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Epicardial fat: a new cardiovascular therapeutic target
Abstract
Epicardial fat is the visceral fat depot of the heart. Given its rapid metabolism, organ fat specificity and simple objective measurability, epicardial fat can serve as target for pharmaceutical agents targeting the adipose tissue. Epicardial fat has shown to significantly respond to thiazolidinediones, glucagon like peptide 1 receptor agonists, dipeptidyl peptidase-4 inhibitors and statins. Epicardial fat may represent a measurable risk factor and modifiable therapeutic target. Targeted pharmaceutical interventions may allow the epicardial fat to resume its physiological role. A drug-induced browning effect on epicardial fat suggests the development of pharmacological strategies to increase energy consumption. The potential of modulating the epicardial fat transcriptome with targeted pharmacological agents can open new avenues in the pharmacotherapy of cardio-metabolic diseases.
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“Given its rapid metabolism, organ fat specificity, and simple measurability, EAT serves as a modifiable therapeutic target for medications modulating the adipose tissue, such as the glucagon-like peptide-1 (GLP-1) receptor agonists [11].”
From Effects of Semaglutide Versus Dulaglutide on Epicardial Fat Thickness in Subjects with Type 2 Diabetes and Obesity (2020) · cites this paper as [11]
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Metadata
- Authors
- Iacobellis, G.
- Affiliations
- University of Miami (US)
- Corresponding author
- Iacobellis, Gianluca
- ORCID
- Iacobellis, Gianluca
- Venue
- Current Opinion in Pharmacology
- Publisher
- Elsevier BV
- Published
- 2016-04
- Volume
- 27
- Pages
- 13-18
- ISSN
- 1471-4892 (ISSN-L)
- OpenAlex
- W2262304120
- Cited by
- 104
- References
- 41
- Citations by year
- 2026: 8 · 2025: 5 · 2024: 10 · 2023: 10 · 2022: 11 · 2021: 6 · 2020: 15 · 2019: 12 · 2018: 10 · 2017: 10 · 2016: 7
- FWCI
- 2.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- epicardial adipose tissue, visceral adipose tissue, thiazolidinediones, GLP-1 receptor agonists, DPP-4 inhibitors, statins, energy expenditure, cardiometabolic disease, adipose tissue metabolism
- MeSH terms
- Adipose Tissue, Animals, Cardiovascular Agents, Cardiovascular Diseases, Cardiovascular System, Fats, Humans, Pericardium, Risk Factors
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