Alterations of cortical GABA neurons and network oscillations in schizophrenia

Gonzalez-Burgos, Guillermo; Hashimoto, Takanori; Lewis, David A.

doi:10.1007/s11920-010-0124-8

Cited by 260Schizophrenia research and treatmentNeural dynamics and brain functionNeuroscience and Neuropharmacology Research

Alterations of cortical GABA neurons and network oscillations in schizophrenia

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Gonzalez-Burgos, Guillermo, Hashimoto, Takanori, Lewis, David A.·2010·Current Psychiatry Reports

DOI 10.1007/s11920-010-0124-8PMC PMC2919752

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Abstract

The hypothesis that alterations of cortical inhibitory gamma-aminobutyric acid (GABA) neurons are a central element in the pathology of schizophrenia has emerged from a series of postmortem studies. How such abnormalities may contribute to the clinical features of schizophrenia has been substantially informed by a convergence with basic neuroscience studies revealing complex details of GABA neuron function in the healthy brain. Importantly, activity of the parvalbumin-containing class of GABA neurons has been linked to the production of cortical network oscillations. Furthermore, growing knowledge supports the concept that gamma band oscillations (30-80 Hz) are an essential mechanism for cortical information transmission and processing. Herein we review recent studies further indicating that inhibition from parvalbumin-positive GABA neurons is necessary to produce gamma oscillations in cortical circuits; provide an update on postmortem studies documenting that deficits in the expression of glutamic acid decarboxylase67, which accounts for most GABA synthesis in the cortex, are widely observed in schizophrenia; and describe studies using novel, noninvasive approaches directly assessing potential relations between alterations in GABA, oscillations, and cognitive function in schizophrenia.

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Schizophrenia onset is linked to disrupted physiological maturation of fast-spiking parvalbumin-positive GABAergic interneurons.
“its onset is linked to a potential disruption of the physiological maturation of inhibitory neural networks consisting of fast-spiking parvalbumin-positive gamma-aminobutric acid (GABAergic) interneurons”
From Perineuronal nets and schizophrenia: The importance of neuronal coatings (2014) · cites this paper as Gonzalez-Burgos et al., 2010

