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Cited by 141Neuroscience and Neuropharmacology ResearchCellular transport and secretionGenetics and Neurodevelopmental Disorders

Linking Nanoscale Dynamics of AMPA Receptor Organization to Plasticity of Excitatory Synapses and Learning

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Choquet, Daniel·2018·The Journal of Neuroscience
DOI 10.1523/jneurosci.2119-18.2018PMC PMC6705996
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Abstract

The spatiotemporal organization of neurotransmitter receptors in the postsynaptic membrane is a fundamental determinant of synaptic transmission and thus of information processing by the brain. The ionotropic AMPA subtype of glutamate receptors (AMPARs) mediate fast excitatory synaptic transmission in the CNS. The number of AMPARs located en face presynaptic glutamate release sites sets the efficacy of synaptic transmission. Understanding how this number is set and regulated has been the topic of intense research in the last two decades. We showed that AMPARs are not stable in the synapse as initially thought. They continuously enter and exit the postsynaptic density by lateral diffusion, and they exchange between the neuronal surface and intracellular compartments by endocytosis and exocytosis at extrasynaptic sites. Regulation of these various trafficking pathways has emerged as a key mechanism for activity-dependent plasticity of synaptic transmission, a process important for learning and memory. I here present my view of these findings. In particular, the advent of super-resolution microscopy and single-molecule tracking has helped to uncover the intricacy of AMPARs' dynamic organization at the nanoscale. In addition, AMPAR surface diffusion is highly regulated by a variety of factors, including neuronal activity, stress hormones, and neurodegeneration, suggesting that AMPAR diffusion-trapping may play a central role in synapse function. Using innovative tools to understand further the link between receptor dynamics and synapse plasticity is now unveiling new molecular mechanisms of learning. Modifying AMPAR dynamics may emerge as a new target to correct synapse dysfunction in the diseased brain.

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  • LTP expression is due to rapid postsynaptic accumulation of AMPARs.

    “Thus, it is now generally accepted that LTP expression is due to the rapid postsynaptic accumulation of AMPARs.”

    From Synaptic memory and CaMKII (2023) · cites this paper as [20]

    The sections on AMPAR trafficking and surface exocytosis describe rapid AMPAR accumulation at synapses and diffusion-trapping of AMPARs during initial potentiation. But the section on the cellular basis of plasticity says LTP expression is *largely* postsynaptic, with a possible presynaptic contribution at some synapses; the unqualified claim omits that limitation. Page numbers are unavailable in our copy. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

  • Long-term potentiation (LTP) is brief repetitive synaptic stimulation that results in long-lasting increases in synaptic strength.

    “long-term potentiation (LTP), in which brief repetitive synaptic stimulation results in long-lasting increases in synaptic strength, was gaining popularity as a cellular model for learning and memory (16–22).”

    From Synaptic memory and CaMKII (2023) · cites this paper as [20]

  • AMPARs are highly mobile in the extrasynaptic membrane and can diffuse into and out of the synapse.

    “Furthermore, AMPARs are highly mobile in the extrasynaptic membrane and can diffuse into and out of the synapse (20).”

    From Synaptic memory and CaMKII (2023) · cites this paper as [20]

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Authors
Choquet, D.
Affiliations
Centre National de la Recherche Scientifique (FR)
Corresponding author
Choquet, Daniel
ORCID
Choquet, Daniel
Venue
The Journal of Neuroscience
Publisher
Society for Neuroscience
Published
2018-10-31
Volume
38
Issue
44
Pages
9318-9329
ISSN
  • 0270-6474 (ISSN-L)
  • 1529-2401
DOI
10.1523/jneurosci.2119-18.2018
PMC
PMC6705996
OpenAlex
W2898785309
Cited by
141
References
170
Citations by year
2026: 13 · 2025: 8 · 2024: 15 · 2023: 16 · 2022: 19 · 2021: 29 · 2020: 28 · 2019: 11 · 2018: 1 · 2012: 1
FWCI
2.23
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion)
Funders
  • Agence Nationale de la Recherche (ANR-16-COEN-0003)
  • Centre National de la Recherche Scientifique
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Keywords
AMPA receptors, glutamate receptors, postsynaptic density, receptor trafficking, lateral diffusion, endocytosis, extrasynaptic receptors, synaptic plasticity, excitatory synapses, learning and memory, activity-dependent plasticity, stress hormones, neurodegeneration, super-resolution microscopy, single-molecule tracking
MeSH terms
Animals, Humans, Learning, Synaptic Transmission, Neuronal Plasticity, Synapses, Protein Structure, Secondary, Receptors, AMPA, Nanotechnology

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