The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Relative Testosterone Deficiency in Older Men: Clinical Definition and Presentation
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“That younger men are more susceptible to fasting-induced HPT axis suppression than older men is in contrast with most other evidence suggesting that older age increases the risk of HPT axis dysfunction in response to physiologic stimuli and pathogenic stressors (6,7).”
From Dysregulation of the Hypothalamic-Pituitary-Testicular Axis due to Energy Deficit (2021) · cites this paper as [7]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Aging of skeletal muscle: a 12-yr longitudinal study
Frontera, W. R., Hughes, V. A., Fielding, R. A., Fiatarone, M. A., Evans, W. J., & Roubenoff, R. (2000) · Journal of Applied Physiology · doi:10.1152/jappl.2000.88.4.1321 · Cited by 1,443
Predictors of skeletal muscle mass in elderly men and women
Baumgartner, R. N., Waters, D. L., Gallagher, D., Morley, J. E., & Garry, P. J. (1999) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(98)00130-4 · Cited by 809 · cited 1×
“Baumgartner, 1999 [59] 121 77 (65–97) 0 Volunteer Handgrip ! 1”
Hughes, V. A., Frontera, W. R., Roubenoff, R., Evans, W. J., & Singh, M. A. F. (2002) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/76.2.473 · Cited by 804
Validation of a screening questionnaire for androgen deficiency in aging males
Morley, J. E., Charlton, E., Patrick, P., Kaiser, F. E., Cadeau, P., McCready, D., & Perry, H. M. (2000) · Metabolism · doi:10.1053/meta.2000.8625 · Cited by 662
Araujo, A. B., O’Donnell, A. B., Brambilla, D. J., Simpson, W. B., Longcope, C., Matsumoto, A. M., & McKinlay, J. B. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031719 · Cited by 591
Bhasin, S., Woodhouse, L., Casaburi, R., Singh, A. B., Mac, R. P., Lee, M., Yarasheski, K. E., Sinha-Hikim, I., Dzekov, C., Dzekov, J., et al. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1184 · Cited by 544 · cited 3×
“The speculation that older men are more prone to adverse effects of testosterone treatment (in particular prostate disease, raised hematocrit, and fluid retention) has been confirmed directly [16].”
BackgroundResultSeeman, T. E., Charpentier, P. A., Berkman, L. F., Tinetti, M. E., Guralnik, J. M., Albert, M., Blazer, D., & Rowe, J. W. (1994) · Journal of Gerontology · doi:10.1093/geronj/49.3.m97 · Cited by 522 · cited 2×
“These declines also are not universal [71], suggesting the possibility that selective preventative strategies are feasible.”
BackgroundEffect of Testosterone Treatment on Bone Mineral Density in Men Over 65 Years of Age
Snyder, P. J. (1999) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.84.6.1966 · Cited by 460
Aging, body composition, and lifestyle: the Fels Longitudinal Study
Guo, S. S., Zeller, C., Chumlea, W. C., & Siervogel, R. M. (1999) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/70.3.405 · Cited by 408
Aversa, A., Isidori, A. M., Spera, G., Lenzi, A., & Fabbri, A. (2003) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2003.01764.x · Cited by 343
Research works printed but not linked: 83
- Feldman, 2002, Age trends in the level of serum testosterone and other hormones in middle-aged men: longitudinal results from the Massachusetts male aging study, J Clin Endocrinol Metab, 87, 589, 10.1210/jcem.87.2.8201 · DOI · Paper page
- Harman, 2001, Longitudinal effects of aging on serum total and free testosterone levels in healthy men. Baltimore Longitudinal Study of Aging, J Clin Endocrinol Metab, 86, 724, 10.1210/jcem.86.2.7219 · DOI · Paper page
- Zitzmann, 2000, Hormone substitution in male hypogonadism, Mol Cell Endocrinol, 161, 73, 10.1016/S0303-7207(99)00227-0 · DOI
