Chain elongation in anaerobic reactor microbiomes to recover resources from waste
Open accessAbstract
Different microbial pathways can elongate the carbon chains of molecules in open cultures of microbial populations (i.e. reactor microbiomes) under anaerobic conditions. Here, we discuss three such pathways: 1. homoacetogenesis to combine two carbon dioxide molecules into acetate; 2. succinate formation to elongate glycerol with one carbon from carbon dioxide; and 3. reverse β oxidation to elongate short-chain carboxylates with two carbons into medium-chain carboxylates, leading to more energy-dense and insoluble products (e.g. easier to separate from solution). The ability to use reactor microbiomes to treat complex substrates can simultaneously address two pressing issues: 1. providing proper waste management; and 2. producing renewable chemicals and fuels.
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Biogas production: current state and perspectives
Weiland, P. (2009) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-009-2246-7 · Cited by 2,824 · see citing works
Microbial electrosynthesis — revisiting the electrical route for microbial production
Rabaey, K., & Rozendal, R. A. (2010) · Nature Reviews Microbiology · doi:10.1038/nrmicro2422 · Cited by 1,646 · see citing works
Self-citationWaste to bioproduct conversion with undefined mixed cultures: the carboxylate platform
Agler, M. T., Wrenn, B. A., Zinder, S. H., & Angenent, L. T. (2010) · Trends in biotechnology · doi:10.1016/j.tibtech.2010.11.006 · Cited by 821 · see citing works
Self-citationAlternative Pathways of Carbon Dioxide Fixation: Insights into the Early Evolution of Life?
Fuchs, G. (2011) · Annual Review of Microbiology · doi:10.1146/annurev-micro-090110-102801 · Cited by 726 · see citing works
The genome of <i>Clostridium kluyveri</i> , a strict anaerobe with unique metabolic features
Seedorf, H., Fricke, W. F., Veith, B., Brüggemann, H., Liesegang, H., Strittmatter, A., Miethke, M., Buckel, W., Hinderberger, J., Li, F., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711093105 · Cited by 506 · see citing works
Bacterial community structures are unique and resilient in full-scale bioenergy systems
Werner, J. J., Knights, D., García, M. L., Scalfone, N. B., Smith, S., Yarasheski, K. E., Cummings, T. A., Beers, A. R., Knight, R. D., & Angenent, L. T. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1015676108 · Cited by 470 · see citing works
Self-citationSteinbusch, K. J. J., Hamelers, H. V. M., Plugge, C. M., & Buisman, C. J. N. (2011) · Energy Environ. Sci. · doi:10.1039/c0ee00282h · Cited by 453 · see citing works
Electrosynthesis of Commodity Chemicals by an Autotrophic Microbial Community
Marshall, C. W., Ross, D. E., Fichot, E. B., Norman, R. S., & May, H. D. (2012) · Applied and Environmental Microbiology · doi:10.1128/aem.02401-12 · Cited by 423 · see citing works
Tracy, B. P., Jones, S. W., Fast, A. G., Indurthi, D. C., & Papoutsakis, E. T. (2011) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2011.10.008 · Cited by 408 · see citing works
Chain elongation with reactor microbiomes: upgrading dilute ethanol to medium-chain carboxylates
Agler, M. T., Spirito, C. M., Usack, J. G., Werner, J. J., & Angenent, L. T. (2012) · Energy & Environmental Science · doi:10.1039/c2ee22101b · Cited by 376 · see citing works
Self-citationMarshall, C. W., Ross, D. E., Fichot, E. B., Norman, R. S., & May, H. D. (2013) · Environmental Science & Technology · doi:10.1021/es400341b · Cited by 356 · see citing works
Pathway engineering and synthetic biology using acetogens
Schiel‐Bengelsdorf, B., & Dürre, P. (2012) · FEBS Letters · doi:10.1016/j.febslet.2012.04.043 · Cited by 265 · see citing works
Cukalovic, A., & Stevens, C. V. (2008) · Biofuels Bioproducts and Biorefining · doi:10.1002/bbb.105 · Cited by 241 · see citing works
Separation and Purification Technologies in Biorefineries
(2013) · Wiley eBooks · doi:10.1002/9781118493441 · Cited by 241 · see citing works
A Generalized Method for Thermodynamic State Analysis of Environmental Systems
Kleerebezem, R., & van Loosdrecht, M. C. M. (2010) · Critical Reviews in Environmental Science and Technology · doi:10.1080/10643380802000974 · Cited by 225 · see citing works
Metabolic and practical considerations on microbial electrosynthesis
Rabaey, K., Girguis, P. R., & Nielsen, L. K. (2011) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2011.01.010 · Cited by 223 · see citing works
Self-citationZhang, F., Ding, J., Zhang, Y., Chen, M., Ding, Z., van Loosdrecht, M. C. M., & Zeng, R. J. (2013) · Water Research · doi:10.1016/j.watres.2013.07.033 · Cited by 207 · see citing works
Bioelectrochemical Production of Caproate and Caprylate from Acetate by Mixed Cultures
Eerten-Jansen, M. C. A. A. V., ter Heijne, A., Grootscholten, T. I. M., Steinbusch, K. J. J., Sleutels, T. H. J. A., Hamelers, H. V. M., & Buisman, C. J. N. (2013) · ACS Sustainable Chemistry & Engineering · doi:10.1021/sc300168z · Cited by 200 · see citing works
Latif, H., Zeidan, A. A., Nielsen, A. T., & Zengler, K. (2014) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2013.12.001 · Cited by 199 · see citing works
Steinbusch, K. J. J., Hamelers, H. V. M., & Buisman, C. J. N. (2008) · Water Research · doi:10.1016/j.watres.2008.05.032 · Cited by 190 · see citing works