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Neuronal Oscillations in Cortical Networks
Buzsáki, G., & Draguhn, A. (2004) · Science · doi:10.1126/science.1099745 · Cited by 6,576 · see citing works
What are the functional consequences of neurocognitive deficits in schizophrenia?
(1996) · American Journal of Psychiatry · doi:10.1176/ajp.153.3.321 · Cited by 3,516 · see citing works
Recent advances in the phencyclidine model of schizophrenia
(1991) · American Journal of Psychiatry · doi:10.1176/ajp.148.10.1301 · Cited by 2,904 · see citing works
Cellular basis of working memory
Goldman-Rakic, P. S. (1995) · Neuron · doi:10.1016/0896-6273(95)90304-6 · Cited by 2,663 · see citing works
Parvalbumin neurons and gamma rhythms enhance cortical circuit performance
Sohal, V. S., Zhang, F., Yizhar, O., & Deisseroth, K. (2009) · Nature · doi:10.1038/nature07991 · Cited by 2,606 · see citing works
Driving fast-spiking cells induces gamma rhythm and controls sensory responses
Cardin, J. A., Carlén, M., Meletis, K., Knoblich, U., Zhang, F., Deisseroth, K., Tsai, L.-H., & Moore, C. I. (2009) · Nature · doi:10.1038/nature08002 · Cited by 2,603 · see citing works
Cortical inhibitory neurons and schizophrenia
Lewis, D. A., Hashimoto, T., & Volk, D. W. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1648 · Cited by 2,297 · see citing works
Self-citation
Abnormal neural oscillations and synchrony in schizophrenia
Uhlhaas, P. J., & Singer, W. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2774 · Cited by 2,120 · see citing works
Neuron Activity Related to Short-Term Memory
Fuster, J. M., & Alexander, G. E. (1971) · Science · doi:10.1126/science.173.3997.652 · Cited by 2,085 · see citing works
Synaptic mechanisms of synchronized gamma oscillations in inhibitory interneuron networks
Bartos, M., Vida, I., & Jonas, P. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2044 · Cited by 2,070 · see citing works
Neuronal Diversity and Temporal Dynamics: The Unity of Hippocampal Circuit Operations
Klausberger, T., & Somogyi, P. (2008) · Science · doi:10.1126/science.1149381 · Cited by 2,050 · see citing works
A novel slow (< 1 Hz) oscillation of neocortical neurons in vivo: depolarizing and hyperpolarizing components
Steriade, M., Nunez, A., & Amzica, F. (1993) · The Journal of Neuroscience · doi:10.1523/jneurosci.13-08-03252.1993 · Cited by 1,903 · see citing works
Neuronal gamma-band synchronization as a fundamental process in cortical computation
Fries, P. (2009) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.051508.135603 · Cited by 1,713 · see citing works
Petilla terminology: nomenclature of features of GABAergic interneurons of the cerebral cortex
The Petilla Interneuron Nomenclature Group (PING) (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2402 · Cited by 1,491 · see citing works
Decrease in Reelin and Glutamic Acid Decarboxylase67 (GAD67) Expression in Schizophrenia and Bipolar Disorder
Guidotti, A., Auta, J., Davis, J. M., Gerevini, V. D. G., Dwivedi, Y., Grayson, D. R., Impagnatiello, F., Pandey, G. N., Pesold, C., Sharma, R. P., et al. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.11.1061 · Cited by 1,203 · see citing works
Working memory
Baddeley, A. (2010) · Current Biology · doi:10.1016/j.cub.2009.12.014 · Cited by 1,149 · see citing works
Neuregulin 1 in neural development, synaptic plasticity and schizophrenia
Mei, L., & Xiong, W.-C. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2392 · Cited by 1,030 · see citing works
Circuit-based framework for understanding neurotransmitter and risk gene interactions in schizophrenia
Lisman, J. E., Coyle, J. T., Green, R. W., Javitt, D. C., Benes, F. M., Heckers, S., & Grace, A. A. (2008) · Trends in Neurosciences · doi:10.1016/j.tins.2008.02.005 · Cited by 1,010 · see citing works
Gene expression for glutamic acid decarboxylase is reduced without loss of neurons in prefrontal cortex of schizophrenics.
Akbarian, S. (1995) · Archives of General Psychiatry · doi:10.1001/archpsyc.1995.03950160008002 · Cited by 1,002 · see citing works
NKCC1 transporter facilitates seizures in the developing brain
Dzhala, V. I., Talos, D. M., Sdrulla, D., Brumback, A. C., Mathews, G. C., Benke, T. A., Delpire, E. J., Jensen, F. E., & Staley, K. J. (2005) · Nature Medicine · doi:10.1038/nm1301 · Cited by 982 · see citing works
Gene Expression Deficits in a Subclass of GABA Neurons in the Prefrontal Cortex of Subjects with Schizophrenia
