Medial prefrontal cortical control of reward‐ and aversion‐based behavioral output: Bottom‐up modulation

Pastor, Verónica; Medina, Jorge Horacio

doi:10.1111/ejn.15168

Cited by 50Neurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology StudiesNeuroscience and Neuropharmacology Research

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Medial prefrontal cortical control of reward‐ and aversion‐based behavioral output: Bottom‐up modulation

Pastor, Verónica, Medina, Jorge Horacio·2021·European Journal of Neuroscience

DOI 10.1111/ejn.15168

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Abstract

How does the brain guide our actions? This is a complex issue, where the medial prefrontal cortex (mPFC) plays a crucial role. The mPFC is essential for cognitive flexibility and decision making. These functions are related to reward‐ and aversion‐based learning, which ultimately drive behavior. Though, cortical projections and modulatory systems that may regulate those processes in the mPFC are less understood. How does the mPFC regulate approach‐avoidance behavior in the case of conflicting aversive and appetitive stimuli? This is likely dependent on the bottom‐up neuromodulation of the mPFC projection neurons. In this review, we integrate behavioral‐, pharmacological‐, and viral‐based circuit manipulation data showing the involvement of mPFC dopaminergic, noradrenergic, cholinergic, and serotoninergic inputs in reward and aversion processing. Given that an incorrect balance of reward and aversion value could be a key problem in mental diseases such as substance use disorders, we discuss outstanding questions for future research on the role of mPFC modulation in reward and aversion.

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The mPFC encodes the expected value of stimuli.
“encode the expected value of stimuli,[ 38 , 39 ]”
From Loneliness and the Social Brain: How Perceived Social Isolation Impairs Human Interactions (2021) · cites this paper as [38]
Reduced mPFC activity might be linked to the attenuated recruitment of the amygdala and the NAcc.
“In addition, the reduced mPFC activity might be linked to the attenuated recruitment of the amygdala and the NAcc.[ 38 , 42 ]”
From Loneliness and the Social Brain: How Perceived Social Isolation Impairs Human Interactions (2021) · cites this paper as [38]
The mPFC interacts with various limbic regions.
“Like the AI, the mPFC is known to interact with various limbic regions, encode the expected value of stimuli,[ 38 , 39 ]”
From Loneliness and the Social Brain: How Perceived Social Isolation Impairs Human Interactions (2021) · cites this paper as [38]

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Lieberz, J., Shamay‐Tsoory, S. G., Saporta, N., Esser, T., Kuskova, E., Stoffel‐Wagner, B., Hurlemann, R., & Scheele, D. (2021) · Advanced Science · doi:10.1002/advs.202102076 · Cited by 116

Authors: Pastor, V., & Medina, J. H.
Affiliations: Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
Corresponding author: Pastor, Verónica
ORCID: Pastor, Verónica
Medina, Jorge Horacio
Venue: European Journal of Neuroscience
Publisher: Wiley
Published: 2021-03-15
Volume: 53
Issue: 9
Pages: 3039-3062
ISSN: 0953-816X (ISSN-L)
1460-9568
DOI: 10.1111/ejn.15168
OpenAlex: W3135675945
Cited by: 50
References: 38
Citations by year: 2026: 16 · 2025: 9 · 2024: 10 · 2023: 7 · 2022: 5 · 2021: 3
FWCI: 0.73
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: European Journal of Neuroscience (publishedVersion)
PubMed (publishedVersion)
Funders: Fondo para la Investigación Científica y Tecnológica (PICT 0034‐2016)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: medial prefrontal cortex, reward processing, approach-avoidance behavior, dopaminergic input, noradrenergic input, cholinergic input, cognitive flexibility, decision-making, substance use disorders, neural circuits
MeSH terms: Affect, Brain, Dopamine, Reward, Prefrontal Cortex

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Medial prefrontal cortical control of reward‐ and aversion‐based behavioral output: Bottom‐up modulation

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