Cited by 2,123Cancer, Lipids, and MetabolismLipid metabolism and biosynthesisCancer, Hypoxia, and Metabolism

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Cellular Fatty Acid Metabolism and Cancer

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Currie, Erin, Schulze, Almut, Zechner, Rudolf, Walther, Tobias C., Farese, Robert V.·2013·Cell Metabolism

DOI 10.1016/j.cmet.2013.05.017PMC PMC3742569

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Abstract

Cancer cells often have characteristic changes in metabolism. Cellular proliferation, a common feature of all cancers, requires fatty acids for synthesis of membranes and signaling molecules. Here, we provide a view of cancer cell metabolism from a lipid perspective, and we summarize evidence that limiting fatty acid availability can control cancer cell proliferation.

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On the origin of cancer cells
Warburg, O. (1956) · Science · doi:10.1126/science.123.3191.309 · Cited by 13,425
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver
Horton, J. D., Goldstein, J. L., & Brown, M. S. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15593 · Cited by 4,794
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver
Horton, J. D., Goldstein, J. L., & Brown, M. S. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215593 · Cited by 4,092
Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis
Menendez, J. A., & Lupu, R. (2007) · Nature Reviews Cancer · doi:10.1038/nrc2222 · Cited by 2,941
Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis
DeBerardinis, R. J., Mancuso, A., Daikhin, E., Nissim, I., Yudkoff, M., Wehrli, S., & Thompson, C. B. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709747104 · Cited by 2,622
Cancer cell metabolism: warburg and beyond
Hsu, P. P., & Sabatini, D. M. (2008) · Cell · doi:10.1016/j.cell.2008.08.021 · Cited by 2,452 · cited 1×
“A better understanding of these metabolic changes has prompted new approaches toward cancer therapy (reviewed in Hsu and Sabatini, 2008; Schulze and Harris, 2012).”
Background
ATP-citrate lyase links cellular metabolism to histone acetylation
Wellen, K. E., Hatzivassiliou, G., Sachdeva, U. M., Bui, T. V., Cross, J. R., & Thompson, C. B. (2009) · Science · doi:10.1126/science.1164097 · Cited by 2,298
Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth
Nieman, K. M., Kenny, H. A., Penicka, C. V., Ladanyi, A., Buell-Gutbrod, R., Zillhardt, M. R., Romero, I. L., Carey, M. S., Mills, G. B., Hotamisligil, G. S., et al. (2011) · Nature Medicine · doi:10.1038/nm.2492 · Cited by 2,279
Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction
Wise, D. R., DeBerardinis, R. J., Mancuso, A., Sayed, N., Zhang, X.-Y., Pfeiffer, H. K., Nissim, I., Daikhin, E., Yudkoff, M., McMahon, S. B., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810199105 · Cited by 2,001
Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia
Metallo, C. M., Gameiro, P. A., Bell, E. L., Mattaini, K. R., Yang, J., Hiller, K., Jewell, C. M., Johnson, Z. R., Irvine, D. J., Guarente, L., et al. (2012) · Nature · doi:10.1038/nature10602 · Cited by 1,791