Hashimoto, T., Volk, D. W., Eggan, S. M., Mirnics, K., Pierri, J. N., Sun, Z., Sampson, A. R., & Lewis, D. A. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-15-06315.2003 · Cited by 938 · see citing works
Induced γ-Band Activity during the Delay of a Visual Short-Term Memory Task in Humans
Tallon‐Baudry, C., Bertrand, O., Peronnet, F., & Pernier, J. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-11-04244.1998 · Cited by 900 · see citing works
What has fMRI told us about the Development of Cognitive Control through Adolescence?
Luna, B., Padmanabhan, A., & O’Hearn, K. (2010) · Brain and Cognition · doi:10.1016/j.bandc.2009.08.005 · Cited by 892 · see citing works
Molecular Characterization of Schizophrenia Viewed by Microarray Analysis of Gene Expression in Prefrontal Cortex
Mirnics, K., Middleton, F. A., Marquez, A., Lewis, D. A., & Levitt, P. (2000) · Neuron · doi:10.1016/s0896-6273(00)00085-4 · Cited by 882 · see citing works
Self-citation
Hemodynamic Signals Correlate Tightly with Synchronized Gamma Oscillations
Niessing, J., Ebisch, B., Schmidt, K. E., Niessing, M., Singer, W., & Galuske, R. A. W. (2005) · Science · doi:10.1126/science.1110948 · Cited by 806 · see citing works
Role of Distinct NMDA Receptor Subtypes at Central Synapses
Cull-Candy, S. G., & Leszkiewicz, D. N. (2004) · Science s STKE · doi:10.1126/stke.2552004re16 · Cited by 804 · see citing works
Gamma Oscillations Correlate with Working Memory Load in Humans
Howard, M. W. (2003) · Cerebral Cortex · doi:10.1093/cercor/bhg084 · Cited by 766 · see citing works
A decrease of reelin expression as a putative vulnerability factor in schizophrenia
Impagnatiello, F., Guidotti, A. R., Pesold, C., Dwivedi, Y., Caruncho, H. J., Pisu, M. G., Uzunov, D. P., Smalheiser, N. R., Davis, J. M., Pandey, G. N., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.26.15718 · Cited by 753 · see citing works
Postnatal NMDA receptor ablation in corticolimbic interneurons confers schizophrenia-like phenotypes
Belforte, J. E., Zsiros, V., Sklar, E. R., Jiang, Z., Yu, G., Li, Y., Quinlan, E. M., & Nakazawa, K. (2010) · Nature Neuroscience · doi:10.1038/nn.2447 · Cited by 752 · see citing works
Decreased Glutamic Acid Decarboxylase67 Messenger RNA Expression in a Subset of Prefrontal Cortical γ-Aminobutyric Acid Neurons in Subjects With Schizophrenia
Volk, D. W., Austin, M. C., Pierri, J. N., Sampson, A. R., & Lewis, D. A. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.3.237 · Cited by 697 · see citing works
GABAergic Hub Neurons Orchestrate Synchrony in Developing Hippocampal Networks
Bonifazi, P., Goldin, M., Picardo, M. A., Jorquera, I., Cattani, A., Bianconi, G., Represa, A., Ben-Ari, Y., & Cossart, R. (2009) · Science · doi:10.1126/science.1175509 · Cited by 695 · see citing works
Inhibitory Postsynaptic Potentials Carry Synchronized Frequency Information in Active Cortical Networks
Hasenstaub, A. R., Shu, Y., Haider, B., Kraushaar, U., Duque, A., & McCormick, D. A. (2005) · Neuron · doi:10.1016/j.neuron.2005.06.016 · Cited by 654 · see citing works
Abnormal neural synchrony in schizophrenia
Spencer, K. M., Nestor, P. G., Niznikiewicz, M. A., Salisbury, D. F., Shenton, M. E., & McCarley, R. W. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-19-07407.2003 · Cited by 624 · see citing works
Excitatory effect of GABAergic axo-axonic cells in cortical microcircuits
Szabadics, J., Varga, C., Molnár, G., Oláh, S., Barzó, P., & Tamás, G. (2006) · Science · doi:10.1126/science.1121325 · Cited by 598 · see citing works
Impairments in frontal cortical γ synchrony and cognitive control in schizophrenia
CHO, R. Y., Konecky, R. O., & Carter, C. S. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609440103 · Cited by 576 · see citing works
GABA Neurons and the Mechanisms of Network Oscillations: Implications for Understanding Cortical Dysfunction in Schizophrenia
González‐Burgos, G., & Lewis, D. A. (2008) · Schizophrenia Bulletin · doi:10.1093/schbul/sbn070 · Cited by 568 · see citing works
Resting GABA concentration predicts peak gamma frequency and fMRI amplitude in response to visual stimulation in humans
Muthukumaraswamy, S. D., Edden, R. A. E., Jones, D. K., Swettenham, J. B., & Singh, K. D. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0900728106 · Cited by 562 · see citing works
Recruitment of Parvalbumin-Positive Interneurons Determines Hippocampal Function and Associated Behavior
