Endocrine-metabolic dysfunction in polycystic ovary syndrome: An evolutionary perspective
Open accessAbstract
Polycystic ovary syndrome (PCOS) is characterized by hyperandrogenism, oligo-anovulation and polycystic ovarian morphology, with metabolic dysfunction from insulin resistance and abdominal fat accumulation worsened by obesity. As ancestral traits, these features could have favored abdominal fat deposition for energy use during starvation, but have evolved into different PCOS phenotypes with variable metabolic dysfunction. Adipose dysfunction in PCOS from hyperandrogenemia and hyperinsulinemia likely constrains subcutaneous (SC) fat storage, promoting lipotoxicity through ectopic lipid accumulation and oxidative stress, insulin resistance and inflammation in non-adipose tissue. Recent findings of inherently exaggerated SC abdominal stem cell development to adipocytes in women with PCOS, and PCOS-like traits in adult female monkeys with natural hyperandrogenemia, imply common ancestral origins of PCOS in both human and nonhuman primates.
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Insulin resistance in PCOS is worsened by hyperandrogenism-related adipose tissue accumulation.
“insulin resistance, a very common condition in PCOS, which is worsened by hyperandrogenism-related adipose tissue accumulation [3] and is involved in both the pathogenesis and the progression of the disease [4].”
From Controversies in the Pathogenesis, Diagnosis and Treatment of PCOS: Focus on Insulin Resistance, Inflammation, and Hyperandrogenism (2022) · cites this paper as [3]
Insulin resistance is a very common condition in PCOS.
“insulin resistance, a very common condition in PCOS, which is worsened by hyperandrogenism-related adipose tissue accumulation [3] and is involved in both the pathogenesis and the progression of the disease [4].”
From Controversies in the Pathogenesis, Diagnosis and Treatment of PCOS: Focus on Insulin Resistance, Inflammation, and Hyperandrogenism (2022) · cites this paper as [3]
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Dynamics of fat cell turnover in humans
Spalding, K. L., Arner, E., Westermark, P. O., Bernard, S., Buchholz, B. A., Bergmann, O., Blomqvist, L., Hoffstedt, J., Näslund, E., Britton, T., et al. (2008) · Nature · doi:10.1038/nature06902 · Cited by 2,357 · see citing works
Diamanti-Kandarakis, E., & Dunaif, A. (2012) · Endocrine Reviews · doi:10.1210/er.2011-1034 · Cited by 1,947 · see citing works
Teede, H. J., Misso, M. L., Costello, M. F., Dokras, A., Laven, J., Moran, L., Piltonen, T., Norman, R. J., & the International PCOS Network (2018) · Clinical Endocrinology · doi:10.1111/cen.13795 · Cited by 1,823 · see citing works
Teede, H. J., Misso, M. L., Costello, M. F., Dokras, A., Laven, J., Moran, L., Piltonen, T., Norman, R. J., International PCOS Network, Andersen, M., et al. (2018) · Human Reproduction · doi:10.1093/humrep/dey256 · Cited by 1,593 · see citing works
Forming functional fat: a growing understanding of adipocyte differentiation
Cristancho, A. G., & Lazar, M. A. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3198 · Cited by 1,382 · see citing works
Lipid-induced insulin resistance: unravelling the mechanism
Samuel, V. T., Petersen, K. F., & Shulman, G. I. (2010) · The Lancet · doi:10.1016/s0140-6736(10)60408-4 · Cited by 1,189 · see citing works
Ectopic Fat in Insulin Resistance, Dyslipidemia, and Cardiometabolic Disease
Shulman, G. I. (2014) · New England Journal of Medicine · doi:10.1056/nejmra1011035 · Cited by 1,126 · see citing works
