Cited by 602Metabolism, Diabetes, and CancerExercise and Physiological ResponsesCancer, Hypoxia, and Metabolism

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Molecular Mechanisms Linking Exercise to Cancer Prevention and Treatment

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Hojman, Pernille, Gehl, Julie, Christensen, Jesper F., Pedersen, Bente K.·2018·Cell Metabolism

DOI 10.1016/j.cmet.2017.09.015

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Abstract

The benefits of exercise training for cancer patients are becoming increasingly evident. Physical exercise has been shown to reduce cancer incidence and inhibit tumor growth. Here we provide the status of the current molecular understanding of the effect of exercise on cancer. We propose that exercise has a role in controlling cancer progression through a direct effect on tumor-intrinsic factors, interplay with whole-body exercise effects, alleviation of cancer-related adverse events, and improvement of anti-cancer treatment efficacy. These findings have wide-ranging societal implications, as this understanding may lead to changes in cancer treatment strategies.

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DeBerardinis, R. J., Lum, J. J., Hatzivassiliou, G., & Thompson, C. B. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2007.10.002 · Cited by 4,088
Exercise as medicine - evidence for prescribing exercise as therapy in 26 different chronic diseases
Pedersen, B. K., & Saltin, B. (2015) · Scandinavian Journal of Medicine & Science in Sports · doi:10.1111/sms.12581 · Cited by 3,514
Muscles, exercise and obesity: skeletal muscle as a secretory organ
Pedersen, B. K., & Febbraio, M. A. (2012) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2012.49 · Cited by 2,909
American College of Sports Medicine Roundtable on Exercise Guidelines for Cancer Survivors
Schmitz, K. H., Courneya, K. S., Matthews, C., Demark-Wahnefried, W., GALVÃO, D. A., Pinto, B. M., IRWIN, M. L., WOLIN, K. Y., SEGAL, R. J., LUCIA, A., et al. (2010) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e3181e0c112 · Cited by 2,781
Muscle as an Endocrine Organ: Focus on Muscle-Derived Interleukin-6
Pedersen, B. K., & Febbraio, M. A. (2008) · Physiological Reviews · doi:10.1152/physrev.90100.2007 · Cited by 2,388
Immune checkpoint targeting in cancer therapy: toward combination strategies with curative potential
Sharma, P., & Allison, J. P. (2015) · Cell · doi:10.1016/j.cell.2015.03.030 · Cited by 2,345
YAP/TAZ at the Roots of Cancer
Zanconato, F., Cordenonsi, M., & Piccolo, S. (2016) · Cancer Cell · doi:10.1016/j.ccell.2016.05.005 · Cited by 1,970
Inhibitory effect of tumor cell-derived lactic acid on human T cells
Fischer, K., Hoffmann, P., Voelkl, S., Meidenbauer, N., Ammer, J., Edinger, M., Gottfried, E., Schwarz, S., Rothe, G., Hoves, S., et al. (2007) · Blood · doi:10.1182/blood-2006-07-035972 · Cited by 1,946
Microenvironmental regulation of tumour angiogenesis
De Palma, M., Biziato, D., & Petrova, T. V. (2017) · Nature Reviews Cancer · doi:10.1038/nrc.2017.51 · Cited by 1,847 · cited 1×
“On the other hand, compromising blood flow to a tumor can also be a treatment strategy in itself, as illustrated by anti-angiogenic therapies that are being utilized in the treatment of, e.g., colorectal cancer (De Palma et al., 2017).”
Background
Exercise for depression
Cooney, G. M., Dwan, K., Greig, C. A., Lawlor, D. A., Rimer, J., Waugh, F. R., McMurdo, M., & Mead, G. E. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004366.pub6 · Cited by 1,834
Physical activity and survival after breast cancer diagnosis
Holmes, M. D. (2005) · JAMA · doi:10.1001/jama.293.20.2479 · Cited by 1,772
Regulation of the Hippo-YAP Pathway by G-Protein-Coupled Receptor Signaling
Yu, F.-X., Zhao, B., Panupinthu, N., Jewell, J. L., Lian, I., Wang, L. H., Zhao, J., Yuan, H., Tumaneng, K., Li, H., et al. (2012) · Cell · doi:10.1016/j.cell.2012.06.037 · Cited by 1,628
Cancer metabolism: a therapeutic perspective
Martinez-Outschoorn, U. E., Peiris-Pagés, M., Pestell, R. G., Sotgia, F., & Lisanti, M. P. (2017) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2016.60 · Cited by 1,505
Mechanisms regulating skeletal muscle growth and atrophy
Schiaffino, S., Dyar, K. A., Ciciliot, S., Blaauw, B., & Sandri, M. (2013) · The FEBS Journal · doi:10.1111/febs.12253 · Cited by 1,492
Association of Leisure-Time Physical Activity With Risk of 26 Types of Cancer in 1.44 Million Adults
Moore, S. C., Lee, I.-M., Weiderpass, E., Campbell, P. T., Sampson, J. N., Kitahara, C. M., Keadle, S. K., Arem, H., Berrington de Gonzalez, A., Hartge, P., et al. (2016) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2016.1548 · Cited by 1,487
Nrf2 Redirects Glucose and Glutamine into Anabolic Pathways in Metabolic Reprogramming
Mitsuishi, Y., Taguchi, K., Kawatani, Y., Shibata, T., Nukiwa, T., Aburatani, H., Yamamoto, M., & Motohashi, H. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.05.016 · Cited by 1,395 · cited 1×
“This reprogramming is driven by distinct oncogenic mutations, as seen in the PI3K pathway, or through a more general upregulation of the metabolic machinery with c-Myc mutations (DeBerardinis et al., 2008; Mitsuishi et al., 2012; Tarrado-Castellarnau et al., 2016).”