Fuchs, E. C., Zivkovic, A. R., Cunningham, M. O., Middleton, S., LeBeau, F. E. N., Bannerman, D. M., Rozov, A., Whittington, M. A., Traub, R. D., Rawlins, J. N. P., et al. (2007) · Neuron · doi:10.1016/j.neuron.2007.01.031 · Cited by 532 · see citing works
Epigenetic targets of HDAC inhibition in neurodegenerative and psychiatric disorders
Abel, T. G., & Zukin, R. S. (2008) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2007.12.002 · Cited by 495 · see citing works
Alterations in GABA-related transcriptome in the dorsolateral prefrontal cortex of subjects with schizophrenia
Hashimoto, T., Arion, D., Unger, T., Maldonado-Avilés, J. G., Morris, H. M., Volk, D. W., Mirnics, K., & Lewis, D. A. (2008) · Molecular Psychiatry · doi:10.1038/sj.mp.4002011 · Cited by 490 · see citing works
Conserved regional patterns of GABA-related transcript expression in the neocortex of subjects with schizophrenia
Hashimoto, T., Bazmi, H. H., Mirnics, K., Wu, Q., Sampson, A. R., & Lewis, D. A. (2008) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2007.07081223 · Cited by 457 · see citing works
A Neural Coding Scheme Formed by the Combined Function of Gamma and Theta Oscillations
Lisman, J. E., & Buzsáki, G. (2008) · Schizophrenia Bulletin · doi:10.1093/schbul/sbn060 · Cited by 433 · see citing works
Membrane potential dynamics of GABAergic neurons in the barrel cortex of behaving mice
Gentet, L. J., Avermann, M., Matyas, F., Staiger, J. F., & Petersen, C. C. H. (2010) · Neuron · doi:10.1016/j.neuron.2010.01.006 · Cited by 429 · cited 1× · see citing works
“Interestingly, up states recruit PV neurons [49, 50], suggesting that PV cells provide the inhibition crucial for cortical up states.”
Background
Density of Glutamic Acid Decarboxylase 67 Messenger RNA–ContainingNeurons That Express the N-Methyl-D-AspartateReceptor Subunit NR2A in the Anterior Cingulate Cortex in Schizophreniaand Bipolar Disorder
Woo, T.-U. W., Walsh, J. P., & Benes, F. M. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.7.649 · Cited by 411 · see citing works
GABA concentration is reduced in visual cortex in schizophrenia and correlates with orientation-specific surround suppression
Yoon, J. H., Maddock, R. J., Rokem, A., Silver, M. A., Minzenberg, M. J., Ragland, J. D., & Carter, C. S. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.6158-09.2010 · Cited by 408 · see citing works
Hippocampal theta rhythm and its coupling with gamma oscillations require fast inhibition onto parvalbumin-positive interneurons
Wulff, P., Ponomarenko, A. A., Bartos, M., Korotkova, T. M., Fuchs, E. C., Bähner, F., Both, M., Tort, A. B. L., Kopell, N. J., Wisden, W., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0813176106 · Cited by 400 · see citing works
Role of GABAergic inhibition in hippocampal network oscillations
Mann, E. O., & Paulsen, O. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.05.003 · Cited by 389 · see citing works
Relationship of Brain-Derived Neurotrophic Factor and Its Receptor TrkB to Altered Inhibitory Prefrontal Circuitry in Schizophrenia
Hashimoto, T., Bergen, S. E., Nguyen, Q. L., Xu, B., Monteggia, L. M., Pierri, J. N., Sun, Z., Sampson, A. R., & Lewis, D. A. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.4035-04.2005 · Cited by 384 · see citing works
Molecular and cellular mechanisms of altered GAD1/GAD67 expression in schizophrenia and related disorders
Akbarian, S., & Huang, H. (2006) · Brain Research Reviews · doi:10.1016/j.brainresrev.2006.04.001 · Cited by 362 · see citing works
Neuroplasticity of Neocortical Circuits in Schizophrenia
Lewis, D. A., & González‐Burgos, G. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301563 · Cited by 362 · see citing works
The development of neural synchrony reflects late maturation and restructuring of functional networks in humans
Uhlhaas, P. J., Roux, F., Singer, W., Haenschel, C., Sireteanu, R., & Rodriguez, E. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0900390106 · Cited by 356 · see citing works
Prefrontal Dysfunction in Schizophrenia Involves Mixed-Lineage Leukemia 1-Regulated Histone Methylation at GABAergic Gene Promoters
Huang, H.-S., Matevossian, A., Whittle, C., Kim, S. Y., Schumacher, A., Baker, S. P., & Akbarian, S. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.3272-07.2007 · Cited by 352 · see citing works
Orientation Discrimination Performance Is Predicted by GABA Concentration and Gamma Oscillation Frequency in Human Primary Visual Cortex