Moran, L. J., Misso, M. L., Wild, R. A., & Norman, R. J. (2010) · Human Reproduction Update · doi:10.1093/humupd/dmq001 · Cited by 1,108 · see citing works
Dumesic, D. A., Oberfield, S. E., Stener-Victorin, E., Marshall, J. C., Laven, J. S., & Legro, R. S. (2015) · Endocrine Reviews · doi:10.1210/er.2015-1018 · Cited by 1,020 · see citing works
Self-citationAdipogenesis: From Stem Cell to Adipocyte
Tang, Q. Q., & Lane, M. D. (2012) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-052110-115718 · Cited by 897 · see citing works
Adipocyte Turnover: Relevance to Human Adipose Tissue Morphology
Arner, E., Westermark, P. O., Spalding, K. L., Britton, T., Rydén, M., Frisén, J., Bernard, S., & Arner, P. (2010) · Diabetes · doi:10.2337/db09-0942 · Cited by 645 · see citing works
Lipid homeostasis, lipotoxicity and the metabolic syndrome
Unger, R. H., Clark, G. O., Scherer, P. E., & Orci, L. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2009.10.006 · Cited by 595 · see citing works
The effect of obesity on polycystic ovary syndrome: a systematic review and meta‐analysis
Lim, S. S., Norman, R. J., Davies, M. J., & Moran, L. J. (2013) · Obesity Reviews · doi:10.1111/j.1467-789x.2012.01053.x · Cited by 539 · see citing works
The Subtle Balance between Lipolysis and Lipogenesis: A Critical Point in Metabolic Homeostasis
Saponaro, C., Gaggini, M., Carli, F., & Gastaldelli, A. (2015) · Nutrients · doi:10.3390/nu7115475 · Cited by 531 · see citing works
McLaughlin, T., Lamendola, C., Liu, A., & Abbasi, F. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-0615 · Cited by 468 · see citing works
Mannerås-Holm, L., Leonhardt, H., Kullberg, J., Jennische, E., Odén, A., Holm, G., Hellström, M., Lönn, L., Olivecrona, G., Stener-Victorin, E., et al. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-1290 · Cited by 369 · see citing works
Insulin resistance associated with lower rates of weight gain in Pima Indians.
Swinburn, B. A., Nyomba, B. L. G., Saad, M. F., ZURLO, F., Raz, I., Knowler, W. C., Lillioja, S., Bogardus, C., & Ravussin, É. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115274 · Cited by 321 · see citing works
It's Not How Fat You Are, It's What You Do with It That Counts
Virtue, S., & Vidal‐Puig, A. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060237 · Cited by 309 · see citing works
Adipose tissue and its role in organ crosstalk
Romacho, T., Elsen, M., Röhrborn, D., & Eckel, J. (2014) · Acta Physiologica · doi:10.1111/apha.12246 · Cited by 278 · see citing works
ROSENBAUM, D. S., Haber, R. S., & Dunaif, A. E. (1993) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1993.264.2.e197 · Cited by 223 · see citing works
Dumesic, D. A., Akopians, A. L., Madrigal, V. K., Ramirez, E., Margolis, D. J., Sarma, M. K., Thomas, A. M., Grogan, T. R., Haykal, R., Schooler, T. A., et al. (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2016-2586 · Cited by 222 · see citing works
Self-citationO’Reilly, M. W., Kempegowda, P., Walsh, M., Taylor, A. E., Manolopoulos, K. N., Allwood, J. W., Semple, R. K., Hebenstreit, D., Dunn, W. B., Tomlinson, J. W., et al. (2017) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2017-00947 · Cited by 215 · see citing works
How to Measure Adipose Tissue Insulin Sensitivity
Søndergaard, E., Ycaza, A. E. E. D., Morgan-Bathke, M. E., & Jensen, M. D. (2017) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2017-00047 · Cited by 202 · see citing works
Corbould, A. (2007) · Journal of Endocrinology · doi:10.1677/joe.1.07070 · Cited by 184 · see citing works