Background
Fever and the thermal regulation of immunity: the immune system feels the heat
Evans, S. S., Repasky, E. A., & Fisher, D. T. (2015) · Nature reviews. Immunology · doi:10.1038/nri3843 · Cited by 1,312
Foxp3 Reprograms T Cell Metabolism to Function in Low-Glucose, High-Lactate Environments
Angelin, A., Gil‐de‐Gómez, L., Dahiya, S., Jiao, J., Guo, L., Levine, M. H., Wang, Z., Quinn, W. J., Kopinski, P. K., Wang, L., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2016.12.018 · Cited by 1,304
Integrative Biology of Exercise
Hawley, J. A., Hargreaves, M., Joyner, M. J., & Zierath, J. R. (2014) · Cell · doi:10.1016/j.cell.2014.10.029 · Cited by 1,152
Immune infiltration in human tumors: a prognostic factor that should not be ignored
Pagès, F., Galon, J., Dieu‐Nosjean, M., Tartour, É., Sautès‐Fridman, C., & Fridman, W. H. (2009) · Oncogene · doi:10.1038/onc.2009.416 · Cited by 1,126
Understanding the mechanisms and treatment options in cancer cachexia
Fearon, K. C. H., Arends, J., & Baracos, V. E. (2012) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2012.209 · Cited by 952
Exercise interventions on health-related quality of life for cancer survivors
Mishra, S. I., Scherer, R. W., Geigle, P. M., Berlanstein, D. R., Topaloglu, Ö., Gotay, C. C., & Snyder, C. F. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007566.pub2 · Cited by 904
Exercise for depression
Cooney, G. M., Dwan, K., Greig, C. A., Lawlor, D. A., Rimer, J., Waugh, F. R., McMurdo, M., & Mead, G. E. (2014) · Advances in Psychiatric Treatment · doi:10.1192/apt.20.1.2 · Cited by 895
Voluntary running suppresses tumor growth through epinephrine- and IL-6-dependent NK cell mobilization and redistribution
Pedersen, L., Idorn, M., Olofsson, G. H., Lauenborg, B., Nookaew, I., Hansen, R. H., Johannesen, H. H., Becker, J. C., Pedersen, K. S., Dethlefsen, C., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.01.011 · Cited by 888
Physical activity and survival after colorectal cancer diagnosis
Meyerhardt, J. A., Giovannucci, E. L., Holmes, M. D., Chan, A. T., Chan, J. A., Colditz, G. A., & Fuchs, C. S. (2006) · Journal of Clinical Oncology · doi:10.1200/jco.2006.06.0855 · Cited by 857
Physical Activity, Biomarkers, and Disease Outcomes in Cancer Survivors: A Systematic Review
Ballard-Barbash, R. R., Friedenreich, C. M., Courneya, K. S., Siddiqi, S. M., McTiernan, A., & Alfano, C. M. (2012) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djs207 · Cited by 832
Obesity and cancer—mechanisms underlying tumour progression and recurrence
Park, J., Morley, T. S., Kim, M. G., Clegg, D. J., & Scherer, P. E. (2014) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2014.94 · Cited by 813
Mechanisms linking physical activity with cancer
McTiernan, A. (2008) · Nature reviews. Cancer · doi:10.1038/nrc2325 · Cited by 743
Skeletal Muscle PGC-1α1 Modulates Kynurenine Metabolism and Mediates Resilience to Stress-Induced Depression
Agudelo, L. Z., Femenía, T., Orhan, F., Porsmyr-Palmertz, M., Goiny, M., Martinez-Redondo, V., Correia, J. C., Izadi, M., Bhat, M., Schuppe-Koistinen, I., et al. (2014) · Cell · doi:10.1016/j.cell.2014.07.051 · Cited by 739
Exercise interventions on health-related quality of life for people with cancer during active treatment
