Transporters and receptors for short-chain fatty acids as the molecular link between colonic bacteria and the host

Structure, function and diversity of the healthy human microbiome

The Human Microbiome Project Consortium (2012) · Nature · doi:10.1038/nature11234 · Cited by 11,726

Diversity, stability and resilience of the human gut microbiota

Lozupone, C. A., Stombaugh, J. I., Gordon, J. I., Jansson, J. K., & Knight, R. (2012) · Nature · doi:10.1038/nature11550 · Cited by 5,533

The human microbiome: at the interface of health and disease

Cho, I., & Blaser, M. J. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3182 · Cited by 3,449

Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43

Maslowski, K. M., Vieira, A. T., Ng, A., Kranich, J., Sierro, F., Yu, D., Schilter, H. C., Rolph, M. S., Mackay, F., Artis, D., et al. (2009) · Nature · doi:10.1038/nature08530 · Cited by 3,241

Colonic Health: Fermentation and Short Chain Fatty Acids

Wong, J. M. W., de Souza, R., Kendall, C. W. C., Emam, A., & Jenkins, D. J. A. (2006) · Journal of Clinical Gastroenterology · doi:10.1097/00004836-200603000-00015 · Cited by 2,739

Human nutrition, the gut microbiome and the immune system

Kau, A. L., Ahern, P. P., Griffin, N. W., Goodman, A. L., & Gordon, J. I. (2011) · Nature · doi:10.1038/nature10213 · Cited by 2,588

Regulation of inflammation by short chain fatty acids

Vinolo, M. A. R., Rodrigues, H. G., Nachbar, R. T., & Curi, R. (2011) · Nutrients · doi:10.3390/nu3100858 · Cited by 1,724

Short-Chain Fatty Acids Activate GPR41 and GPR43 on Intestinal Epithelial Cells to Promote Inflammatory Responses in Mice

Kim, M. H., Kang, S. G., Park, J. H., Yanagisawa, M., & Kim, C. H. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.04.056 · Cited by 1,127

Food, nutrition and the prevention of cancer: a global perspective

Ávila-Curiel, A. (1998) · Salud Pública de México · doi:10.1590/s0036-36341998000200015 · Cited by 1,027

PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect

Tunaru, S., Kero, J. T., Schaub, A., Wufka, C., Blaukat, A., Pfeffer, K., & Offermanns, S. (2003) · Nature Medicine · doi:10.1038/nm824 · Cited by 801

Lactobacillus plantarum GKM3 promotes longevity, memory retention, and reduces brain oxidation stress in SAMP8 mice

Lin, S.-W., Tsai, Y.-S., Chen, Y.-L., Wang, M.-F., Chen, C.-C., Lin, W.-H., & Fang, T. J. (2021) · Nutrients · doi:10.3390/nu13082860 · Cited by 53

Gut microbiota and metabolites of α-synuclein transgenic monkey models with early stage of Parkinson’s disease

Yan, Y., Ren, S., Duan, Y., Lu, C., Niu, Y., Wang, Z., Inglis, B., Ji, W., Zheng, Y., & Si, W. (2021) · npj Biofilms and Microbiomes · doi:10.1038/s41522-021-00242-3 · Cited by 51

Regulation of CD4+CD8−CD25+ and CD4+CD8+CD25+ T cells by gut microbiota in chicken

Lee, I. K., Gu, M. J., Ko, K. H., Bae, S., Kim, G., Jin, G.-D., Kim, E. B., Kong, Y., Park, T. S., Park, B., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-26763-0 · Cited by 53

Altered gut microbiota and intestinal permeability in Parkinson’s disease: Pathological highlight to management

Sharma, S., Awasthi, A., & Singh, S. (2019) · Neuroscience Letters · doi:10.1016/j.neulet.2019.134516 · Cited by 55

Gut microbiota short-chain fatty acids and their impact on the host thyroid function and diseases

Mendoza-León, M. J., Mangalam, A. K., Regaldiz, A., González-Madrid, E., Rangel-Ramírez, M. A., Álvarez-Mardones, O., Vallejos, O. P., Méndez, C., Bueno, S. M., Melo-González, F., et al. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1192216 · Cited by 56

Cancer-Associated Fibroblasts Expressing Sulfatase 1 Facilitate VEGFA-Dependent Microenvironmental Remodeling to Support Colorectal Cancer