Ek, I., Arner, P., Rydén, M., Holm, C., Thörne, A., Hoffstedt, J., & Wahrenberg, H. (2002) · Diabetes · doi:10.2337/diabetes.51.2.484 · Cited by 174 · see citing works
Androgens inhibit adipogenesis during human adipose stem cell commitment to preadipocyte formation
Chazenbalk, G. D., Singh, P., Irge, D., Shah, A., Abbott, D. H., & Dumesic, D. A. (2013) · Steroids · doi:10.1016/j.steroids.2013.05.001 · Cited by 167 · see citing works
Self-citationEffect of testosterone on lipolysis in human pre-adipocytes from different fat depots
Dicker, A., Rydén, M., Näslund, E. B., Muehlen, I. E., Wirén, M., Lafontan, M., & Arner, P. (2004) · Diabetologia · doi:10.1007/s00125-003-1324-0 · Cited by 163 · see citing works
Palomba, S., Marotta, R., Di Cello, A., Russo, T., Falbo, A., Orio, F., Tolino, A., Zullo, F., Esposito, R., & Sala, G. B. L. (2012) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2012.04443.x · Cited by 144 · see citing works
Subcutaneous adipose cell size and distribution: Relationship to insulin resistance and body fat
McLaughlin, T., Lamendola, C. A., Coghlan, N., Liu, T.-C., Lerner, K., Sherman, A., & Cushman, S. W. (2013) · Obesity · doi:10.1002/oby.20209 · Cited by 136 · see citing works
Hyperandrogenic origins of polycystic ovary syndrome-Implications for Pathophysiology and Therapy
Abbott, D. H., Dumesic, D. A., & Levine, J. E. (2019) · Expert Review of Endocrinology & Metabolism · doi:10.1080/17446651.2019.1576522 · Cited by 131 · see citing works
Self-citationFaulds, G., Rydén, M., Ek, I., Wahrenberg, H., & Arner, P. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021573 · Cited by 125 · see citing works
Ek, I., Arner, P., Bergqvist, A., Carlström, K., & Wahrenberg, H. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.4.3899 · Cited by 116 · see citing works
Adipose tissue expandability and the early origins of PCOS
de Zegher, F., López‐Bermejo, A., & Ibáñez, L. (2009) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2009.06.003 · Cited by 108 · see citing works
Mechanisms of intergenerational transmission of polycystic ovary syndrome
Dumesic, D. A., Hoyos, L. R., Chazenbalk, G. D., Naik, R., Padmanabhan, V., & Abbott, D. H. (2020) · Reproduction · doi:10.1530/rep-19-0197 · Cited by 101 · see citing works
Self-citationAdipose morphology and metabolic disease
Tandon, P., Wafer, R., & Minchin, J. E. N. (2018) · Journal of Experimental Biology · doi:10.1242/jeb.164970 · Cited by 100 · see citing works
Growth and development of adipose tissue
Poissonnet, C. M., LaVelle, M., & Burdi, A. R. (1988) · The Journal of Pediatrics · doi:10.1016/s0022-3476(88)80520-1 · Cited by 99 · see citing works
Arner, P. (2004) · Biochimie · doi:10.1016/j.biochi.2004.11.012 · Cited by 98 · see citing works
Adipose Insulin Resistance in Normal-Weight Women With Polycystic Ovary Syndrome
Dumesic, D. A., Phan, J. D., Leung, K. L., Grogan, T. R., Ding, X., Li, X., Hoyos, L. R., Abbott, D. H., & Chazenbalk, G. D. (2019) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2018-02086 · Cited by 92 · see citing works
Self-citationEk, I. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.82.4.1147 · Cited by 75 · see citing works
Tosi, F., Di Sarra, D., Kaufman, J.-M., Bonin, C., Moretta, R., Bonora, E., Zanolin, E., & Moghetti, P. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-2786 · Cited by 70 · see citing works
Longo, M., Raciti, G. A., Zatterale, F., Parrillo, L., Desiderio, A., Spinelli, R., Hammarstedt, A., Hedjazifar, S., Hoffmann, J. M., Nigro, C., et al. (2017) · Diabetologia · doi:10.1007/s00125-017-4471-4 · Cited by 70 · see citing works
The Polycystic Ovary Syndrome and recent human evolution