Edden, R. A. E., Muthukumaraswamy, S. D., Freeman, T. C. A., & Singh, K. D. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.4426-09.2009 · Cited by 350 · see citing works
Transcriptional and Electrophysiological Maturation of Neocortical Fast-Spiking GABAergic Interneurons
Okaty, B. W., Miller, M. N., Sugino, K., Hempel, C. M., & Nelson, S. B. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.0105-09.2009 · Cited by 309 · see citing works
Cortical oscillatory activity is critical for working memory as revealed by deficits in early-onset schizophrenia
Haenschel, C., Bittner, R. A., Waltz, J., Haertling, F., Wibral, M., Singer, W., Linden, D. E. J., & Rodriguez, E. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.1428-09.2009 · Cited by 303 · see citing works
Neuregulin 1 regulates pyramidal neuron activity via ErbB4 in parvalbumin-positive interneurons
Wen, L., Lu, Y.-S., Zhu, X.-H., Li, X.-M., Woo, R., Chen, Y., Yin, D., Lai, C., Terry, A. V., Vazdarjanova, A. I., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0910302107 · Cited by 302 · see citing works
Neuregulin-1 Enhances Depolarization-Induced GABA Release
Woo, R., Li, X.-M., Tao, Y., Carpenter‐Hyland, E. P., Huang, Y. Z., Weber, J., Neiswender, H., Dong, X., Wu, J., Gassmann, M., et al. (2007) · Neuron · doi:10.1016/j.neuron.2007.04.009 · Cited by 297 · see citing works
GABAergic Depolarization of the Axon Initial Segment in Cortical Principal Neurons Is Caused by the Na–K–2Cl Cotransporter NKCC1
Khirug, S., Yamada, J., Afzalov, R. A., Voipio, J., Khiroug, L. S., & Kaila, K. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0908-08.2008 · Cited by 291 · see citing works
Ventral Tegmental Area Afferents to the Prefrontal Cortex Maintain Membrane Potential 'Up' States in Pyramidal Neurons via D1 Dopamine Receptors
Lewis, B. L. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.12.1168 · Cited by 287 · see citing works
Subunit-Selective Modulation of GABA Type A Receptor Neurotransmission and Cognition in Schizophrenia
Lewis, D. A., Cho, R. Y., Carter, C. S., Eklund, K. E., Förster, S., Kelly, M. A., & Montrose, D. M. (2008) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2008.08030395 · Cited by 286 · see citing works
Allelic variation in GAD1 (GAD67) is associated with schizophrenia and influences cortical function and gene expression
Straub, R. E., Lipska, B. K., Egan, M. F., Goldberg, T. E., Callicott, J. H., Mayhew, M. B., Vakkalanka, R., Kolachana, B. S., Kleinman, J. E., & Weinberger, D. R. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001988 · Cited by 275 · see citing works
Microarray analysis of gene expression in the prefrontal cortex in schizophrenia: a preliminary study
Vawter, M. (2002) · Schizophrenia Research · doi:10.1016/s0920-9964(01)00377-2 · Cited by 275 · see citing works
Left auditory cortex gamma synchronization and auditory hallucination symptoms in schizophrenia
Spencer, K. M., Niznikiewicz, M. A., Nestor, P. G., Shenton, M. E., & McCarley, R. W. (2009) · BMC Neuroscience · doi:10.1186/1471-2202-10-85 · Cited by 253 · see citing works
Postnatal Differentiation of Basket Cells from Slow to Fast Signaling Devices
Doischer, D., Aurel Hosp, J., Yanagawa, Y., Obata, K., Jonas, P., Vida, I., & Bartos, M. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.2890-08.2008 · Cited by 248 · see citing works
Synch before you speak: Auditory hallucinations in schizophrenia
Ford, J. M., Roach, B. J., Faustman, W. O., & Mathalon, D. H. (2007) · American Journal of Psychiatry · doi:10.1176/ajp.2007.164.3.458 · Cited by 245 · cited 1× · see citing works
“Furthermore, abnormal γ oscillations observed in individuals with schizophrenia during auditory processing tasks [66] may reflect altered GABA neurotransmission in auditory cortices [55].”
Background
Interneurons hyperpolarize pyramidal cells along their entire somatodendritic axis
Glickfeld, L. L., Roberts, J. D. B., Somogyi, P., & Scanziani, M. (2008) · Nature Neuroscience · doi:10.1038/nn.2230 · Cited by 238 · see citing works
Control of hippocampal gamma oscillation frequency by tonic inhibition and excitation of interneurons
Mann, E. O., & Mody, I. (2010) · Nature Neuroscience · doi:10.1038/nn.2464 · Cited by 222 · see citing works
Selective Expression of ErbB4 in Interneurons, But Not Pyramidal Cells, of the Rodent Hippocampus
