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Comparison of frontostriatal circuits in adolescent nicotine addiction and internet gaming disorder

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von Deneen, Karen M., Hussain, Hadi, Waheed, Junaid, Xinwen, Wen, Yu, Dahua, Yuan, Kai·2022·Journal of Behavioral Addictions
DOI 10.1556/2006.2021.00086PMC PMC9109629
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Abstract

Background: Recently, there has been significantly increased participation in online gaming and other addictive behaviors particularly in adolescents. Tendencies to avoid social interaction and become more involved in technology-based activities pose the danger of creating unhealthy addictions. Thus, the presence of relatively immature cognitive control and high risk-taking properties makes adolescence a period of major changes leading to an increased rate of emotional disorders and addiction. Aims: The critical roles of frontostriatal circuits in addiction have become the primary focus associated with reward in the striatum and cognitive control in the PFC. Internet gaming disorder (IGD) and nicotine addiction are currently becoming more and more serious. Methods: In the light of neuroimaging, the similarity between brain mechanisms causing substance use disorder (SUD) and IGD have been described in previous literature. Results: In particular, two distinct brain systems affect the way we act accounting for uncharacteristic neural function in addiction: the affective system comprises of the striatum driven by emotional, reward-related, and internal stimuli, and a cognitive system consisting of the prefrontal cortex (PFC) supporting the ventral affective system's actions via inhibitory control. Discussion and Conclusion: Therefore, as a novel concept, we focused on the implication of frontostriatal circuits in nicotine addiction and IGD by reviewing the main findings from our studies compared to those of others. We hope that all of these neuroimaging findings can lead to effective intervention and treatment for addiction especially during this critical period.

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  • Excessive internet gaming and nicotine addiction in adolescents result in similar deficits in functional connectivity throughout the frontostriatal network.

    “According to Von Deenen et al. (2022), excessive internet gaming and nicotine addiction in adolescents result in similar deficits in functional connectivity throughout the frontostriatal network, which is required for both cognitive regulation and reward processing [34].”

    From The Impact of Social Media & Technology on Child and Adolescent Mental Health (2025) · cites this paper as [34]

    The Resting state functional connectivity abnormalities section (page unavailable) reports reduced connectivity in specific regions in both groups, and the Discussion and conclusion describes similarities in frontostriatal resting-state abnormalities. But the paper also reports increased connectivity and differences between the disorders; it does not establish similar deficits throughout the network or that either addiction causes them. The Introduction links frontostriatal circuits to cognitive control and reward. (LLM, conf=0.87)

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Cited by

Sorted by citations

Authors
von Deneen, K. M., Hussain, H., Waheed, J., Xinwen, W., Yu, D., & Yuan, K.
Affiliations
  • School of Life Science and Technology, Xidian University, Xi'an, Shaanxi 710071, Peoples R China
  • Xi'an Jiaotong University (CN)
  • Xidian University (CN)
  • Inner Mongolia University of Science and Technology (CN)
Corresponding author
  • Yu, Dahua
  • Yuan, Kai
ORCID
Venue
Journal of Behavioral Addictions
Publisher
Akademiai Kiado Zrt.
Published
2022-03-28
Volume
11
Issue
1
Pages
26-39
ISSN
  • 2062-5871 (ISSN-L)
  • 2063-5303
DOI
10.1556/2006.2021.00086
PMC
PMC9109629
OpenAlex
W4205263882
Cited by
51
References
16
Citations by year
2026: 9 · 2025: 24 · 2024: 7 · 2023: 9 · 2022: 2
FWCI
1.76
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Behavioral Addictions (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • Repository of the Academy's Library (Library of the Hungarian Academy of Sciences) (acceptedVersion)
Funders
  • National Natural Science Foundation of China (81871426, 81871430)
  • Young Talents of Science and Technology in Universities of Inner Mongolia Autonomous Region (NJYT-17-B11)
  • R & D projects in Hunan Province (2019SK2131)
  • Natural Science Foundation of Inner Mongolia (2019JQ07)
  • Inner Mongolia Autonomous Region (2019GG109)
  • Chunhui Program of the Ministry of Education of the People's Republic of China (2018–45)
Topics
  • Social Sciences › Sociology and Political Science › Impact of Technology on Adolescents
  • Social Sciences › Psychology › Clinical Psychology › Gambling Behavior and Treatments
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
frontostriatal circuits, nicotine dependence, internet gaming disorder, adolescents, prefrontal cortex, striatum, cognitive control, reward processing, substance use disorders, addiction treatment
MeSH terms
Internet Addiction Disorder, Adolescent, Brain, Humans, Magnetic Resonance Imaging, Tobacco Use Disorder, Behavior, Addictive

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