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Cited by 857Physical Activity and HealthCancer survivorship and careCancer Risks and Factors

Physical activity and survival after colorectal cancer diagnosis

Meyerhardt, Jeffrey A., Giovannucci, Edward L., Holmes, Michelle D., Chan, Andrew T., Chan, Jennifer A., Colditz, Graham A., Fuchs, Charles S.·2006·Journal of Clinical Oncology
DOI 10.1200/jco.2006.06.0855
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Abstract

PURPOSE: Physically active individuals have a lower risk of developing colorectal cancer but the influence of exercise on cancer survival is unknown. PATIENTS AND METHODS: By a prospective, observational study of 573 women with stage I to III colorectal cancer, we studied colorectal cancer-specific and overall mortality according to predefined physical activity categories before and after diagnosis and by change in activity after diagnosis. To minimize bias by occult recurrences, we excluded women who died within 6 months of their postdiagnosis physical activity assessment. RESULTS: Increasing levels of exercise after diagnosis of nonmetastatic colorectal cancer reduced cancer-specific mortality (P for trend = .008) and overall mortality (P for trend = .003). Compared with women who engaged in less than 3 metabolic equivalent task [MET] -hours per week of physical activity, those engaging in at least 18 MET-hours per week had an adjusted hazard ratio for colorectal cancer-specific mortality of 0.39 (95% CI, 0.18 to 0.82) and an adjusted hazard ratio for overall mortality of 0.43 (95% CI, 0.25 to 0.74). These results remained unchanged even after excluding women who died within 12 and 24 months of activity assessment. Prediagnosis physical activity was not predictive of mortality. Women who increased their activity (when comparing prediagnosis to postdiagnosis values) had a hazard ratio of 0.48 (95% CI, 0.24 to 0.97) for colorectal cancer deaths and a hazard ratio of 0.51 (95% CI, 0.30 to 0.85) for any-cause death, compared with those with no change in activity. CONCLUSION: Recreational physical activity after the diagnosis of stages I to III colorectal cancer may reduce the risk of colorectal cancer-specific and overall mortality.

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  • Some evidence suggests that physical activity postdiagnosis may improve cancer survival for some cancers, including breast and colorectal.

    “Some evidence also suggests that physical activity postdiagnosis may improve cancer survival for some cancers, including breast (38) and colorectal (39).”

    From Diabetes and Cancer (2010) · cites this paper as [39]

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Authors
Meyerhardt, J. A., Giovannucci, E. L., Holmes, M. D., Chan, A. T., Chan, J. A., Colditz, G. A., & Fuchs, C. S.
Affiliations
Brigham and Women's Hospital (US)
ORCID
Venue
Journal of Clinical Oncology
Publisher
American Society of Clinical Oncology (ASCO)
Published
2006-08-01
Volume
24
Issue
22
Pages
3527-3534
ISSN
  • 0732-183X (ISSN-L)
  • 1527-7755
DOI
10.1200/jco.2006.06.0855
OpenAlex
W2114841681
Cited by
857
References
55
Citations by year
2026: 13 · 2025: 26 · 2024: 19 · 2023: 24 · 2022: 32 · 2021: 41 · 2020: 43 · 2019: 31 · 2018: 51 · 2017: 62 · 2016: 53 · 2015: 66 · 2014: 36 · 2013: 63 · 2012: 57
FWCI
30.27
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Clinical Oncology (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Cancer Institute (P01CA087969, K07CA097992)
Topics
  • Health Sciences › Medicine › Physiology › Physical Activity and Health
  • Health Sciences › Medicine › Oncology › Cancer survivorship and care
  • Health Sciences › Medicine › Oncology › Cancer Risks and Factors
Keywords
physical activity, colorectal cancer, cancer-specific mortality, all-cause mortality, recreational exercise, metabolic equivalent hours, women, non-metastatic colorectal cancer, survival
MeSH terms
Aged, Physical Exertion, Female, Humans, Life Style, Middle Aged, Motor Activity, Neoplasm Staging, Nurses, Prospective Studies, Surveys and Questionnaires, Risk Factors, United States, Colorectal Neoplasms, Exercise, Survival Rate, Multivariate Analysis, Odds Ratio

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