Nicotinamide Improves Aspects of Healthspan, but Not Lifespan, in Mice

The Pathobiology of Diabetic Complications

Brownlee, M. (2005) · Diabetes · doi:10.2337/diabetes.54.6.1615 · Cited by 5,339

Lysine acetylation targets protein complexes and co-regulates major cellular functions

Choudhary, C., Kumar, C., Gnad, F., Nielsen, M. L., Rehman, M., Walther, T. C., Olsen, J. V., & Mann, M. (2009) · Science · doi:10.1126/science.1175371 · Cited by 4,040

Negative Control of p53 by Sir2α Promotes Cell Survival under Stress

Luo, J., Nikolaev, A. Y., Imai, S.-I., Chen, D., Su, F., Shiloh, A., Guarente, L., & Gu, W. (2001) · Cell · doi:10.1016/s0092-8674(01)00524-4 · Cited by 2,081

Regulation of cellular metabolism by protein lysine acetylation

Zhao, S., Xu, W., Jiang, W., Yu, W., Lin, Y., Zhang, T., Yao, J., Zhou, L., Zeng, Y., Li, H., et al. (2010) · Science · doi:10.1126/science.1179689 · Cited by 1,910

NAD+ Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus

Cantó, C., Menzies, K. J., & Auwerx, J. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.05.023 · Cited by 1,648

High-Fat Diet Disrupts Behavioral and Molecular Circadian Rhythms in Mice

Kohsaka, A., Laposky, A. D., Ramsey, K. M., Estrada, C., Joshu, C., Kobayashi, Y., Turek, F. W., & Bass, J. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.09.006 · Cited by 1,528

Substrate and Functional Diversity of Lysine Acetylation Revealed by a Proteomics Survey

Kim, S. C., Sprung, R., Chen, Y., Xu, Y., Ball, H., Pei, J., Cheng, T., Kho, Y., Xiao, H., Xiao, L., et al. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.06.026 · Cited by 1,487

Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging

Gomes, A. P., Price, N. L., Ling, A. J. Y., Moslehi, J. J., Montgomery, M. K., Rajman, L., White, J. P., Teodoro, J. S., Wrann, C. D., Hubbard, B. P., et al. (2013) · Cell · doi:10.1016/j.cell.2013.11.037 · Cited by 1,482

Nicotinamide Mononucleotide, a Key NAD+ Intermediate, Treats the Pathophysiology of Diet- and Age-Induced Diabetes in Mice

Yoshino, J., Mills, K. F., Yoon, M. J., & Imai, S.-I. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.08.014 · Cited by 1,340

NAD + in aging, metabolism, and neurodegeneration

Verdin, E. (2015) · Science · doi:10.1126/science.aac4854 · Cited by 1,319

NAD+ metabolism and its roles in cellular processes during ageing

Covarrubias, A. J., Perrone, R., Grozio, A., & Verdin, E. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-00313-x · Cited by 1,617

Autophagy in healthy aging and disease

Aman, Y., Schmauck-Medina, T., Hansen, M., Morimoto, R. I., Simon, A. K., Bjedov, I., Palikaras, K., Simonsen, A., Johansen, T., Tavernarakis, N., et al. (2021) · Nature Aging · doi:10.1038/s43587-021-00098-4 · Cited by 1,313

The intestinal microbiota fuelling metabolic inflammation

Tilg, H., Zmora, N., Adolph, T. E., & Elinav, E. (2020) · Nature Reviews Immunology · doi:10.1038/s41577-019-0198-4 · Cited by 1,089

Small molecule metabolites: discovery of biomarkers and therapeutic targets

Qiu, S., Cai, Y., Yao, H., Lin, C., Xie, Y., Tang, S., & Zhang, A. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01399-3 · Cited by 993

Epigenetic regulation of aging: implications for interventions of aging and diseases

Kang, W., Liu, H., Hu, Q., Wang, L., Liu, J., Zheng, Z., Zhang, W., Ren, J., Zhu, F., & Liu, G. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01211-8 · Cited by 732

Caloric Restriction Mimetics against Age-Associated Disease: Targets, Mechanisms, and Therapeutic Potential