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Ge, T., Gu, X., Jia, R., Ge, S., Chai, P., Zhuang, A., & Fan, X. (2022) · 癌症：英文版 · doi:10.1002/cac2.12374 · Cited by 220
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Schönenberger, M. J. (2015) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2015.00042 · Cited by 203
When less may be more: calorie restriction and response to cancer therapy
O’Flanagan, C. H., Smith, L. A., McDonell, S. B., & Hursting, S. D. (2017) · BMC Medicine · doi:10.1186/s12916-017-0873-x · Cited by 213
Compartmentalized activities of the pyruvate dehydrogenase complex sustain lipogenesis in prostate cancer
Chen, J., Guccini, I., Mitri, D. D., Brina, D., Revandkar, A., Sarti, M., Pasquini, E., Alajati, A., Pinton, S., Losa, M., et al. (2018) · Nature Genetics · doi:10.1038/s41588-017-0026-3 · Cited by 202
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Gyamfi, J., Kim, J., & Choi, J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031155 · Cited by 206
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Nath, A., & Chan, C. (2016) · Scientific Reports · doi:10.1038/srep18669 · Cited by 202
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Dias, A. S., Almeida, C. R., Helguero, L. A., & Duarte, I. F. (2019) · European Journal of Cancer · doi:10.1016/j.ejca.2019.09.002 · Cited by 206
Mutant GNAS drives pancreatic tumourigenesis by inducing PKA-mediated SIK suppression and reprogramming lipid metabolism
Patra, K. C., Kato, Y., Mizukami, Y., Widholz, S., Boukhali, M., Revenco, I., Grossman, E. A., Ji, F., Sadreyev, R. I., Liss, A. S., et al. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0122-3 · Cited by 192
Toll-like receptor mediated inflammation requires FASN-dependent MYD88 palmitoylation
Kim, Y.-C., Lee, S. E., Kim, S. K., Jang, H.-D., Hwang, I., Jin, S., Hong, E.-B., Jang, K.-S., & Kim, H.-S. (2019) · Nature Chemical Biology · doi:10.1038/s41589-019-0344-0 · Cited by 184
The fat and the bad: Mature adipocytes, key actors in tumor progression and resistance
Duong, M. N., Geneste, A., Fallone, F., Li, X., Dumontet, C., & Muller, C. (2017) · Oncotarget · doi:10.18632/oncotarget.18038 · Cited by 198
ACSL3 and ACSL4, Distinct Roles in Ferroptosis and Cancers
Yang, Y., Zhu, T., Wang, X., Xiong, F., Hu, Z., Qiao, X., Yuan, X., & Wang, D. (2022) · Cancers · doi:10.3390/cancers14235896 · Cited by 202
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Zhou, Q., Xiang, J., Qiu, N., Wang, Y., Piao, Y., Shao, S., Tang, J., Zhou, Z., & Shen, Y. (2023) · Chemical Reviews · doi:10.1021/acs.chemrev.3c00062 · Cited by 203
Metabolic adaptation of cancer and immune cells mediated by hypoxia-inducible factors
Samanta, D., & Semenza, G. L. (2018) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2018.07.002 · Cited by 190
Lipid desaturation – the next step in targeting lipogenesis in cancer?
Peck, B., & Schulze, A. (2016) · FEBS Journal · doi:10.1111/febs.13681 · Cited by 185
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Tan, Z., Luo, X., Xiao, L., Tang, M., Bode, A. M., Dong, Z., & Cao, Y. (2016) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-15-0621 · Cited by 198
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Ning, Z., Guo, X., Liu, X., Lu, C., Wang, A., Wang, X., Wang, W., Chen, H., Qin, W., Liu, X., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-29846-9 · Cited by 196
Direct Visualization of De novo Lipogenesis in Single Living Cells
Li, J., & Cheng, J. (2014) · Scientific Reports · doi:10.1038/srep06807 · Cited by 183
FABP5 promotes lymph node metastasis in cervical cancer by reprogramming fatty acid metabolism
Zhang, C., Liao, Y., Liu, P., Du, Q., Liang, Y., Ooi, S., Qin, S., He, S., Yao, S., & Wang, W. (2020) · Theranostics · doi:10.7150/thno.44868 · Cited by 186
MicroRNA-195 inhibits proliferation, invasion and metastasis in breast cancer cells by targeting FASN, HMGCR, ACACA and CYP27B1
Singh, R., Yadav, V., Kumar, S., & Saini, N. (2015) · Scientific Reports · doi:10.1038/srep17454 · Cited by 183
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Ma, Y., Shen, N., Wicha, M. S., & Luo, M. (2021) · Cells · doi:10.3390/cells10092415 · Cited by 188
Phenotypic plasticity and genetic control in colorectal cancer evolution
Househam, J., Heide, T., Cresswell, G. D., Spiteri, I., Kimberley, C., Zapata, L., Lynn, C., James, C. T., Mossner, M., Fernández-Mateos, J., et al. (2022) · Nature · doi:10.1038/s41586-022-05311-x · Cited by 187
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Zeng, Q., Gong, Y., Zhu, N., Shi, Y., Zhang, C., & Li, Q. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102294 · Cited by 192
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Demicco, M., Liu, X., Leithner, K., & Fendt, S. (2024) · Nature Metabolism · doi:10.1038/s42255-023-00963-z · Cited by 186
Rapid and comprehensive ‘shotgun’ lipidome profiling of colorectal cancer cell derived exosomes
Lydic, T. A., Townsend, S., Adda, C. G., Collins, C., Mathivanan, S., & Reid, G. E. (2015) · Methods · doi:10.1016/j.ymeth.2015.04.014 · Cited by 183
