Cited by 87Schizophrenia research and treatmentNeuroscience and Neuropharmacology ResearchNeural dynamics and brain function

Perisomatic inhibition and cortical circuit dysfunction in schizophrenia

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Lewis, David A, Fish, Kenneth N, Arion, Dominique, Gonzalez-Burgos, Guillermo·2011·Current Opinion in Neurobiology

Abstract

Deficits of cognitive control in schizophrenia are associated with altered gamma oscillations in the prefrontal cortex. Paralbumin basket interneurons, which innervate the perisomatic region of pyramidal neurons, appear to play a key role in generating cortical gamma oscillations. In the prefrontal cortex of subjects with schizophrenia, alterations are present in both pre- and post-synaptic markers of the strength of GABA inputs from parvalbumin basket neurons to pyramidal neurons. These alterations may contribute to the neural substrate for impaired gamma oscillations in schizophrenia.

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Crossref · 10.1016/j.conb.2011.05.013

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Authors
Lewis, D. A., Fish, K. N., Arion, D., & Gonzalez-Burgos, G.
Affiliations
University of Pittsburgh (US)
Corresponding author
Lewis, David A
Venue
Current Opinion in Neurobiology
Publisher
Elsevier BV
Published
2011-12
Volume
21
Issue
6
Pages
866-872
ISSN
0959-4388 (ISSN-L)
OpenAlex
W1985328167
Cited by
87
References
73
Citations by year
2026: 2 · 2025: 2 · 2024: 1 · 2023: 3 · 2022: 4 · 2021: 4 · 2020: 5 · 2019: 5 · 2018: 3 · 2017: 6 · 2016: 7 · 2015: 11 · 2014: 8 · 2013: 9 · 2012: 11
FWCI
1.42
Type
journal article
Language
en
Open access
Locations
  • Current Opinion in Neurobiology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Mental Health (P50MH084053, R21MH085108, R01MH043784, R01MH071533, R01MH051234)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords
schizophrenia, perisomatic inhibition, gamma oscillations, prefrontal cortex, cognitive control, GABAergic inhibition, pyramidal neurons
MeSH terms
Humans, Neural Pathways, Synaptic Transmission, Neurons, Schizophrenia, Prefrontal Cortex

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