Madeo, F., Carmona-Gutierrez, D., Hofer, S. J., & Kroemer, G. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.01.018 · Cited by 630

T cells with dysfunctional mitochondria induce multimorbidity and premature senescence

Desdín-Micó, G., Soto-Heredero, G., Aranda, J. F., Oller, J., Carrasco, E., Gabandé-Rodríguez, E., Blanco, E. M., Alfranca, A., Cussó, L., Desco, M., et al. (2020) · Science · doi:10.1126/science.aax0860 · Cited by 572

The ageing epigenome and its rejuvenation

Zhang, W., Qu, J., Liu, G.-H., & Belmonte, J. C. I. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0204-5 · Cited by 458

Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages

Covarrubias, A. J., Kale, A., Perrone, R., Lopez-Dominguez, J. A., Pisco, A. O., Kasler, H. G., Schmidt, M. S., Heckenbach, I., Kwok, R., Wiley, C. D., et al. (2020) · Nature Metabolism · doi:10.1038/s42255-020-00305-3 · Cited by 420

Daily Fasting Improves Health and Survival in Male Mice Independent of Diet Composition and Calories

Mitchell, S. J., Bernier, M., Mattison, J. A., Aon, M. A., Kaiser, T. A., Anson, R. M., Ikeno, Y., Anderson, R. M., Ingram, D. K., & de Cabo, R. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.08.011 · Cited by 305

Interconnections between Inflammageing and Immunosenescence during Ageing

Teissier, T., Boulanger, É., & Cox, L. S. (2022) · Cells · doi:10.3390/cells11030359 · Cited by 323

Nicotinamide mononucleotide (NMN) supplementation rescues cerebromicrovascular endothelial function and neurovascular coupling responses and improves cognitive function in aged mice

Tarantini, S., Valcarcel‐Ares, M. N., Tóth, P., Yabluchanskiy, A., Tucsek, Z., Kiss, T., Hertelendy, P., Kinter, M. T., Ballabh, P., Süle, Z., et al. (2019) · Redox Biology · doi:10.1016/j.redox.2019.101192 · Cited by 285

Kynurenine pathway, NAD+ synthesis, and mitochondrial function: Targeting tryptophan metabolism to promote longevity and healthspan

Castro-Portuguez, R., & Sutphin, G. L. (2020) · Experimental Gerontology · doi:10.1016/j.exger.2020.110841 · Cited by 296

NAD metabolism: Implications in aging and longevity

Yaku, K., Okabe, K., & Nakagawa, T. (2018) · Ageing Research Reviews · doi:10.1016/j.arr.2018.05.006 · Cited by 269

Targeting Autophagy in Aging and Aging-Related Cardiovascular Diseases

Ren, J. T., & Zhang, Y. (2018) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2018.10.005 · Cited by 281

NAD + Metabolism in Cardiac Health, Aging, and Disease

Abdellatif, M., Sedej, S., & Kroemer, G. (2021) · Circulation · doi:10.1161/circulationaha.121.056589 · Cited by 267

Obesity and aging: Molecular mechanisms and therapeutic approaches

Santos, A. L., & Sinha, S. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101268 · Cited by 249

Implications of altered NAD metabolism in metabolic disorders

Okabe, K., Yaku, K., Tobe, K., & Nakagawa, T. (2019) · Journal of Biomedical Science · doi:10.1186/s12929-019-0527-8 · Cited by 223

Neurogenesis in aging and age-related neurodegenerative diseases

Čulig, L., Chu, X., & Bohr, V. A. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101636 · Cited by 235

Nicotinamide for the treatment of heart failure with preserved ejection fraction

Abdellatif, M., Trummer-Herbst, V., Koser, F., Durand, S., Adão, R., Vasques‐Nóvoa, F., Freundt, J. K., Voglhuber, J., Pricolo, M. R., Kasa, M., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abd7064 · Cited by 217

Restoration of energy homeostasis by SIRT6 extends healthy lifespan

Roichman, A., Elhanati, S., Aon, M. A., Abramovich, I., Di Francesco, A., Shahar, Y., Avivi, M. Y., Shurgi, M., Rubinstein, A., Wiesner, Y., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-23545-7 · Cited by 214