Mishra, S. I., Scherer, R. W., Snyder, C. F., Geigle, P. M., Berlanstein, D. R., & Topaloglu, Ö. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008465.pub2 · Cited by 729
Redistribution, Hyperproliferation, Activation of Natural Killer Cells and CD8 T Cells, and Cytokine Production During First-in-Human Clinical Trial of Recombinant Human Interleukin-15 in Patients With Cancer
Conlon, K. C., Lugli, E., Welles, H. C., Rosenberg, S. A., Fojo, A. T., Morris, J. C., Fleisher, T. A., Dubois, S. P., Perera, L. P., Stewart, D. M., et al. (2014) · Journal of Clinical Oncology · doi:10.1200/jco.2014.57.3329 · Cited by 728
Tumour-derived PTH-related protein triggers adipose tissue browning and cancer cachexia
Kır, S., White, J. P., Kleiner, S., Kazak, L., Cohen, P., Baracos, V. E., & Spiegelman, B. M. (2014) · Nature · doi:10.1038/nature13528 · Cited by 690
Combined Resistance and Aerobic Exercise Program Reverses Muscle Loss in Men Undergoing Androgen Suppression Therapy for Prostate Cancer Without Bone Metastases: A Randomized Controlled Trial
Galvão, D. A., Taaffe, D. R., Spry, N., Joseph, D., & Newton, R. U. (2010) · Journal of Clinical Oncology · doi:10.1200/jco.2009.23.2488 · Cited by 657
The metabolic checkpoint kinase mTOR is essential for IL-15 signaling during the development and activation of NK cells
Marçais, A., Cherfils‐Vicini, J., Viant, C., Degouve, S., Viel, S., Fenis, A., Rabilloud, J., Mayol, K., Tavares, A., Bienvenu, J., et al. (2014) · Nature Immunology · doi:10.1038/ni.2936 · Cited by 643
Physical Activity and Survival After Prostate Cancer Diagnosis in the Health Professionals Follow-Up Study
Kenfield, S. A., Stampfer, M. J., Giovannucci, E., & Chan, J. M. (2011) · Journal of Clinical Oncology · doi:10.1200/jco.2010.31.5226 · Cited by 601
Exploiting the critical perioperative period to improve long-term cancer outcomes
Horowitz, M., Neeman, E., Sharon, E., & Ben-Eliyahu, S. (2015) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2014.224 · Cited by 487
Selective activation of AMPK‐PGC‐1α or PKB‐TSC2‐mTOR signaling can explain specific adaptive responses to endurance or resistance training‐like electrical muscle stimulation
Atherton, P. J., Babraj, J. A., Smith, K., Singh, J., Rennie, M. J., & Wackerhage, H. (2005) · The FASEB Journal · doi:10.1096/fj.04-2179fje · Cited by 475
Understanding the Cellular and Molecular Mechanisms of Physical Activity-Induced Health Benefits
Neufer, P. D., Bamman, M. M., Muoio, D. M., Bouchard, C., Cooper, D. M., Goodpaster, B. H., Booth, F. W., Kohrt, W. M., Gerszten, R. E., Mattson, M. P., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.05.011 · Cited by 474
Exercise as an anti-inflammatory therapy for rheumatic diseases—Myokine regulation
Benatti, F. B., & Pedersen, B. K. (2015) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2014.193 · Cited by 474 · cited 2×
“…the vicious cycle of chronic inflammation, both directly through induction of anti-inflammatory cytokines during each bout of exercise and indirectly by improving comorbidities and cardiovascular risk factors, in particular by decreasing the amount of visceral fat (Benatti and Pedersen, 2015).”
