TGF-β Superfamily Signaling in Embryonic Development and Homeostasis

TGFβ in Cancer

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Epithelial-Mesenchymal Transition: At the Crossroads of Development and Tumor Metastasis

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Smad transcription factors

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SPECIFICITY AND VERSATILITY IN TGF-β SIGNALING THROUGH SMADS

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SMAD proteins control DROSHA-mediated microRNA maturation

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New insights into TGF-β–Smad signalling

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Distinct endocytic pathways regulate TGF-β receptor signalling and turnover

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Regulation of the Polarity Protein Par6 by TGFß Receptors Controls Epithelial Cell Plasticity

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Extracellular control of TGFβ signalling in vascular development and disease

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A combined syndrome of juvenile polyposis and hereditary haemorrhagic telangiectasia associated with mutations in MADH4 ( SMAD4)

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A gene regulatory network orchestrates neural crest formation

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Regulation of neural induction by the Chd and Bmp-4 antagonistic patterning signals in Xenopus

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Activin Receptor-like Kinase (ALK)1 Is an Antagonistic Mediator of Lateral TGFβ/ALK5 Signaling

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Clathrin-Mediated Internalization Is Essential for Sustained EGFR Signaling but Dispensable for Degradation

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DORSAL-VENTRAL PATTERNING AND NEURAL INDUCTION IN XENOPUS EMBRYOS

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TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal

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Zebrafish organizer development and germ-layer formation require nodal-related signals

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Role of transforming growth factor-β superfamily signaling pathways in human disease

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Nodal Signaling in Vertebrate Development

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TGFβ1 Inhibits the Formation of Benign Skin Tumors, but Enhances Progression to Invasive Spindle Carcinomas in Transgenic Mice

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Genetic Analysis of the Roles of BMP2, BMP4, and BMP7 in Limb Patterning and Skeletogenesis

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TRAF6 Mediates Smad-Independent Activation of JNK and p38 by TGF-β

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Integrating Patterning Signals: Wnt/GSK3 Regulates the Duration of the BMP/Smad1 Signal

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The type I TGF-β receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner

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Alterations in components of the TGF-β superfamily signaling pathways in human cancer

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TGF‐β activates Erk MAP kinase signalling through direct phosphorylation of ShcA

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The molecular nature of zebrafish swirl: BMP2 function is essential during early dorsoventral patterning

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Target Protectors Reveal Dampening and Balancing of Nodal Agonist and Antagonist by miR-430

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The role of epithelial-to-mesenchymal transition in renal fibrosis

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Graded changes in dose of a Xenopus activin A homologue elicit stepwise transitions in embryonic cell fate

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PPM1A Functions as a Smad Phosphatase to Terminate TGFβ Signaling

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The Role of Maternal VegT in Establishing the Primary Germ Layers in Xenopus Embryos

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The molecular genetics of Marfan syndrome and related disorders

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Balancing BMP Signaling through Integrated Inputs into the Smad1 Linker

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Cleavage of Chordin by Xolloid Metalloprotease Suggests a Role for Proteolytic Processing in the Regulation of Spemann Organizer Activity

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Kinetics of Morphogen Gradient Formation

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Hematopoiesis Controlled by Distinct TIF1γ and Smad4 Branches of the TGFβ Pathway

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The Decapentaplegic morphogen gradient: from pattern formation to growth regulation

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How the Smads regulate transcription

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Nodal Signals to Smads through Cripto-Dependent and Cripto-Independent Mechanisms

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The zebrafish nodal-related gene southpaw is required for visceral and diencephalic left-right asymmetry

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Germ-Layer Specification and Control of Cell Growth by Ectodermin, a Smad4 Ubiquitin Ligase

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Disruption of human limb morphogenesis by a dominant negative mutation in CDMP1

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Multiple joint and skeletal patterning defects caused by single and double mutations in the mouse Gdf6 and Gdf5 genes

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SIGNALING PATHWAYS THAT ESTABLISH THE DORSAL-VENTRAL PATTERN OF THE DROSOPHILA EMBRYO

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Smad4 Dependency Defines Two Classes of Transforming Growth Factor β (TGF-β) Target Genes and Distinguishes TGF-β-Induced Epithelial-Mesenchymal Transition from Its Antiproliferative and Migratory Responses

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The zebrafish Nodal signal Squint functions as a morphogen

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Type IV collagens regulate BMP signalling in Drosophila

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Nodal antagonists regulate formation of the anteroposterior axis of the mouse embryo

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Nodal activity in the node governs left-right asymmetry

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Shaping BMP morphogen gradients in the Drosophila embryo and pupal wing

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Cooperative Assembly of TGF-β Superfamily Signaling Complexes Is Mediated by Two Disparate Mechanisms and Distinct Modes of Receptor Binding