Lactate and Acrylate Metabolism by Megasphaera elsdenii under Batch and Steady-State Conditions
Prabhu, R., Altman, E., & Eiteman, M. A. (2012) · Applied and Environmental Microbiology · doi:10.1128/aem.02443-12 · Cited by 186 · see citing works
Upgrading dilute ethanol from syngas fermentation to n-caproate with reactor microbiomes
Vasudevan, D., Richter, H., & Angenent, L. T. (2014) · Bioresource Technology · doi:10.1016/j.biortech.2013.09.105 · Cited by 174 · see citing works
Self-citationEnabling Unbalanced Fermentations by Using Engineered Electrode-Interfaced Bacteria
Flynn, J. M., Ross, D. E., Hunt, K. A., Bond, D. R., & Gralnick, J. A. (2010) · mBio · doi:10.1128/mbio.00190-10 · Cited by 174 · see citing works
Chain elongation of acetate and ethanol in an upflow anaerobic filter for high rate MCFA production
Grootscholten, T. I. M., Steinbusch, K. J. J., Hamelers, H. V. M., & Buisman, C. J. N. (2012) · Bioresource Technology · doi:10.1016/j.biortech.2012.10.165 · Cited by 171 · see citing works
A Two-Stage Continuous Fermentation System for Conversion of Syngas into Ethanol
Richter, H., Martin, M. E., & Angenent, L. T. (2013) · Energies · doi:10.3390/en6083987 · Cited by 170 · see citing works
Self-citationMuñoz‐Tamayo, R., Laroche, B., Walter, É., Dore, J. M., Duncan, S. H., Flint, H. J., & Leclerc, M. (2011) · FEMS Microbiology Ecology · doi:10.1111/j.1574-6941.2011.01085.x · Cited by 164 · see citing works
Grootscholten, T. I. M., Steinbusch, K. J. J., Hamelers, H. V. M., & Buisman, C. J. N. (2013) · Bioresource Technology · doi:10.1016/j.biortech.2013.02.114 · Cited by 157 · see citing works
Fatty acid alkyl esters: perspectives for production of alternative biofuels
Röttig, A., Wenning, L., Bröker, D., & Steinbüchel, A. (2009) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-009-2383-z · Cited by 144 · see citing works
Munasinghe, P. C., & Khanal, S. K. (2010) · Biotechnology Progress · doi:10.1002/btpr.473 · Cited by 142 · see citing works
Kim, S. A., & Rhee, M. S. (2013) · Applied and Environmental Microbiology · doi:10.1128/aem.02164-13 · Cited by 137 · see citing works
Linking thermodynamics and kinetics to assess pathway reversibility in anaerobic bioprocesses
González‐Cabaleiro, R., Lema, J. M., Rodríguez, J., & Kleerebezem, R. (2013) · Energy & Environmental Science · doi:10.1039/c3ee42754d · Cited by 136 · see citing works
Sharma, M., Aryal, N., Sarma, P. M., Vanbroekhoven, K., Lal, B., Benetton, X. D., & Pant, D. (2013) · Chemical Communications · doi:10.1039/c3cc42570c · Cited by 131 · see citing works
1-Hexene: a renewable C6 platform for full-performance jet and diesel fuels
Harvey, B. G., & Meylemans, H. A. (2013) · Green Chemistry · doi:10.1039/c3gc41554f · Cited by 130 · see citing works
Glycerol fermentation by (open) mixed cultures: A chemostat study
Temudo, M. F., Poldermans, R., Kleerebezem, R., & van Loosdrecht, M. C. M. (2008) · Biotechnology and Bioengineering · doi:10.1002/bit.21857 · Cited by 129 · see citing works
Chowdhury, N. P., Mowafy, A. M., Demmer, J. K., Upadhyay, V., Koelzer, S., Jayamani, E., Kahnt, J., Hornung, M., Demmer, U., Ermler, U., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.521013 · Cited by 128 · see citing works
McKinlay, J. B., Laivenieks, M., Schindler, B. D., McKinlay, A., Siddaramappa, S., Challacombe, J. F., Lowry, S. R., Clum, A., Lapidus, A. L., Burkhart, K. B., et al. (2010) · BMC Genomics · doi:10.1186/1471-2164-11-680 · Cited by 126 · see citing works
Perez, J. M., Richter, H., Loftus, S. E., & Angenent, L. T. (2013) · Biotechnology and Bioengineering · doi:10.1002/bit.24786 · Cited by 126 · see citing works
Self-citationReaction engineering analysis of hydrogenotrophic production of acetic acid by Acetobacterium woodii
Demler, M., & Weuster‐Botz, D. (2010) · Biotechnology and Bioengineering · doi:10.1002/bit.22935 · Cited by 126 · see citing works
Production of fuels and chemicals from waste by microbiomes
Marshall, C. W., LaBelle, E. V., & May, H. D. (2013) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2013.03.016 · Cited by 120 · see citing works
Weimer, P. J., & Moen, G. N. (2012) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-012-4645-4 · Cited by 119 · see citing works
Zaks, D. P. M., Winchester, N., Kucharik, C. J., Barford, C. C., Paltsev, S., & Reilly, J. M. (2011) · Environmental Science & Technology · doi:10.1021/es104227y · Cited by 105 · see citing works
Microbial Conversion of Waste Glycerol from Biodiesel Production into Value-Added Products
Li, C., Lesnik, K. L., & Liu, H. (2013) · Energies · doi:10.3390/en6094739 · Cited by 101 · see citing works
High rate heptanoate production from propionate and ethanol using chain elongation
Grootscholten, T. I. M., Steinbusch, K. J. J., Hamelers, H. V. M., & Buisman, C. J. N. (2013) · Bioresource Technology · doi:10.1016/j.biortech.2013.02.085 · Cited by 96 · see citing works
Agler, M. T., Spirito, C. M., Usack, J. G., Werner, J. J., & Angenent, L. T. (2014) · Water Science and Technology · doi:10.2166/wst.2013.549 · Cited by 92 · cited 4× · see citing works
“Extraction Operating conditions with lower pH values result in toxic environments when short-chain or medium-chain carboxylates are being generated [33], and therefore a need was identified to continuously extract the product from the fermentation broth [24].”