Wang, H., Chen, J., Chen, X., Liu, Y., Wang, J., Meng, Q., Wang, H., He, Y., Song, Y., Li, J., et al. (2024) · Cancer Research · doi:10.1158/0008-5472.can-23-3987 · Cited by 55

Microbes Tickling Your Tummy: the Importance of the Gut-Brain Axis in Parkinson’s Disease

Perez‐Pardo, P., Hartog, M., Garssen, J., & Kraneveld, A. D. (2017) · Current Behavioral Neuroscience Reports · doi:10.1007/s40473-017-0129-2 · Cited by 53

Critical roles of G protein-coupled receptors in regulating intestinal homeostasis and inflammatory bowel disease

Feng, Z., Sun, R., Cong, Y., & Liu, Z. (2022) · Mucosal Immunology · doi:10.1038/s41385-022-00538-3 · Cited by 50

The Gut Microbiome and Ferroptosis in MAFLD

Ji, J., Wu, L., Wei, J., Wu, J., & Guo, C. (2022) · Journal of Clinical and Translational Hepatology · doi:10.14218/jcth.2022.00136 · Cited by 50

Helicobacter pylori and gut microbiota in multiple sclerosis versus Alzheimer's disease: 10 pitfalls of microbiome studies

Park, A.-M., Omura, S., Fujita, M., Sato, F., & Tsunoda, I. (2017) · Clinical and Experimental Neuroimmunology · doi:10.1111/cen3.12401 · Cited by 55

Short‐chain fatty acids induce tissue plasminogen activator in airway epithelial cells via GPR 41&43

Imoto, Y., Kato, A., Takabayashi, T., Sakashita, M., Norton, J. E., Suh, L. A., Carter, R. G., Weibman, A. R., Hulse, K. E., Stevens, W. W., et al. (2018) · Clinical & Experimental Allergy · doi:10.1111/cea.13119 · Cited by 50

Understanding host-microbiota interactions in the commercial piglet around weaning

Saladrigas-García, M., D’Angelo, M., Ko, H., Nolis, P., Ramayo‐Caldas, Y., Folch, J. M., Llonch, P., Solà‐Oriol, D., Pérez, J. F., & Martín-Orúe, S. M. (2021) · Scientific Reports · doi:10.1038/s41598-021-02754-6 · Cited by 55

Potential role of gut microbiota in prostate cancer: immunity, metabolites, pathways of action?

Zha, C., Peng, Z., Huang, K., Tang, K., Wang, Q., Zhu, L. J., Che, B., Li, W., Xu, S., Huang, T., et al. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1196217 · Cited by 49

Gut Microbiota Metabolite Messengers in Brain Function and Pathology at a View of Cell Type-Based Receptor and Enzyme Reaction

Lee, B., Lee, S. M., Song, J. W., & Choi, J. W. (2024) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2024.009 · Cited by 49

The Role of the Gut Microbiome in Colorectal Cancer

Chen, G. (2018) · Clinics in Colon and Rectal Surgery · doi:10.1055/s-0037-1602239 · Cited by 49

Microbiota-derived short chain fatty acids: Their role and mechanisms in viral infections

Feng, C., Jin, C., Liu, K., & Yang, Z. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114414 · Cited by 51

Prevotella-rich enterotype may benefit gut health in finishing pigs fed diet with a high amylose-to-amylopectin ratio

Ren, W., Yan, H., Yu, B., Walsh, M. C., Yu, J., Zheng, P., Huang, Z., Luo, J., Mao, X., He, J., et al. (2021) · Animal nutrition · doi:10.1016/j.aninu.2020.08.007 · Cited by 46

Cellular and molecular mechanisms of probiotics effects on colorectal cancer

Faghfoori, Z., Gargari, B. P., Gharamaleki, A. S., Bagherpour, H., & Khosroushahi, A. Y. (2015) · Journal of Functional Foods · doi:10.1016/j.jff.2015.08.013 · Cited by 46

The Gut Microbiota: How Does It Influence the Development and Progression of Liver Diseases

Kanmani, P., Kanmani, S., & Kim, H. (2020) · Biomedicines · doi:10.3390/biomedicines8110501 · Cited by 44

Lactobacillus plantarum-derived metabolites sensitize the tumor-suppressive effects of butyrate by regulating the functional expression of SMCT1 in 5-FU-resistant colorectal cancer cells