Background
BRD4 Connects Enhancer Remodeling to Senescence Immune Surveillance
Tasdemir, N., Banito, A., Roe, J.-S., Alonso-Curbelo, D., Camiolo, M., Tschaharganeh, D. F., Huang, C.-H., Aksoy, O., Bolden, J. E., Chen, C.-C., et al. (2016) · Cancer Discovery · doi:10.1158/2159-8290.cd-16-0217 · Cited by 415
Improving radiotherapy in cancer treatment: Promises and challenges
Chen, H. H. W., & Kuo, M. T. (2017) · Oncotarget · doi:10.18632/oncotarget.18409 · Cited by 398
A novel myokine, secreted protein acidic and rich in cysteine (SPARC), suppresses colon tumorigenesis via regular exercise
Aoi, W., Naito, Y., Takagi, T., Tanimura, Y., Takanami, Y., Kawai, Y., Sakuma, K., Hang, L. P., Mizushima, K., Hirai, Y., et al. (2013) · Gut · doi:10.1136/gutjnl-2011-300776 · Cited by 347
Reduced Levels of IGF-I Mediate Differential Protection of Normal and Cancer Cells in Response to Fasting and Improve Chemotherapeutic Index
Lee, C. D., Safdie, F. M., Raffaghello, L., Wei, M., Madia, F., Parrella, E., Hwang, D., Cohen, P., Bianchi, G., & Longo, V. D. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-3228 · Cited by 326
Tissue-specific tumorigenesis: context matters
Schneider, G., Schmidt‐Supprian, M., Rad, R., & Saur, D. (2017) · Nature reviews. Cancer · doi:10.1038/nrc.2017.5 · Cited by 322
PTH/PTHrP Receptor Mediates Cachexia in Models of Kidney Failure and Cancer
Kır, S., Komaba, H., Garcia, A. P., Economopoulos, K. P., Liu, W., Lanske, B., Hodin, R. A., & Spiegelman, B. M. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.11.003 · Cited by 312
Modulation of murine breast tumor vascularity, hypoxia and chemotherapeutic response by exercise
Betof, A. S., Lascola, C. D., Weitzel, D., Landon, C., Scarbrough, P. M., Devi, G. R., Palmer, G., Jones, L. W., & Dewhirst, M. W. (2015) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/djv040 · Cited by 309
IL-7 and IL-15 independently program the differentiation of intestinal CD3−NKp46+ cell subsets from Id2-dependent precursors
Satoh‐Takayama, N., Lesjean‐Pottier, S., Vieira, P., Sawa, S., Eberl, G., Vosshenrich, C. A. J., & Santo, J. P. D. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20092029 · Cited by 307
Dynamics of the skeletal muscle secretome during myoblast differentiation
Henningsen, J., Rigbolt, K. T. G., Blagoev, B., Pedersen, B. K., & Kratchmarova, I. (2010) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m110.002113 · Cited by 303
Physical activity and telomere length: Impact of aging and potential mechanisms of action
Arsenis, N. C., You, T., Ogawa, E. F., Tinsley, G. M., & Zuo, L. (2017) · Oncotarget · doi:10.18632/oncotarget.16726 · Cited by 303
The Ever-Expanding Myokinome: Discovery Challenges and Therapeutic Implications
Whitham, M., & Febbraio, M. A. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.153 · Cited by 279
Preoperative exercise training for patients with non-small cell lung cancer
Cavalheri, V., & Granger, C. L. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012020.pub2 · Cited by 262
Exercise-induced muscle-derived cytokines inhibit mammary cancer cell growth
Hojman, P., Dethlefsen, C., Brandt, C., Hansen, J., Pedersen, L., & Pedersen, B. K. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00520.2010 · Cited by 259 · cited 2×
“…a few preclinical studies have demonstrated that muscle-derived Oncostatin M (OSM) and Irisin inhibit breast cancer cell viability in vitro (Gannon et al., 2015; Hojman et al., 2011), while the myokine SPARC has been shown to reduce tumorigenesis in the colon of exercising mice (Aoi et al., 2013).”
Background
Muscle dysfunction in cancer patients
Christensen, J. F., Jones, L. W., Andersen, J. L., Daugaard, G., Rørth, M. R., & Højman, P. (2014) · Annals of Oncology · doi:10.1093/annonc/mdt551 · Cited by 257
Effects of a Caloric Restriction Weight Loss Diet and Exercise on Inflammatory Biomarkers in Overweight/Obese Postmenopausal Women: A Randomized Controlled Trial
Imayama, I., Ulrich, C. M., Alfano, C. M., Wang, C., Xiao, L., Wener, M. H., Campbell, K. L., Duggan, C. R., Foster‐Schubert, K. E., Kong, A., et al. (2012) · Cancer Research · doi:10.1158/0008-5472.can-11-3092 · Cited by 252
Dual Roles for Immunity in Gastrointestinal Cancers
Ferrone, C. R., & Dranoff, G. (2010) · Journal of Clinical Oncology · doi:10.1200/jco.2010.27.9992 · Cited by 245
Fever-range thermal stress promotes lymphocyte trafficking across high endothelial venules via an interleukin 6 trans-signaling mechanism
Chen, Q., Fisher, D. T., CLANCY, K. A., Gauguet, J.-M., Wang, W., Unger, E., Rose‐John, S., von Andrian, U. H., Baumann, H., & Evans, S. S. (2006) · Nature Immunology · doi:10.1038/ni1406 · Cited by 233
IL-6 trans-signaling licenses mouse and human tumor microvascular gateways for trafficking of cytotoxic T cells.