BackgroundMethodInfluentialSelf-citationZhang, X., Li, C., Wang, Y., Luo, J., & Xu, T. (2011) · Journal of Membrane Science · doi:10.1016/j.memsci.2011.05.059 · Cited by 91 · see citing works
Zou, W., Zhu, L., Li, H., & Ya-jie Tang, A. (2011) · Microbial Cell Factories · doi:10.1186/1475-2859-10-87 · Cited by 76 · see citing works
Dennis, P. G., Harnisch, F., Yeoh, Y. K., Tyson, G. W., & Rabaey, K. (2013) · Applied and Environmental Microbiology · doi:10.1128/aem.00569-13 · Cited by 75 · see citing works
Self-citationNi, B., Liu, H., Nie, Y., Zeng, R. J., Du, G., Chen, J., & Yu, H. (2010) · Biotechnology and Bioengineering · doi:10.1002/bit.22908 · Cited by 65 · see citing works
Impact of dissolved hydrogen partial pressure on mixed culture fermentations
de Kok, S., Meijer, J., van Loosdrecht, M. C. M., & Kleerebezem, R. (2012) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-012-4400-x · Cited by 56 · see citing works
Huang, H., & Ramaswamy, S. (2013) · doi:10.1002/9781118493441.ch1 · Cited by 56 · see citing works
Enhanced succinic acid production by Actinobacillus succinogenes after genome shuffling
Zheng, P., Zhang, K., Yan, Q., Xu, Y., & Sun, Z. (2013) · Journal of Industrial Microbiology & Biotechnology · doi:10.1007/s10295-013-1283-5 · Cited by 52 · see citing works
Forrest, A. K., Hernández, J. E., & Holtzapple, M. T. (2010) · Bioresource Technology · doi:10.1016/j.biortech.2010.04.049 · Cited by 46 · see citing works
Inactivation of Ascaris suum by Short-Chain Fatty Acids
Butkus, M., Hughes, K. T., Bowman, D. D., Liotta, J. L., Jenkins, M. B., & Labare, M. P. (2010) · Applied and Environmental Microbiology · doi:10.1128/aem.01675-10 · Cited by 35 · see citing works
Microbial electrocatalysis to guide biofuel and biochemical bioprocessing
Angenent, L. T., & Rosenbaum, M. A. (2013) · Biofuels · doi:10.4155/bfs.12.93 · Cited by 25 · see citing works
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Flagged first, then by citations
1 of the 55 references couldn’t be matched to a known paper.