- Liu, 2005, Analysis of bidirectional pattern synchrony of concentration–secretion pairs: implementation in the human testicular and adrenal axes, Am J Physiol Regul Integr Comp Physiol, 288, R440, 10.1152/ajpregu.00414.2004 · DOI
- Smith, 2000, Construction and field validation of a self-administered screener for testosterone deficiency (hypogonadism) in ageing men, Clin Endocrinol (Oxf), 53, 703, 10.1046/j.1365-2265.2000.01152.x · DOI · Paper page
- McLachlan, 2004, Relationship between serum gonadotropins and spermatogenic suppression in men undergoing steroidal contraceptive treatment, J Clin Endocrinol Metab, 89, 142, 10.1210/jc.2003-030616 · DOI
- Conway, 2000, Use, misuse and abuse of androgens. The Endocrine Society of Australia consensus guidelines for androgen prescribing, Med J Aust, 172, 220, 10.5694/j.1326-5377.2000.tb123913.x · DOI
- McLachlan, 2004, Defining the prevalence and incidence of androgen deficiency in aging men: where are the goal posts?, J Clin Endocrinol Metab, 89, 5916, 10.1210/jc.2004-2035 · DOI
- Vasan, 2001, Impact of high-normal blood pressure on the risk of cardiovascular disease, N Engl J Med, 345, 1291, 10.1056/NEJMoa003417 · DOI · Paper page
- Writing Team for the Diabetes Control Complications Trial/Epidemiology of Diabetes Interventions Complications Research Group, 2003, Sustained effect of intensive treatment of type 1 diabetes mellitus on development and progression of diabetic nephropathy: the Epidemiology of Diabetes Interventions and Complications (EDIC) study, JAMA, 290, 2159, 10.1001/jama.290.16.2159 · DOI · Paper page
- Szulc, 2003, Increased risk of falls and increased bone resorption in elderly men with partial androgen deficiency: the MINOS study, J Clin Endocrinol Metab, 88, 5240, 10.1210/jc.2003-030200 · DOI
- Vermeulen, 2001, Androgen replacement therapy in the aging male—a critical evaluation, J Clin Endocrinol Metab, 86, 2380
- Vermeulen, 1999, A critical evaluation of simple methods for the estimation of free testosterone in serum, J Clin Endocrinol Metab, 84, 3666, 10.1210/jcem.84.10.6079 · DOI · Paper page
- Liu, 2003, Androgens and cardiovascular disease, Endocr Rev, 24, 313, 10.1210/er.2003-0005 · DOI · Paper page
- Kelleher, 2004, Blood testosterone threshold for androgen deficiency symptoms, J Clin Endocrinol Metab, 89, 3813, 10.1210/jc.2004-0143 · DOI
- Heinemann, 1999, A new aging males symptoms rating scale, Aging Male, 2, 105, 10.3109/13685539909003173 · DOI · Paper page
- Daig, 2003, The Aging Males Symptoms (AMS) scale: review of its methodological characteristics, Health Qual Life Outcomes, 1, 77, 10.1186/1477-7525-1-77 · DOI
- Moore, 2004, The Aging Males Symptoms scale (AMS) as outcome measure for treatment of androgen deficiency, Eur Urol, 46, 80, 10.1016/j.eururo.2004.01.009 · DOI
- Macfarlane, 1996, The relationship between sexual life and urinary condition in the French community, J Clin Epidemiol, 49, 1171, 10.1016/0895-4356(96)00213-2 · DOI
- Laumann, 1999, Sexual dysfunction in the United States: prevalence and predictors, JAMA, 281, 537, 10.1001/jama.281.6.537 · DOI · Paper page
- Blanker, 2001, Correlates for erectile and ejaculatory dysfunction in older Dutch men: a community-based study, J Am Geriatr Soc, 49, 436, 10.1046/j.1532-5415.2001.49088.x · DOI
- Shiri, 2003, Effect of chronic diseases on incidence of erectile dysfunction, Urology, 62, 1097, 10.1016/j.urology.2003.07.001 · DOI
- Pinnock, 1999, Erectile dysfunction in the community: a prevalence study, Med J Aust, 171, 353, 10.5694/j.1326-5377.1999.tb123691.x · DOI
- Morillo, 2002, Prevalence of erectile dysfunction in Colombia, Ecuador, and Venezuela: a population-based study (DENSA), Int J Impot Res, 14, S10, 10.1038/sj.ijir.3900893 · DOI