Fisher, D., Chen, Q., Skitzki, J. J., Muhitch, J., Zhou, L., Appenheimer, M. M., Vardam, T. D., Weis, E. L., Passanese, J., Wang, W.-C., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci44952 · Cited by 225
Exercise-Dependent Regulation of NK Cells in Cancer Protection
Idorn, M., & Højman, P. (2016) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2016.05.007 · Cited by 223
Human thermoregulation and the cardiovascular system
González‐Alonso, J. (2012) · Experimental Physiology · doi:10.1113/expphysiol.2011.058701 · Cited by 221
Weight management and its role in breast cancer rehabilitation
Demark‐Wahnefried, W., Campbell, K. L., & Hayes, S. C. (2012) · QUT ePrints (Queensland University of Technology) · Cited by 219
Efficacy and Mechanisms of Aerobic Exercise on Cancer Initiation, Progression, and Metastasis: A Critical Systematic Review of In Vivo Preclinical Data
Ashcraft, K. A., Peace, R. M., Betof, A. S., Dewhirst, M. W., & Jones, L. W. (2016) · Cancer Research · doi:10.1158/0008-5472.can-16-0887 · Cited by 217
Cancer, obesity, diabetes, and antidiabetic drugs: is the fog clearing?
Klil-Drori, A. J., Azoulay, L., & Pollak, M. (2016) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2016.120 · Cited by 212
A systematic review of pre-surgical exercise intervention studies with cancer patients
Singh, F., Newton, R. U., Galvao, D. A., Spry, N. A., & Baker, M. K. (2013) · Surgical Oncology · doi:10.1016/j.suronc.2013.01.004 · Cited by 210
Exercise interventions on health‐related quality of life for people with cancer during active treatment
Mishra, S. I., Scherer, R. W., Snyder, C. F., Geigle, P. M., Berlanstein, D. R., & Topaloglu, Ö. (2012) · Clinical Otolaryngology · doi:10.1111/coa.12015 · Cited by 206
Depressive spectrum disorders in cancer: prevalence, risk factors and screening for depression: a critical review
Caruso, R., Nanni, M. G., Riba, M., Sabato, S., Mitchell, A. J., Croce, E., & Grassi, L. (2017) · Acta Oncologica · doi:10.1080/0284186x.2016.1266090 · Cited by 203
Tumor vessel normalization after aerobic exercise enhances chemotherapeutic efficacy
Schadler, K. L., Thomas, N. J., Galie, P. A., Bhang, D. H., Roby, K. C., Addai, P., Till, J. E., Sturgeon, K., Zaslavsky, A., Chen, C. S., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.11748 · Cited by 199
A framework for prescription in exercise‐oncology research
SASSO, J. P., Eves, N. D., Christensen, J. F., Koelwyn, G. J., Scott, J. M., & Jones, L. W. (2015) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12042 · Cited by 196
Effects of the exercise‐inducible myokine irisin on malignant and non‐malignant breast epithelial cell behavior in vitro
Gannon, N. P., Vaughan, R. A., Garcia‐Smith, R., Bisoffi, M., & Trujillo, K. A. (2014) · International Journal of Cancer · doi:10.1002/ijc.29142 · Cited by 193
The Limits of Exercise Physiology: From Performance to Health
Gabriel, B. M., & Zierath, J. R. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.04.018 · Cited by 193
Exercise interventions on health‐related quality of life for cancer survivors
Roland, N. J., & Rogers, S. N. (2012) · Clinical Otolaryngology · doi:10.1111/coa.12032 · Cited by 189
Exercise-Induced Catecholamines Activate the Hippo Tumor Suppressor Pathway to Reduce Risks of Breast Cancer Development
Dethlefsen, C., Hansen, L. S., Lillelund, C., Andersen, C., Gehl, J., Christensen, J. F., Pedersen, B. K., & Højman, P. (2017) · Cancer Research · doi:10.1158/0008-5472.can-16-3125 · Cited by 189
The impact of T‐cell immunity on ovarian cancer outcomes
Nelson, B. H. (2008) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00614.x · Cited by 184
Transmission of donor melanoma by organ transplantation
Strauß, D., & Thomas, J. M. (2010) · The Lancet Oncology · doi:10.1016/s1470-2045(10)70024-3 · Cited by 183
The Hippo Transducer YAP1 Transforms Activated Satellite Cells and Is a Potent Effector of Embryonal Rhabdomyosarcoma Formation
