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Structural plasticity of dendritic spines

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Bosch, Miquel, Hayashi, Yasunori·2012·Current Opinion in Neurobiology

DOI 10.1016/j.conb.2011.09.002PMC PMC4281347

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Abstract

Dendritic spines are small mushroom-like protrusions arising from neurons where most excitatory synapses reside. Their peculiar shape suggests that spines can serve as an autonomous postsynaptic compartment that isolates chemical and electrical signaling. How neuronal activity modifies the morphology of the spine and how these modifications affect synaptic transmission and plasticity are intriguing issues. Indeed, the induction of long-term potentiation (LTP) or depression (LTD) is associated with the enlargement or shrinkage of the spine, respectively. This structural plasticity is mainly controlled by actin filaments, the principal cytoskeletal component of the spine. Here we review the pioneering microscopic studies examining the structural plasticity of spines and propose how changes in actin treadmilling might regulate spine morphology.

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Long‐lasting potentiation of synaptic transmission in the dentate area of the unanaesthetized rabbit following stimulation of the perforant path
Bliss, T. V. P., & Gardner-Medwin, A. R. (1973) · The Journal of Physiology · doi:10.1113/jphysiol.1973.sp010274 · Cited by 7,424
Tripartite synapses: glia, the unacknowledged partner
Araque, A., Parpura, V., Sanzgiri, R. P., & Haydon, P. G. (1999) · Trends in Neurosciences · doi:10.1016/s0166-2236(98)01349-6 · Cited by 2,529
Structural basis of long-term potentiation in single dendritic spines
Matsuzaki, M., Honkura, N., Ellis-Davies, G. C. R., & Kasai, H. (2004) · Nature · doi:10.1038/nature02617 · Cited by 2,483
Dendritic spine geometry is critical for AMPA receptor expression in hippocampal CA1 pyramidal neurons
Matsuzaki, M., Ellis-Davies, G. C. R., Nemoto, T., Miyashita, Y., Iino, M., & Kasai, H. (2001) · Nature Neuroscience · doi:10.1038/nn736 · Cited by 1,563 · cited 2×
“[28 ,46 ] employed a two-photon-induced glutamate uncaging technique, which allows the controlled release of glutamate in a very small volume compared with other approaches (such as local glutamate application through pipette or conventional UV-mediated uncaging method).”
BackgroundMethod
The importance of dendritic mitochondria in the morphogenesis and plasticity of spines and synapses
Li, Z., Okamoto, K.-I., Hayashi, Y., & Sheng, M. (2004) · Cell · doi:10.1016/j.cell.2004.11.003 · Cited by 1,498
Self-citation
Dendritic spine changes associated with hippocampal long-term synaptic plasticity
Engert, F., & Bonhoeffer, T. (1999) · Nature · doi:10.1038/19978 · Cited by 1,412
Dendritic spines of CA 1 pyramidal cells in the rat hippocampus: serial electron microscopy with reference to their biophysical characteristics
Harris, K., & Stevens, J. (1989) · The Journal of Neuroscience · doi:10.1523/jneurosci.09-08-02982.1989 · Cited by 1,073
Three-dimensional structure of dendritic spines and synapses in rat hippocampus (CA1) at postnatal day 15 and adult ages: implications for the maturation of synaptic physiology and long-term potentiation [published erratum appears in J Neurosci 1992 Aug;12(8):following table of contents]
Harris, K. M., Jensen, F. E., & Tsao, B. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-07-02685.1992 · Cited by 1,036
Shrinkage of dendritic spines associated with long-term depression of hippocampal synapses
Zhou, Q., Homma, K. J., & Poo, M.-M. (2004) · Neuron · doi:10.1016/j.neuron.2004.11.011 · Cited by 1,025
Rapid Dendritic Morphogenesis in CA1 Hippocampal Dendrites Induced by Synaptic Activity
Maletic-Savatic, M., Malinow, R., & Svoboda, K. (1999) · Science · doi:10.1126/science.283.5409.1923 · Cited by 1,009

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Authors: Bosch, M., & Hayashi, Y.
Affiliations: Massachusetts Institute of Technology (US)
RIKEN Center for Brain Science (JP)
Corresponding author: Hayashi, Yasunori
ORCID: Bosch, Miquel
Hayashi, Yasunori
Venue: Current Opinion in Neurobiology
Publisher: Elsevier BV
Published: 2012-06
Volume: 22
Issue: 3
Pages: 383-388
ISSN: 0959-4388 (ISSN-L)
DOI: 10.1016/j.conb.2011.09.002
PMC: PMC4281347
OpenAlex: W1983230142
Cited by: 415
References: 73
Citations by year: 2026: 14 · 2025: 19 · 2024: 22 · 2023: 21 · 2022: 14 · 2021: 37 · 2020: 29 · 2019: 30 · 2018: 39 · 2017: 31 · 2016: 27 · 2015: 38 · 2014: 44 · 2013: 33 · 2012: 15
FWCI: 2.79
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Current Opinion in Neurobiology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: RIKEN
NIH (R01DA17310)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: dendritic spines, structural plasticity, dendritic spine morphology, actin cytoskeleton, actin treadmilling, long-term potentiation, long-term depression, synaptic plasticity, postsynaptic compartment, excitatory synapses
MeSH terms: Animals, Models, Biological, Neuronal Plasticity, Neurons, Ultrasonography, Dendritic Spines

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