Age-related NAD+ decline

McReynolds, M. R., Chellappa, K., & Baur, J. A. (2020) · Experimental Gerontology · doi:10.1016/j.exger.2020.110888 · Cited by 179

The multifaceted benefits of walking for healthy aging: from Blue Zones to molecular mechanisms

Ungvari, Z. I., Fazekas‐Pongor, V., Csiszár, A., & Kunutsor, S. K. (2023) · GeroScience · doi:10.1007/s11357-023-00873-8 · Cited by 208

Nicotinamide mononucleotide (NMN) supplementation promotes neurovascular rejuvenation in aged mice: transcriptional footprint of SIRT1 activation, mitochondrial protection, anti-inflammatory, and anti-apoptotic effects

Kiss, T., Nyúl-Tóth, Á., Balasubramanian, P., Tarantini, S., Ahire, C., Yabluchanskiy, A., Csipo, T., Farkas, E., Wren, J. D., Garman, L., et al. (2020) · GeroScience · doi:10.1007/s11357-020-00165-5 · Cited by 163

Indole-3-Propionic Acid Protects Against Heart Failure With Preserved Ejection Fraction

Wang, Y.-C., Koay, Y. C., Pan, C., Zhou, Z., Tang, W. H. W., Wilcox, J. D., Li, X. S., Zagouras, A. A., Marques, F. Z., Allayee, H., et al. (2024) · Circulation Research · doi:10.1161/circresaha.123.322381 · Cited by 156

Nicotinamide riboside does not alter mitochondrial respiration, content or morphology in skeletal muscle from obese and insulin‐resistant men

Dollerup, O. L., Chubanava, S., Agerholm, M., Søndergård, S. D., Altıntaş, A., Møller, A. B., Høyer, K. F., Ringgaard, S., Stødkilde‐Jørgensen, H., Lavery, G. G., et al. (2020) · The Journal of Physiology · doi:10.1113/jp278752 · Cited by 145

Epigenetic drift of H3K27me3 in aging links glycolysis to healthy longevity in Drosophila

Ma, Z., Wang, H., Cai, Y. A., Wang, H., Niu, K., Wu, X., Ma, H., Yang, Y., Tong, W., Liu, F., et al. (2018) · eLife · doi:10.7554/elife.35368 · Cited by 135

NAD metabolism: Role in senescence regulation and aging

Chini, C. C. S., Cordeiro, H. S., Tran, N. L. K., & Chini, E. N. (2023) · Aging Cell · doi:10.1111/acel.13920 · Cited by 148

A toolbox for the longitudinal assessment of healthspan in aging mice

Bellantuono, I., de Cabo, R., Ehninger, D., Di Germanio, C., Lawrie, A., Miller, J., Mitchell, S. J., Navas-Enamorado, I., Potter, P. K., Tchkonia, T., et al. (2020) · Nature Protocols · doi:10.1038/s41596-019-0256-1 · Cited by 145

Preclinical and clinical evidence of NAD+ precursors in health, disease, and ageing

Reiten, O. K., Wilvang, M. A., Mitchell, S. J., Hu, Z., & Fang, E. F. (2021) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2021.111567 · Cited by 136

Rapid differentiation of the human RPE cell line, ARPE-19, induced by nicotinamide

Hazim, R. A., Volland, S., Yen, A., Burgess, B. L., & Williams, D. S. (2019) · Experimental Eye Research · doi:10.1016/j.exer.2018.10.009 · Cited by 126

The road ahead for health and lifespan interventions

Gonzalez-Freire, M., Diaz-Ruiz, A., Hauser, D., Martinez-Romero, J., Ferrucci, L., Bernier, M., & de Cabo, R. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101037 · Cited by 118

Chronic nicotinamide mononucleotide supplementation elevates blood nicotinamide adenine dinucleotide levels and alters muscle function in healthy older men

Igarashi, M., Nakagawa-Nagahama, Y., Miura, M., Kashiwabara, K., Yaku, K., Sawada, M., Sekine, R., Fukamizu, Y., Sato, T., Sakurai, T., et al. (2022) · npj Aging · doi:10.1038/s41514-022-00084-z · Cited by 125