Corbett, S., & Morin-Papunen, L. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.01.001 · Cited by 68 · see citing works
Pancreatic Steatosis: An Emerging Clinical Entity
Ramkissoon, R. A., & Gardner, T. B. (2019) · The American Journal of Gastroenterology · doi:10.14309/ajg.0000000000000262 · Cited by 59 · see citing works
Polycystic Ovary Syndrome: Impact of Lipotoxicity on Metabolic and Reproductive Health
Brennan, K. M., Kroener, L. L., Chazenbalk, G. D., & Dumesic, D. A. (2019) · Obstetrical & Gynecological Survey · doi:10.1097/ogx.0000000000000661 · Cited by 44 · see citing works
Self-citationPolycystic Ovary Syndrome and Hyperandrogenic States
Chang, R. J., & Dumesic, D. A. (2019) · Elsevier eBooks · doi:10.1016/b978-0-323-47912-7.00021-4 · Cited by 41 · see citing works
Self-citationFisch, S. C., Nikou, A. F., Wright, E. A., Phan, J. D., Leung, K. L., Grogan, T., Abbott, D. H., Chazenbalk, G. D., & Dumesic, D. A. (2018) · Fertility and Sterility · doi:10.1016/j.fertnstert.2018.08.042 · Cited by 40 · see citing works
Self-citationİlhan, G. A., Yıldızhan, B., & Pekin, T. (2018) · Gynecological Endocrinology · doi:10.1080/09513590.2018.1519794 · Cited by 27 · see citing works
yen and jaffe's reproductive endocrinology: physiology, pathophysiology, and clinical management
Băculescu, N. (2009) · Acta Endocrinologica (Bucharest) · doi:10.4183/aeb.2009.562 · Cited by 26 · see citing works
Flagged first, then by citations
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Update on PCOS: consequences, challenges, and guiding treatment
Hoeger, K. M., Dokras, A., & Piltonen, T. (2021) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaa839 · Cited by 610 · see citing works
Polycystic Ovary Syndrome: A Comprehensive Review of Pathogenesis, Management, and Drug Repurposing
Sadeghi, H. M., Adeli, I., Calina, D., Docea, A. O., Mousavi, T., Daniali, M., Nikfar, S., Tsatsakis, A., & Abdollahi, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23020583 · Cited by 445 · see citing works
Armanini, D., Boscaro, M., Bordin, L., & Sabbadin, C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23084110 · Cited by 324 · see citing works
Atherosclerosis Development and Progression: The Role of Atherogenic Small, Dense LDL
Vekić, J., Zeljković, A., Cicero, A. F. G., Janež, A., Stoian, A. P., Sönmez, A., & Rizzo, M. (2022) · Medicina · doi:10.3390/medicina58020299 · Cited by 150 · see citing works
Adipose Tissue Dysfunction in Polycystic Ovary Syndrome
Bril, F., Ezeh, U., Amiri, M., Hatoum, S., Pace, L., Chen, Y.-H., Bertrand, F., Gower, B., & Azziz, R. (2023) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgad356 · Cited by 123 · see citing works
PCOS and nutritional approaches: Differences between lean and obese phenotype
Barrea, L., Frias-Toral, E., Verde, L., Ceriani, F., Cucalón, G., Garcia-Velasquez, E., Moretti, D., Savastano, S., Colao, A., & Muscogiuri, G. (2021) · Metabolism Open · doi:10.1016/j.metop.2021.100123 · Cited by 86 · see citing works
Machado, V., Escalda, C., Proença, L., Mendes, J. J., & Botelho, J. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9061961 · Cited by 52 · see citing works
Prevalence and Etiology of Eating Disorders in Polycystic Ovary Syndrome: A Scoping Review
Lalonde-Bester, S., Malik, M., Masoumi, R., Ng, K., Sidhu, S., Ghosh, M., & Vine, D. F. (2024) · Advances in Nutrition · doi:10.1016/j.advnut.2024.100193 · Cited by 50 · see citing works
Polycystic ovary syndrome and obesity: clinical aspects and nutritional management
