Perisomatic inhibition and cortical circuit dysfunction in schizophrenia
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Deficits of cognitive control in schizophrenia are associated with altered gamma oscillations in the prefrontal cortex. Paralbumin basket interneurons, which innervate the perisomatic region of pyramidal neurons, appear to play a key role in generating cortical gamma oscillations. In the prefrontal cortex of subjects with schizophrenia, alterations are present in both pre- and post-synaptic markers of the strength of GABA inputs from parvalbumin basket neurons to pyramidal neurons. These alterations may contribute to the neural substrate for impaired gamma oscillations in schizophrenia.
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Decreased GAD67 expression and reduced gamma oscillations in PFC of SZ patients.
“including the decreased GAD67 expression and reduced gamma oscillations, suggesting deficient GABA synthesis and GABAergic synaptic transmission, respectively 180.”
From Mechanisms of synaptic transmission dysregulation in the prefrontal cortex: pathophysiological implications (2022) · cites this paper as [180]
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- Authors
- Lewis, D. A., Fish, K. N., Arion, D., & Gonzalez-Burgos, G.
- Affiliations
- University of Pittsburgh (US)
- Corresponding author
- Lewis, David A
- Venue
- Current Opinion in Neurobiology
- Publisher
- Elsevier BV
- Published
- 2011-12
- Volume
- 21
- Issue
- 6
- Pages
- 866-872
- ISSN
- 0959-4388 (ISSN-L)
- PMC
- PMC3183273
- OpenAlex
- W1985328167
- Cited by
- 87
- References
- 73
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 1 · 2023: 3 · 2022: 4 · 2021: 4 · 2020: 5 · 2019: 5 · 2018: 3 · 2017: 6 · 2016: 7 · 2015: 11 · 2014: 8 · 2013: 9 · 2012: 11
- FWCI
- 1.42
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Current Opinion in Neurobiology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (P50MH084053, R21MH085108, R01MH043784, R01MH071533, R01MH051234)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- schizophrenia, perisomatic inhibition, gamma oscillations, prefrontal cortex, cognitive control, GABAergic inhibition, pyramidal neurons
- MeSH terms
- Humans, Neural Pathways, Synaptic Transmission, Neurons, Schizophrenia, Prefrontal Cortex
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