The esophageal microbiota in health and disease
Open accessAbstract
The esophageal mucosa is among the sites colonized by human microbiota, the complex microbial ecosystem that colonizes various body surfaces and is increasingly recognized to play roles in several physiological and pathological processes. Our understanding of the composition of the esophageal microbiota in health and disease is challenged by the need for invasive sampling procedures and by the dynamic nature of the esophageal environment and remains limited in comparison with the information available for other body sites. Members of the genus Streptococcus appear to be the major components of the microbiota of the healthy esophagus, although the presence of several other taxa has also been reported. Dysbiosis, consisting of enrichment in some Gram‐negative taxa (including Veillonella, Prevotella, Haemophilus, Neisseria, Campylobacter, and Fusobacterium), has been reported in association with gastroesophageal reflux disease and is hypothesized to contribute to the evolution of this condition toward Barrett's esophagus (which is the most common esophageal precancerous lesion) and, eventually, adenocarcinoma. Some Campylobacter species (mostly C. concisus) are also putatively involved in the progression of disease toward adenocarcinoma. However, variable findings have recently been reported in additional studies. Causative relationships between dysbiosis or specific bacterial species and esophageal diseases remain controversial and warrant further investigations.
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The switch in favor of Gram-negative bacteria in the esophagus could cause an LPS-mediated activation of innate immunity, inducing a dangerous cycle of dysbiosis-inflammation-dysbiosis and mucosal damage.
“It is likely that this switch in favor of Gram-negative bacteria could cause an LPS-mediated activation of innate immunity, inducing a dangerous cycle of dysbiosis-inflammation-dysbiosis and mucosal damage[38].”
From Proton pump inhibitors and dysbiosis: current knowledge and aspects to be clarified (2019) · cites this paper as [38]
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Proton pump inhibitors and dysbiosis: current knowledge and aspects to be clarified
Bruno, G., Zaccari, P., Rocco, G., Scalese, G., Panetta, C., Porowska, B., Pontone, S., & Severi, C. (2019) · World Journal of Gastroenterology · doi:10.3748/wjg.v25.i22.2706 · Cited by 258 · see citing works
- Authors
- Di Pilato, V., Freschi, G., Ringressi, M. N., Pallecchi, L., Rossolini, G. M., & Bechi, P.
- Affiliations
- Department of Surgery and Translational Medicine University of Florence Florence Italy
- Azienda Ospedaliero-Universitaria Careggi (IT)
- University of Siena (IT)
- Department of Medical Biotechnologies University of Siena Siena Italy
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 2016-07-14
- Volume
- 1381
- Issue
- 1
- Pages
- 21-33
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- OpenAlex
- W2483668820
- Cited by
- 139
- References
- 86
- Citations by year
- 2026: 5 · 2025: 2 · 2024: 13 · 2023: 19 · 2022: 10 · 2021: 15 · 2020: 44 · 2019: 9 · 2018: 14 · 2017: 6 · 2016: 2
- FWCI
- 0.94
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Annals of the New York Academy of Sciences (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Florence Research (University of Florence) (submittedVersion, other-oa)
- CINECA IRIS Institutial Research Information System (University of Genoa) (submittedVersion, other-oa)
- Use Siena air (University of Siena) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Medicine › Surgery › Esophageal Cancer Research and Treatment
- Keywords
- esophageal microbiota, Streptococcus, gastroesophageal reflux disease, Barrett's esophagus, esophageal adenocarcinoma, Veillonella, Fusobacterium, Neisseria, Haemophilus, Prevotella, Campylobacter, esophageal precancerous lesions, microbial colonization
- MeSH terms
- Animals, Anti-Bacterial Agents, Barrett Esophagus, Esophageal Diseases, Esophageal Neoplasms, Esophagus, Health Status, Humans, Microbiota
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Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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