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Cited by 411

The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.

β-catenin Activity in the Dermal Papilla Regulates Morphogenesis and Regeneration of Hair

Open access
Enshell-Seijffers, David, Lindon, Catherine, Kashiwagi, Mariko, Morgan, Bruce A.·2010·Developmental Cell
DOI 10.1016/j.devcel.2010.01.016
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Abstract

SUMMARY The activity of keratinocytes in the hair follicle is regulated by signals from a specialized mesenchymal niche, the dermal papilla. Here, mice expressing cre recombinase in the dermal papilla were developed to probe the interaction between follicular keratinocyte populations and the dermal papilla in vivo. Inactivation of the β-catenin gene within the dermal papilla of fully developed hair follicles results in dramatically reduced proliferation of the progenitors and their immediate progeny that generate the hair shaft and, subsequently, premature induction of the destructive phase of the hair cycle (catagen). It also prevents regeneration of the cycling follicle from stem cells resident in the permanent portion of the follicle. Gene expression analysis reveals that β-catenin activity in the dermal papilla regulates at least two signaling pathways, FGF and IGF, that can mediate the inductive effects of the DP on keratinocytes. This study reveals a reciprocal signaling loop that employs Wnt/β-catenin signaling in both epithelial progenitor cells and their mesenchymal niche to govern and coordinate the interactions that are essential for the function of these two compartments.

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Metadata

Authors
Enshell-Seijffers, D., Lindon, C., Kashiwagi, M., & Morgan, B. A.
Venue
Developmental Cell
Publisher
Elsevier BV
Published
2010-04
Volume
18
Issue
4
Pages
633-642
ISSN
1534-5807 (ISSN-L)
DOI
10.1016/j.devcel.2010.01.016
OpenAlex
W2041819610
Cited by
411
References
40
FWCI
27.12
Type
journal article
Language
en
Open access
bronze

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