Frías-Toral, E., Garcia-Velasquez, E., Carignano, M. D. L. A., Veintimilla, D. R., ALVARADO-AGUILERA, I., & Litardo, N. B. (2021) · Minerva Endocrinology · doi:10.23736/s2724-6507.21.03349-6 · Cited by 41 · see citing works
Leung, K. L., Sanchita, S., Pham, C. T., Davis, B. A., Okhovat, M., Ding, X., Dumesic, P., Grogan, T. R., Williams, K. J., Morselli, M., et al. (2020) · Clinical Epigenetics · doi:10.1186/s13148-020-00970-x · Cited by 33 · see citing works
Self-citationDumesic, D. A., Tulberg, A., Leung, K. L., Fisch, S. C., Grogan, T., Abbott, D. H., Naik, R., & Chazenbalk, G. D. (2020) · Fertility and Sterility · doi:10.1016/j.fertnstert.2020.10.003 · Cited by 28 · see citing works
Self-citationSharifi, M., Saber, A., Moludi, J., Salimi, Y., & Jahan-Mihan, A. (2024) · Nutrition Journal · doi:10.1186/s12937-024-01056-7 · Cited by 24 · see citing works
The Role of the Liver in the Pathophysiology of PCOS: A Literature Review
Alhermi, A., Perks, H., Vadassery, V. N., Altahoo, N., Atkin, S. L., & Butler, A. E. (2025) · Biomolecules · doi:10.3390/biom15010051 · Cited by 24 · see citing works
The effects of phthalate exposure on metabolic parameters in polycystic ovary syndrome
Milankov, A., Milanović, M., Milosevic, N. P., Sudji, J., Pejaković, S., Milić, N., Bjelica, A., & Medic‐Stojanoska, M. (2023) · Clinica Chimica Acta · doi:10.1016/j.cca.2023.117225 · Cited by 21 · see citing works
Assessment of Type 2 Diabetes Risk in Young Women with Polycystic Ovary Syndrome
Livadas, S., Paparodis, R. D., Anagnostis, P. G., Gambineri, A., Μacut, D., Petrović, T., Yıldız, B. O., Micić, D., Mastorakos, G. P., & Μacut, D. (2023) · Diagnostics · doi:10.3390/diagnostics13122067 · Cited by 20 · see citing works
Dumesic, D. A., Turcu, A. F., Liu, H., Grogan, T., Abbott, D. H., Lu, G., Dharanipragada, D., & Chazenbalk, G. D. (2023) · Journal of the Endocrine Society · doi:10.1210/jendso/bvad079 · Cited by 18 · see citing works
Self-citationBashir, A.-A. M., & Olaniyi, K. S. (2023) · BMC Pharmacology and Toxicology · doi:10.1186/s40360-023-00692-9 · Cited by 17 · see citing works
Parker, J., O'Brien, C. L., Yeoh, C., Gersh, F. L., & Brennecke, S. P. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13061774 · Cited by 18 · see citing works
Passing on PCOS: new insights into its epigenetic transmission
Abbott, D. H., & Dumesic, D. A. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.02.008 · Cited by 17 · see citing works
Self-citationUnlocking the Potential of Mesenchymal Stem Cells in Gynecology: Where Are We Now?
Ivkošić, I. E., Fureš, R., Ćosić, V., Mikelin, N., Bulić, L., Dobranić, D., Brlek, P., & Primorac, D. (2023) · Journal of Personalized Medicine · doi:10.3390/jpm13081253 · Cited by 16 · see citing works
Parveen, S., Khan, S., Ahsan, H., Manger, P. T., Gupta, B., & Alam, R. (2022) · Human Nutrition & Metabolism · doi:10.1016/j.hnm.2022.200174 · Cited by 15 · see citing works
Li, J., Chen, S., Qin, R., Liu, X., Fan, L., Wei, M., Wei, J., Lin, J., & Zheng, F. (2023) · Gynecological Endocrinology · doi:10.1080/09513590.2023.2231085 · Cited by 15 · see citing works
Geng, Y., Liu, Z., Hu, R., Ma, W., Wu, X., Dong, H., Song, K., Xu, X., Huang, Y., Li, F., et al. (2023) · Journal of Ovarian Research · doi:10.1186/s13048-023-01236-9 · Cited by 14 · see citing works
Bushell, A., & Crespi, B. J. (2024) · Frontiers in Reproductive Health · doi:10.3389/frph.2024.1475132 · Cited by 14 · see citing works
Foda, A. M., Ibrahim, S. S., Ibrahim, S. M., & Elbaz, E. M. (2024) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.4c00352 · Cited by 13 · see citing works