CNS myelination and remyelination depend on fatty acid synthesis by oligodendrocytes
Dimas, P., Montani, L., Pereira, J. A., Moreno, D., Trötzmüller, M., Gerber, J., Semenkovich, C. F., Köfeler, H. C., & Suter, U. (2019) · eLife · doi:10.7554/elife.44702 · Cited by 178
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Matsuura, K., Canfield, K., Feng, W. W., & Kurokawa, M. (2016) · International review of cytology · doi:10.1016/bs.ircmb.2016.06.006 · Cited by 183
Lipid Metabolic Reprogramming in Hepatocellular Carcinoma
Nakagawa, H., Hayata, Y., Kawamura, S., Yamada, T., Fujiwara, N., & Koike, K. (2018) · Cancers · doi:10.3390/cancers10110447 · Cited by 176
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Cassim, S., Vučetić, M., Ždralević, M., & Pouysségur, J. (2020) · Cancers · doi:10.3390/cancers12051119 · Cited by 183
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Han, S., Wei, R., Zhang, X., Jiang, N., Fan, M., Huang, J., Xie, B., Zhang, L., Miao, W., Butler, A. C.-P., et al. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.01201 · Cited by 174
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Peng, Z., Chang, Y., Fan, J., Ji, W., & Su, C. (2020) · Cancer Letters · doi:10.1016/j.canlet.2020.10.021 · Cited by 176
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He, W., Li, Q., & Li, X. (2022) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2022.188837 · Cited by 182
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Corbet, C., & Féron, O. (2017) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2017.01.002 · Cited by 174
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Du, J., Su, Y., Qian, C., Yuan, D., Miao, K., Lee, D., Ng, A. H. C., Wijker, R. S., Ribas, A., Levine, R. D., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-18376-x · Cited by 171
Systematic Analysis of Gene Expression Alterations and Clinical Outcomes for Long-Chain Acyl-Coenzyme A Synthetase Family in Cancer
Chen, W.-C., Wang, C., Hung, Y.-H., Weng, T., Yen, M., & Lai, M.-D. (2016) · PLoS ONE · doi:10.1371/journal.pone.0155660 · Cited by 173
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The expanded role of fatty acid metabolism in cancer: new aspects and targets
Chen, M., & Huang, J. (2019) · Precision Clinical Medicine · doi:10.1093/pcmedi/pbz017 · Cited by 172
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Kim, S., Lee, Y., & Koo, J. S. (2015) · PLoS ONE · doi:10.1371/journal.pone.0119473 · Cited by 164
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Lipids and Their Trafficking: An Integral Part of Cellular Organization
Jackson, C. L., Walch, L., & Verbavatz, J. (2016) · Developmental Cell · doi:10.1016/j.devcel.2016.09.030 · Cited by 166
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Chandler, P. D., Song, Y., Lin, J., Zhang, S., Sesso, H. D., Mora, S., Giovannucci, E. L., Rexrode, K. M., Moorthy, M. V., Li, C., et al. (2016) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.115.124321 · Cited by 160
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Zaytseva, Y. Y., Harris, J. W., Mitov, M. I., Kim, J. T., Butterfield, D. A., Lee, E. Y., Weiss, H. L., Gao, T., & Evers, B. M. (2015) · Oncotarget · doi:10.18632/oncotarget.3783 · Cited by 153
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Wang, O., Liu, J., Cheng, Q., Guo, X., Wang, Y., Zhao, L., Zhou, F. L., & Ji, B. (2015) · PLoS ONE · doi:10.1371/journal.pone.0118135 · Cited by 159
Acetyl‐coenzyme A carboxylase alpha promotion of glucose‐mediated fatty acid synthesis enhances survival of hepatocellular carcinoma in mice and patients
Wang, M., Wu, H., Fu, G., Zhang, H., Zhou, X., Tang, L., Dong, L., Qin, C., Huang, S., Zhao, L., et al. (2015) · Hepatology · doi:10.1002/hep.28415 · Cited by 149
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Kelly, R. S., Heiden, M. G. V., Giovannucci, E. L., & Mucci, L. A. (2016) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-15-1223 · Cited by 150
When fats commit crimes: fatty acid metabolism, cancer stemness and therapeutic resistance
Kuo, C., & Ann, D. K. (2018) · 癌症：英文版 · doi:10.1186/s40880-018-0317-9 · Cited by 153
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Yang, P., Su, C., Luo, X., Zeng, H., Zhao, L., Li, W., Zhang, X., Varghese, Z., Moorhead, J. F., Chen, Y., et al. (2018) · Cancer Letters · doi:10.1016/j.canlet.2018.09.006 · Cited by 147
Acetyl-CoA carboxylase (ACC) as a therapeutic target for metabolic syndrome and recent developments in ACC1/2 inhibitors
Chen, L., Duan, Y., Wei, H., Ning, H., Bi, C., Zhao, Y., Qin, Y. W., & Li, Y. (2019) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2019.1657825 · Cited by 149
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Wu, Z., Bagarolo, G. I., Thoröe‐Boveleth, S., & Jankowski, J. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.06.009 · Cited by 148
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Zhang, C., Liu, J., Huang, G., Zhao, Y., Yue, X., Wu, H., Li, J., Zhu, J., Shen, Z., Haffty, B. G., et al. (2016) · Genes & Development · doi:10.1101/gad.283283.116 · Cited by 140
