Mitotic catastrophe and cancer drug resistance: A link that must to be broken

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The DNA damage response and cancer therapy

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ATR: an essential regulator of genome integrity

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The DNA Damage Response: Ten Years After

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A Mitochondria-K+ Channel Axis Is Suppressed in Cancer and Its Normalization Promotes Apoptosis and Inhibits Cancer Growth

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DRAM, a p53-Induced Modulator of Autophagy, Is Critical for Apoptosis

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The ATM–Chk2 and ATR–Chk1 Pathways in DNA Damage Signaling and Cancer

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On the road to cancer: aneuploidy and the mitotic checkpoint

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ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks

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The role of the cyclin-dependent kinase inhibitor p21 in apoptosis.

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Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis

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Mitotic catastrophe: a mechanism for avoiding genomic instability

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From polyploidy to aneuploidy, genome instability and cancer

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Centrosome aberrations: cause or consequence of cancer progression?

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Aneuploidy and cancer

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If not apoptosis, then what? Treatment-induced senescence and mitotic catastrophe in tumor cells

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Histone H2AX phosphorylation: a marker for DNA damage.

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Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomesPreprint

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Shared and separate functions of polo-like kinases and aurora kinases in cancer

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Concerning the Origin of Malignant Tumours by Theodor Boveri. Translated and annotated by Henry Harris

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Centrosome Amplification Can Initiate Tumorigenesis in Flies

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Animal Cytokinesis: From Parts List to Mechanisms

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New Insights into Checkpoint Kinase 1 in the DNA Damage Response Signaling Network

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Antifolates in cancer therapy: Structure, activity and mechanisms of drug resistance

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Spindle Multipolarity Is Prevented by Centrosomal Clustering

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Aneuploidy: Cells Losing Their Balance

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Managing the centrosome numbers game: from chaos to stability in cancer cell division

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Chk2 activates E2F-1 in response to DNA damage

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A Clinical Overview of Centrosome Amplification in Human Cancers

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Survivin: A new target for anti-cancer therapy

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How do anti-mitotic drugs kill cancer cells?

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Parkinson's Disease–Associated Kinase PINK1 Regulates Miro Protein Level and Axonal Transport of Mitochondria

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The consequences of tetraploidy and aneuploidy

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Phosphorylation of Mcl‐1 by CDK1–cyclin B1 initiates its Cdc20‐dependent destruction during mitotic arrest

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Sustained Mps1 activity is required in mitosis to recruit O-Mad2 to the Mad1–C-Mad2 core complex

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Elevating the frequency of chromosome mis-segregation as a strategy to kill tumor cells

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DNA damage induces reactive oxygen species generation through the H2AX-Nox1/Rac1 pathway

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How cell death shapes cancer

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A positive feedback loop between the p53 and Lats2 tumor suppressors prevents tetraploidizationPreprint

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Spatiotemporal regulation of the anaphase-promoting complex in mitosis

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A threshold mechanism mediates p53 cell fate decision between growth arrest and apoptosis.

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Oxidative stress promotes pathologic polyploidization in nonalcoholic fatty liver disease

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PML-dependent apoptosis after DNA damage is regulated by the checkpoint kinase hCds1/Chk2

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Bub1 mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis

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The influence of subclonal resistance mutations on targeted cancer therapy

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TruncatingAPCmutations have dominant effects on proliferation, spindle checkpoint control, survival and chromosome stability

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Kinesin motor proteins as targets for cancer therapy

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Rationally designed nanovehicles to overcome cancer chemoresistance

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The cell cycle checkpoint kinase Chk2 is a negative regulator of mitotic catastrophe

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ATG5 is induced by DNA-damaging agents and promotes mitotic catastrophe independent of autophagy

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p53 protects against genome instability following centriole duplication failure

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DNA damage and innate immunity: links and trade-offs

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Regulatory networks integrating cell cycle control with DNA damage checkpoints and double-strand break repair

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p53 regulates a non-apoptotic death induced by ROS

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HPV 5 and 8 E6 Abrogate ATR Activity Resulting in Increased Persistence of UVB Induced DNA Damage

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Activation of DSB Processing Requires Phosphorylation of CtIP by ATR

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The Aneuploidy Paradox in Cell Growth and Tumorigenesis

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Damage alert

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iASPP and Chemoresistance in Ovarian Cancers: Effects on Paclitaxel-Mediated Mitotic Catastrophe

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