Pharmacotherapy to prevent PTSD: Results from a randomized controlled proof‐of‐concept trial in physically injured patients
Abstract
Acute physical injury is frequently associated with mental health sequelae, which then accentuate disability and worsen functional outcomes. A pharmacological prevention approach to this problem has been proposed. This proof‐of‐concept study was a double‐blind, randomized controlled trial of 14 days of the beta‐blocker propranolol ( n = 17), the anxiolytic anticonvulsant gabapentin ( n = 14), or placebo ( n = 17), administered within 48 hours of injury to patients admitted to a surgical trauma center. Of 569 accessible, potentially eligible subjects, 48 (8%) participated. Outcomes assessments were conducted at 1, 4, and 8 months postinjury. Although well tolerated, neither study drug showed a significant benefit over placebo on depressive or posttraumatic stress symptoms. Implications are discussed for future pharmacological prevention studies in survivors of acute traumatic injury.
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Prolonged administration of the beta-receptor blocking agent propranolol early after trauma did not result in fewer PTSD symptoms.
“Pharmacologically, prolonged administration of the beta-receptor blocking agent propranolol early after trauma did not result in fewer PTSD symptoms [13,14].”
From Efficacy of oxytocin administration early after psychotrauma in preventing the development of PTSD: study protocol of a randomized controlled trial (2014) · cites this paper as [14]
Administration of propranolol in the hours after trauma exposure does not prevent overall PTSD.
“although it does not prevent overall PTSD 69,70 .”
From Post‐traumatic stress disorder: a state‐of‐the‐art review of evidence and challenges (2019) · cites this paper as [69]
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- Authors
- Stein, M. B., Kerridge, C., Dimsdale, J. E., & Hoyt, D. B.
- Affiliations
- University of California San Diego (US)
- University of California, Irvine (US)
- Corresponding author
- Stein, Murray B.
- ORCID
- Stein, Murray B.
- Venue
- Journal of Traumatic Stress
- Publisher
- Wiley
- Published
- 2007-12
- Volume
- 20
- Issue
- 6
- Pages
- 923-932
- ISSN
- 0894-9867 (ISSN-L)
- 1573-6598
- OpenAlex
- W1974348021
- Cited by
- 249
- References
- 55
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 6 · 2023: 7 · 2022: 7 · 2021: 11 · 2020: 6 · 2019: 12 · 2018: 11 · 2017: 10 · 2016: 13 · 2015: 23 · 2014: 27 · 2013: 23 · 2012: 21
- FWCI
- 15.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Traumatic Stress (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r21mh062037-03)
- National Institute of Mental Health (K24MH064122, K24MH64122, R21MH62037)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
- Health Sciences › Medicine › Emergency Medicine › Trauma and Emergency Care Studies
- Keywords
- post-traumatic stress disorder, pharmacological prophylaxis, propranolol, gabapentin, beta-blockers, traumatic brain injury, depressive symptoms, posttraumatic stress symptoms
- MeSH terms
- Gabapentin, Adolescent, Adult, Amines, California, Cyclohexanecarboxylic Acids, Female, gamma-Aminobutyric Acid, Humans, Male, Middle Aged, Placebos, Propranolol, Stress Disorders, Post-Traumatic, Anti-Anxiety Agents, Vasodilator Agents, Wounds and Injuries
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