Vullhorst, D., Neddens, J., Karavanova, I. D., Tricoire, L., Petralia, R. S., McBain, C. J., & Buonanno, A. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.2454-09.2009 · Cited by 221 · see citing works
Distinct Roles of GABAA and GABAB Receptors in Balancing and Terminating Persistent Cortical Activity
Mann, E. O., Kohl, M. M., & Paulsen, O. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.6162-08.2009 · Cited by 205 · see citing works
Dendritic Mechanisms Underlying Rapid Synaptic Activation of Fast-Spiking Hippocampal Interneurons
Hu, H., Martina, M., & Jonas, P. (2010) · Science · doi:10.1126/science.1177876 · Cited by 202 · see citing works
Cell Type-Specific Development of NMDA Receptors in the Interneurons of Rat Prefrontal Cortex
Wang, H.-X., & Gao, W. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.20 · Cited by 198 · see citing works
Complex Events Initiated by Individual Spikes in the Human Cerebral Cortex
Molnár, G., Oláh, S., Komlósi, G., Füle, M., Szabadics, J., Varga, C., Barzó, P., & Tamás, G. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060222 · Cited by 197 · see citing works
Decreased glutamic acid decarboxylase67 mRNA expression in multiple brain areas of patients with schizophrenia and mood disorders
Thompson, M., Weickert, C. S., Wyatt, E. J., & Webster, M. J. (2009) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2009.02.005 · Cited by 185 · see citing works
Prefrontal GABAA receptor α-subunit expression in normal postnatal human development and schizophrenia
Duncan, C. E., Webster, M. J., Rothmond, D. A., Bahn, S., Elashoff, M., & Shannon Weickert, C. (2010) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2009.12.007 · Cited by 169 · see citing works
Spike-Timing-Dependent Plasticity of Neocortical Excitatory Synapses on Inhibitory Interneurons Depends on Target Cell Type
Lu, J.-T., Li, C.-Y., Zhao, J.-P., Poo, M.-M., & Zhang, X.-H. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.2513-07.2007 · Cited by 163 · see citing works
Region-Specific Changes in Gamma and Beta2 Rhythms in NMDA Receptor Dysfunction Models of Schizophrenia
Roopun, A. K., Cunningham, M. O., Racca, C., Alter, K., Traub, R. D., & Whittington, M. A. (2008) · Schizophrenia Bulletin · doi:10.1093/schbul/sbn059 · Cited by 163 · see citing works
Depolarizing effect of neocortical chandelier neurons
Woodruff, A. (2009) · Frontiers in Neural Circuits · doi:10.3389/neuro.04.015.2009 · Cited by 163 · see citing works
Neuregulin-1 Modulates Hippocampal Gamma Oscillations: Implications for Schizophrenia
Fisahn, A., Neddens, J., Yan, L., & Buonanno, A. (2008) · Cerebral Cortex · doi:10.1093/cercor/bhn107 · Cited by 162 · see citing works
Does schizophrenia arise from oxidative dysregulation of parvalbumin-interneurons in the developing cortex?
Behrens, M. M., & B, T. J. S. A. (2009) · Neuropharmacology · doi:10.1016/j.neuropharm.2009.06.002 · Cited by 160 · see citing works
Functional Properties of Fast Spiking Interneurons and Their Synaptic Connections With Pyramidal Cells in Primate Dorsolateral Prefrontal Cortex
González‐Burgos, G., Krimer, L. S., Povysheva, N. V., Barrionuevo, G., & Lewis, D. A. (2004) · Journal of Neurophysiology · doi:10.1152/jn.00787.2004 · Cited by 159 · see citing works
Network mechanisms of gamma oscillations in the CA3 region of the hippocampus
Hájos, N., & Paulsen, O. (2009) · Neural Networks · doi:10.1016/j.neunet.2009.07.024 · Cited by 153 · see citing works
Protracted Developmental Trajectories of GABAA Receptor α1 and α2 Subunit Expression in Primate Prefrontal Cortex
Hashimoto, T., Nguyen, Q. L., Rotaru, D., Keenan, T., Arion, D., Beneyto, M., Gonzalez-Burgos, G., & Lewis, D. A. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.01.004 · Cited by 151 · see citing works
Postsynaptic mechanisms govern the differential excitation of cortical neurons by thalamic inputs
Hull, C., Isaacson, J. S., & Scanziani, M. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.5971-08.2009 · Cited by 147 · see citing works
Glutamatergic deficits and parvalbumin-containing inhibitory neurons in the prefrontal cortex in schizophrenia
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[22]Wang HX Gao WJ Cell type-specific development of NMDA receptors in the interneurons of rat prefrontal cortex Neuropsychopharmacology 2009 34 2028 2040 19242405 PMC2730038
[49]Puig MV Ushimaru M Kawaguchi Y Cell type-specific control of neuronal responsiveness by gamma-band oscillatory inhibition Proc Natl Acad Sci U S A 2008 105 8428 8433 18550841 PMC2448853