Illuminating NAD+ Metabolism in Live Cells and In Vivo Using a Genetically Encoded Fluorescent Sensor

Zou, Y., Wang, A., Huang, L. Z., Zhu, X., Hu, Q., Zhang, Y., Chen, X., Li, F., Wang, Q., Wang, H., et al. (2020) · Developmental Cell · doi:10.1016/j.devcel.2020.02.017 · Cited by 117

17‐a‐estradiol late in life extends lifespan in aging UM‐HET3 male mice; nicotinamide riboside and three other drugs do not affect lifespan in either sex

Harrison, D. E., Strong, R., Reifsnyder, P. C., Kumar, N., Fernández, E., Flurkey, K., Javors, M. A., Lopez‐Cruzan, M., Macchiarini, F., Nelson, J. F., et al. (2021) · Aging Cell · doi:10.1111/acel.13328 · Cited by 116

NAD+ flux is maintained in aged mice despite lower tissue concentrations

McReynolds, M. R., Chellappa, K., Chiles, E., Jankowski, C., Shen, Y., Chen, L., Descamps, H. C., Mukherjee, S., Bhat, Y. R., Lingala, S. R., et al. (2021) · Cell Systems · doi:10.1016/j.cels.2021.09.001 · Cited by 112

Nicotinamide mononucleotide (NMN) supplementation promotes anti-aging miRNA expression profile in the aorta of aged mice, predicting epigenetic rejuvenation and anti-atherogenic effects

Kiss, T., Giles, C. B., Tarantini, S., Yabluchanskiy, A., Balasubramanian, P., Gautam, T., Csípő, T., Nyúl‐Tóth, Á., Lipécz, Á., Szabó, C., et al. (2019) · GeroScience · doi:10.1007/s11357-019-00095-x · Cited by 112

The autophagy–NAD axis in longevity and disease

Wilson, N., Kataura, T., Korsgen, M. E., Sun, C., Sarkar, S., & Korolchuk, V. I. (2023) · Trends in Cell Biology · doi:10.1016/j.tcb.2023.02.004 · Cited by 108

The chemistry of the vitamin B3 metabolome

Makarov, M. V., Trammell, S. A. J., & Migaud, M. E. (2018) · Biochemical Society Transactions · doi:10.1042/bst20180420 · Cited by 115

NAD+ rescues aging-induced blood-brain barrier damage via the CX43-PARP1 axis

Zhan, R., Meng, X., Tian, D., Xu, J., Cui, H., Yang, J., Xu, Y., Shi, M., Xue, J., Yu, W., et al. (2023) · Neuron · doi:10.1016/j.neuron.2023.08.010 · Cited by 109

NAD+ therapy in age-related degenerative disorders: A benefit/risk analysis

Braidy, N., & Liu, Y. (2020) · Experimental Gerontology · doi:10.1016/j.exger.2020.110831 · Cited by 98

Targeting metabolic pathways for extension of lifespan and healthspan across multiple species

Parkhitko, A. A., Filine, E., Mohr, S. E., Moskalev, A., & Perrimon, N. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101188 · Cited by 91

A cross-sectional study of functional and metabolic changes during aging through the lifespan in male mice

Petr, M. A., Alfaras, I., Krawcyzk, M., Bair, W.-N., Mitchell, S. J., Morrell, C. H., Studenski, S. A., Price, N. L., Fishbein, K. W., Spencer, R. G. S., et al. (2021) · eLife · doi:10.7554/elife.62952 · Cited by 87

Metabolic Communication and Healthy Aging: Where Should We Focus Our Energy?

