Post-learning hippocampal replay selectively reinforces spatial memory for highly rewarded locations
Open accessAbstract
Offline replay of hippocampal neural patterns supports the acquisition of new tasks in novel contexts, but its contribution to consolidation of salient experiences in a familiar context is unknown. Here, we show that in a highly familiar spatial memory task, large rewards selectively enhanced performance for demanding task configurations. The reward-related enhancement was sensitive to ripple-specific disruption, and the proportion of replay events positively correlated with reward size and task demands. Hippocampal replay thus selectively enhances memory of highly rewarded locations in a familiar context.
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Representations of rewarded spatial locations are preferentially reactivated in both wake and sleep states, although there are also findings of a bias in the opposite direction.
“representations of rewarded spatial locations are preferentially reactivated in both wake and sleep states, 80,81,[142][143][144] although there are also findings of a bias of reactivations in the opposite direction.”
From Sleep—A brain-state serving systems memory consolidation (2023) · cites this paper as [143]
The Discussion (p. 8) reports a bias toward replay of the highly rewarded arm during awake learning and the subsequent rest period. The Results (p. 5) describe the delay period as quiescence, not a measured sleep state, so this paper does not establish preferential reactivation specifically during sleep. The opposite-direction finding appears after the citation and is not attributed to this source. (LLM, conf=0.86)
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Replay as a Basis for Backpropagation Through Time in the Brain
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A unifying account of replay as context-driven memory reactivationPreprint
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Proactive and reactive construction of memory-based preferences
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An open-source, ready-to-use and validated ripple detector plugin for the Open Ephys GUI
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Exposure to sounds during sleep impairs hippocampal sharp wave ripples and memory consolidationPreprint
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A unifying account of replay as context-driven memory reactivationPreprint
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A unifying account of replay as context-driven memory reactivationPreprint
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- Authors
- Michon, F., Sun, J.-J., Kim, C. Y., Ciliberti, D., & Kloosterman, F.
- Affiliations
- Vlaams Instituut voor Biotechnologie (BE)
- IMEC (BE)
- Seoul National University (KR)
- Corresponding author
- Kloosterman, Fabian
- Venue
- Current Biology
- Publisher
- Elsevier BV
- Published
- 2019-05
- Volume
- 29
- Issue
- 9
- Pages
- 1436-1444.e5
- ISSN
- 0960-9822 (ISSN-L)
- OpenAlex
- W2941554531
- Cited by
- 86
- References
- 52
- Citations by year
- 2026: 4 · 2025: 14 · 2024: 12 · 2023: 14 · 2022: 10 · 2021: 14 · 2020: 12 · 2019: 5 · 2018: 1
- FWCI
- 5.92
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Current Biology (publishedVersion)
- PubMed (publishedVersion)
- Lirias (submittedVersion, other-oa)
- Funders
- Fonds Wetenschappelijk Onderzoek (G0D7516N)
- KU Leuven (C14/17/042)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Keywords
- hippocampal replay, spatial memory, reward, hippocampal ripples, memory enhancement, task demands
- MeSH terms
- Animals, Food Deprivation, Hippocampus, Male, Reinforcement, Psychology, Reward, Rats, Long-Evans, Rats, Spatial Memory
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