Miao, H., Hu, S., Ye, L., Zhang, M., Jing, X., & Hong, Y. (2023) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2023.08.004 · Cited by 12 · see citing works
Olaniyi, K. S., & Areloegbe, S. E. J. (2024) · The Journal of Physiological Sciences · doi:10.1186/s12576-024-00908-5 · Cited by 11 · see citing works
Puttabyatappa, M., Guo, X., Dou, J., Dumesic, D. A., Bakulski, K. M., & Padmanabhan, V. (2020) · Endocrinology · doi:10.1210/endocr/bqaa094 · Cited by 8 · see citing works
Self-citationDumesic, D. A., Rasouli, M. A., Katz, J. D., Lu, G., Dharanipragada, D., Turcu, A. F., Grogan, T., Flores, K., Magyar, C. E., Abbott, D. H., et al. (2024) · Journal of the Endocrine Society · doi:10.1210/jendso/bvae162 · Cited by 8 · see citing works
Self-citationPathophysiology of Polycystic Ovarian Syndrome
Manu, Soni, T., Victoria, V., & Prabhakar, P. K. (2022) · IntechOpen eBooks · doi:10.5772/intechopen.101921 · Cited by 8 · see citing works
Activity of isoflavone in managing polycystic ovary syndrome symptoms (Review)
Raihanah, C., Sukrasno, S., & Kurniati, N. F. (2024) · Biomedical Reports · doi:10.3892/br.2024.1768 · Cited by 7 · see citing works
Lahoda, D. O., Artyomenko, V., Velychko, V. I., & Danylchuk, H. O. (2023) · Journal of Medicine and Life · doi:10.25122/jml-2023-0057 · Cited by 7 · see citing works
Wang, W., Barkat, M. Q., Amin, S., Alshammari, A., Albekairi, N. A., Manzoor, H., Chauhdary, Z., Bazmi, R. R., Hussain, L., & Chen, Q. (2024) · Journal of Food Biochemistry · doi:10.1155/jfbc/1184854 · Cited by 7 · see citing works
Jiang-yu, H., Manzoor, M., Siddique, R., Manzoor, H., Moazzam, S., Bazmi, R. R., & Hussain, L. (2025) · Journal of Food Biochemistry · doi:10.1155/jfbc/8015756 · Cited by 6 · see citing works
Brink, H. V., Pea, J., & Lujan, M. E. (2020) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2020.10.008 · Cited by 6 · see citing works
Zangeneh, F. Z. (2022) · Journal of Family & Reproductive Health · doi:10.18502/jfrh.v16i4.11348 · Cited by 5 · see citing works
Koçak, S., Çalışkan, H., Ömercioğlu, G., Akat, F., Billur, D., İnanç, İ., Fıçıcılar, H., & Baştuğ, M. (2024) · Physiology & Behavior · doi:10.1016/j.physbeh.2024.114794 · Cited by 5 · see citing works
Namysł, M., Matczak, S., Dachowska, S., Haraj, J., Majcherek, E., Sobkowiak, M., Bieniek, M., & Woźniak, K. (2026) · Cureus · doi:10.7759/cureus.101431 · Cited by 5 · see citing works
Min, Q., Chen, Y., Geng, H., Gao, Q., Zhang, X., & Xu, M. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1282056 · Cited by 4 · see citing works
A Heuristic Model For Personalised Risk Assesment of PCOS
Singh, N., Sharma, V., & Gupta, V. (2024) · International Conference on Innovative Practices in Technology and Management (ICIPTM) · doi:10.1109/iciptm59628.2024.10563299 · Cited by 4 · see citing works
Wang, Y., Chen, J., Dong, H., Ma, R., Zou, Y., Wang, W., Zheng, Q., Feng, Y., Tan, Z., Zeng, X.-Q., et al. (2022) · BioMed Research International · doi:10.1155/2022/9778678 · Cited by 2 · see citing works
RetractedA Bibliometric Analysis of Global Research Trends in Polycystic Ovary Syndrome and Metformin
Tang, B., Tan, T., Huang, Y., Zhang, M., Li, M., Lei, X., & Nong, W. (2024) · Clinical and Experimental Obstetrics & Gynecology · doi:10.31083/j.ceog5104086 · Cited by 3 · see citing works
Saini, P., Kumar, S., Jangra, H., Solanki, A., Verma, R., Kumar, R., Kaushik, R., Grakh, K., Saini, G., Bangar, Y. C., et al. (2025) · Theriogenology · doi:10.1016/j.theriogenology.2025.01.007 · Cited by 3 · see citing works
Mishra, S., & Mittal, P. (2025) · Phytomedicine Plus · doi:10.1016/j.phyplu.2025.100741 · Cited by 3 · see citing works
