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Loss of Individual MicroRNAs Causes Mutant Phenotypes in Sensitized Genetic Backgrounds in C. elegans
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“Yet, in physiological contexts, their individual impact may be less noticeable due to compensatory mechanisms and functional redundancy among several miRNAs and/or their targetomes [110], as it is exemplified by miRNA knockout models showing a phenotype only in combination with an additional stress-inducing factor [111, 112].”
From microRNA-132 attenuates inflammation in induced pluripotent stem cell-derived microglia from Alzheimer’s disease patients (2026) · cites this paper as [112]
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Most Caenorhabditis elegans microRNAs Are Individually Not Essential for Development or Viability
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“elegans, the majority of individual miRNAs are not required for viability or for development, as most loss of function miRNA mutants display no obvious developmental abnormalities [1].”
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Research works printed but not linked: 31
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Cited by
Sorted by citations
Pervasive roles of microRNAs in cardiovascular biology
Small, E. M., & Olson, E. N. (2011) · Nature · doi:10.1038/nature09783 · Cited by 1,180
Evolution of microRNA diversity and regulation in animals
Berezikov, E. (2011) · Nature Reviews Genetics · doi:10.1038/nrg3079 · Cited by 712
MicroRNAs shape the neuronal landscape
McNeill, E., & Van Vactor, D. (2012) · Neuron · doi:10.1016/j.neuron.2012.07.005 · Cited by 274
MicroRNAs and neurodegeneration: role and impact
Abe, M., & Bonini, N. M. (2013) · Trends in Cell Biology · doi:10.1016/j.tcb.2012.08.013 · Cited by 190
Xu, B., Hsu, P.-K., Stark, K. L., Karayiorgou, M., & Gogos, J. A. (2013) · Cell · doi:10.1016/j.cell.2012.11.052 · Cited by 145
Control by a hair’s breadth: the role of microRNAs in the skin
Ning, M. S., & Andl, T. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1117-z · Cited by 48
Penning, A., Snoeck, S., Ormaechea, O. R., Ayyildiz, D., Polzer, O., Buitrago-Arango, M., Capobianco, R., de Winter, F., Balusu, S., Verhaagen, J., et al. (2026) · Acta Neuropathologica Communications · doi:10.1186/s40478-026-02228-8 · Cited by 6
Metadata
- Authors
- Brenner, J. L., Jasiewicz, K. L., Fahley, A. F., Kemp, B. J., & Abbott, A. L.
- Venue
- Current Biology
- Publisher
- Elsevier BV
- Published
- 2010-07
- Volume
- 20
- Issue
- 14
- Pages
- 1321-1325
- ISSN
- 0960-9822
- PMC
- PMC2946380
- Cited by
- 123
- References
- 1
- Language
- en
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