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The evolutionarily conserved BMP-binding protein Twisted gastrulation promotes BMP signalling

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Transforming Growth Factor β-Induced Smad1/5 Phosphorylation in Epithelial Cells Is Mediated by Novel Receptor Complexes and Is Essential for Anchorage-Independent Growth

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GADD34–PP1c recruited by Smad7 dephosphorylates TGFβ type I receptor

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SMAD4 mutations found in unselected HHT patients

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Regulation of ADMP and BMP2/4/7 at Opposite Embryonic Poles Generates a Self-Regulating Morphogenetic Field

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Scaling of the BMP activation gradient in Xenopus embryos

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The BMP Signaling Gradient Patterns Dorsoventral Tissues in a Temporally Progressive Manner along the Anteroposterior Axis

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Activating and deactivating mutations in the receptor interaction site of GDF5 cause symphalangism or brachydactyly type A2

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Spatial bistability of Dpp–receptor interactions during Drosophila dorsal–ventral patterning

Wang, Y., & Ferguson, E. L. (2005) · Nature · doi:10.1038/nature03318 · Cited by 211

Integration of TGF-ß and Ras/MAPK Signaling Through p53 Phosphorylation

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FoxH1(Fast) functions to specify the anterior primitive streak in the mouse

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Mathematical modeling identifies Smad nucleocytoplasmic shuttling as a dynamic signal-interpreting system

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Pulmonary Hypertension Due to BMPR2 Mutation: A New Paradigm for Tissue Remodeling?

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MicroRNA control of Nodal signalling

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The activity of the Nodal antagonist Cerl-2 in the mouse node is required for correct L/R body axisPreprint

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TGFβ‐stimulated Smad1/5 phosphorylation requires the ALK5 L45 loop and mediates the pro‐migratory TGFβ switch

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Smads orchestrate specific histone modifications and chromatin remodeling to activate transcription

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Molecular Basis of Vertebrate Endoderm Development

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The BMP-Binding Protein Crossveinless 2 Is a Short-Range, Concentration-Dependent, Biphasic Modulator of BMP Signaling in Drosophila

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Functional differences among Xenopus nodal-related genes in left-right axis determination

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IKKα is a critical coregulator of a Smad4-independent TGFβ-Smad2/3 signaling pathway that controls keratinocyte differentiation

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Multiple Transforming Growth Factor-β Isoforms and Receptors Function during Epithelial-Mesenchymal Cell Transformation in the Embryonic Heart

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Zebrafish Bmp4 regulates left–right asymmetry at two distinct developmental time points

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A Simple Molecular Complex Mediates Widespread BMP-Induced Repression during Drosophila Development

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Cell-Type-Specific Activation of PAK2 by Transforming Growth Factor β Independent of Smad2 and Smad3

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Identification of phosphatases for Smad in the BMP/DPP pathwayPreprint

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Genome-wide Impact of the BRG1 SWI/SNF Chromatin Remodeler on the Transforming Growth Factor β Transcriptional Program

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The activity and signaling range of mature BMP-4 is regulated by sequential cleavage at two sites within the prodomain of the precursorPreprint

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Signalling by TGF-β family members: short-range effects of Xnr-2 and BMP-4 contrast with the long-range effects of activin

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Transcriptional regulation of the Drosophila gene zen by competing Smad and Brinker inputsPreprint

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The zebrafish dorsal axis is apparent at the four-cell stage

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A New Subtype of Brachydactyly Type B Caused by Point Mutations in the Bone Morphogenetic Protein Antagonist NOGGIN

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Unique players in the BMP pathway: Small C-terminal domain phosphatases dephosphorylate Smad1 to attenuate BMP signaling

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Vg1 is an essential signaling molecule in Xenopus development

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Crystal Structure Analysis Reveals How the Chordin Family Member Crossveinless 2 Blocks BMP-2 Receptor Binding

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Robust Stability of the Embryonic Axial Pattern Requires a Secreted Scaffold for Chordin Degradation

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Extracellular modulation of BMP activity in patterning the dorsoventral axis

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Physical properties of Tld, Sog, Tsg and Dpp protein interactions are predicted to help create a sharp boundary in Bmp signals during dorsoventral patterning of the Drosophila embryo

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Crossveinless 2 is an essential positive feedback regulator of Bmp signaling during zebrafish gastrulation

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Crossveinless-2 Is a BMP Feedback Inhibitor that Binds Chordin/BMP to Regulate Xenopus Embryonic Patterning

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Nodal Stability Determines Signaling Range

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Molecular Integration of Wingless, Decapentaplegic, and Autoregulatory Inputs into Distalless during Drosophila Leg Development

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