Research Trends of Acupuncture Therapy on Polycystic Ovary Syndrome: A Bibliometric Analysis
Wang, Y., Xia, Y., Li, R., Sun, R., & Fang, J. (2022) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2022/1989401 · Cited by 3 · see citing works
Understanding Polycystic Ovary Syndrome (PCOS):
Chakravorty, T. A. (2023) · The Physician · doi:10.38192/1.8.2.3 · Cited by 3 · see citing works
An Update on the Genetics of Polycystic Ovary Syndrome
Sharma, P., Jain, M., Tripathi, M. K., Sharma, M., & Halder, A. (2024) · Journal of Endocrinology & Reproduction · doi:10.18311/jer/2023/34654 · Cited by 3 · see citing works
Taha, A. M., Michel, C. G., Abdelrahman, E. H., Nagy, A. M., Abdelhameed, M. F., ElMosbah, D. E., & Hashem, M. M. (2026) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2026.121285 · Cited by 2 · see citing works
Intergenerational Implications of PCOS
Willging, M. M., Abbott, D. H., & Dumesic, D. A. (2022) · Springer eBooks · doi:10.1007/978-3-030-92589-5_27 · Cited by 2 · see citing works
Self-citationStatins for women with polycystic ovary syndrome not actively trying to conceive
Xiong, T., Fraison, É., Kolibianaki, E., Costello, M., Venetis, C. A., & Kostova, E. (2023) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008565.pub3 · Cited by 2 · see citing works
Sun, Y., Liu, X., Ding, Q., Yin, S., & Yang, H. (2022) · Medicine · doi:10.1097/md.0000000000032234 · Cited by 2 · see citing works
Divya, Thakur, A., Hajam, Y. A., & Kumar, R. (2025) · Pharmacological Research - Natural Products · doi:10.1016/j.prenap.2025.100278 · Cited by 1 · see citing works
Insulin Resistance in the Pathophysiology of Polycystic Ovary Syndrome
Chada, S. R., & Sahay, R. K. (2025) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/9798898810931125010014 · Cited by 1 · see citing works
Insulin Resistance and Lipotoxicity in PCOS: Causes and Consequences
Carreau, A., Battista, M., & Baillargeon, J. (2022) · Springer eBooks · doi:10.1007/978-3-030-92589-5_8 · Cited by 1 · see citing works
DEALING WITH INSULIN RESISTANCE AMONG WOMEN WITH POLYCYSTIC OVARIAN SYNDROME
Aziz, U., AFZAL, M., YOUSAF, R., Imran, S., SARFRAZ, T., JAVED, H., & SULTAN, W. (2023) · Biological and Clinical Sciences Research Journal · doi:10.54112/bcsrj.v2023i1.276 · Cited by 1 · see citing works
Rashad, N. M., Saraya, Y. S., Aziz, E. A., Gobran, A. M., Atef, R. M., El-Fatah, A. H. A., & Mousa, M. M. (2024) · Zagazig University Medical Journal · doi:10.21608/zumj.2024.305018.3481 · Cited by 1 · see citing works
Landing Eyes on Unnoticed Disorder: A Polycystic Ovary Syndrome
Davariya, J. (2022) · International Journal of Current Science Research and Review · doi:10.47191/ijcsrr/v5-i12-01
Polycystic Ovarian Syndrome and Increased Risk of Female Cancers
Sodeifin, F., Kian, N., Mohamed, K., & Rezaei, N. (2022) · Interdisciplinary cancer research · doi:10.1007/16833_2022_22 · Cited by 1 · see citing works
Síndrome de ovario poliquístico como factor de riesgo cardiometabólico
Vilela, E. M. C., & González, D. M. (2022) · Anatomía Digital · doi:10.33262/anatomiadigital.v5i3.2.2256
Honour, J. W. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-818124-9.00004-8
Hormonelle Regulation des menstruellen Zyklus und ihre Störungen
Ludwig, M. Z., & Weiss, J. M. (2024) · Springer eBooks · doi:10.1007/978-3-662-65517-7_3
Nature's Remedy: Exploring Herbal Treatments for Polycystic Ovarian Syndrome
Attri, M., Raghav, A., & Chaudhary, H. (2024) · Current Nutraceuticals · doi:10.2174/0126659786282036240503112128
Bakhashab, S., Batarfi, A. A., Alhartani, M. M., Turki, R. F., & Mady, W. (2024) · Biomarker Insights · doi:10.1177/11772719241258585