- Moreira, 2003, Incidence of erectile dysfunction in men 40- to 69-years old: results from a population-based cohort study in Brazil, Urology, 61, 431, 10.1016/S0090-4295(02)02158-1 · DOI
- Johannes, 2000, Incidence of erectile dysfunction in men 40- to 69-years old: longitudinal results from the Massachusetts male aging study, J Urol, 163, 460, 10.1016/S0022-5347(05)67900-1 · DOI · Paper page
- Panser, 1995, Sexual function of men ages 40 to 79 years: the Olmsted County Study of Urinary Symptoms and Health Status Among Men, J Am Geriatr Soc, 43, 1107, 10.1111/j.1532-5415.1995.tb07009.x · DOI
- Akkus, 2002, Prevalence and correlates of erectile dysfunction in Turkey: a population-based study, Eur Urol, 41, 298, 10.1016/S0302-2838(02)00027-1 · DOI
- Rosen, 2003, Lower urinary tract symptoms and male sexual dysfunction: the multi-national survey of the aging male (MSAM-7), Eur Urol, 44, 637, 10.1016/j.eururo.2003.08.015 · DOI · Paper page
- Buena, 1993, Sexual function does not change when serum testosterone levels are pharmacologically varied within the normal male range, Fertil Steril, 59, 1118, 10.1016/S0015-0282(16)55938-X · DOI · Paper page
- Bagatell, 1994, Effects of endogenous testosterone and estradiol on sexual behaviour in normal young men, J Clin Endocrinol Metab, 78, 711
- Fischer, 2004, A twin study of erectile dysfunction, Arch Intern Med, 164, 165, 10.1001/archinte.164.2.165 · DOI
- Penson, 1996, Androgen and pituitary control of penile nitric oxide synthase and erectile function in the rat, Biol Reprod, 55, 567, 10.1095/biolreprod55.3.567 · DOI
- Morelli, 2004, Androgens regulate phosphodiesterase type 5 expression and functional activity in corpora cavernosa, Endocrinology, 145, 2253, 10.1210/en.2003-1699 · DOI · Paper page
- Kandeel, 2001, Male sexual function and its disorders: physiology, pathophysiology, clinical investigation, and treatment, Endocr Rev, 22, 342, 10.1210/edrv.22.3.0430 · DOI · Paper page
- Siervogel, 2000, Annual changes in total body fat and fat-free mass in children from 8 to 18 years in relation to changes in body mass index. The Fels Longitudinal Study, Ann N Y Acad Sci, 904, 420, 10.1111/j.1749-6632.2000.tb06494.x · DOI
- Siervogel, 1998, Serial changes in body composition throughout adulthood and their relationships to changes in lipid and lipoprotein levels. The Fels Longitudinal Study, Arterioscler Thromb Vasc Biol, 18, 1759, 10.1161/01.ATV.18.11.1759 · DOI
- Keys, 1973, Basal metabolism and age of adult man, Metabolism, 22, 579, 10.1016/0026-0495(73)90071-1 · DOI
- Chien, 1975, Longitudinal measurements of blood volume and essential body mass in human subjects, J Appl Physiol, 39, 818, 10.1152/jappl.1975.39.5.818 · DOI
- Jackson, 1995, Changes in aerobic power of men, ages 25–70 yr, Med Sci Sports Exerc, 27, 113, 10.1249/00005768-199501000-00020 · DOI
- Flynn, 1989, Total body potassium in aging humans: a longitudinal study, Am J Clin Nutr, 50, 713, 10.1093/ajcn/50.4.713 · DOI
- Flegal, 1998, Overweight and obesity in the United States: prevalence and trends, 1960–1994, Int J Obes, 22, 39, 10.1038/sj.ijo.0800541 · DOI · Paper page
- Bennett, 1994, Trends in cardiovascular risk factors in Australia. Results from the National Heart Foundation's Risk Factor Prevalence study, 1980–1989, Med J Aust, 161, 519, 10.5694/j.1326-5377.1994.tb127594.x · DOI
- Rantanen, 1998, Grip strength changes over 27 yr in Japanese American men, J Appl Physiol, 85, 2047, 10.1152/jappl.1998.85.6.2047 · DOI · Paper page
- Lee, 1993, Body weight and mortality: a 27-year follow-up of middle-aged men, JAMA, 270, 2823, 10.1001/jama.1993.03510230061036 · DOI