Smith, H. J., Sharma, A., & Mair, W. B. (2020) · Developmental Cell · doi:10.1016/j.devcel.2020.06.011 · Cited by 83

Cardiac Aging: From Basic Research to Therapeutics

Yan, M., Sun, S., Xu, K., Huang, X., Dou, L., Pang, J., Tang, W., Shen, T., & Li, J. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/9570325 · Cited by 86

Therapeutic potential of boosting NAD+ in aging and age-related diseases

Aman, Y., Qiu, Y., Tao, J., & Fang, E. F. (2018) · Translational Medicine of Aging · doi:10.1016/j.tma.2018.08.003 · Cited by 92

NAD+ salvage governs mitochondrial metabolism, invigorating natural killer cell antitumor immunity

Guo, X., Tan, S., Wang, T., Sun, R., Li, S., Tian, P., Li, M., Wang, Y., Zhang, Y., Yan, Y., et al. (2022) · Hepatology · doi:10.1002/hep.32658 · Cited by 81

Antiaging effects of bioactive molecules isolated from plants and fungi

Martel, J., Ojcius, D. M., Ko, Y., Chang, C., & Young, J. D. (2019) · Medicinal Research Reviews · doi:10.1002/med.21559 · Cited by 79

Molecular properties and regulation of NAD+ kinase (NADK)

Oka, S., Titus, A. S., Zablocki, D., & Sadoshima, J. (2022) · Redox Biology · doi:10.1016/j.redox.2022.102561 · Cited by 80

NAD+ Homeostasis and NAD+-Consuming Enzymes: Implications for Vascular Health

Campagna, R., & Vignini, A. (2023) · Antioxidants · doi:10.3390/antiox12020376 · Cited by 76

Obesity accelerates cardiovascular ageing

Ruperez, C., Madeo, F., de Cabo, R., Kroemer, G., & Abdellatif, M. (2025) · European Heart Journal · doi:10.1093/eurheartj/ehaf216 · Cited by 73

Aberrant NAD+ metabolism underlies Zika virus–induced microcephaly

Pang, H., Jiang, Y., Li, J., Wang, Y., Nie, M., Xiao, N., Wang, S., Song, Z., Ji, F., Chang, Y., et al. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00437-0 · Cited by 77

Frailty index as a biomarker of lifespan and healthspan: Focus on pharmacological interventions

Palliyaguru, D. L., Moats, J. M., Germanio, C. D., Bernier, M., & de Cabo, R. (2019) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2019.03.005 · Cited by 75

Keeping the balance in NAD metabolism

Strømland, Ø., Niere, M., Nikiforov, A. A., VanLinden, M. R., Heiland, I., & Ziegler, M. (2019) · Biochemical Society Transactions · doi:10.1042/bst20180417 · Cited by 73

Nicotinamide adenine dinucleotide metabolism in the immune response, autoimmunity and inflammageing

Navarro, M. N., Heras, M. M. G. D. L., & Mittelbrunn, M. (2021) · British Journal of Pharmacology · doi:10.1111/bph.15477 · Cited by 72

Are We Ill Because We Age?

Fülöp, T., Larbi, A., Khalil, A., Cohen, A. A., & Witkowski, J. M. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.01508 · Cited by 79

Dietary strategies with anti-aging potential: Dietary patterns and supplements

Duan, H., Pan, J., Guo, M., Li, J., Yu, L., & Fan, L. (2022) · Food Research International · doi:10.1016/j.foodres.2022.111501 · Cited by 72

Identification of evolutionary and kinetic drivers of NAD-dependent signaling

Bockwoldt, M., Houry, D., Niere, M., Gossmann, T. I., Reinartz, I., Schug, A. H., Ziegler, M., & Heiland, I. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1902346116 · Cited by 68

Mitochondrial pathways in human health and aging

Bornstein, R., González, B., & Johnson, S. C. (2020) · Mitochondrion · doi:10.1016/j.mito.2020.07.007 · Cited by 71

Mito-Nuclear Communication by Mitochondrial Metabolites and Its Regulation by B-Vitamins

Janssen, J. J. E., Grefte, S., Keijer, J., & de Boer, V. C. J. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00078 · Cited by 70

Antidepressant activity of crocin-I is associated with amelioration of neuroinflammation and attenuates oxidative damage induced by corticosterone in mice

Xiao, Q., Xiong, Z., Yu, C., Zhou, J., Shen, Q., Wang, L., Xie, X., & Fu, Z. (2019) · Physiology & Behavior · doi:10.1016/j.physbeh.2019.112699 · Cited by 67

New horizons in life extension, healthspan extension and exceptional longevity

Couteur, D. G. L., & Barzilai, N. (2022) · Age and Ageing · doi:10.1093/ageing/afac156 · Cited by 63