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Chain elongation with reactor microbiomes: open-culture biotechnology to produce biochemicals
Angenent, L. T., Richter, H., Buckel, W., Spirito, C. M., Steinbusch, K. J. J., Plugge, C. M., Strik, D. P. B. T. B., Grootscholten, T. I. M., Buisman, C. J. N., & Hamelers, H. V. M. (2016) · Environmental Science & Technology · doi:10.1021/acs.est.5b04847 · Cited by 689 · see citing works
Self-citationKehrein, P., van Loosdrecht, M. C. M., Osseweijer, P., Garfí, M., Dewulf, J. P., & Posada, J. A. (2020) · Environmental Science Water Research & Technology · doi:10.1039/c9ew00905a · Cited by 499 · see citing works
Liew, F., Martin, M. E., Tappel, R. C., Heijstra, B. D., Mihalcea, C., & Köpke, M. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.00694 · Cited by 485 · see citing works
Dahiya, S., Sarkar, O., Swamy, Y. V., & Mohan, S. V. (2015) · Bioresource Technology · doi:10.1016/j.biortech.2015.01.007 · Cited by 372 · see citing works
Anaerobic fermentation for n-caproic acid production: A review
Cavalcante, W. D. A., Leitão, R. C., Gehring, T. A., Angenent, L. T., & Santaella, S. T. (2016) · Process Biochemistry · doi:10.1016/j.procbio.2016.12.024 · Cited by 360 · see citing works
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Wu, Q., Bao, X., Guo, W., Wang, B., Li, Y., Luo, H., Wang, H., & Ren, N. (2019) · Biotechnology Advances · doi:10.1016/j.biotechadv.2019.03.003 · Cited by 329 · see citing works
Conversion of l-lactate into n-caproate by a continuously fed reactor microbiome
Kucek, L. A., Nguyen, M. T., & Angenent, L. T. (2016) · Water Research · doi:10.1016/j.watres.2016.02.018 · Cited by 279 · see citing works
Self-citationGe, S., Usack, J. G., Spirito, C. M., & Angenent, L. T. (2015) · Environmental Science & Technology · doi:10.1021/acs.est.5b00238 · Cited by 269 · see citing works
Self-citationZhu, X., Zhou, Y., Wang, Y., Wu, T., Li, X., Li, D., & Tao, Y. (2017) · Biotechnology for Biofuels · doi:10.1186/s13068-017-0788-y · Cited by 260 · see citing works
Zhu, X., Tao, Y., Liang, C., Li, X., Wei, N., Zhang, W., Zhou, Y., Yang, Y., & Bo, T. (2015) · Scientific Reports · doi:10.1038/srep14360 · Cited by 249 · see citing works
Biological production of medium-chain carboxylates through chain elongation: An overview
Wang, J., & Yin, Y. (2021) · Biotechnology Advances · doi:10.1016/j.biotechadv.2021.107882 · Cited by 241 · see citing works
Production of Caproic Acid from Mixed Organic Waste: An Environmental Life Cycle Perspective
Chen, W., Strik, D. P. B. T. B., Buisman, C. J. N., & Kroeze, C. (2017) · Environmental Science & Technology · doi:10.1021/acs.est.6b06220 · Cited by 225 · see citing works
Contreras-Dávila, C. A., Carrión, V. J., Vonk, V. R., Buisman, C. N. J., & Strik, D. P. B. T. B. (2019) · Water Research · doi:10.1016/j.watres.2019.115215 · Cited by 223 · see citing works
Significant enhancement by biochar of caproate production via chain elongation
Liu, Y., He, P., Shao, L., Zhang, H., & Lü, F. (2017) · Water Research · doi:10.1016/j.watres.2017.04.050 · Cited by 218 · see citing works
On the Edge of Research and Technological Application: A Critical Review of Electromethanogenesis
Blasco-Gómez, R., Batlle‐Vilanova, P., Villano, M., Balaguer, M. D., Colprim, J., & Puig, S. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18040874 · Cited by 217 · see citing works
Biohydrogen production from food waste: Current status, limitations, and future perspectives
Yun, Y., Lee, M., Im, S., Marone, A., Trably, É., Shin, S.-R., Kim, M.-G., Cho, S., & Kim, D. (2017) · Bioresource Technology · doi:10.1016/j.biortech.2017.06.107 · Cited by 205 · see citing works
Kucek, L. A., Spirito, C. M., & Angenent, L. T. (2016) · Energy & Environmental Science · doi:10.1039/c6ee01487a · Cited by 203 · see citing works
Self-citationJourdin, L., Raes, S. M. T., Buisman, C. J. N., & Strik, D. P. B. T. B. (2018) · Frontiers in Energy Research · doi:10.3389/fenrg.2018.00007 · Cited by 203 · see citing works
Fang, W., Zhang, X., Zhang, P., Wan, J., Guo, H., Ghasimi, D. S. M., Morera, X. C., & Zhang, T. (2019) · Journal of Environmental Sciences · doi:10.1016/j.jes.2019.05.027 · Cited by 202 · see citing works
Microbial electrosynthesis of butyrate from carbon dioxide: Production and extraction
Batlle‐Vilanova, P., Ganigué, R., Ramió‐Pujol, S., Bañeras, L., Jiménez, G., Hidalgo, M., Balaguer, M. D., Colprim, J., & Puig, S. (2017) · Bioelectrochemistry · doi:10.1016/j.bioelechem.2017.06.004 · Cited by 200 · see citing works