Kim, H., An, J., & Ha, E.-M. (2021) · The Journal of Microbiology · doi:10.1007/s12275-022-1533-1 · Cited by 45

The microbial epigenome in metabolic syndrome

Remely, M., & Haslberger, A. G. (2016) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2016.09.003 · Cited by 42

Fishing for the right probiotic: host–microbe interactions at the interface of effective aquaculture strategies

Langlois, L., Akhtar, N., Tam, K. C., Dixon, B., & Reid, G. (2021) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuab030 · Cited by 50

The Triple Alliance: Microbiome, Mitochondria, and Metabolites in the Context of Age-Related Cognitive Decline and Alzheimer’s Disease

Prajapati, S. K., Shah, R., Alford, N., Mishra, S. P., Jain, S., HANSEN, B. C., Sanberg, P. R., Molina, A. J. A., & Yadav, H. (2023) · The Journals of Gerontology Series A · doi:10.1093/gerona/glad226 · Cited by 42

Lipids in Clinical Nutrition and Health: Narrative Review and Dietary Recommendations

Frydrych, A., Kulita, K., Jurowski, K., & Piekoszewski, W. (2025) · Foods · doi:10.3390/foods14030473 · Cited by 49

Postbiotics, Metabolic Signaling, and Cancer

Vrzáčková, N., Ruml, T., & Zelenka, J. (2021) · Molecules · doi:10.3390/molecules26061528 · Cited by 41

Regulation of immune-driven pathogenesis in Parkinson’s disease by gut microbiota

Zheng, W., He, R., Yan, Z., Huang, Y., Huang, W., Cai, Z., Su, Y., Liu, S., Deng, Y., Wang, Q., et al. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.01.009 · Cited by 40

Emerging role of nutritional short-chain fatty acids (SCFAs) against cancer via modulation of hematopoiesis

Thiruvengadam, M., Subramanian, U., Venkidasamy, B., Thirupathi, P., Samynathan, R., Shariati, M. A., Ребезов, М. Б., Chung, I., & Rengasamy, K. R. R. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.1954874 · Cited by 40

Achievement of Tolerance Induction to Prevent Acute Graft-vs.-Host Disease

Thangavelu, G., & Blazar, B. R. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00309 · Cited by 37

Gut microbiota mediate the protective effects on endometritis induced by Staphylococcus aureus in mice

Hu, X., Mu, R., Xu, M., Yuan, X., Jiang, P., Guo, J., Cao, Y., Zhang, N., & Fu, Y. (2020) · Food & Function · doi:10.1039/c9fo02963j · Cited by 39

Melatonin-Mediated Colonic Microbiota Metabolite Butyrate Prevents Acute Sleep Deprivation-Induced Colitis in Mice

Gao, T., Wang, Z., Dong, Y., Cao, J., & Chen, Y. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111894 · Cited by 38

Association of Intestinal Microbial Dysbiosis With Chronic Obstructive Pulmonary Disease

Ananya, F. N., Ahammed, M. R., Fahem, M. M. M., Kafle, S., Viswanathan, M., Desai, D. M., Akku, R., Khan, F., Hernandez, T. E., Bala, S. K., et al. (2021) · Cureus · doi:10.7759/cureus.19343 · Cited by 39

Immunomodulation by foods and microbes: Unravelling the molecular tango

Forde, B. M., Yao, L., Shaha, R., Murphy, S., Lunjani, N., & O’Mahony, L. (2022) · Allergy · doi:10.1111/all.15455 · Cited by 35

Role of microbiome and its metabolite, short chain fatty acid in prostate cancer

Yang, H. J., & Kim, J. H. (2023) · Korean journal of urology · doi:10.4111/icu.20220370 · Cited by 35

Gut Microbiome and Colon Cancer: Role of Bacterial Metabolites and Their Molecular Targets in the Host

Bhutia, Y. D., Ogura, J., Sivaprakasam, S., & Ganapathy, V. (2017) · Current Colorectal Cancer Reports · doi:10.1007/s11888-017-0362-9 · Cited by 34

Microbial monotherapy with Prevotella histicola for patients with multiple sclerosis

Mangalam, A. K., & Murray, J. A. (2018) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2019.1555473 · Cited by 34