The metabolomic signature of extreme longevity: naked mole rats versus mice

Viltard, M., Durand, S., Pérez-Lanzón, M., Aprahamian, F., Lefevre, D., Leroy, C., Madeo, F., Kroemer, G., & Friedlander, G. (2019) · Aging · doi:10.18632/aging.102116 · Cited by 63

Aging alters acetylation status in skeletal and cardiac muscles

Yeo, D., Kang, C., & Ji, L. L. (2020) · GeroScience · doi:10.1007/s11357-020-00171-7 · Cited by 63

Re‐equilibration of imbalanced NAD metabolism ameliorates the impact of telomere dysfunction

Sun, C., Wang, K., Stock, A. J., Gong, Y., Demarest, T. G., Yang, B., Giri, N., Harrington, L. A., Alter, B. P., Savage, S. A., et al. (2020) · The EMBO Journal · doi:10.15252/embj.2019103420 · Cited by 67

The balance between NAD+ biosynthesis and consumption in ageing

Strømland, Ø., Diab, J., Ferrario, E., Sverkeli, L. J., & Ziegler, M. (2021) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2021.111569 · Cited by 64

Mitochondrial Quality Control in Sarcopenia: Updated Overview of Mechanisms and Interventions

Liu, D., Fan, Y., Tao, X., Pan, W., Wu, Y., Wang, X., He, Y., Xiao, W., & Li, Y. (2021) · Aging and Disease · doi:10.14336/ad.2021.0427 · Cited by 62

Low-dose quercetin positively regulates mouse healthspan

Geng, L., Liu, Z., Wang, S., Sun, S., Ma, S., Liu, X., Chan, P., Sun, L., Song, M., Zhang, W., et al. (2019) · Protein & Cell · doi:10.1007/s13238-019-0646-8 · Cited by 60

The NAD+-mitophagy axis in healthy longevity and in artificial intelligence-based clinical applications

Aman, Y., Frank, J., Lautrup, S., Matysek, A., Niu, Z., Yang, G., Shi, L., Bergersen, L. H., Storm‐Mathisen, J., Rasmussen, L. J., et al. (2019) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2019.111194 · Cited by 63

Sarcopenia in aging, obesity, and cancer

Ligibel, J. A., Schmitz, K. H., & Berger, N. A. (2020) · Translational Cancer Research · doi:10.21037/tcr-2019-eaoc-05 · Cited by 60

Coffee consumption and cardiometabolic health: a comprehensive review of the evidence

Ungvari, Z. I., & Kunutsor, S. K. (2024) · GeroScience · doi:10.1007/s11357-024-01262-5 · Cited by 69

NAD+ and NAFLD – caution, causality and careful optimism

Dall, M., Hassing, A. S., & Treebak, J. T. (2021) · The Journal of Physiology · doi:10.1113/jp280908 · Cited by 57

Evaluating the beneficial effects of dietary restrictions: A framework for precision nutrigeroscience

Wilson, K. A., Chamoli, M., Hilsabeck, T. A. U., Pandey, M., Bansal, S., Chawla, G., & Kapahi, P. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.08.018 · Cited by 57

Doped Graphene To Mimic the Bacterial NADH Oxidase for One-Step NAD + Supplementation in Mammals

Liu, X., Li, J., Zitolo, A., Gao, M., Jiang, J., Geng, X., Xie, Q., Wu, D., Zheng, H., Cai, X., et al. (2023) · Journal of the American Chemical Society · doi:10.1021/jacs.2c12336 · Cited by 55

Downregulation of the tyrosine degradation pathway extends Drosophila lifespan

Parkhitko, A. A., Ramesh, D., Wang, L., Leshchiner, D. R., Filine, E., Binari, R. C., Olsen, A. L., Asara, J. M., Cracan, V., Rabinowitz, J. D., et al. (2020) · eLife · doi:10.7554/elife.58053 · Cited by 52

The free radical theory of frailty: Mechanisms and opportunities for interventions to promote successful aging

Viña, J. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.01.045 · Cited by 53

