Cited by 263Nicotinic Acetylcholine Receptors StudySmoking Behavior and CessationNeurotransmitter Receptor Influence on Behavior

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Nicotine: from molecular mechanisms to behaviour

Wonnacott, Susan, Sidhpura, Nimish, Balfour, David JK·2005·Current Opinion in Pharmacology

DOI 10.1016/j.coph.2004.12.002

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Abstract

The addictive potential of nicotine is clearly recognized by the tenacity of tobacco smoking for most users, and has prompted extensive psychopharmacological studies in animals. In parallel, the interaction of nicotine with the many subtypes of its eponymous receptor has been the focus of molecular and cellular investigations. More recently, a convergence of these approaches has been stimulated by the generation of transgenic animals, which facilitates analysis of the impact of molecular changes on behaviour. Nicotine, like other addictive drugs including psychomotor stimulants, promotes dopamine release in the nucleus accumbens. This transmitter system has been a major focus of both neurochemical and behavioural investigations, although recently the pre-eminence of this system in nicotine dependence has been challenged. Complexities in the brain circuitry (including the subdivisions of the nucleus accumbens) and differences between behavioural models help to rationalise the current controversy.

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Authors: Wonnacott, S., Sidhpura, N., & Balfour, D. J.
Affiliations: University of Bath (GB)
University of Dundee (GB)
Corresponding author: Wonnacott, Susan
ORCID: Wonnacott, Susan
Balfour, David JK
Venue: Current Opinion in Pharmacology
Publisher: Elsevier BV
Published: 2005-02
Volume: 5
Issue: 1
Pages: 53-59
ISSN: 1471-4892 (ISSN-L)
DOI: 10.1016/j.coph.2004.12.002
OpenAlex: W2039694871
Cited by: 263
References: 59
Citations by year: 2025: 5 · 2024: 3 · 2023: 6 · 2022: 2 · 2021: 6 · 2020: 3 · 2019: 11 · 2018: 9 · 2017: 6 · 2016: 7 · 2015: 10 · 2014: 10 · 2013: 12 · 2012: 14
FWCI: 7.58
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Current Opinion in Pharmacology (publishedVersion)
PubMed (publishedVersion)
Funders: Wellcome Trust
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: nicotine, nicotine dependence, dopamine release, nucleus accumbens, transgenic animals, psychostimulants, smoking, brain circuits, behavioural models
MeSH terms: Animals, Behavior, Animal, Brain, Ganglionic Stimulants, Humans, Molecular Biology, Nicotine, Psychopharmacology, Receptors, Nicotinic

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