Wu, S.-L., Sun, J., Chen, X., Wei, W., Song, L., Dai, X., & Ni, B. (2019) · Water Research · doi:10.1016/j.watres.2019.115218 · Cited by 200 · see citing works
Richter, H., Molitor, B., Diender, M., Sousa, D. Z., & Angenent, L. T. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.01773 · Cited by 193 · see citing works
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Molitor, B., Richter, H., Martin, M. E., Jensen, R. O., Juminaga, A., Mihalcea, C., & Angenent, L. T. (2016) · Bioresource Technology · doi:10.1016/j.biortech.2016.03.094 · Cited by 183 · see citing works
Self-citationSadhukhan, J., Lloyd, J. R., Scott, K., Premier, G. C., Yu, E. H., Curtis, T. P., & Head, I. M. (2015) · Renewable and Sustainable Energy Reviews · doi:10.1016/j.rser.2015.11.015 · Cited by 179 · see citing works
Qian, W., Lu, Z., Chai, L., Zhang, X., Li, Q., Wang, S., Shen, C., Shi, J., & Xu, Z. (2021) · Food Research International · doi:10.1016/j.foodres.2021.110449 · Cited by 179 · see citing works
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Han, W., He, P., Shao, L., & Lü, F. (2018) · Applied and Environmental Microbiology · doi:10.1128/aem.01614-18 · Cited by 172 · see citing works
Medium Chain Carboxylic Acids from Complex Organic Feedstocks by Mixed Culture Fermentation
Groof, V. D., Coma, M., Arnot, T., Leak, D. J., & Lanham, A. B. (2019) · Molecules · doi:10.3390/molecules24030398 · Cited by 171 · see citing works
Wu, S.-L., Wei, W., Sun, J., Xu, Q., Dai, X., & Ni, B. (2020) · Water Research · doi:10.1016/j.watres.2020.116381 · Cited by 171 · see citing works
Energy Efficiency and Productivity Enhancement of Microbial Electrosynthesis of Acetate
LaBelle, E. V., & May, H. D. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.00756 · Cited by 157 · see citing works
Lei, Y., Sun, D., Dang, Y., Feng, X., Huo, D., Liu, C., Zheng, K., & Holmes, D. E. (2019) · Water Research · doi:10.1016/j.watres.2019.06.038 · Cited by 157 · see citing works
Opportunities and challenges in microbial medium chain fatty acids production from waste biomass
Wu, Q., Jiang, Y. G., Ying, C., Liu, M., Bao, X., & Guo, W. (2021) · Bioresource Technology · doi:10.1016/j.biortech.2021.125633 · Cited by 156 · see citing works
Urban, C., Xu, J., Sträuber, H., Dantas, T. R. D. S., Mühlenberg, J., Härtig, C., Angenent, L. T., & Harnisch, F. (2017) · Energy & Environmental Science · doi:10.1039/c7ee01303e · Cited by 155 · see citing works
Self-citationLi, L., He, J., Xin, X., Wang, M., Xu, J., & Zhang, J. (2017) · Chemical Engineering Journal · doi:10.1016/j.cej.2017.09.103 · Cited by 153 · see citing works
Nzeteu, C., Trego, A. C., Abram, F., & O’Flaherty, V. (2018) · Biotechnology for Biofuels · doi:10.1186/s13068-018-1101-4 · Cited by 152 · see citing works
In-line and selective phase separation of medium-chain carboxylic acids using membrane electrolysis
Xu, J., Guzman, J. J. L., Andersen, S. J., Rabaey, K., & Angenent, L. T. (2015) · Chemical Communications · doi:10.1039/c5cc01897h · Cited by 149 · see citing works
Self-citationBiological caproate production by Clostridium kluyveri from ethanol and acetate as carbon sources
Yin, Y., Zhang, Y., Karakashev, D. B., Wang, J., & Angelidaki, İ. (2017) · Bioresource Technology · doi:10.1016/j.biortech.2017.05.184 · Cited by 148 · see citing works
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Ganigué, R., Sánchez-Paredes, P., Bañeras, L., & Colprim, J. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.00702 · Cited by 147 · see citing works
Kucek, L. A., Xu, J., Nguyen, M. T., & Angenent, L. T. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.01892 · Cited by 147 · see citing works
Self-citationInfluence of Acidic pH on Hydrogen and Acetate Production by an Electrosynthetic Microbiome
LaBelle, E. V., Marshall, C. W., Gilbert, J. A., & May, H. D. (2014) · PLoS ONE · doi:10.1371/journal.pone.0109935 · Cited by 145 · see citing works
Product Diversity Linked to Substrate Usage in Chain Elongation by Mixed-Culture Fermentation
Coma, M., Vilchez‐Vargas, R., Roume, H., Jáuregui, R., Pieper, D. H., & Rabaey, K. (2016) · Environmental Science & Technology · doi:10.1021/acs.est.5b06021 · Cited by 143 · see citing works
Self-citationUpgrading syngas fermentation effluent using Clostridium kluyveri in a continuous fermentation
Gildemyn, S., Molitor, B., Usack, J. G., Nguyen, M. T., Rabaey, K., & Angenent, L. T. (2017) · Biotechnology for Biofuels · doi:10.1186/s13068-017-0764-6 · Cited by 143 · see citing works