Epigenetic Regulation of Metabolism and Inflammation by Calorie Restriction

Hernández‐Saavedra, D., Moody, L., Xu, G. B., Chen, H., & Pan, Y. (2018) · Advances in Nutrition · doi:10.1093/advances/nmy129 · Cited by 52

Bodywide ecological interventions on cancer

Kroemer, G., McQuade, J. L., Mérad, M., André, F., & Zitvogel, L. (2023) · Nature Medicine · doi:10.1038/s41591-022-02193-4 · Cited by 51

Geroprotectors: A role in the treatment of frailty

Trendelenburg, A., Scheuren, A. C., Potter, P. K., Müller, R., & Bellantuono, I. (2019) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2019.03.002 · Cited by 52

Nicotinamide mononucleotide inhibits hepatic stellate cell activation to prevent liver fibrosis via promoting PGE2 degradation

Zong, Z., Liu, J., Wang, N., Yang, C., Wang, Q., Zhang, W., Chen, Y., Liu, X., & Deng, H. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.11.014 · Cited by 51

Nicotinamide enhances natural killer cell function and yields remissions in patients with non-Hodgkin lymphoma

Cichocki, F. M., Zhang, B., Wu, C.-Y., Chiu, E., Day, A., O’Connor, R. S., Yackoubov, D., Simantov, R., McKenna, D. H., Cao, Q., et al. (2023) · Science Translational Medicine · doi:10.1126/scitranslmed.ade3341 · Cited by 49

Pharmacology and Potential Implications of Nicotinamide Adenine Dinucleotide Precursors

She, J., Sheng, R., & Qin, Z. (2021) · Aging and Disease · doi:10.14336/ad.2021.0523 · Cited by 50

Roles of NAD + in Health and AgingPreprint

Lautrup, S., Hou, Y., Fang, E. F., & Bohr, V. A. (2023) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a041193 · Cited by 53

Nicotinamide Adenine Dinucleotide Augmentation in Overweight or Obese Middle-Aged and Older Adults: A Physiologic Study

Pencina, K. M., Valderrábano, R. J., Wipper, B., Orkaby, A. R., Reid, K. F., Storer, T. W., Lin, A. P., Merugumala, S. K., Wilson, L. A., Latham, N. K., et al. (2023) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgad027 · Cited by 48

Common Pathogenetic Mechanisms Underlying Aging and Tumor and Means of Interventions

Shen, W., He, J., Hou, T., Si, J., & Chen, S. (2022) · Aging and Disease · doi:10.14336/ad.2021.1208 · Cited by 45

ADCK2 Haploinsufficiency Reduces Mitochondrial Lipid Oxidation and Causes Myopathy Associated with CoQ Deficiency

Vázquez-Fonseca, L., Schäfer, J., Navas‐Enamorado, I., Santos‐Ocaña, C., Hernández‐Camacho, J. D., Guerra, I., Cascajo, M. V., Sánchez‐Cuesta, A., Horvath, Z., Siendones, E., et al. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8091374 · Cited by 42

NAD+ and its possible role in gut microbiota: Insights on the mechanisms by which gut microbes influence host metabolism

Ren, Z., Xu, Y., Li, T., Sun, W., Tang, Z., Wang, Y., Zhou, K., Li, J., Ding, Q., Liang, K., et al. (2022) · Animal Nutrition · doi:10.1016/j.aninu.2022.06.009 · Cited by 44

NAD+ Metabolism and Immune Regulation: New Approaches to Inflammatory Bowel Disease Therapies

Chen, C., Yan, W., Tao, M., & Fu, Y. (2023) · Antioxidants · doi:10.3390/antiox12061230 · Cited by 44

Nicotinamide Adenine Dinucleotide in Aging Biology: Potential Applications and Many Unknowns

Bhasin, S., Seals, D. R., Migaud, M. E., Musi, N., & Baur, J. A. (2023) · Endocrine Reviews · doi:10.1210/endrev/bnad019 · Cited by 50

Roles of vitamins in stem cells

Godoy-Parejo, C., Deng, C., Zhang, Y., Liu, W., & Chen, G. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03352-6 · Cited by 45

Mitochondria and Calcium Homeostasis: Cisd2 as a Big Player in Cardiac Ageing

Yeh, C., Chou, Y.-J., Kao, C., & Tsai, T. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21239238 · Cited by 46