- Stevens, 1998, The effect of age on the association between body-mass index and mortality, N Engl J Med, 338, 1, 10.1056/NEJM199801013380101 · DOI · Paper page
- Ford, 2002, Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination survey, JAMA, 287, 356, 10.1001/jama.287.3.356 · DOI · Paper page
- Metter, 1997, Age-associated loss of power and strength in the upper extremities in women and men, J Gerontol A Biol Sci Med Sci, 52, B267, 10.1093/gerona/52A.5.B267 · DOI · Paper page
- Bassey, 1993, Normal values for handgrip strength in 920 men and women aged over 65 years, and longitudinal changes over 4 years in 620 survivors, Clin Sci, 84, 331, 10.1042/cs0840331 · DOI · Paper page
- Clement, 1974, Longitudinal and cross-sectional assessments of age changes in physical strength as related to sex, social class, and mental ability, J Gerontol, 29, 423, 10.1093/geronj/29.4.423 · DOI
- Lindle, 1997, Age and gender comparisons of muscle strength in 654 women and men aged 20–93 yr, J Appl Physiol, 83, 1581, 10.1152/jappl.1997.83.5.1581 · DOI
- Larsson, 1979, Muscle strength and speed of movement in relation to age and muscle morphology, J Appl Physiol, 46, 451, 10.1152/jappl.1979.46.3.451 · DOI · Paper page
- Hughes, 2001, Longitudinal muscle strength changes in older adults: influence of muscle mass, physical activity, and health, J Gerontol A Biol Sci Med Sci, 56, B209, 10.1093/gerona/56.5.B209 · DOI
- Rantanen, 1997, Physical activity and the changes in maximal isometric strength in men and women from the age of 75 to 80 years, J Am Geriatr Soc, 45, 1439, 10.1111/j.1532-5415.1997.tb03193.x · DOI · Paper page
- Grimby, 1995, Muscle performance and structure in the elderly as studied cross-sectionally and longitudinally, J Gerontol A Biol Sci Med Sci, 50, 17
- Sunnerhagen, 2000, Muscle performance in an urban population sample of 40- to 79-year-old men and women, Scand J Rehabil Med, 32, 159, 10.1080/003655000750060904 · DOI
- Gibbs, 1996, Predictors of change in walking velocity in older adults, J Am Geriatr Soc, 44, 126, 10.1111/j.1532-5415.1996.tb02427.x · DOI
- Hughes, 1997, Predictors of decline in manual performance in older adults, J Am Geriatr Soc, 45, 905, 10.1111/j.1532-5415.1997.tb02957.x · DOI
- Penninx, 2000, Lower extremity performance in nondisabled older persons as a predictor of subsequent hospitalization, J Gerontol A Biol Sci Med Sci, 55, M691, 10.1093/gerona/55.11.M691 · DOI · Paper page
- Vellas, 1997, One-leg balance is an important predictor of injurious falls in older persons, J Am Geriatr Soc, 45, 735, 10.1111/j.1532-5415.1997.tb01479.x · DOI
- Dargent-Molina, 1996, Fall-related factors and risk of hip fracture: the EPIDOS prospective study, Lancet, 348, 145, 10.1016/S0140-6736(96)01440-7 · DOI · Paper page
- Guralnik, 1995, Lower-extremity function in persons over the age of 70 years as a predictor of subsequent disability, N Engl J Med, 332, 556, 10.1056/NEJM199503023320902 · DOI · Paper page
- Reuben, 1992, The predictive validity of self-report and performance-based measures of function and health, J Gerontol, 47, M106, 10.1093/geronj/47.4.M106 · DOI · Paper page
- Tinetti, 1988, Risk factors for falls among elderly persons living in the community, N Engl J Med, 319, 1701, 10.1056/NEJM198812293192604 · DOI
- Ferrucci, 2000, Characteristics of nondisabled older persons who perform poorly in objective tests of lower extremity function, J Am Geriatr Soc, 48, 1102, 10.1111/j.1532-5415.2000.tb04787.x · DOI
- Judge, 1996, The relationship between physical performance measures and independence in instrumental activities of daily living. The FICSIT Group. Frailty and injury: cooperative studies of intervention trials, J Am Geriatr Soc, 44, 1332, 10.1111/j.1532-5415.1996.tb01404.x · DOI · Paper page