Self-citationZagrodnik, R., Duber, A., Lezyk, M. J., & Oleśkowicz-Popiel, P. (2020) · Environmental Science & Technology · doi:10.1021/acs.est.9b07651 · Cited by 127 · see citing works
Acidogenic fermentation of the main substrates of food waste to produce volatile fatty acids
Yin, J., Yu, X., Wang, K., & Shen, D. (2016) · International Journal of Hydrogen Energy · doi:10.1016/j.ijhydene.2016.07.094 · Cited by 126 · see citing works
Magdalena, J. A., Greses, S., & González‐Fernández, C. (2019) · Scientific Reports · doi:10.1038/s41598-019-54914-4 · Cited by 120 · see citing works
Andersen, S. J., Candry, P., Basadre, T., Khor, W. C., Roume, H., Hernandez‐Sanabria, E., Coma, M., & Rabaey, K. (2015) · Biotechnology for Biofuels · doi:10.1186/s13068-015-0396-7 · Cited by 119 · see citing works
Self-citationLiu, Y., Lü, F., Shao, L., & He, P. (2016) · Bioresource Technology · doi:10.1016/j.biortech.2016.07.067 · Cited by 118 · see citing works
Andersen, S. J., Groof, V. D., Khor, W. C., Roume, H., Props, R., Coma, M., & Rabaey, K. (2017) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2017.00008 · Cited by 109 · see citing works
Self-citationDomingos, J. M. B., Puccio, S., Martínez, G. A., Amaral, N., Reis, M. A. M., Bandini, S., Fava, F., & Bertin, L. (2017) · Chemical Engineering Journal · doi:10.1016/j.cej.2017.11.024 · Cited by 108 · see citing works
Medium chain fatty acids production from anaerobic fermentation of waste activated sludge
Wu, S.-L., Luo, G., Sun, J., Wei, W., Song, L., & Ni, B. (2020) · Journal of Cleaner Production · doi:10.1016/j.jclepro.2020.123482 · Cited by 104 · see citing works
Continuous Long‐Term Bioelectrochemical Chain Elongation to Butyrate
Raes, S. M. T., Jourdin, L., Buisman, C. J. N., & Strik, D. P. B. T. B. (2016) · ChemElectroChem · doi:10.1002/celc.201600587 · Cited by 103 · see citing works
Effect of pH, yeast extract and inorganic carbon on chain elongation for hexanoic acid production
San‐Valero, P., Abubackar, H. N., Veiga, M. C., & Kennes, C. (2019) · Bioresource Technology · doi:10.1016/j.biortech.2019.122659 · Cited by 103 · see citing works
Tao, Y., Wang, X., Li, X., Wei, N., Jin, H., Zhan-cheng, X., Tang, Q., & Zhu, X. (2017) · Microbial Biotechnology · doi:10.1111/1751-7915.12729 · Cited by 102 · see citing works
Chain elongators, friends, and foes
Candry, P., & Ganigué, R. (2021) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2021.01.005 · Cited by 102 · see citing works
Spirito, C. M., Marzilli, A. M., & Angenent, L. T. (2018) · Environmental Science & Technology · doi:10.1021/acs.est.8b03856 · Cited by 101 · see citing works
Self-citationScarborough, M., Lawson, C. E., Hamilton, J. J., Donohue, T. J., & Noguera, D. R. (2018) · mSystems · doi:10.1128/msystems.00221-18 · Cited by 101 · see citing works
Electricity-assisted production of caproic acid from grass
Khor, W. C., Andersen, S. J., Vervaeren, H., & Rabaey, K. (2017) · Biotechnology for Biofuels · doi:10.1186/s13068-017-0863-4 · Cited by 101 · see citing works
Self-citationElectro-fermentation: Sustainable bioproductions steered by electricity
Virdis, B., Hoelzle, R. D., Marchetti, A., Boto, S. T., Rosenbaum, M. A., Blasco-Gómez, R., Puig, S., Freguia, S., & Villano, M. (2022) · Biotechnology Advances · doi:10.1016/j.biotechadv.2022.107950 · Cited by 100 · see citing works
Selecting for lactic acid producing and utilising bacteria in anaerobic enrichment cultures
Rombouts, J. L., Kranendonk, E. M. M., Regueira, A., Weissbrodt, D. G., Kleerebezem, R., & van Loosdrecht, M. C. M. (2020) · Biotechnology and Bioengineering · doi:10.1002/bit.27301 · Cited by 97 · see citing works
Esquivel‐Elizondo, S., Bağcı, C., Temovska, M., Jeon, B. S., Bessarab, I. N., Williams, R. B. H., Huson, D. H., & Angenent, L. T. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.594524 · Cited by 95 · see citing works
Self-citationZou, W., Ye, G., & Zhang, K. (2018) · Journal of Food Science · doi:10.1111/1750-3841.14134 · Cited by 94 · see citing works
Dong, W., You-li, Y., Liu, C., Zhang, J., Pan, J., Luo, L., Wu, G., Awasthi, M. K., & Yan, B. (2023) · Renewable and Sustainable Energy Reviews · doi:10.1016/j.rser.2023.113181 · Cited by 94 · see citing works
Valorization of C1 gases to value-added chemicals using acetogenic biocatalysts
Bae, J., Song, Y., Lee, H., Shin, J., Jin, S., Kang, S., & Cho, B. (2021) · Chemical Engineering Journal · doi:10.1016/j.cej.2021.131325 · Cited by 93 · see citing works
High‐rate volatile fatty acid (VFA) production by a granular sludge process at low pH
