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Cited by 70Ovarian function and disordersDiabetes, Cardiovascular Risks, and LipoproteinsAdipokines, Inflammation, and Metabolic Diseases

Total body fat and central fat mass independently predict insulin resistance but not hyperandrogenemia in women with polycystic ovary syndrome

Tosi, Flavia, Di Sarra, Daniela, Kaufman, Jean-Marc, Bonin, Cecilia, Moretta, Rosa, Bonora, Enzo, Zanolin, Elisabetta, Moghetti, Paolo·2015·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jc.2014-2786
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Abstract

CONTEXT/OBJECTIVE: Obesity is a common feature of women with polycystic ovary syndrome (PCOS). The aim of this study was to assess the role of body fat on insulin resistance and androgen excess in these subjects. PATIENTS/DESIGN: One hundred sixteen consecutive Caucasian women with PCOS, diagnosed by the Rotterdam criteria, underwent accurate assessment of clinical, anthropometric, hormonal, and metabolic features. In particular, total fat mass and fat distribution were assessed by dual-energy x-ray absorptiometry, serum-free T by liquid chromatography mass spectrometry and equilibrium dialysis and insulin sensitivity by the glucose clamp technique. RESULTS: Total fat mass and truncal fat were significantly higher in insulin-resistant than in insulin-sensitive PCOS subjects (+89% and +127%, respectively, both P < .001), and both tended to be higher in hyperandrogenemic than in normoandrogenemic women (+22% and +28%, respectively, P = .087 and P = .090). All parameters of adiposity correlated inversely with insulin sensitivity (P < .001) and directly with serum-free T (P ≤ .001). A statistically significant inverse relationship was observed between insulin sensitivity and serum-free T concentrations (r = -0.527, P < .001). In a multiple regression analysis, either total fat mass or truncal fat, in addition to serum-free T and age, were independent predictors of insulin sensitivity. However, insulin sensitivity, but not total fat mass or truncal fat, was an independent predictor of free T concentrations. CONCLUSIONS: These data suggest that body fat contributes to determining insulin resistance in PCOS women. However, the association between body fat and hyperandrogenism seems to be to a large extent explained by insulin resistance.

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Crossref · 10.1210/jc.2014-2786

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  • Tosi et al. demonstrated that total or trunk fat mass is strongly and inversely associated with insulin-induced glucose clearance during clamping in a large cohort of women with PCOS.

    “In a large cohort of women with PCOS, Tosi et al. demonstrated that total or trunk fat mass is strongly and inversely associated with insulin-induced glucose clearance during clamping, considered the gold standard for evaluating IR [35].”

    From PCOS and nutritional approaches: Differences between lean and obese phenotype (2021) · cites this paper as [35]

  • Excess body fat may be an essential determinant of IR in PCOS.

    “This finding supports the hypothesis that excess body fat may be an essential determinant of IR in PCOS [35].”

    From PCOS and nutritional approaches: Differences between lean and obese phenotype (2021) · cites this paper as [35]

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Authors
Tosi, F., Di Sarra, D., Kaufman, J.-M., Bonin, C., Moretta, R., Bonora, E., Zanolin, E., & Moghetti, P.
Affiliations
  • University of Verona (IT)
  • Ghent University Hospital (BE)
Corresponding author
Moghetti, Paolo
ORCID
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2015-02
Volume
100
Issue
2
Pages
661-669
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jc.2014-2786
OpenAlex
W2051196987
Cited by
70
References
43
Citations by year
2025: 6 · 2024: 5 · 2023: 10 · 2022: 2 · 2021: 7 · 2020: 11 · 2019: 5 · 2018: 6 · 2017: 3 · 2016: 10 · 2015: 5
FWCI
7.27
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • Ghent University Academic Bibliography (Ghent University) (submittedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Keywords
polycystic ovary syndrome, insulin resistance, hyperandrogenemia, total body fat, truncal fat, free testosterone, insulin sensitivity, obesity, adiposity, women
MeSH terms
Adipose Tissue, Adult, Body Composition, Female, Humans, Insulin, Insulin Resistance, Polycystic Ovary Syndrome, Testosterone, Hyperandrogenism, Young Adult

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