Disorder-Related Sex Steroid Hormonal Production: Polycystic Ovarian Syndrome
Sentosa, I. G. A. N. A., & Wisan, A. B. (2024) · IntechOpen eBooks · doi:10.5772/intechopen.1007169
Ghani, I. A. A., Mohammed, N. H., Mshimesh, B. A. R., & Zayed, R. A. E. (2025) · Al Mustansiriyah Journal of Pharmaceutical Sciences · doi:10.32947/ajps.v25i4.1203
Wangange, S. M. P., Bosenge-Nguma, J.-D., O’yandjo, A. M., Lobo, A. M., & Mboloko, J. E. (2025) · Open Journal of Obstetrics and Gynecology · doi:10.4236/ojog.2025.1512168
Leung, K. L., Sanchita, S., Pham, C. T., Davis, B. A., Okhovat, M., Ding, X., Dumesic, P. A., Grogan, T. R., Williams, K. J., Morselli, M., et al. (2020) · Figshare · doi:10.6084/m9.figshare.13279512
Self-citationLeung, K. L., Sanchita, S., Pham, C. T., Davis, B. A., Okhovat, M., Ding, X., Dumesic, P. A., Grogan, T. R., Williams, K. J., Morselli, M., et al. (2020) · Figshare · doi:10.6084/m9.figshare.13279509
Self-citationAntoniou-Tsigkos, A., Καρράς, Γ., Papagianni, M., CHRISTOPOULOS, P. F., Vlahos, N. F., & Mastorakos, G. M. (2025) · Endocrine · doi:10.1007/s12020-025-04527-x
Fatima, S., Kori, J. A., Vankwani, S., Mirza, M. R., & Rehman, R. (2026) · Steroids · doi:10.1016/j.steroids.2026.109791
Li, H., Wang, M., Chen, X., Guan, H., Zhao, J., Song, H. S., Song, J., Tang, H., & Tang, L. (2026) · International Journal of Women s Health · doi:10.2147/ijwh.s611363
Ekici, E. M., Akçakaya, S. D., Şakar, V. S., & Çelik, Ö. M. (2026) · Food Science & Nutrition · doi:10.1002/fsn3.72007
Senthilkumar, H., Palanisamy, T. B., & Arumugam, M. (2026) · doi:10.1002/9781394416905.ch17
Editorial: Sex steroid metabolism and obesity: insights from animal studies
den Hartigh, L. J., & Varghese, M. (2026) · Frontiers in Endocrinology · doi:10.3389/fendo.2026.1940053
Ceviz, B. B., Baykan, Ö., Çamili, F. E., Afşar, S., Taşkın, M. İ., & Çetin, O. (2026) · BMC Endocrine Disorders · doi:10.1186/s12902-026-02507-4
Polycystic Ovarian Syndrome and Diabetes Mellitus: A Bidirectional Endocrine Disorder
Barman, I., Malik, S., Bora, J., Sharma, T., Sarma, J., Priya, S., Rustagi, S., Thapliyal, S., Deshwal, R. K., Ray, S., et al. (2026) · Biomedical & Pharmacology Journal · doi:10.13005/bpj/3486
- Authors
- Dumesic, D. A., Abbott, D. H., Sanchita, S., & Chazenbalk, G. D.
- Affiliations
- University of California, Los Angeles (US)
- University of Wisconsin–Madison (US)
- Corresponding author
- Dumesic, Daniel A.
- Venue
- Current Opinion in Endocrine and Metabolic Research
- Publisher
- Elsevier BV
- Published
- 2020-06
- Volume
- 12
- Pages
- 41-48
- ISSN
- 2451-9650 (ISSN-L)
- PMC
- PMC7194185
- OpenAlex
- W3011966340
- Cited by
- 76
- References
- 49
- Citations by year
- 2026: 9 · 2025: 9 · 2024: 19 · 2023: 14 · 2022: 14 · 2021: 3 · 2020: 8
- FWCI
- 1.44
- Type
- journal article
- Language
- en
- Update notices
- erratum (2021-04-01)
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Current Opinion in Endocrine and Metabolic Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- Oregon National Primate Research Center
- University of Virginia
- Eunice Kennedy Shriver National Institute of Child Health and Human Development
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- polycystic ovary syndrome, evolutionary medicine, hyperandrogenism, insulin resistance, abdominal obesity, adipose tissue dysfunction, ectopic fat deposition, lipotoxicity, oxidative stress, inflammation, subcutaneous adipose tissue, adipose-derived stem cells, hyperinsulinemia, non-human primates, ancestral traits
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