Tamis, J., Joosse, B., van Loosdrecht, M. C. M., & Kleerebezem, R. (2015) · Biotechnology and Bioengineering · doi:10.1002/bit.25640 · Cited by 88 · see citing works
Wu, S.-L., Wei, W., Xu, Q., Huang, X., Sun, J., Dai, X., & Ni, B. (2021) · ACS ES&T Water · doi:10.1021/acsestwater.0c00278 · Cited by 87 · see citing works
Lonkar, S., Fu, Z., & Holtzapple, M. T. (2016) · Biotechnology and Bioengineering · doi:10.1002/bit.26024 · Cited by 87 · see citing works
de Leeuw, K. D., Buisman, C. J. N., & Strik, D. P. B. T. B. (2019) · Environmental Science & Technology · doi:10.1021/acs.est.8b07256 · Cited by 86 · see citing works
Towards the sustainable and circular bioeconomy: Insights on spent coffee grounds valorization
Gebreeyessus, G. D. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2022.155113 · Cited by 86 · see citing works
Liang, S., McDonald, A. G., & Coats, E. R. (2015) · Waste Management · doi:10.1016/j.wasman.2015.02.004 · Cited by 86 · see citing works
Li, L., He, J., Wang, M., Xin, X., Xu, J., & Zhang, J. (2018) · ACS Sustainable Chemistry & Engineering · doi:10.1021/acssuschemeng.8b04115 · Cited by 85 · see citing works
Patel, A., Mahboubi, A., Horváth, I. S., Taherzadeh, M. J., Rova, U., Christakopoulos, P., & Μάτσακας, Λ. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.614612 · Cited by 85 · see citing works
Sträuber, H., Lucas, R., & Kleinsteuber, S. (2015) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-015-6996-0 · Cited by 83 · see citing works
Leng, L., Yang, P., Mao, Y., Wu, Z., Zhang, T., & Lee, P.-H. H. (2017) · Water Research · doi:10.1016/j.watres.2017.02.023 · Cited by 83 · see citing works
Concentrating lactate-carbon flow on medium chain carboxylic acids production by hydrogen supply
Wu, Q., Guo, W., You, S., Bao, X., Luo, H., Wang, H., & Ren, N. (2019) · Bioresource Technology · doi:10.1016/j.biortech.2019.121573 · Cited by 83 · see citing works
Wood, J. C., Grové, J., Marcellin, E., Heffernan, J. K., Hu, S., Yuan, Z., & Virdis, B. (2021) · Water Research · doi:10.1016/j.watres.2021.117306 · Cited by 83 · see citing works
Shi, X., Wu, L., Wei, W., & Ni, B. (2021) · Critical Reviews in Environmental Science and Technology · doi:10.1080/10643389.2021.1957342 · Cited by 83 · see citing works
Jiang, Y. G., & Zeng, R. J. (2018) · Bioresource Technology · doi:10.1016/j.biortech.2018.08.101 · Cited by 82 · see citing works
Reddy, M. V., Kumar, G., Mohanakrishna, G., Shobana, S., & Al‐Raoush, R. I. (2020) · Bioresource Technology · doi:10.1016/j.biortech.2020.123400 · Cited by 81 · see citing works
Zhang, Y., Pan, X.-R., Zuo, J., & Hu, J. (2021) · Bioresource Technology · doi:10.1016/j.biortech.2021.126144 · Cited by 81 · see citing works
Candry, P., Daele, T. V., Denis, K., Amerlinck, Y., Andersen, S. J., Ganigué, R., Arends, J., Ingmar Nopens, A., & Rabaey, K. (2018) · Scientific Reports · doi:10.1038/s41598-018-27594-9 · Cited by 80 · see citing works
Self-citationOne-step production of C6–C8 carboxylates by mixed culture solely grown on CO
He, P., Han, W., Shao, L., & Lü, F. (2018) · Biotechnology for Biofuels · doi:10.1186/s13068-017-1005-8 · Cited by 79 · see citing works
Stamatopoulou, P., Malkowski, J., Conrado, L., Brown, K. P., & Scarborough, M. (2020) · Processes · doi:10.3390/pr8121571 · Cited by 79 · see citing works
Engineering Clostridium organisms as microbial cell-factories: challenges & opportunities
Charubin, K., Bennett, R. K., Fast, A. G., & Papoutsakis, E. T. (2018) · Metabolic Engineering · doi:10.1016/j.ymben.2018.07.012 · Cited by 78 · see citing works
Microbial acclimatization to lipidic-waste facilitates the efficacy of acidogenic fermentation
Saha, S., Jeon, B.-H., Kurade, M. B., Chatterjee, P. K., Chang, S. W., Markkandan, K., Salama, E., Govindwar, S. P., & Roh, H. (2018) · Chemical Engineering Journal · doi:10.1016/j.cej.2018.09.220 · Cited by 78 · see citing works
Road to full bioconversion of biowaste to biochemicals centering on chain elongation: A mini review
Han, W., He, P., Shao, L., & Lü, F. (2019) · Journal of Environmental Sciences · doi:10.1016/j.jes.2019.05.018 · Cited by 77 · see citing works
The occurrence and ecology of microbial chain elongation of carboxylates in soils
Joshi, S., Robles, A., Aguiar, S., & Delgado, A. G. (2021) · The ISME Journal · doi:10.1038/s41396-021-00893-2 · Cited by 77 · see citing works
Caproate production from xylose by mesophilic mixed culture fermentation
Qian, D.-K., Geng, Z.-Q., Sun, T., Dai, K., Zhang, W., Zeng, R. J., & Zhang, F. (2020) · Bioresource Technology · doi:10.1016/j.biortech.2020.123318 · Cited by 76 · see citing works