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Pietersen, C. Y., Mauney, S. A., Kim, S. S., Passeri, E., Lim, M. P., Rooney, R. J., Goldstein, J. M., Petryshen, T. L., Seidman, L. J., Shenton, M. E., et al. (2014) · Journal of Neurogenetics · doi:10.3109/01677063.2013.878339 · Cited by 67 · see citing works
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Starc, M., Murray, J. D., Santamauro, N. P., Savić, A., Diehl, C., Cho, Y., Srihari, V. H., MORGAN, P. T., Krystal, J. H., Wang, X., et al. (2016) · Schizophrenia Research · doi:10.1016/j.schres.2016.10.011 · Cited by 65 · see citing works
Differential effects of NMDA receptor antagonists at lower and higher doses on basal gamma band oscillation power in rat cortical electroencephalograms
Hiyoshi, T., Kambe, D., Karasawa, J.-I., & Chaki, S. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.05.037 · Cited by 65 · see citing works
GluN2D N-Methyl-d-Aspartate Receptor Subunit Contribution to the Stimulation of Brain Activity and Gamma Oscillations by Ketamine: Implications for Schizophrenia
Sapkota, K., Mao, Z., Synowicki, P., Lieber, D., Liu, M., Ikezu, T., Gautam, V., & Monaghan, D. T. (2015) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.115.230391 · Cited by 64 · see citing works
Functional maturation of GABA synapses during postnatal development of the monkey dorsolateral prefrontal cortex
Gonzalez-Burgos, G., Miyamae, T., Pafundo, D. E., Yoshino, H., Rotaru, D. C., Hoftman, G., Datta, D., Zhang, Y., Hammond, M., Sampson, A. R., et al. (2015) · Cerebral Cortex · doi:10.1093/cercor/bhu122 · Cited by 64 · see citing works
Gabaergic Interneurons in Early Brain Development: Conducting and Orchestrated by Cortical Network Activity
Warm, D., Schroer, J., & Sinning, A. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.807969 · Cited by 60 · see citing works
Sleep correlates of cognition in early course psychotic disorders
Keshavan, M. S., Montrose, D. M., Miewald, J. M., & Jindal, R. D. (2011) · Schizophrenia Research · doi:10.1016/j.schres.2011.05.027 · Cited by 62 · see citing works
Neuroglialpharmacology: white matter pathophysiologies and psychiatric treatments
Bartzokis, G. (2011) · Frontiers in bioscience · doi:10.2741/3881 · Cited by 60 · see citing works
In vivo gamma-aminobutyric acid and glutamate levels in people with first-episode schizophrenia: A proton magnetic resonance spectroscopy study
Chiu, P. W., Lui, S. S. Y., Hung, K. S. Y., Chan, R. C. K., Chan, Q., Sham, P. C., Cheung, E. F. C., & Mak, H. K. (2017) · Schizophrenia Research · doi:10.1016/j.schres.2017.07.021 · Cited by 60 · see citing works
Altered Gradients of Glutamate and Gamma-Aminobutyric Acid Transcripts in the Cortical Visuospatial Working Memory Network in Schizophrenia
Hoftman, G. D., Dienel, S. J., Bazmi, H. H., Zhang, Y., Chen, K., & Lewis, D. A. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.11.029 · Cited by 60 · see citing works
The Role of the Gadd45 Family in the Nervous System: A Focus on Neurodevelopment, Neuronal Injury, and Cognitive Neuroepigenetics
Sultan, F. A., & Sweatt, J. D. (2013) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-8289-5_6 · Cited by 58 · see citing works
The influence of NMDA and GABAA receptors and glutamic acid decarboxylase (GAD) activity on attention
Pehrson, A. L., Bondi, C. O., Totah, N. K. B., & Moghaddam, B. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2792-z · Cited by 60 · see citing works
White matter neuron biology and neuropathology in schizophrenia
Duchatel, R. J., Weickert, C. S., & Tooney, P. A. (2019) · Schizophrenia · doi:10.1038/s41537-019-0078-8 · Cited by 56 · see citing works
Toxoplasma infection induces microglia‐neuron contact and the loss of perisomatic inhibitory synapses
Carrillo, G. L., Ballard, V. A., Glausen, T. G., Boone, Z., Teamer, J., Hinkson, C. L., Wohlfert, E. A., Blader, I. J., & Fox, M. A. (2020) · Glia · doi:10.1002/glia.23816 · Cited by 54 · see citing works
Early Alterations in Hippocampal Circuitry and Theta Rhythm Generation in a Mouse Model of Prenatal Infection: Implications for Schizophrenia
Ducharme, G., Lowe, G. C., Goutagny, R., & Williams, S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0029754 · Cited by 56 · see citing works
Glycine transporter 1 as a potential therapeutic target for schizophrenia-related symptoms: Evidence from genetically modified mouse models and pharmacological inhibition
Möhler, H., Boison, D., Singer, P., Feldon, J., Pauly-Evers, M., & Yee, B. K. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.02.003 · Cited by 52 · see citing works
Neurobiological Determinants of Tobacco Smoking in Schizophrenia
Lucatch, A. M., Lowe, D. J. E., Clark, R. C., Kozak, K., & George, T. P. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00672 · Cited by 53 · see citing works
Cortical Opioid Markers in Schizophrenia and across Postnatal Development
Volk, D. W., Radchenkova, P., Er, W., Sengupta, E. J., & Lewis, D. A. (2011) · Cerebral Cortex · doi:10.1093/cercor/bhr202 · Cited by 51 · see citing works
GABAergic System Dysfunction and Challenges in Schizophrenia Research
Jahangir, M., Zhou, J., Lang, B., & Wang, X. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.663854 · Cited by 52 · see citing works
Serotonin enhances excitability and gamma frequency temporal integration in mouse prefrontal fast-spiking interneurons
Athilingam, J. C., Ben-Shalom, R., Keeshen, C. M., Sohal, V. S., & Bender, K. J. (2017) · eLife · doi:10.7554/elife.31991 · Cited by 49 · see citing works
Abnormal interneuron development in disrupted-in-schizophrenia-1 L100P mutant mice
Lee, F. H., Zai, C. C., Cordes, S. P., Roder, J. C., & Wong, A. H. (2013) · Molecular Brain · doi:10.1186/1756-6606-6-20 · Cited by 49 · see citing works
Excitation-Inhibition Discoordination in Rodent Models of Mental Disorders
Fenton, A. A. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.03.013 · Cited by 49 · see citing works
Neurobehavioral effects of long‐term maternal fructose intake in rat offspring
Erbaş, O., Erdoğan, M. A., Khalilnezhad, A., Gürkan, F. T., Yiğittürk, G., Meral, A., & Taşkıran, D. (2018) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2018.07.001 · Cited by 49 · see citing works