Tremblay, A. M., Missiaglia, E., Galli, G. G., Hettmer, S., Urcia, R., Carrara, M., Judson, R. N., Thway, K., Nadal, G., Selfe, J. L., et al. (2014) · Cancer Cell · doi:10.1016/j.ccr.2014.05.029 · Cited by 178
Association of CTNNB1 (β-Catenin) Alterations, Body Mass Index, and Physical Activity With Survival in Patients With Colorectal Cancer
Morikawa, T. (2011) · JAMA · doi:10.1001/jama.2011.513 · Cited by 178
Endurance exercise increases skeletal muscle kynurenine aminotransferases and plasma kynurenic acid in humans
Schlittler, M., Goiny, M., Agudelo, L. Z., Venckūnas, T., Brazaitis, M., Skurvydas, A., Kamandulis, S., Ruas, J. L., Erhardt, S., Westerblad, H., et al. (2016) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00053.2016 · Cited by 178
Type I Interferons and Natural Killer Cell Regulation in Cancer
Müller, L., Aigner, P., & Stoiber, D. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00304 · Cited by 173
Oncogenic regulation of tumor metabolic reprogramming
Tarrado‐Castellarnau, M., de Atauri, P., & Cascante, M. (2016) · Oncotarget · doi:10.18632/oncotarget.10911 · Cited by 165
Breast cancer oral anti-cancer medication adherence: a systematic review of psychosocial motivators and barriers
Lin, C., Clark, R., Tu, P., Bosworth, H. B., & Zullig, L. L. (2017) · Breast Cancer Research and Treatment · doi:10.1007/s10549-017-4317-2 · Cited by 160
Modulation of blood flow, hypoxia, and vascular function in orthotopic prostate tumors during exercise
McCullough, D. J., Stabley, J. N., Siemann, D. W., & Behnke, B. J. (2014) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/dju036 · Cited by 159
Effects of Exercise on Tumor Physiology and Metabolism
Pedersen, L., Christensen, J. F., & Højman, P. (2015) · The Cancer Journal · doi:10.1097/ppo.0000000000000096 · Cited by 142
Effect of Exercise on Markers of Inflammation in Breast Cancer Survivors: The Yale Exercise and Survivorship Study
Jones, S. B., Thomas, G. A., Hesselsweet, S. D., Alvarez-Reeves, M., Yu, H., & Irwin, M. L. (2012) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-12-0278 · Cited by 132
Regular exercise decreases liver tumors development in hepatocyte-specific PTEN-deficient mice independently of steatosis
Piguet, A., Saran, U., Simillion, C., Keller, I., Terracciano, L., Reeves, H. L., & Dufour, J. (2015) · Journal of Hepatology · doi:10.1016/j.jhep.2015.01.017 · Cited by 127
Myostatin Gene Inactivation Prevents Skeletal Muscle Wasting in Cancer
Gallot, Y. S., Durieux, A., Castells, J., Desgeorges, M. M., Vernus, B., Plantureux, L., Rémond, D., Jahnke, V. E., Lefai, É., Dardevet, D. P., et al. (2014) · Cancer Research · doi:10.1158/0008-5472.can-14-0057 · Cited by 123
Exercise regulates breast cancer cell viability: systemic training adaptations versus acute exercise responses
Dethlefsen, C., Lillelund, C., Midtgaard, J., Andersen, C., Pedersen, B. K., Christensen, J. F., & Højman, P. (2016) · Breast Cancer Research and Treatment · doi:10.1007/s10549-016-3970-1 · Cited by 120
Effect of Acute Exercise on Prostate Cancer Cell Growth
Rundqvist, H., Augsten, M., Strömberg, A., Rullman, E., Mijwel, S., Kharaziha, P., Panaretakis, T., Gustafsson, T. P., & Östman, A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0067579 · Cited by 118
Every exercise bout matters: linking systemic exercise responses to breast cancer control
Dethlefsen, C., Pedersen, K. S., & Højman, P. (2017) · Breast Cancer Research and Treatment · doi:10.1007/s10549-017-4129-4 · Cited by 103
Exercise‐induced lung cancer regression: Mechanistic findings from a mouse model
Higgins, K. A., Park, D., Lee, G. Y., Curran, W. J., & Deng, X. (2014) · Cancer · doi:10.1002/cncr.28878 · Cited by 98
Inflammation‐induced activation of the indoleamine 2,3‐dioxygenase pathway: Relevance to cancer‐related fatigue
Kim, S., Miller, B. J., Stefanek, M. E., & Miller, A. H. (2015) · Cancer · doi:10.1002/cncr.29302 · Cited by 93
Effects of exercise training on tumor hypoxia and vascular function in the rodent preclinical orthotopic prostate cancer model
McCullough, D. J., Nguyen, L. M. ‐., Siemann, D. W., & Behnke, B. J. (2013) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00949.2013 · Cited by 89