Liu, B., Kleinsteuber, S., Centler, F., Harms, H., & Sträuber, H. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.00336 · Cited by 75 · see citing works
Fernández‐Blanco, C., Veiga, M. C., & Kennes, C. (2021) · Journal of Environmental Management · doi:10.1016/j.jenvman.2021.113992 · Cited by 75 · see citing works
Key sub-community dynamics of medium-chain carboxylate production
Lambrecht, J., Cichocki, N., Schattenberg, F., Kleinsteuber, S., Harms, H., Müller, S., & Sträuber, H. (2019) · Microbial Cell Factories · doi:10.1186/s12934-019-1143-8 · Cited by 74 · see citing works
Tang, J., Dai, K., Wang, Q.-T., Zheng, S.-J., Hong, S.-D., Zeng, R. J., & Zhang, F. (2022) · Bioresource Technology · doi:10.1016/j.biortech.2022.126978 · Cited by 74 · see citing works
Nano zero-valent iron: A pH buffer, electron donor and activator for chain elongation
Fu, X., Jin, X., Ye, R., & Lü, W. (2021) · Bioresource Technology · doi:10.1016/j.biortech.2021.124899 · Cited by 73 · see citing works
Domingos, J. M. B., Martínez, G. A., Scoma, A., Fraraccio, S., Kerckhof, F., Boon, N., Reis, M. A. M., Fava, F., & Bertin, L. (2016) · ACS Sustainable Chemistry & Engineering · doi:10.1021/acssuschemeng.6b01901 · Cited by 72 · see citing works
Microbial Electrosynthesis for Producing Medium Chain Fatty Acids
Chu, N., Wen, H., Wu, Q., Liang, Q., Jiang, Y. G., Liang, P., Ren, Z. J., & Zeng, R. J. (2021) · Engineering · doi:10.1016/j.eng.2021.03.025 · Cited by 72 · see citing works
Guan, T., Wu, X., Hou, R., Tian, L., Huang, Q., Zhao, F., Liu, Y., Jiao, S., Xiang, S., Zhang, J., et al. (2023) · Food Research International · doi:10.1016/j.foodres.2023.112885 · Cited by 72 · see citing works
Kim, H., Kang, S., & Sang, B. (2021) · Bioresource Technology · doi:10.1016/j.biortech.2021.126211 · Cited by 71 · see citing works
Groof, V. D., Coma, M., Arnot, T., Leak, D. J., & Lanham, A. B. (2021) · Waste Management · doi:10.1016/j.wasman.2021.04.023 · Cited by 69 · see citing works
Kondaveeti, S., & Min, B. (2015) · Water Research · doi:10.1016/j.watres.2015.09.011 · Cited by 68 · see citing works
Kim, H., Jeon, B. S., & Sang, B. (2019) · Scientific Reports · doi:10.1038/s41598-019-48591-6 · Cited by 67 · see citing works
Caproic Acid-Producing Bacteria in Chinese Baijiu Brewing
Yuan, S., Jin, Z., Ali, A., Wang, C., & Liu, J. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.883142 · Cited by 67 · see citing works
- Authors
- Spirito, C. M., Richter, H., Rabaey, K., Stams, A. J., & Angenent, L. T.
- Affiliations
- Cornell University (US)
- Ghent University (BE)
- Wageningen University & Research (NL)
- Corresponding author
- Angenent, Largus T
- Venue
- Current Opinion in Biotechnology
- Publisher
- Elsevier BV
- Published
- 2014-06
- Volume
- 27
- Pages
- 115-122
- ISSN
- 0958-1669 (ISSN-L)
- OpenAlex
- W2111185205
- Cited by
- 479
- References
- 55
- Citations by year
- 2026: 56 · 2025: 48 · 2024: 56 · 2023: 46 · 2022: 46 · 2021: 59 · 2020: 43 · 2019: 34 · 2018: 24 · 2017: 31 · 2016: 19 · 2015: 15 · 2014: 1
- FWCI
- 4.04
- Type
- journal article
- Language
- en
- Open access
- green
- research.wur.nl
- Locations
- Current Opinion in Biotechnology (publishedVersion)
- PubMed (publishedVersion)
- Socio-Environmental Systems Modeling (acceptedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion)
- Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion, cc-by-nc-nd)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- U. S. Army Research Office (W911NF-12-1-0555)
- Cornell University Agricultural Experiment Station (NYC-123452)
- National Institutes for Food and Agriculture (NIFA)
- U.S. Department of Agriculture
- European Research Council Starter Grant Electrotalk
- the Multidisciplinary Research Partnership Ghent Bio-Economy
- Netherlands Science Foundation (CW-TOP 700.55.343)
- European Research Council (323009)
- Topics
- Physical Sciences › Engineering › Building and Construction › Anaerobic Digestion and Biogas Production
- Physical Sciences › Environmental Science › Environmental Engineering › Microbial Fuel Cells and Bioremediation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
- Keywords
- chain extension, homoacetogenesis, reverse β-oxidation, CO2 utilization, glycerol, waste management, renewable chemicals, renewable fuels, microbial metabolism
- MeSH terms
- Acetates, Anaerobiosis, Carbon Dioxide, Carboxylic Acids, Electrodes, Oxidation-Reduction, Waste Management, Bioreactors, Succinic Acid, Recycling, Microbiota
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