oRGs and mitotic somal translocation — a role in development and disease
Open accessAbstract
The evolution of the human brain has been characterized by an increase in the size of the neocortex. Underlying this expansion is a significant increase in the number of neurons produced by neural stem cells during early stages of cortical development. Here we highlight recent advances in our understating of these cell populations, consisting of ventricular radial glia and outer radial glia. We highlight how gene expression studies have identified molecular signatures for radial glial cell populations and outline what has been learned about the mechanisms underlying the characteristic mode of division observed in outer radial glia cells, mitotic somal translocation. Understanding the significance of this behavior may help us explain human cortical expansion and further elucidate neurodevelopmental diseases.
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Time-lapse confocal microscopy of organoid cells displaying the characteristic mitotic behaviour of oRGs provided further evidence of their identity.
“Time-lapse confocal microscopy of organoid cells displaying the characteristic mitotic behaviour of oRGs provided further evidence of their identity49,50, and single-cell transcriptome sequencing has been used to confirm the presence of cells with oRG gene expression signatures50.”
From The use of brain organoids to investigate neural development and disease (2017) · cites this paper as [49]
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The use of brain organoids to investigate neural development and disease
Di Lullo, E., & Kriegstein, A. R. (2017) · Nature Reviews Neuroscience · doi:10.1038/nrn.2017.107 · Cited by 788 · see citing works
Self-citation
- Authors
- Ostrem, B., Di Lullo, E., & Kriegstein, A.
- Affiliations
- University of California, San Francisco (US)
- Corresponding author
- Kriegstein, Arnold
- Venue
- Current Opinion in Neurobiology
- Publisher
- Elsevier BV
- Published
- 2017-02
- Volume
- 42
- Pages
- 61-67
- ISSN
- 0959-4388 (ISSN-L)
- PMC
- PMC5638645
- OpenAlex
- W2564517474
- Cited by
- 61
- References
- 46
- Citations by year
- 2026: 4 · 2025: 1 · 2024: 7 · 2023: 12 · 2022: 3 · 2021: 7 · 2020: 9 · 2019: 7 · 2018: 5 · 2017: 6
- FWCI
- 0.75
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Current Opinion in Neurobiology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- California Institute for Regenerative Medicine (TG2-01153)
- Bernard Osher Foundation
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Fetal and Pediatric Neurological Disorders
- Keywords
- radial glia, outer radial glia, neural stem cells, neocortex expansion, cortical development, gene expression signatures, neurodevelopmental disorders, human brain evolution
- MeSH terms
- Cell Division, Cell Movement, Gene Expression Regulation, Humans, Mitosis, Neuroglia, Neocortex, Neurodevelopmental Disorders
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