Progress in Research on Colorectal Cancer-Related Microorganisms and Metabolites

Han, S., Jing, Z., Wu, Y., Wu, W., & Yang, X. (2020) · Cancer Management and Research · doi:10.2147/cmar.s268943 · Cited by 34

Short-chain fatty acids reprogram metabolic profiles with the induction of reactive oxygen species production in human colorectal adenocarcinoma cells

Huang, C., Deng, W., Xu, H., Zhou, C., Zhang, F., Chen, J., Bao, Q., Zhou, X. H., Liu, M., Li, J., et al. (2023) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2023.02.022 · Cited by 33

Butyrate Ameliorates Mitochondrial Respiratory Capacity of The Motor-Neuron-like Cell Line NSC34-G93A, a Cellular Model for ALS

Li, X., Dong, L., Li, A., Yi, J., Brotto, M., & Zhou, J. (2022) · Biomolecules · doi:10.3390/biom12020333 · Cited by 33

Metabolic Activity of Intestinal Microflora in Patients with Bronchial Asthma

Ivashkin, V. T., Zolnikova, O. Y., Potskhverashvili, N. D., Трухманов, А. С., Kokina, N., Dzhakhaya, N., Sedova, A., & Леонидовна, Б. Е. (2019) · Clinics and Practice · doi:10.4081/cp.2019.1126 · Cited by 33

Role of the microbiome in the normal and aberrant glycemic response

Suez, J., Shapiro, H., & Elinav, E. (2016) · Clinical Nutrition Experimental · doi:10.1016/j.yclnex.2016.01.001 · Cited by 31

The Association of Gut Microbiota and Treg Dysfunction in Autoimmune Diseases

Liu, Y., Tran, D. Q., Lindsey, J. W., & Rhoads, J. M. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-981-15-6407-9_10 · Cited by 32

In Silico and in Vitro Interactions between Short Chain Fatty Acids and Human Histone Deacetylases.

Ho, R.-H., Chan, J., Fan, H., Kioh, D. Y. Q., Lee, B.-W., & Chan, E. C. (2017) · Biochemistry · doi:10.1021/acs.biochem.7b00508 · Cited by 28

The causal relationship between gut microbiota and leukemia: a two-sample Mendelian randomization study

Chen, G., Kuang, Z., Li, F., & Li, J. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1293333 · Cited by 31

Studying the Differences of Bacterial Metabolome and Microbiome in the Colon between Landrace and Meihua Piglets

Yan, S., Zhu, C., Yu, T. Y., Huang, W., Huang, J., Kong, Q., Shi, J., Chen, Z., Liu, Q., Wang, S., et al. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01812 · Cited by 31

Dental Biofilm Microbiota Dysbiosis Is Associated With the Risk of Acute Graft-Versus-Host Disease After Allogeneic Hematopoietic Stem Cell Transplantation

Heidrich, V., Bruno, J. S., Knebel, F. H., de Molla, V. C., Miranda‐Silva, W., Asprino, P. F., Tucunduva, L. T. C. D. M., Rocha, V., Novis, Y. A. S., Arrais‐Rodrigues, C., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.692225 · Cited by 30

Characteristic chromatographic fingerprint study of short-chain fatty acids in human milk, infant formula, pure milk and fermented milk by gas chromatography–mass spectrometry

Jiang, Z., Liu, Y., Zhu, Y., Yang, J., Sun, L., Chai, X., & Wang, Y. (2016) · International Journal of Food Sciences and Nutrition · doi:10.1080/09637486.2016.1195798 · Cited by 29

Microbiome-Derived Metabolites in Allogeneic Hematopoietic Stem Cell Transplantation

Masetti, R., Zama, D., Leardini, D., Muratore, E., Turroni, S., Brigidi, P., & Pession, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22031197 · Cited by 30

Research progress on the potential delaying skin aging effect and mechanism of tea for oral and external use

Feng, M., Zheng, X., Wan, J., Pan, W., Xie, X., Hu, B., Wang, Y., Wen, H., & Cai, S. (2021) · Food & Function · doi:10.1039/d0fo02921a · Cited by 29

Autoinducer-2 promotes the colonization of Lactobacillus rhamnosus GG to improve the intestinal barrier function in a neonatal mouse model of antibiotic-induced intestinal dysbiosis

Hu, R., Yang, T., Ai, Q., Shi, Y., Ji, Y.-C., Sun, Q., Tong, B., Chen, J., & Wang, Z. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-04991-5 · Cited by 28

