 59
Obesity and endocrine therapy resistance in breast cancer: Mechanistic insights and perspectives
Barone, I., Caruso, A., Gelsomino, L., Giordano, C., Bonofiglio, D., Catalano, S., & Andò, S. (2021) · Obesity Reviews · doi:10.1111/obr.13358 · Cited by 62
Chen, Q., Du, J., Cui, K., Fang, W. Y., Zhao, Z., Chen, Q., Mai, K., & Ai, Q. (2021) · iScience · doi:10.1016/j.isci.2021.103244 · Cited by 55
Lipidomic landscape in cancer: Actionable insights for membrane‐based therapy and diagnoses
Agarwala, P. K., Aneja, R., & Kapoor, S. (2021) · Medicinal Research Reviews · doi:10.1002/med.21868 · Cited by 55
Reprogrammed Lipid Metabolism and the Lipid-Associated Hallmarks of Colorectal Cancer
Salita, T., Rustam, Y. H., Mouradov, D., Sieber, O. M., & Reid, G. E. (2022) · Cancers · doi:10.3390/cancers14153714 · Cited by 55
Bengoechea-Alonso, M. T., & Ericsson, J. (2016) · Cell Cycle · doi:10.1080/15384101.2016.1220456 · Cited by 55
Zheng, Z. G., Xu, L., Zhang, S., Li, W., Tou, F., He, Q., Rao, J., & Shen, Q. (2017) · Oncotarget · doi:10.18632/oncotarget.17411 · Cited by 55
Yin, F., Sharen, G., Yuan, F., Peng, Y., Chen, R., Zhou, X., Wei, H., Li, B., Jing, W., & Zhao, J. (2017) · Oncogenesis · doi:10.1038/oncsis.2017.49 · Cited by 46
Fan, X., Leung, E. L., Xie, Y., Liu, Z. Q., Zheng, Y. F., Yao, X., Lu, L., Wu, J., He, J., Yuan, Z., et al. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7090 · Cited by 55
Metabolism of Innate Immune Cells in Cancer
Talty, R., & Olino, K. L. (2021) · Cancers · doi:10.3390/cancers13040904 · Cited by 55
MicroRNA expression profile in serum reveals novel diagnostic biomarkers for endometrial cancer
Fan, X., Zou, X., Liu, C., Cheng, W., Zhang, S., Geng, X., & Zhu, W. (2021) · Bioscience Reports · doi:10.1042/bsr20210111 · Cited by 55
Metabolic regulation in the immune response to cancer
Wu, Q., Yu, X., Li, J., Sun, S., & Tu, Y. (2021) · 癌症：英文版 · doi:10.1002/cac2.12182 · Cited by 57
Metabolic Reprogramming in Cancer: Implications for Immunosuppressive Microenvironment
Aden, D., Sureka, N., Zaheer, S., Chaurasia, J. K., & Zaheer, S. (2024) · Immunology · doi:10.1111/imm.13871 · Cited by 58
Zhao, Z., Lü, J., Han, L., Wang, X., Man, Q., & Liu, S. (2015) · Tumor Biology · doi:10.1007/s13277-015-4720-4 · Cited by 53
Xu, G., Lou, N., Shi, H., Xu, Y., Ruan, H., Xiao, W., Liu, L., Li, X., Xiao, H., Qiu, B., et al. (2018) · BMC Cancer · doi:10.1186/s12885-017-3761-z · Cited by 52
Zhao, Z., Liu, Y., Liu, Q., Wu, F., Liu, X., Qu, H., Yuan, Y., Ge, J., Xu, Y., & Wang, H. (2019) · Journal of Cancer · doi:10.7150/jca.33024 · Cited by 55
Xu, L., Hao, L., Ma, J. Q., Liu, J. K., & Hasim, A. (2019) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-019-03644-2 · Cited by 54
Pham, D., Pun, N. T., & Park, P. (2020) · Molecular Oncology · doi:10.1002/1878-0261.12860 · Cited by 56
Wu, Y., Hurren, R., MacLean, N., Gronda, M., Jitkova, Y., Sukhai, M. A., Minden, M. D., & Schimmer, A. D. (2015) · APOPTOSIS · doi:10.1007/s10495-015-1137-x · Cited by 54
Lipidomic Signatures for Colorectal Cancer Diagnosis and Progression Using UPLC-QTOF-ESI+MS
Răchieriu, C., Eniu, D. T., Moiș, E. I., Graur, F., Socaciu, C., SOCACIU, M. A., & Hajjar, N. A. (2021) · Biomolecules · doi:10.3390/biom11030417 · Cited by 55
Lipid droplets in prostate cancer cells and effect of irradiation studied by Raman microspectroscopy
Roman, M., Wróbel, T. P., Panek, A., Paluszkiewicz, C., & Kwiatek, W. M. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2020.158753 · Cited by 53
Endogenous toxic metabolites and implications in cancer therapy
Lee, N., Spears, M. E., Carlisle, A. E., & Kim, D. (2020) · Oncogene · doi:10.1038/s41388-020-01395-9 · Cited by 56
Zheng, Y., Zhou, Q., Zhao, C., Li, J., Yu, Z., & Zhu, Q. (2021) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16235 · Cited by 53