A review study on the modulation of SIRT1 expression by miRNAs in aging and age-associated diseases

Zia, A., Sahebdel, F., Farkhondeh, T., Ashrafizadeh, M., Zarrabi, A., Hushmandi, K., & Samarghandian, S. (2021) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2021.08.013 · Cited by 45

Modulating Sirtuin Biology and Nicotinamide Adenine Diphosphate Metabolism in Cardiovascular Disease—From Bench to Bedside

Wang, Y.-J., Paneni, F., Stein, S., & Matter, C. M. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.755060 · Cited by 44

Targeting NAD+ in translational research to relieve diseases and conditions of metabolic stress and ageing

Gilmour, B. C., Gudmundsrud, R., Frank, J., Hov, A., Lautrup, S., Aman, Y., Røsjø, H. R., Brenner, C., Ziegler, M., Tysnes, O., et al. (2020) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2020.111208 · Cited by 44

Metabolic remodelling of glucose, fatty acid and redox pathways in the heart of type 2 diabetic mice

Cortassa, S. C., Caceres, V., Tocchetti, C. G., Bernier, M., de Cabo, R., Paolocci, N., Sollott, S. J., & Aon, M. A. (2018) · The Journal of Physiology · doi:10.1113/jp276824 · Cited by 42

Dual control of NAD+ synthesis by purine metabolites in yeast

Pinson, B., Ceschin, J., Saint‐Marc, C., & Daignan‐Fornier, B. (2019) · eLife · doi:10.7554/elife.43808 · Cited by 43

Nicotinamide, Nicotinamide Riboside and Nicotinic Acid—Emerging Roles in Replicative and Chronological Aging in Yeast

Orlandi, I., Alberghina, L., & Vai, M. (2020) · Biomolecules · doi:10.3390/biom10040604 · Cited by 40

Balancing NAD+ deficits with nicotinamide riboside: therapeutic possibilities and limitations

Cercillieux, A., Ciarlo, E., & Cantó, C. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04499-5 · Cited by 42

NAD+ Metabolism, Metabolic Stress, and Infection

Groth, B., Venkatakrishnan, P., & Lin, S.-J. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.686412 · Cited by 42

Maintenance of NAD+ Homeostasis in Skeletal Muscle during Aging and Exercise

Ji, L. L., & Yeo, D. (2022) · Cells · doi:10.3390/cells11040710 · Cited by 44

Long-term NMN treatment increases lifespan and healthspan in mice in a sex dependent mannerPreprint

Kane, A. E., Chellappa, K., Schultz, M., Carr, A. V., Arnold, M. W., Li, J., Amorim, J., Zheng, M., Gao, Y., Rich, K., et al. (2026) · Research Square · doi:10.21203/rs.3.rs-10913337/v1

Hepatic NAD+ levels and NAMPT abundance are unaffected during prolonged high-fat diet consumption in C57BL/6JBomTac mice

Dall, M., Penke, M., Sulek, K., Matz‐Soja, M., Holst, B., Garten, A., Kieß, W., & Treebak, J. T. (2018) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2018.01.025 · Cited by 45

Mitochondrial function in liver cells is resistant to perturbations in NAD+ salvage capacity

Dall, M., Trammell, S. A. J., Asping, M., Hassing, A. S., Agerholm, M., Vienberg, S. G., Gillum, M. P., Larsen, S., & Treebak, J. T. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.006756 · Cited by 40

Hepatic NAD salvage pathway is enhanced in mice on a high-fat diet

Penke, M., Larsen, P. S., Schuster, S., Dall, M., Jensen, B. A. H., Gorski, T., Meusel, A., Richter, S., Vienberg, S. G., Treebak, J. T., et al. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.05.028 · Cited by 35

Use of the Dietary Supplements NR and NMN to Increase Nicotinamide Adenine Dinucleotide, Impact Mitochondrial Function, and Improve Metabolic Health

Bloomer, R. J., Timmcke, J. Q., & Ramanathan, C. (2025) · Clinical bioenergetics · doi:10.3390/clinbioenerg1020009 · Cited by 1