Protective effects of sodium butyrate on rotavirus inducing endoplasmic reticulum stress-mediated apoptosis via PERK-eIF2α signaling pathway in IPEC-J2 cells

Zhao, Y., Hu, N., Jiang, Q. L., Zhu, L., Zhang, M., Jiang, J. H., Xiong, M., Yang, M., Yang, J., Shen, L., et al. (2021) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-021-00592-0 · Cited by 27

Regulation of the Expression of SARS-CoV-2 Receptor Angiotensin-Converting Enzyme 2 in Nasal Mucosa

Takabayashi, T., Yoshida, K., Imoto, Y., Schleimer, R. P., & Fujieda, S. (2021) · American Journal of Rhinology and Allergy · doi:10.1177/19458924211027798 · Cited by 28

Propionibacterium acnes Induces Autophagy in Keratinocytes: Involvement of Multiple Mechanisms

Megyeri, K., Orosz, L. I., Bolla, B. S., Erdei, L., Rázga, Z., Seprényi, G., Urbán, E. Z., Szabó, K., & Kemény, L. V. (2017) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2017.11.018 · Cited by 28

Effects of niacin on intestinal epithelial Barrier, intestinal Immunity, and microbial community in weaned piglets challenged by PDCoV

Chen, Y., Li, P., Zhen, R., Wang, L., Feng, J., Xie, Y., Yang, B., Xiong, Y., Niu, J., Wu, Q., et al. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.109054 · Cited by 25

Monomethyl fumarate inhibits pain behaviors and amygdala activity in a rat arthritis model

Kim, H., Thompson, J. M., Ji, G., Ganapathy, V., & Neugebauer, V. (2017) · Pain · doi:10.1097/j.pain.0000000000001042 · Cited by 25

Effects of dietary soluble or insoluble fiber intake in late gestation on litter performance, milk composition, immune function, and redox status of sows around parturition

Liu, Y., Chen, N., Li, D., Li, H., Fang, Z., Lin, Y., Xu, S., Feng, B., Zhuo, Y., Wu, D., et al. (2020) · Journal of Animal Science · doi:10.1093/jas/skaa303 · Cited by 25

The Role of Butyric Acid and Microorganisms in Chronic Inflammatory Diseases and Microbiome-Based Therapeutics

Liu, Z., Jiang, Y., Fan, Q., Li, S., & Wang, Y. (2025) · Journal of Inflammation Research · doi:10.2147/jir.s540163 · Cited by 24

Polycystic ovary syndrome and iron overload: biochemical link and underlying mechanisms with potential novel therapeutic avenues

Mathew, M., Sivaprakasam, S., Phy, J. L., Bhutia, Y. D., & Ganapathy, V. (2022) · Bioscience Reports · doi:10.1042/bsr20212234 · Cited by 25

Butyrate Ameliorates Intraocular Bacterial Infection by Promoting Autophagy and Attenuating the Inflammatory Response

Singh, S., Singh, P. K., & Kumar, A. (2022) · Infection and Immunity · doi:10.1128/iai.00252-22 · Cited by 23

The roles of ABCB1/P-glycoprotein drug transporters in regulating gut microbes and inflammation: insights from animal models, old and new

Stoeltje, L., Luc, J. K., Haddad, T., & Schrankel, C. S. (2024) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2023.0074 · Cited by 24

SLC6A14 deficiency is linked to obesity, fatty liver, and metabolic syndrome but only under conditions of a high-fat diet

Sivaprakasam, S., Sikder, M. O. F., Ramalingam, L., Kaur, G., Dufour, J. M., Moustaïd‐Moussa, N., Wachtel, M. S., & Ganapathy, V. (2021) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2021.166087 · Cited by 24

Cell-based screening assay for anti-inflammatory activity of bioactive compounds

Meijer, K., Vonk, R. J., Priebe, M. G., & Roelofsen, H. (2014) · Food Chemistry · doi:10.1016/j.foodchem.2014.06.053 · Cited by 23

Does gut brain axis has an impact on Parkinson’s disease (PD)?