Autophagy and cardiovascular aging
Nair, S., & Ren, J. T. (2012) · Cell Cycle · doi:10.4161/cc.20317 · Cited by 85
Exercise Improves V˙O2max and Body Composition in Androgen Deprivation Therapy–treated Prostate Cancer Patients
Wall, B. A., Galvao, D. A., Fatehee, N. N., Taaffe, D. R., Spry, N. A., Joseph, D. J., Hébert, J. J., & Newton, R. U. (2017) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000001277 · Cited by 84
Local hyperthermia in head and neck cancer: mechanism, application and advance
Gao, S., Zheng, M. H., Ren, X., Tang, Y., & Liang, X. (2016) · Oncotarget · doi:10.18632/oncotarget.10350 · Cited by 77
Cancer Immunosurveillance and Immunoediting by Natural Killer Cells
Gross, E. T. E., Sunwoo, J. B., & Bui, J. D. (2013) · The Cancer Journal · doi:10.1097/ppo.0000000000000005 · Cited by 68
Exercise‐induced changes in tumour LDH‐B and MCT1 expression are modulated by oestrogen‐related receptor alpha in breast cancer‐bearing BALB/c mice
Aveseh, M., Nikooie, R., & Aminaie, M. (2015) · The Journal of Physiology · doi:10.1113/jp270463 · Cited by 67
Impact of Acute Intermittent Exercise on Natural Killer Cells in Breast Cancer Survivors
Evans, E. S., Hackney, A. C., McMurray, R. G., Randell, S. H., Muss, H. B., Deal, A. M., & Battaglini, C. L. (2015) · Integrative Cancer Therapies · doi:10.1177/1534735415580681 · Cited by 65
Inhibition of Human Lung Cancer Cell Proliferation and Survival by Post-Exercise Serum Is Associated with the Inhibition of Akt, mTOR, p70 S6K, and Erk1/2
Kurgan, N., Tsakiridis, E. E., Kouvelioti, R., Moore, J., Klentrou, P., & Tsiani, E. (2017) · Cancers · doi:10.3390/cancers9050046 · Cited by 62
Exercise and Prognosis on the Basis of Clinicopathologic and Molecular Features in Early-Stage Breast Cancer: The LACE and Pathways Studies
Jones, L. W., Kwan, M. L., Weltzien, E. K., Chandarlapaty, S., Sternfeld, B., Sweeney, C., Bernard, P. S., Castillo, A., Habel, L. A., Kroenke, C. H., et al. (2016) · Cancer Research · doi:10.1158/0008-5472.can-15-3307 · Cited by 61
Exercise effects on tumorigenesis in a p53-deficient mouse model of breast cancer
COLBERT, L. H., WESTERLIND, K. C., PERKINS, S. N., HAINES, D. C., BERRIGAN, D., DONEHOWER, L. A., FUCHS-YOUNG, R., & HURSTING, S. D. (2009) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31819f1f05 · Cited by 60
Candidate mechanisms accounting for effects of physical activity on breast carcinogenesis
Thompson, H. J., Jiang, W., & Zhu, Z. (2009) · IUBMB Life · doi:10.1002/iub.233 · Cited by 59 · cited 2×
“In contrast, the Akt/mTOR pathway has been shown to be deactivatedwith endurance exercise in several models ofmurine tumors (Thompson et al., 2009).”
Background
Voluntary Exercise Prevents Cisplatin-Induced Muscle Wasting during Chemotherapy in Mice
Højman, P., Fjelbye, J., Zerahn, B., Christensen, J. F., Dethlefsen, C., Lønkvist, C. K., Brandt, C., Gissel, H., Pedersen, B. K., & Gehl, J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0109030 · Cited by 58
Blood flow responses to mild-intensity exercise in ectopic vs. orthotopic prostate tumors; dependence upon host tissue hemodynamics and vascular reactivity
Garcia, E., Becker, V. G. C., McCullough, D. J., Stabley, J. N., Gittemeier, E. M., Opoku-Acheampong, A. B., Sieman, D. W., & Behnke, B. J. (2016) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00266.2016 · Cited by 57
Interventions that may reduce depressive symptoms among prostate cancer patients: a systematic review and meta‐analysis
Newby, T. A., Graff, J. N., Ganzini, L. K., & McDonagh, M. S. (2015) · Psycho-Oncology · doi:10.1002/pon.3781 · Cited by 52
The Hippo signal transduction network for exercise physiologists
Gabriel, B. M., Hamilton, D. L., Tremblay, A. M., & Wackerhage, H. (2016) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01076.2015 · Cited by 48 · cited 1×
“Recent studies have demonstrated that this pathway is downregulated by exercise and catecholamines (Gabriel et al., 2016; Yu et al., 2012).”