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Wang, L., Zhang, T., Wang, L., Cai, Y., Zhong, X., He, X., Hu, L., Tian, S., Wu, M., Hui, L., et al. (2017) · The EMBO Journal · doi:10.15252/embj.201695417 · Cited by 136
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Petan, T. (2020) · Reviews of physiology, biochemistry and pharmacology · doi:10.1007/112_2020_51 · Cited by 145
mTORC2 in the center of cancer metabolic reprogramming
Masui, K., Cavenee, W. K., & Mischel, P. S. (2014) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2014.04.002 · Cited by 140
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Cheng, X., Li, J., & Guo, D. (2018) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026618666180523104541 · Cited by 139
Metabolic communication in tumors: a new layer of immunoregulation for immune evasion
Ho, P.-C., & Liu, P.-S. (2016) · Journal for ImmunoTherapy of Cancer · doi:10.1186/s40425-016-0109-1 · Cited by 124
Proteomic analysis of archival breast cancer clinical specimens identifies biological subtypes with distinct survival outcomes
Asleh, K., Negri, G. L., Miko, S. E. S., Colborne, S., Hughes, C. S., Wang, X. Q., Gao, D., Gilks, C. B., Chia, S., Nielsen, T. O., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-28524-0 · Cited by 132
Targeting STAT3 and oxidative phosphorylation in oncogene-addicted tumors
Lee, M., Hirpara, J. L., Eu, J. Q., Sethi, G., Wang, L., Goh, B.-C., & Wong, A. L. A. (2018) · Redox Biology · doi:10.1016/j.redox.2018.101073 · Cited by 129
Investigation of lipid metabolism dysregulation and the effects on immune microenvironments in pan-cancer using multiple omics data
Hao, Y., Li, D., Xu, Y., Ouyang, J., Wang, Y., Zhang, Y., Li, B., Xie, L., & Qin, G. (2019) · BMC Bioinformatics · doi:10.1186/s12859-019-2734-4 · Cited by 127
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Metabolic crosstalk in the tumor microenvironment regulates antitumor immunosuppression and immunotherapy resisitance
Wei, F., Wang, D., Wei, J., Tang, N., Tang, L. M., Xiong, F., Guo, C. J., Zhou, M., Li, X., Li, G., et al. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03581-0 · Cited by 128
Fatty acid metabolism of immune cells: a new target of tumour immunotherapy
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Metabolic rivalry: circadian homeostasis and tumorigenesis
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Metabolic Switch in the Tumor Microenvironment Determines Immune Responses to Anti-cancer Therapy
Wegiel, B., Vuerich, M., Daneshmandi, S., & Seth, P. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00284 · Cited by 129
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Armitage, E. G., & Southam, A. D. (2016) · Metabolomics · doi:10.1007/s11306-016-1093-7 · Cited by 125
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Lee, B. W. L., Ghode, P. B., & Ong, D. S. T. (2018) · Redox Biology · doi:10.1016/j.redox.2018.11.014 · Cited by 122
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Zhao, S., Lu, C., Shi, Y., Li, J., Yun, Q., & Yang, H. (2021) · Cell Death and Disease · doi:10.1038/s41419-020-03336-6 · Cited by 118
From obesity to cancer: a review on proposed mechanisms
Tahergorabi, Z., Khazaei, M., Moodi, M., & Chamani, E. (2016) · Cell Biochemistry and Function · doi:10.1002/cbf.3229 · Cited by 118
Adiponectin triggers breast cancer cell death via fatty acid metabolic reprogramming
Pham, D., & Park, P. (2022) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-021-02223-y · Cited by 123
Lipid metabolism in chronic obstructive pulmonary disease
Chen, H., Li, Z., Dong, L., Wu, Y., Shen, H., & Chen, Z. (2019) · International Journal of COPD · doi:10.2147/copd.s196210 · Cited by 125
Modeling Nonalcoholic Fatty Liver Disease with Human Pluripotent Stem Cell-Derived Immature Hepatocyte-Like Cells Reveals Activation of PLIN2 and Confirms Regulatory Functions of Peroxisome Proliferator-Activated Receptor Alpha
Graffmann, N., Ring, S., Kawala, M.-A., Wruck, W., Ncube, A., Trompeter, H., & Adjaye, J. (2016) · Stem Cells and Development · doi:10.1089/scd.2015.0383 · Cited by 109
Recent insights into the molecular pathophysiology of lipid droplet formation in hepatocytes
Sahini, N., & Borlak, J. T. (2014) · Progress in Lipid Research · doi:10.1016/j.plipres.2014.02.002 · Cited by 117
The implications of signaling lipids in cancer metastasis
Luo, X., Zhao, X., Cheng, C., Li, N., Liu, Y., & Cao, Y. (2018) · Experimental & Molecular Medicine · doi:10.1038/s12276-018-0150-x · Cited by 115
The roles of sirtuins family in cell metabolism during tumor development
Zhu, S., Dong, Z., Ke, X., Hou, J., Zhao, E., Zhang, K., Wang, F., Yang, L., Xiang, Z., & Cui, H. (2018) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2018.11.003 · Cited by 113
Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism
Aregger, M., Lawson, K. A., Billmann, M., Costanzo, M., Tong, A. H. Y., Chan, K., Rahman, M., Brown, K. R., Ross, C., Usaj, M., et al. (2020) · Nature Metabolism · doi:10.1038/s42255-020-0211-z · Cited by 115