Xiong, Q., Feng, D., Wang, Z., Ying, Y., Xu, C., Wei, Q., Zeng, S., & Yang, L. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.836939 · Cited by 53
Zheng, X., Ma, H., Wang, J., Huang, M., Fu, D., Qin, L., & Yin, Q. (2022) · Translational Oncology · doi:10.1016/j.tranon.2022.101534 · Cited by 59
Applications of metabolomics in the study and management of preeclampsia: a review of the literature
Kelly, R. S., Giorgio, R. T., Chawes, B., Palacios, N., Gray, K. J., Mirzakhani, H., Wu, A. C., Blighe, K., Weiss, S. T., & Lasky-Su, J. A. (2017) · Metabolomics · doi:10.1007/s11306-017-1225-8 · Cited by 53
Osawa, T., Shimamura, T., Saito, K., Hasegawa, Y., Ishii, N., Nishida, M., Ando, R., Kondo, A., Anwar, M., Tsuchida, R., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.08.087 · Cited by 54
Tumor metabolic reprogramming in lung cancer progression (Review)
Li, X., Liu, M., Liu, H., & Chen, J. (2022) · Oncology Letters · doi:10.3892/ol.2022.13407 · Cited by 52
Jian, H., Xu, Q., Wang, X., Liu, Y., Miao, S., Li, Y., Mou, T., Dong, X., & Zou, X. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.849767 · Cited by 57
The lipid metabolism remodeling: A hurdle in breast cancer therapy
Xiao, Q., Xia, M. H., Tang, W., Hu, Z., Chen, Y., & Zhong, J. (2023) · Cancer Letters · doi:10.1016/j.canlet.2023.216512 · Cited by 52
Role of cystathionine beta synthase in lipid metabolism in ovarian cancer
Chakraborty, P. K., Xiong, X., Mustafi, S. B., Saha, S., Dhanasekaran, D. N., Mandal, N. A., McMeekin, S., Bhattacharya, R., & Mukherjee, P. (2015) · Oncotarget · doi:10.18632/oncotarget.5424 · Cited by 51
Zhou, Y., Song, R., Zhang, Z., Lu, X., Zeng, Z., Hu, C., Liu, X., Li, Y., Hou, J., Sun, Y., et al. (2016) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-016-9797-0 · Cited by 52
USP30: Structure, Emerging Physiological Role, and Target Inhibition
Wang, F., Gao, Y. P., Zhou, L., Chen, J., Xie, Z., Ye, Z., & Wang, Y. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.851654 · Cited by 53
Dian, L.-L., Xu, Z., Sun, Y., Li, J., Lu, H., Zheng, M., Wang, J., Дробот, Л. Б., & Horak, I. R. (2022) · Phytochemistry · doi:10.1016/j.phytochem.2022.113217 · Cited by 51
Crosstalk between gut microbiotas and fatty acid metabolism in colorectal cancer
Zhang, H., Tian, Y., Xu, C., Chen, M., Xiang, Z., Gu, L., Xue, H., & Xu, Q. R. (2025) · Cell Death Discovery · doi:10.1038/s41420-025-02364-5 · Cited by 53
The epigenetic drug 5-azacytidine interferes with cholesterol and lipid metabolism
Poirier, S., Samami, S., Mamarbachi, M., Demers, A., Chang, T. Y., Vance, D. E., Hatch, G. M., & Mayer, G. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.563650 · Cited by 47
G0S2 Suppresses Oncogenic Transformation by Repressing a MYC-Regulated Transcriptional Program
Yim, C. Y., Sekula, D., Hever-Jardine, M. P., Liu, X., Warzecha, J. M., Tam, J. K. V., Freemantle, S. J., Dmitrovsky, E., & Spinella, M. J. (2016) · Cancer Research · doi:10.1158/0008-5472.can-15-2265 · Cited by 51
Prognostic Metabolite Biomarkers for Soft Tissue Sarcomas Discovered by Mass Spectrometry Imaging
Lou, S., Balluff, B., Cleven, A. H. G., Bovée, J. V. M. G., & McDonnell, L. A. (2016) · Journal of the American Society for Mass Spectrometry · doi:10.1007/s13361-016-1544-4 · Cited by 54
Ibrahim, H., Jurčić, K., Wang, J. S.-H., Whitehead, S. N., & Yeung, K. K. ‐. (2017) · Analytical Chemistry · doi:10.1021/acs.analchem.7b03284 · Cited by 51
γ-Oryzanol Improves Cognitive Function and Modulates Hippocampal Proteome in Mice
Rungratanawanich, W., Cenini, G., Mastinu, A., Sylvester, M., Wilkening, A., Abate, G., Bonini, S. A., Aria, F., Marziano, M., Maccarinelli, G., et al. (2019) · Nutrients · doi:10.3390/nu11040753 · Cited by 52
Emodin Induced SREBP1-Dependent and SREBP1-Independent Apoptosis in Hepatocellular Carcinoma Cells
