Place cells in the hippocampus: Eleven maps for eleven rooms
Open accessAbstract
Significance: The hippocampus is thought to store a large number of experiences that, despite their similarity, can be individually retrieved with minimal interference. Studies have shown that place cells in hippocampal area CA3 form statistically independent representations of pairs of environments. It has remained unclear, however, whether CA3 place cells maintain this independence when the number of environments is increased. We recorded activity from CA3 in 11 environments with nearly identical geometric features. Spatial firing patterns remained uncorrelated across all 55 pairs of environments, with minimal overlap in the populations of active cells. The data suggest that the capacity of the CA3 network is large and speak against extensive recurrence of spatial motifs across experiences.
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Mammalian PCs are notable for their representational flexibility, while other spatial cells exhibit more coherent shifts across environments.
“Mammalian PCs are notable for their representational flexibility10,40,41, while other spatial cells exhibit more coherent shifts across environments42–44.”
From A population code for spatial representation in the zebrafish telencephalon (2024) · cites this paper as [41]
Remapping is thought to underlie the ability of the HPC to store multiple unique representations of similar environments or altered states of the same environment.
“Remapping is thought to underlie the ability of the HPC to store multiple unique representations of similar environments or altered states of the same environment 12 .”
From From cognitive maps to spatial schemas (2023) · cites this paper as [12]
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- Authors
- Alme, C. B., Miao, C., Jezek, K., Treves, A., Moser, E. I., & Moser, M.-B.
- Affiliations
- Norwegian University of Science and Technology (NO)
- Kavli Institute for Systems Neuroscience and Centre for Neural Computation, Norwegian University of Science and Technology, 7491 Trondheim, Norway;
- Scuola Internazionale Superiore di Studi Avanzati (IT)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2014-12-08
- Volume
- 111
- Issue
- 52
- Pages
- 18428-18435
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC4284589
- OpenAlex
- W2001783678
- Cited by
- 296
- References
- 36
- Citations by year
- 2026: 20 · 2025: 33 · 2024: 35 · 2023: 28 · 2022: 28 · 2021: 24 · 2020: 20 · 2019: 40 · 2018: 21 · 2017: 18 · 2016: 15 · 2015: 14
- FWCI
- 8.74
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- SDL (submittedVersion)
- BIBSYS Brage (BIBSYS (Norway)) (submittedVersion)
- NORA - Norwegian Open Research Archives (submittedVersion, other-oa)
- Funders
- EC | European Research Council (ERC) (268598)
- Kavli Foundation (No number)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Physical Sciences › Engineering › Automotive Engineering › Spatial Cognition and Navigation
- Keywords
- place cells, hippocampus, CA3, episodic memory, spatial firing patterns, orthogonal representations, memory capacity, spatial maps, rats
- MeSH terms
- Animals, Behavior, Animal, Brain Mapping, Male, Nerve Net, Rats, Long-Evans, Rats, CA3 Region, Hippocampal
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