Cited by 2,123Cancer, Lipids, and MetabolismLipid metabolism and biosynthesisCancer, Hypoxia, and Metabolism

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Cellular Fatty Acid Metabolism and Cancer

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Currie, Erin, Schulze, Almut, Zechner, Rudolf, Walther, Tobias C., Farese, Robert V.·2013·Cell Metabolism

DOI 10.1016/j.cmet.2013.05.017PMC PMC3742569

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Abstract

Cancer cells often have characteristic changes in metabolism. Cellular proliferation, a common feature of all cancers, requires fatty acids for synthesis of membranes and signaling molecules. Here, we provide a view of cancer cell metabolism from a lipid perspective, and we summarize evidence that limiting fatty acid availability can control cancer cell proliferation.

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Authors: Currie, E., Schulze, A., Zechner, R., Walther, T. C., & Farese, R. V.
Affiliations: University of California, San Francisco (US)
Cancer Research UK (GB)
University of Graz (AT)
Yale University (US)
Corresponding author: Farese, Robert V.
ORCID: Schulze, Almut
Zechner, Rudolf
Walther, Tobias C.
Farese, Robert V.
Venue: Cell Metabolism
Publisher: Elsevier BV
Published: 2013-08
Volume: 18
Issue: 2
Pages: 153-161
ISSN: 1550-4131 (ISSN-L)
DOI: 10.1016/j.cmet.2013.05.017
PMC: PMC3742569
OpenAlex: W1980568044
Cited by: 2,123
References: 82
Citations by year: 2026: 118 · 2025: 221 · 2024: 228 · 2023: 221 · 2022: 266 · 2021: 204 · 2020: 193 · 2019: 177 · 2018: 139 · 2017: 122 · 2016: 115 · 2015: 72 · 2014: 41 · 2013: 1
FWCI: 6.32
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 370 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Cell Metabolism (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of General Medical Sciences (R01GM099844, R01GM097194)
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK056084, P30DK063720, P30DK026743)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Keywords: fatty acid metabolism, cancer metabolism, lipid metabolism, tumor cell proliferation, fatty acid availability, membrane lipid synthesis
MeSH terms: Energy Metabolism, Fatty Acids, Humans, Neoplasms, Cell Proliferation, Lipid Metabolism

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