Yang, N., Li, C., Li, H., Liu, M., Cai, X., Cao, F., Feng, Y., Li, M., & Wang, X. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00709 · Cited by 51
Cell cycle regulation of ER membrane biogenesis protects against chromosome missegregation
Merta, H., Rodrı́guez, J. W. C., Anjur-Dietrich, M. I., Vitale, T., Granade, M. E., Harris, T. E., Needleman, D. J., & Bahmanyar, S. (2021) · Developmental Cell · doi:10.1016/j.devcel.2021.11.009 · Cited by 46
There and back again: The journey of the estrogen-related receptors in the cancer realm
Tam, I. S., & Giguère, V. (2015) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2015.06.009 · Cited by 53
Auslander, N., Yizhak, K., Weinstock, A., Budhu, A., Tang, W., Wang, X. W., Ambs, S., & Ruppin, E. (2016) · Scientific Reports · doi:10.1038/srep29662 · Cited by 50
You, X., Tian, J., Zhang, H., Guo, Y., Yang, J., Zhu, C., Song, M., Wang, P., Liu, Z., Cancilla, J. C., et al. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2021.101203 · Cited by 50
PPARα at the crossroad of metabolic–immune regulation in cancer
Zeng, W., Yin, X., Jiang, Y., Jin, L., & Liang, W. P. (2021) · FEBS Journal · doi:10.1111/febs.16181 · Cited by 52
Fatty Acid Metabolism and Cancer Immunotherapy
Luo, Y., Wang, H., Liu, B., & Wei, J. (2022) · Current Oncology Reports · doi:10.1007/s11912-022-01223-1 · Cited by 53
Gao, Y., Song, Z., Li, J. X., Tang, Y., Wang, C., Zhao, X., Hu, H., Chen, D., & Qiao, M. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121902 · Cited by 51
Yang, C.-S., Matsuura, K., Huang, N.-J., Robeson, A. C., Huang, B., Zhang, L., & Kornbluth, S. A. (2014) · Oncogene · doi:10.1038/onc.2014.271 · Cited by 50
Immunometabolism: A new target for improving cancer immunotherapy
Guo, C., Chen, S., Liu, W., Ma, Y., Li, J., Fisher, P. B., Fang, X., & Wang, X. (2019) · Advances in cancer research · doi:10.1016/bs.acr.2019.03.004 · Cited by 56
Wu, S., & Näär, A. M. (2019) · Scientific Reports · doi:10.1038/s41598-019-46594-x · Cited by 51
Macciò, A., Sanna, E., Neri, M., Oppi, S., & Madeddu, C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22062890 · Cited by 49
OLR1 is a prognostic factor and correlated with immune infiltration in breast cancer
Sun, X., Fu, X., Xu, S., Qiu, P., Lv, Z., Cui, M., Zhang, Q., & Xu, Y. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2021.108275 · Cited by 49
Leemans, M., Bauër, P., Cuzuel, V., Audureau, É., & Fromantin, I. (2022) · Biomarker Insights · doi:10.1177/11772719221100709 · Cited by 50
Metadata
- Authors
- Currie, E., Schulze, A., Zechner, R., Walther, T. C., & Farese, R. V.
- Affiliations
- University of California, San Francisco (US)
- Cancer Research UK (GB)
- University of Graz (AT)
- Yale University (US)
- Corresponding author
- Farese, Robert V.
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2013-08
- Volume
- 18
- Issue
- 2
- Pages
- 153-161
- ISSN
- 1550-4131 (ISSN-L)
- PMC
- PMC3742569
- OpenAlex
- W1980568044
- Cited by
- 2,123
- References
- 82
- Citations by year
- 2026: 118 · 2025: 221 · 2024: 228 · 2023: 221 · 2022: 266 · 2021: 204 · 2020: 193 · 2019: 177 · 2018: 139 · 2017: 122 · 2016: 115 · 2015: 72 · 2014: 41 · 2013: 1
- FWCI
- 6.32
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 370 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of General Medical Sciences (R01GM099844, R01GM097194)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK056084, P30DK063720, P30DK026743)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Keywords
- fatty acid metabolism, cancer metabolism, lipid metabolism, tumor cell proliferation, fatty acid availability, membrane lipid synthesis
- MeSH terms
- Energy Metabolism, Fatty Acids, Humans, Neoplasms, Cell Proliferation, Lipid Metabolism
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