- Guralnik, 1994, A short physical performance battery assessing lower extremity function: association with self-reported disability and prediction of mortality and nursing home admission, J Gerontol, 49, M85, 10.1093/geronj/49.2.M85 · DOI · Paper page
- Skoog, 2004, Psychiatric epidemiology of old age: the H70 study—the NAPE lecture 2003, Acta Psychiatr Scand, 109, 4, 10.1046/j.1600-0447.2003.00260.x · DOI
- Seidman, 2002, Low testosterone levels in elderly men with dysthymic disorder, Am J Psychiatry, 159, 456, 10.1176/appi.ajp.159.3.456 · DOI
- Seidman, 2001, Testosterone level, androgen receptor polymorphism, and depressive symptoms in middle-aged men, Biol Psychiatry, 50, 371, 10.1016/S0006-3223(01)01148-9 · DOI
- Seidman, 2001, Testosterone replacement therapy for hypogonadal men with major depressive disorder: a randomized, placebo-controlled clinical trial, J Clin Psychiatry, 62, 406, 10.4088/JCP.v62n0602 · DOI
- Barrett-Connor, 1999, Endogenous sex hormones and cognitive function in older men, J Clin Endocrinol Metab, 84, 3681
- Moffat, 2002, Longitudinal assessment of serum free testosterone concentration predicts memory performance and cognitive status in elderly men, J Clin Endocrinol Metab, 87, 5001, 10.1210/jc.2002-020419 · DOI · Paper page
- O'Connor, 2001, Activational effects of testosterone on cognitive function in men, Neuropsychologia, 39, 1385, 10.1016/S0028-3932(01)00067-7 · DOI
- Wolf, 2000, Testosterone and cognition in elderly men: a single testosterone injection blocks the practice effect in verbal fluency, but has no effect on spatial or verbal memory, Biol Psychiatry, 47, 650, 10.1016/S0006-3223(99)00145-6 · DOI
- Cherrier, 2001, Testosterone supplementation improves spatial and verbal memory in healthy older men, Neurology, 57, 80, 10.1212/WNL.57.1.80 · DOI · Paper page
- Janowsky, 2000, Sex steroids modify working memory, J Cogn Neurosci, 12, 407, 10.1162/089892900562228 · DOI
- Janowsky, 1994, Testosterone influences spatial cognition in older men, Behav Neurosci, 108, 325, 10.1037/0735-7044.108.2.325 · DOI · Paper page
- Cherrier, 2002, Cognitive effects of short-term manipulation of serum sex steroids in healthy young men, J Clin Endocrinol Metab, 87, 3090, 10.1210/jcem.87.7.8570 · DOI
- Ly, 2001, A double-blind, placebo-controlled, randomized clinical trial of transdermal dihydrotestosterone gel on muscular strength, mobility, and quality of life in older men with partial androgen deficiency, J Clin Endocrinol Metab, 86, 4078, 10.1210/jcem.86.9.7821 · DOI
- Sih, 1997, Testosterone replacement in older hypogonadal men: a 12-month randomized controlled trial, J Clin Endocrinol Metab, 82, 1661, 10.1210/jcem.82.6.3988 · DOI
- Moffat, 1996, A curvilinear relationship between testosterone and spatial cognition in humans: possible influence of hand preference, Psychoneuroendocrinology, 21, 323, 10.1016/0306-4530(95)00051-8 · DOI · Paper page
- Fisher, 1990, Maximal isometric torque of knee extension as a function of muscle length in subjects of advancing age, Arch Phys Med Rehabil, 71, 729
Cited by
Dysregulation of the Hypothalamic-Pituitary-Testicular Axis due to Energy Deficit
Grossmann, M., & Wittert, G. A. (2021) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgab517 · Cited by 24
Metadata
- Authors
- Liu, P. Y., Swerdloff, R. S., & Wang, C.
- Venue
- Endocrinology and Metabolism Clinics of North America
- Publisher
- Elsevier BV
- Published
- 2005-12
- Volume
- 34
- Issue
- 4
- Pages
- 957-972
- ISSN
- 0889-8529
- Cited by
- 5
- References
- 11
- Language
- en
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.