The DOI matches its Crossref record; 40 of the 41 references it cites were found in a registry or an index.
Epicardial fat: a new cardiovascular therapeutic target
Abstract
Epicardial fat is the visceral fat depot of the heart. Given its rapid metabolism, organ fat specificity and simple objective measurability, epicardial fat can serve as target for pharmaceutical agents targeting the adipose tissue. Epicardial fat has shown to significantly respond to thiazolidinediones, glucagon like peptide 1 receptor agonists, dipeptidyl peptidase-4 inhibitors and statins. Epicardial fat may represent a measurable risk factor and modifiable therapeutic target. Targeted pharmaceutical interventions may allow the epicardial fat to resume its physiological role. A drug-induced browning effect on epicardial fat suggests the development of pharmacological strategies to increase energy consumption. The potential of modulating the epicardial fat transcriptome with targeted pharmacological agents can open new avenues in the pharmacotherapy of cardio-metabolic diseases.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Given its rapid metabolism, organ fat specificity, and simple measurability, EAT serves as a modifiable therapeutic target for medications modulating the adipose tissue, such as the glucagon-like peptide-1 (GLP-1) receptor agonists [11].”
From Effects of Semaglutide Versus Dulaglutide on Epicardial Fat Thickness in Subjects with Type 2 Diabetes and Obesity (2020) · cites this paper as [11]
Citations
Cites
Human epicardial adipose tissue is a source of inflammatory mediators
Mazurek, T., Zhang, L., Zalewski, A., Mannion, J. D., Diehl, J. T., Arafat, H., Sarov-Blat, L., O’Brien, S., Keiper, E. A., Johnson, A. G., et al. (2003) · Circulation · doi:10.1161/01.cir.0000099542.57313.c5 · Cited by 1,966
Epicardial adipose tissue: Anatomic, biomolecular and clinical relationships with the heart
Iacobellis, G., Corradi, D., & Sharma, A. M. (2005) · Nature Clinical Practice Cardiovascular Medicine · doi:10.1038/ncpcardio0319 · Cited by 1,015
Self-citationIacobellis, G., Ribaudo, M. C., Assael, F., Vecci, E., Tiberti, C., Zappaterreno, A., Di Mario, U., & Leonetti, F. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030698 · Cited by 842
Epicardial fat from echocardiography: A new method for visceral adipose tissue prediction
Iacobellis, G., Assael, F., Ribaudo, M. C., Zappaterreno, A., Alessi, G., Di Mario, U., & Leonetti, F. (2003) · Obesity Research · doi:10.1038/oby.2003.45 · Cited by 779
Echocardiographic epicardial fat: a review of research and clinical applications
Iacobellis, G., & Willens, H. J. (2009) · Journal of the American Society of Echocardiography · doi:10.1016/j.echo.2009.10.013 · Cited by 700
Epicardial adipose tissue: emerging physiological, pathophysiological and clinical features
Iacobellis, G., & Bianco, A. C. (2011) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2011.07.003 · Cited by 612
Local and systemic effects of the multifaceted epicardial adipose tissue depot
Iacobellis, G. (2015) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2015.58 · Cited by 605
GLP-1 agonism stimulates brown adipose tissue thermogenesis and browning through hypothalamic AMPK
Beiroa, D., Imbernon, M., Gallego, R., Senra, A., Herranz, D., Villarroya, F., Serrano, M., Fernø, J., Salvador, J., Escalada, J., et al. (2014) · Diabetes · doi:10.2337/db14-0302 · Cited by 602
Mahabadi, A. A., Berg, M. H., Lehmann, N., Kälsch, H., Bauer, M., Kara, K., Dragano, N., Moebus, S., Jöckel, K.-H., Erbel, R., et al. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2012.11.062 · Cited by 529
Shah, Z., Kampfrath, T., Deiuliis, J. A., Zhong, J., Pineda, C. A., Ying, Z., Xu, X., Lü, B., Moffatt, S. D., Durairaj, R., et al. (2011) · Circulation · doi:10.1161/circulationaha.111.041418 · Cited by 378
Flagged first, then by citations
1 of the 41 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Iacobellis, 2014, Epícardial fat thickness and nonalcoholic fatty liver disease in obese subjects, Obesity (Silver Spring), 22, 332, 10.1002/oby.20624 · DOI
Cited by
Sorted by citations
Epicardial adipose tissue in contemporary cardiology
Iacobellis, G. (2022) · Nature Reviews Cardiology · doi:10.1038/s41569-022-00679-9 · Cited by 797
Self-citationLiraglutide causes large and rapid epicardial fat reduction
Iacobellis, G., Mohseni, M., Bianco, S. D., & Banga, P. K. (2017) · Obesity · doi:10.1002/oby.21718 · Cited by 251
Self-citationLivshits, G., & Kalinkovich, A. (2019) · Ageing Research Reviews · doi:10.1016/j.arr.2019.100980 · Cited by 245
Iacobellis, G., & Villasante Fricke, A. C. (2020) · Journal of the Endocrine Society · doi:10.1210/jendso/bvz042 · Cited by 168
Clinical importance of epicardial adipose tissue
Nagy, E., Jermendy, A. L., Merkely, B., & Maurovich-Horvat, P. (2017) · Archives of Medical Science · doi:10.5114/aoms.2016.63259 · Cited by 121
Metadata
- Authors
- Iacobellis, G.
- Affiliations
- University of Miami (US)
- Corresponding author
- Iacobellis, Gianluca
- ORCID
- Iacobellis, Gianluca
- Venue
- Current Opinion in Pharmacology
- Publisher
- Elsevier BV
- Published
- 2016-04
- Volume
- 27
- Pages
- 13-18
- ISSN
- 1471-4892 (ISSN-L)
- OpenAlex
- W2262304120
- Cited by
- 104
- References
- 41
- Citations by year
- 2026: 8 · 2025: 5 · 2024: 10 · 2023: 10 · 2022: 11 · 2021: 6 · 2020: 15 · 2019: 12 · 2018: 10 · 2017: 10 · 2016: 7
- FWCI
- 2.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- epicardial adipose tissue, visceral adipose tissue, thiazolidinediones, GLP-1 receptor agonists, DPP-4 inhibitors, statins, energy expenditure, cardiometabolic disease, adipose tissue metabolism
- MeSH terms
- Adipose Tissue, Animals, Cardiovascular Agents, Cardiovascular Diseases, Cardiovascular System, Fats, Humans, Pericardium, Risk Factors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