Elangovan, A., Dahiya, B., Kirola, L., Iyer, M., Jeeth, P., Maharaj, S., Kumari, N., Lakhanpal, V., Michel, T. M., Rao, K. R. S. S., et al. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102171 · Cited by 22

Gut–brain axis and environmental factors in Parkinson’s disease: bidirectional link between disease onset and progression

Park, S. J., Kim, K. W., & Lee, E. J. (2024) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-24-00994 · Cited by 27

Dissecting Microbiome-Derived SCFAs in Prostate Cancer: Analyzing Gut Microbiota, Racial Disparities, and Epigenetic Mechanisms

Miya, T. V., Marima, R. M., Damane, B. P., Ledet, E. M., & Dlamini, Z. (2023) · Cancers · doi:10.3390/cancers15164086 · Cited by 29

Gut microbes in gastrointestinal cancers

Wang, F., Song, M., Lu, X., Zhu, X., & Deng, J. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.03.037 · Cited by 21

Specific vaginal and gut microbiome and the anti-tumor effect of butyrate in cervical cancer women

Han, M., Wang, N., Han, W., Liu, X., Sun, T., & Xu, J. (2024) · Translational Oncology · doi:10.1016/j.tranon.2024.101902 · Cited by 23

Not Just an Alternative Energy Source: Diverse Biological Functions of Ketone Bodies and Relevance of HMGCS2 to Health and Disease

Suresh, V. V., Sivaprakasam, S., Bhutia, Y. D., Prasad, P. D., Thangaraju, M., & Ganapathy, V. (2025) · Biomolecules · doi:10.3390/biom15040580 · Cited by 19

Fecal levels of SCFA and BCFA during capecitabine in patients with metastatic or unresectable colorectal cancer

Ziemons, J., Aarnoutse, R., Heuft, A., Hillege, L. E., Waelen, J., de Vos‐Geelen, J., Iersel, L. V., van Hellemond, I. E. G., Creemers, G., Baars, A., et al. (2023) · Clinical and Experimental Medicine · doi:10.1007/s10238-023-01048-7 · Cited by 20

Effect of Short-Chain Fatty Acids on Inflammatory and Metabolic Function in an Obese Skeletal Muscle Cell Culture Model

Van, K., Burns, J. L., & Monk, J. M. (2024) · Nutrients · doi:10.3390/nu16040500 · Cited by 19

Exploring the Benefit of 2-Methylbutyric Acid in Patients Undergoing Hemodialysis Using a Cardiovascular Proteomics Approach

Wu, P., Chiu, Y., Zou, H.-B., Hsu, C., Lee, S., Lin, Y., Tsai, Y., Kuo, M., & Hwang, S. (2019) · Nutrients · doi:10.3390/nu11123033 · Cited by 19

Niacin modulates depressive-like behavior in experimental colitis through GPR109A-dependent mechanisms

Wadie, W., Mohamed, S. S., El-Haleim, E. A. A., & Khayyal, M. T. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.122004 · Cited by 18

Involvement of butyrate in electrogenic K+ secretion in rat rectal colon

Inagaki, A., Hayashi, M., Andharia, N., & Matsuda, H. (2018) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-018-2208-y · Cited by 18

Diet, lipids and colon cancer

Choi, S., & Snider, A. J. (2019) · International review of cytology · doi:10.1016/bs.ircmb.2019.07.001 · Cited by 17

Obesity, cancer, and response to immune checkpoint inhibitors: Could the gut microbiota be the mechanistic link?

Delaye, M., Rousseau, A., Mailly-Giacchetti, L., Assoun, S., Sokol, H., & Neuzillet, C. (2023) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2023.108442 · Cited by 19

Gut microbiota: a perspective for colorectal cancer

Milani, P. G., Soleimani, R. A., Khani, N., & Rad, A. H. (2023) · Gastrointestinal Nursing · doi:10.12968/gasn.2023.21.7.26 · Cited by 19

Noval advance of histone modification in inflammatory skin diseases and related treatment methods

Zhang, L., Chai, R., Tai, Z., Miao, F., Shi, X., Chen, Z., & Zhu, Q. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1286776 · Cited by 18

Butyrate reduction and HDAC4 increase underlie maternal high fructose-induced metabolic dysfunction in hippocampal astrocytes in female rats

Wu, K. L. H., Liu, W., Wu, C., Fu, M., Huang, H., Tain, Y., Liang, C., Hung, C., Chen, I., Hung, P., et al. (2024) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2024.109571 · Cited by 17