Gamma band oscillations
McNally, J. M., & McCarley, R. W. (2016) · Current Opinion in Psychiatry · doi:10.1097/yco.0000000000000244 · Cited by 144 · see citing works
GABA Neuron Alterations, Cortical Circuit Dysfunction and Cognitive Deficits in Schizophrenia
González‐Burgos, G., Fish, K. N., & Lewis, D. A. (2011) · Neural Plasticity · doi:10.1155/2011/723184 · Cited by 244 · see citing works
GABA Neurons and the Mechanisms of Network Oscillations: Implications for Understanding Cortical Dysfunction in Schizophrenia
González‐Burgos, G., & Lewis, D. A. (2008) · Schizophrenia Bulletin · doi:10.1093/schbul/sbn070 · Cited by 568 · see citing works
Alterations in Cortical Network Oscillations and Parvalbumin Neurons in Schizophrenia
Gonzalez-Burgos, G., Cho, R. Y., & Lewis, D. A. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.03.010 · Cited by 497 · see citing works
Review Article GABA Neuron Alterations, Cortical Circuit Dysfunction and Cognitive Deficits in Schizophrenia
González‐Burgos, G., Fish, K. N., & Lewis, D. A. (2011)

Authors: Gonzalez-Burgos, G., Hashimoto, T., & Lewis, D. A.
Affiliations: Kanazawa University (JP)
University of Pittsburgh (US)
ORCID: Hashimoto, Takanori
Lewis, David A.
Venue: Current Psychiatry Reports
Publisher: Springer Science and Business Media LLC
Published: 2010-06-17
Volume: 12
Issue: 4
Pages: 335-344
ISSN: 1523-3812 (ISSN-L)
1535-1645
DOI: 10.1007/s11920-010-0124-8
PMC: PMC2919752
OpenAlex: W2073239561
Cited by: 260
References: 97
Citations by year: 2026: 7 · 2025: 7 · 2024: 10 · 2023: 11 · 2022: 9 · 2021: 10 · 2020: 12 · 2019: 8 · 2018: 9 · 2017: 15 · 2016: 14 · 2015: 21 · 2014: 21 · 2013: 30 · 2012: 29
FWCI: 4.78
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Current Psychiatry Reports (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Mental Health (P50MH084053, R01MH051234)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: schizophrenia, GABAergic neurons, parvalbumin, gamma oscillations, cortical inhibition, glutamic acid decarboxylase 67, postmortem brain studies, cognitive function
MeSH terms: Biological Clocks, Cerebral Cortex, gamma-Aminobutyric Acid, Humans, Nerve Net, Synaptic Transmission, Neurons, Schizophrenia

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Alterations of cortical GABA neurons and network oscillations in schizophrenia

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