Authors: Currie, E., Schulze, A., Zechner, R., Walther, T. C., & Farese, R. V.
Affiliations: University of California, San Francisco (US)
Cancer Research UK (GB)
University of Graz (AT)
Yale University (US)
Corresponding author: Farese, Robert V.
ORCID: Schulze, Almut
Zechner, Rudolf
Walther, Tobias C.
Farese, Robert V.
Venue: Cell Metabolism
Publisher: Elsevier BV
Published: 2013-08
Volume: 18
Issue: 2
Pages: 153-161
ISSN: 1550-4131 (ISSN-L)
DOI: 10.1016/j.cmet.2013.05.017
PMC: PMC3742569
OpenAlex: W1980568044
Cited by: 2,123
References: 82
Citations by year: 2026: 118 · 2025: 221 · 2024: 228 · 2023: 221 · 2022: 266 · 2021: 204 · 2020: 193 · 2019: 177 · 2018: 139 · 2017: 122 · 2016: 115 · 2015: 72 · 2014: 41 · 2013: 1
FWCI: 6.32
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 370 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Cell Metabolism (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of General Medical Sciences (R01GM099844, R01GM097194)
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK056084, P30DK063720, P30DK026743)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Keywords: fatty acid metabolism, cancer metabolism, lipid metabolism, tumor cell proliferation, fatty acid availability, membrane lipid synthesis
MeSH terms: Energy Metabolism, Fatty Acids, Humans, Neoplasms, Cell Proliferation, Lipid Metabolism

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