Immunomodulation of Avian Dendritic Cells under the Induction of Prebiotics

Zmrhal, V., & Sláma, P. (2020) · Animals · doi:10.3390/ani10040698 · Cited by 18

Effect of bioactive compounds in processed Camellia sinensis tea on the intestinal barrier

Chen, N., Yao, P., Farid, M. S., Zhang, T., Luo, Y., & Zhao, C. (2024) · Food Research International · doi:10.1016/j.foodres.2024.115383 · Cited by 15

Sodium Butyrate Enhances Intestinal Riboflavin Uptake via Induction of Expression of Riboflavin Transporter-3 (RFVT3)

Subramanian, V. S., Sabui, S., Heskett, C. W., & Said, H. M. (2018) · Digestive Diseases and Sciences · doi:10.1007/s10620-018-5305-z · Cited by 16

The role of gut microbiota in the treatment of irritable bowel syndrome

Leylabadlo, H. E., Heravi, F. S., Soltani, E., Abbasi, A., Kafil, H. S., Parsaei, M., Sanaie, S., Ahmadian, Z., & Ghotaslou, R. (2021) · Reviews in Medical Microbiology · doi:10.1097/mrm.0000000000000284 · Cited by 16

Gut microbiome influences efficacy of Endostatin combined with PD-1 blockade against colorectal cancer

Xu, J., Tian, Y., Zhao, B., Hu, D., Wu, S., Ma, J., & Yang, L. (2024) · Molecular Biomedicine · doi:10.1186/s43556-024-00200-3 · Cited by 16

Deficiency of Dietary Fiber in Slc5a8-Null Mice Promotes Bacterial Dysbiosis and Alters Colonic Epithelial Transcriptome towards Proinflammatory Milieu

Sivaprakasam, S., Ganapathy, P. K., Sikder, M., Elmassry, M., Ramachandran, S., Kottapalli, K., & Ganapathy, V. (2019) · Canadian Journal of Gastroenterology and Hepatology · doi:10.1155/2019/2543082 · Cited by 16

Multi-Omic Analyses Reveal Bifidogenic Effect and Metabolomic Shifts in Healthy Human Cohort Supplemented With a Prebiotic Dietary Fiber Blend

Kang, J. W., Tang, X., Walton, C. J., Brown, M. J., Brewer, R. A., Maddela, R. L., Zheng, J. J., Agus, J., & Zivkovic, A. M. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.908534 · Cited by 19

Models to Evaluate the Prebiotic Potential of Foods

Aquino, J. D. S., Batista, K. S., Menezes, F. N. D. D., Lins, P. P., Gomes, J. A. D. S., & da Silva, L. A. (2017) · InTech eBooks · doi:10.5772/intechopen.69174 · Cited by 17

A Proton-Coupled Transport System for β-Hydroxy-β-Methylbutyrate (HMB) in Blood–Brain Barrier Endothelial Cell Line hCMEC/D3

Higuchi, K., Sivaprakasam, S., Sennoune, S. R., Ogura, J., Bhutia, Y. D., Rueda, R., Pereira, S. L., & Ganapathy, V. (2021) · Nutrients · doi:10.3390/nu13093220 · Cited by 15

Pathogenesis of gout: Exploring more therapeutic target

Xiao, N., Xie, Z., He, Z., Xu, Y., Zheng, S., Wei, Y., Zhang, X., Shen, J., Wang, J., Tian, Y., et al. (2024) · International Journal of Rheumatic Diseases · doi:10.1111/1756-185x.15147 · Cited by 15

Colonic ketogenesis, a microbiota-regulated process, contributes to blood ketones and protects against colitis in mice

Bass, K. N., Sivaprakasam, S., Dharmalingam-Nandagopal, G., Thangaraju, M., & Ganapathy, V. (2024) · Biochemical Journal · doi:10.1042/bcj20230403 · Cited by 14

Gut Microbiome and Autism: Recent Advances and Future Perspectives

Liu, J., Zhang, M., & Kong, X. (2016) · North American Journal of Medicine and Science · Cited by 14

Effect of different dosages of sodium butyrate and niacin on growth, faecal microbiota and Vitamin B metabolism in weaned piglets

Zhen, R., Liu, C., Wei, C., Luo, Y., Hu, X., Liu, G., Yi, H., & Huang, Y. (2022) · Journal of Applied Microbiology · doi:10.1111/jam.15545 · Cited by 14

