Cited by 479Anaerobic Digestion and Biogas ProductionMicrobial Fuel Cells and BioremediationMicrobial Metabolic Engineering and Bioproduction

Chain elongation in anaerobic reactor microbiomes to recover resources from waste

Open access
Spirito, Catherine M, Richter, Hanno, Rabaey, Korneel, Stams, Alfons JM, Angenent, Largus T·2014·Current Opinion in Biotechnology

Abstract

Different microbial pathways can elongate the carbon chains of molecules in open cultures of microbial populations (i.e. reactor microbiomes) under anaerobic conditions. Here, we discuss three such pathways: 1. homoacetogenesis to combine two carbon dioxide molecules into acetate; 2. succinate formation to elongate glycerol with one carbon from carbon dioxide; and 3. reverse β oxidation to elongate short-chain carboxylates with two carbons into medium-chain carboxylates, leading to more energy-dense and insoluble products (e.g. easier to separate from solution). The ability to use reactor microbiomes to treat complex substrates can simultaneously address two pressing issues: 1. providing proper waste management; and 2. producing renewable chemicals and fuels.

Integrity signals

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Crossref · 10.1016/j.copbio.2014.01.003

Cites

54 of 54 references verified0 citation errors · 0 not checkable

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Authors
Spirito, C. M., Richter, H., Rabaey, K., Stams, A. J., & Angenent, L. T.
Affiliations
  • Cornell University (US)
  • Ghent University (BE)
  • Wageningen University & Research (NL)
Corresponding author
Angenent, Largus T
Venue
Current Opinion in Biotechnology
Publisher
Elsevier BV
Published
2014-06
Volume
27
Pages
115-122
ISSN
0958-1669 (ISSN-L)
OpenAlex
W2111185205
Cited by
479
References
55
Citations by year
2026: 56 · 2025: 48 · 2024: 56 · 2023: 46 · 2022: 46 · 2021: 59 · 2020: 43 · 2019: 34 · 2018: 24 · 2017: 31 · 2016: 19 · 2015: 15 · 2014: 1
FWCI
4.04
Type
journal article
Language
en
Open access
Locations
  • Current Opinion in Biotechnology (publishedVersion)
  • PubMed (publishedVersion)
  • Socio-Environmental Systems Modeling (acceptedVersion)
  • Ghent University Academic Bibliography (Ghent University) (submittedVersion)
  • Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion, cc-by-nc-nd)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
Funders
  • U. S. Army Research Office (W911NF-12-1-0555)
  • Cornell University Agricultural Experiment Station (NYC-123452)
  • National Institutes for Food and Agriculture (NIFA)
  • U.S. Department of Agriculture
  • European Research Council Starter Grant Electrotalk
  • the Multidisciplinary Research Partnership Ghent Bio-Economy
  • Netherlands Science Foundation (CW-TOP 700.55.343)
  • European Research Council (323009)
Topics
  • Physical Sciences › Engineering › Building and Construction › Anaerobic Digestion and Biogas Production
  • Physical Sciences › Environmental Science › Environmental Engineering › Microbial Fuel Cells and Bioremediation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
Keywords
chain extension, homoacetogenesis, reverse β-oxidation, CO2 utilization, glycerol, waste management, renewable chemicals, renewable fuels, microbial metabolism
MeSH terms
Acetates, Anaerobiosis, Carbon Dioxide, Carboxylic Acids, Electrodes, Oxidation-Reduction, Waste Management, Bioreactors, Succinic Acid, Recycling, Microbiota

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