Cited by 86Memory and Neural MechanismsSleep and Wakefulness ResearchMemory Processes and Influences

Post-learning hippocampal replay selectively reinforces spatial memory for highly rewarded locations

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Michon, Frédéric, Sun, Jyh-Jang, Kim, Chae Young, Ciliberti, Davide, Kloosterman, Fabian·2019·Current Biology

Abstract

Offline replay of hippocampal neural patterns supports the acquisition of new tasks in novel contexts, but its contribution to consolidation of salient experiences in a familiar context is unknown. Here, we show that in a highly familiar spatial memory task, large rewards selectively enhanced performance for demanding task configurations. The reward-related enhancement was sensitive to ripple-specific disruption, and the proportion of replay events positively correlated with reward size and task demands. Hippocampal replay thus selectively enhances memory of highly rewarded locations in a familiar context.

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Crossref · 10.1016/j.cub.2019.03.048

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  • Representations of rewarded spatial locations are preferentially reactivated in both wake and sleep states, although there are also findings of a bias in the opposite direction.

    “representations of rewarded spatial locations are preferentially reactivated in both wake and sleep states, 80,81,[142][143][144] although there are also findings of a bias of reactivations in the opposite direction.”

    From Sleep—A brain-state serving systems memory consolidation (2023) · cites this paper as [143]

    The Discussion (p. 8) reports a bias toward replay of the highly rewarded arm during awake learning and the subsequent rest period. The Results (p. 5) describe the delay period as quiescence, not a measured sleep state, so this paper does not establish preferential reactivation specifically during sleep. The opposite-direction finding appears after the citation and is not attributed to this source. (LLM, conf=0.86)

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Research works printed but not linked: 1

  1. [32]32. [Silva,D.,Feng,T.,andFoster,D.J.(2015).Trajectoryeventsacrosshippocampal place cells require previous experience. Nat. Neurosci. 18 , 1772-1779.](http://refhub.elsevier.com/S0960-9822(19)30346-X/sref32)

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Authors
Michon, F., Sun, J.-J., Kim, C. Y., Ciliberti, D., & Kloosterman, F.
Affiliations
  • Vlaams Instituut voor Biotechnologie (BE)
  • IMEC (BE)
  • Seoul National University (KR)
Corresponding author
Kloosterman, Fabian
Venue
Current Biology
Publisher
Elsevier BV
Published
2019-05
Volume
29
Issue
9
Pages
1436-1444.e5
ISSN
0960-9822 (ISSN-L)
OpenAlex
W2941554531
Cited by
86
References
52
Citations by year
2026: 4 · 2025: 14 · 2024: 12 · 2023: 14 · 2022: 10 · 2021: 14 · 2020: 12 · 2019: 5 · 2018: 1
FWCI
5.92
Type
journal article
Language
en
Open access
Locations
  • Current Biology (publishedVersion)
  • PubMed (publishedVersion)
  • Lirias (submittedVersion, other-oa)
Funders
  • Fonds Wetenschappelijk Onderzoek (G0D7516N)
  • KU Leuven (C14/17/042)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
Keywords
hippocampal replay, spatial memory, reward, hippocampal ripples, memory enhancement, task demands
MeSH terms
Animals, Food Deprivation, Hippocampus, Male, Reinforcement, Psychology, Reward, Rats, Long-Evans, Rats, Spatial Memory

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