Background
Effects of strength training on muscle cellular outcomes in prostate cancer patients on androgen deprivation therapy
Nilsen, T. S., Thorsen, L., Fosså, S. D., Wiig, M., Kirkegaard, C., Skovlund, E., Benestad, H. B., & Raastad, T. (2015) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/sms.12543 · Cited by 46
Metabolic Approaches to Treatment of Melanoma
Hersey, P., Watts, R. N., Zhang, X. D., & Hackett, J. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-0251 · Cited by 38
Endurance training improves insulin sensitivity and body composition in prostate cancer patients treated with androgen deprivation therapy
Hvid, T., Winding, K. M., Rinnov, A., Dejgaard, T. F., Thomsen, C., Iversen, P., Brasso, K., Mikines, K. J., van Hall, G., Lindegaard, B., et al. (2013) · Endocrine Related Cancer · doi:10.1530/erc-12-0393 · Cited by 38
Stimulatory effect of voluntary exercise or fat removal (partial lipectomy) on apoptosis in the skin of UVB light-irradiated mice
Lu, Y., Lou, Y.-R., Nolan, B., Peng, Q., Xie, J., Wagner, G. C., & Conney, A. H. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607789103 · Cited by 33
Inflammatory Marker Changes in Postmenopausal Women after a Year-long Exercise Intervention Comparing High Versus Moderate Volumes
Friedenreich, C. M., O’Reilly, R., Shaw, E., Stanczyk, F. Z., Yasui, Y., Brenner, D. R., & Courneya, K. S. (2015) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-15-0284 · Cited by 33
Association between changes in fat distribution and biomarkers for breast cancer
van Gemert, W. A., Monninkhof, E. M., May, A. M., Elias, S. G., van der Palen, J. A. M., Veldhuis, W. B., Stapper, M., Stellato, R. K., Schuit, A. J., & Peeters, P. H. M. (2017) · Endocrine Related Cancer · doi:10.1530/erc-16-0490 · Cited by 26
Voluntary physical activity abolishes the proliferative tumor growth microenvironment created by adipose tissue in animals fed a high fat diet
Theriau, C. F., Shpilberg, Y., Riddell, M. C., & Connor, M. K. (2016) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00862.2015 · Cited by 25
Effects of limiting energy availability via diet and physical activity on mammalian target of rapamycin-related signaling in rat mammary carcinomas
Jiang, W., Zhu, Z., & Thompson, H. J. (2012) · Carcinogenesis · doi:10.1093/carcin/bgs350 · Cited by 18

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Muscle–Organ Crosstalk: The Emerging Roles of Myokines
Severinsen, M. C. K., & Pedersen, B. K. (2020) · Endocrine Reviews · doi:10.1210/endrev/bnaa016 · Cited by 1,226
“com/edrv A few mechanistic studies have demonstrated a potential role of other myokines, including Oncostatin M, irisin, and SPARC in the suppression of breast and colon cancer growth (41, 224-227).”
BackgroundInfluential
American College of Sports Medicine Roundtable Report on Physical Activity, Sedentary Behavior, and Cancer Prevention and Control
PATEL, A. V., FRIEDENREICH, C. M., MOORE, S. C., HAYES, S. C., SILVER, J. K., CAMPBELL, K. L., WINTERS-STONE, K., GERBER, L. H., GEORGE, S. M., FULTON, J. E., et al. (2019) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000002117 · Cited by 861
American Cancer Society guideline for diet and physical activity for cancer prevention
Rock, C. L., Thomson, C., Gansler, T., Gapstur, S. M., McCullough, M. L., Patel, A. V., Andrews, K. S., Bandera, E. V., Spees, C. K., Robien, K., et al. (2020) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21591 · Cited by 789
Physical activity and muscle-brain crosstalk
Pedersen, B. K. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0174-x · Cited by 772
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Physical activity and risks of breast and colorectal cancer: a Mendelian randomisation analysis
Papadimitriou, N., Dimou, N. L., Tsilidis, K. K., Banbury, B. L., Martin, R. M., Lewis, S. J., Kazmi, N., Robinson, T., Albanes, D., Aleksandrova, K., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-14389-8 · Cited by 664
“Multiple biological mechanisms are hypothesised to mediate the potential bene ﬁ cial role of physical activity on cancer development 21,22 .”

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Authors: Hojman, P., Gehl, J., Christensen, J. F., & Pedersen, B. K.
Affiliations: Herlev Hospital (DK)
University of Copenhagen (DK)
ORCID: Gehl, Julie
Christensen, Jesper F.
Pedersen, Bente K.
Venue: Cell Metabolism
Publisher: Elsevier BV
Published: 2018-01
Volume: 27
Issue: 1
Pages: 10-21
ISSN: 1550-4131 (ISSN-L)
DOI: 10.1016/j.cmet.2017.09.015
OpenAlex: W2765400080
Cited by: 600
References: 112
Citations by year: 2026: 63 · 2025: 78 · 2024: 86 · 2023: 71 · 2022: 90 · 2021: 77 · 2020: 70 · 2019: 38 · 2018: 25
FWCI: 3.43
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 374 d)
Locations: Cell Metabolism (publishedVersion)
PubMed (publishedVersion)
Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
Funders: Danmarks Grundforskningsfond (DNRF55)
Strategiske ForskningsrÃ¥d (09-067009, 09-075724)
TrygFonden
KrÃ¦ftens BekÃ¦mpelse
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Keywords: physical activity, cancer prevention, cancer therapy, tumor growth inhibition, tumor progression, tumor-intrinsic factors, exercise-induced metabolic changes, molecular mechanisms
MeSH terms: Humans, Immunity, Models, Biological, Neoplasms, Exercise, Carcinogenesis

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Molecular Mechanisms Linking Exercise to Cancer Prevention and Treatment

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