Metabolites: deciphering the molecular language between DCs and their environment

Minarrieta, L., Ghorbani, P., Sparwasser, T. D., & Berod, L. (2016) · Seminars in Immunopathology · doi:10.1007/s00281-016-0609-6 · Cited by 15

Gut Microorganisms and Neurological Disease Perspectives

Faruqui, N. A., Prium, D. H., Mowna, S. A., Ullah, M. A., Araf, Y., Sarkar, B., Zohora, U. S., & Rahman, M. S. (2021) · Future Neurology · doi:10.2217/fnl-2020-0026 · Cited by 15

Editorial: Human Microbiome: Symbiosis to Pathogenesis

Lee, L., Wong, S. H., Chin, S., Singh, V., & Mutalib, N. A. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.605783 · Cited by 17

Impact of non-digestible carbohydrates and prebiotics on immunity, infections, inflammation and vaccine responses: a systematic review of evidence in healthy humans and a discussion of mechanistic proposals

Tunc, H. A., Calder, P. C., Cait, A., Dodd, G. F., Gasaly, N., Guillemet, D., James, D., Korzeniowski, K. J., Lubkowska, A., Meynier, A., et al. (2025) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2025.2514700 · Cited by 22

The effect of delayed feeding post-hatch on caeca development in broiler chickens

Qu, Y., Kahl, S., Miska, K. B., Schreier, L. L., Russell, B., Elsasser, T. H., & Proszkowiec‐Weglarz, M. (2021) · British Poultry Science · doi:10.1080/00071668.2021.1912291 · Cited by 13

Alcohol use disorder, neuroinflammation, and intake of dietary fibers: a new approach for treatment

Pérez-Reytor, D., & Karahanian, E. (2022) · The American Journal of Drug and Alcohol Abuse · doi:10.1080/00952990.2022.2114005 · Cited by 13

Acetate Upregulates GPR43 Expression and Function via PI3K-AKT-SP1 Signaling in Mammary Epithelial Cells during Milk Fat Synthesis

Yang, Y., Liu, C., Zhang, C., Xu, Z., Zhang, L., Cui, Y., Wang, C., Lin, Y., & Hou, X. (2023) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.3c00965 · Cited by 12

In Vitro Targeted Delivery of Simvastatin and Niacin to Macrophages Using Mannan-Grafted Magnetite Nanoparticles

Rastegari, B., Talepoor, A. G., Khosropanah, S., & Doroudchi, M. (2023) · ACS Omega · doi:10.1021/acsomega.3c06389 · Cited by 12

Gut microbial dysbiosis in the pathogenesis of leukemia: an immune-based perspective

Goswami, M., & Bose, P. D. (2024) · Experimental Hematology · doi:10.1016/j.exphem.2024.104211 · Cited by 13

Lactucin reverses liver fibrosis by inhibiting TGF-β1/STAT3 signaling pathway and regulating short-chain fatty acids metabolism

Qin, D., Han, C. L., Gao, Y., Li, H., & Zhu, L. (2024) · Scientific Reports · doi:10.1038/s41598-024-70253-5 · Cited by 13

Cell-Surface and Nuclear Receptors in the Colon as Targets for Bacterial Metabolites and Its Relevance to Colon Health

Sivaprakasam, S., Bhutia, Y. D., Ramachandran, S., & Ganapathy, V. (2017) · Nutrients · doi:10.3390/nu9080856 · Cited by 79

A critical role for Slc5a8 in the suppression of colonic inflammation by commensal bacteria-derived metabolites (MUC9P.821)

Gurav, A., Singh, N., & Ganapathy, V. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.192.supp.199.8 · Cited by 2

From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites

Koh, A., De Vadder, F., Kovatcheva-Datchary, P., & Bäckhed, F. (2016) · Cell · doi:10.1016/j.cell.2016.05.041 · Cited by 7,070

A Molecular Mechanism For Suppression Of Colonic Inflammation By Gut Bacteria

Gurav, A., Singh, N., & Ganapathy, V. (2012) · The FASEB Journal · doi:10.1096/fasebj.26.1_supplement.1156.6

Protection Against Colonic Inflammation and Colon Cancer by Commensal Bacterial Metabolites: An Obligatory Role for the Short- Chain Fatty Acid Transporter Slc5a8

Gurav, A. (2014)