Excitotoxicity: Bridge to various triggers in neurodegenerative disorders

Mitochondrial Dysfunction and Oxidative Stress in Neurodegenerative Diseases

Lin, M. T., & Beal, M. F. (2006) · Nature · doi:10.1038/nature05292 · Cited by 6,455

Parkinson's disease: clinical features and diagnosis

Jankovic, J. (2008) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.2007.131045 · Cited by 5,720

Parkinson's Disease

Dauer, W., & Przedborski, S. (2003) · Neuron · doi:10.1016/s0896-6273(03)00568-3 · Cited by 5,469

Nitric oxide synthases: structure, function and inhibition

ALDERTON, W. K., COOPER, C. E., & KNOWLES, R. G. (2001) · Biochemical Journal · doi:10.1042/bj3570593 · Cited by 4,110

Cloned Glutamate Receptors

Hollmann, M., & Heinemann, S. (1994) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.17.030194.000335 · Cited by 3,975

Mitochondrial membrane permeabilization in cell death

Kroemer, G., Galluzzi, L., & Brenner, C. (2007) · Physiological Reviews · doi:10.1152/physrev.00013.2006 · Cited by 3,598

Mechanisms underlying inflammation in neurodegeneration

Glass, C. K., Saijo, K., Winner, B., Marchetto, M. C., & Gage, F. H. (2010) · Cell · doi:10.1016/j.cell.2010.02.016 · Cited by 3,580

Huntington's disease

Walker, F. O. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60111-1 · Cited by 2,603

Excitatory actions of gaba during development: the nature of the nurture

Ben-Ari, Y. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn920 · Cited by 2,448

NMDA-receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurones

MacDermott, A. B., Mayer, M. L., Westbrook, G. L., Smith, S. J., & Barker, J. L. (1986) · Nature · doi:10.1038/321519a0 · Cited by 1,835

Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders

Hardingham, G. E., & Bading, H. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2911 · Cited by 1,644 · cited 3×

An amino-acid taste receptor

Nelson, G., Chandrashekar, J., Hoon, M. A., Feng, L., Zhao, G., Ryba, N. J. P., & Zuker, C. S. (2002) · Nature · doi:10.1038/nature726 · Cited by 1,518

Molecular mechanisms of excitotoxicity and their relevance to pathogenesis of neurodegenerative diseases

Dong, X.-X., Wang, Y., & Qin, Z.-H. (2009) · Acta Pharmacologica Sinica · doi:10.1038/aps.2009.24 · Cited by 1,297

Pathways to neuronal injury and apoptosis in HIV-associated dementia

Kaul, M., Garden, G. A., & Lipton, S. A. (2001) · Nature · doi:10.1038/35073667 · Cited by 1,210

Life and death partners: apoptosis, autophagy and the cross-talk between them

Eisenberg-Lerner, A., Bialik, S., Simon, H.-U., & Kimchi, A. (2009) · Cell Death & Differentiation · doi:10.1038/cdd.2009.33 · Cited by 1,183

Glutamate release in severe brain ischaemia is mainly by reversed uptake

Rossi, D. J., Oshima, T., & Attwell, D. (2000) · Nature · doi:10.1038/35002090 · Cited by 1,122

Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders

Jeffrey Conn, P., Christopoulos, A., & Lindsley, C. W. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd2760 · Cited by 1,063

The neural architecture of the language comprehension network: converging evidence from lesion and connectivity analyses.

Turken, A. U., & Dronkers, N. F. (2011) · Frontiers in System Neuroscience · doi:10.3389/fnsys.2011.00001 · Cited by 1,012

Pharmacology of glutamate neurotoxicity in cortical cell culture: attenuation by NMDA antagonists

Choi, D., Koh, J., & Peters, S. (1988) · The Journal of Neuroscience · doi:10.1523/jneurosci.08-01-00185.1988 · Cited by 986

Apoptotic DNA Fragmentation

Nagata, S. (2000) · Experimental Cell Research · doi:10.1006/excr.2000.4834 · Cited by 905

Cation–chloride co-transporters in neuronal communication, development and trauma

Payne, J. A., Rivera, C., Voipio, J., & Kaila, K. (2003) · Trends in Neurosciences · doi:10.1016/s0166-2236(03)00068-7 · Cited by 832

Mitochondrial mutations in cancer

Brandon, M., Baldi, P., & Wallace, D. C. (2006) · Oncogene · doi:10.1038/sj.onc.1209607 · Cited by 818

Mechanisms of Disease: astrocytes in neurodegenerative disease

Maragakis, N. J., & Rothstein, J. D. (2006) · Nature Clinical Practice Neurology · doi:10.1038/ncpneuro0355 · Cited by 812

Molecular Physiology and Pathophysiology of Electroneutral Cation-Chloride Cotransporters

Gamba, G. (2005) · Physiological Reviews · doi:10.1152/physrev.00011.2004 · Cited by 810

Glutamate excitotoxicity in a model of multiple sclerosis

Pitt, D., Werner, P., & Raine, C. S. (2000) · Nature Medicine · doi:10.1038/71555 · Cited by 744

Why did NMDA receptor antagonists fail clinical trials for stroke and traumatic brain injury?

Ikonomidou, C., & Turski, L. (2002) · The Lancet Neurology · doi:10.1016/s1474-4422(02)00164-3 · Cited by 721

Unveiling the Functions of Presynaptic Metabotropic Glutamate Receptors in the Central Nervous System

Schoepp, D. D. (2001) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)29296-x · Cited by 690

Glia and their cytokines in progression of neurodegeneration

Mrak, R. E., & Griffin, W. S. T. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.05.010 · Cited by 592

The Diagnostic Challenge of Psychiatric Symptoms in Neurodegenerative Disease: Rates of and Risk Factors for Prior Psychiatric Diagnosis in Patients With Early Neurodegenerative Disease

Woolley, J. D., Khan, B. K., Murthy, N. K., Miller, B. L., & Rankin, K. P. (2011) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.10m06382oli · Cited by 549

Cleavage of the Plasma Membrane Na+/Ca2+ Exchanger in Excitotoxicity

Bano, D., Young, K. W., Guerin, C. J., LeFeuvre, R., Rothwell, N. J., Naldini, L., Rizzuto, R., Carafoli, E., & Nicotera, P. (2005) · Cell · doi:10.1016/j.cell.2004.11.049 · Cited by 533

Evidence for the involvement of TNF and NF-?B in hippocampal synaptic plasticity

Albensi, B. C., & Mattson, M. P. (2000) · Synapse · doi:10.1002/(sici)1098-2396(200002)35:2<151::aid-syn8>3.0.co;2-p · Cited by 521

Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses

Papadia, S., Soriano, F. X., Léveillé, F., Martel, M.-A., Dakin, K. A., Hansen, H. H., Kaindl, A., Sifringer, M., Fowler, J., Stefovska, V., et al. (2008) · Nature Neuroscience · doi:10.1038/nn2071 · Cited by 498

Epigenetic targets of HDAC inhibition in neurodegenerative and psychiatric disorders

ABEL, T., & ZUKIN, R. (2008) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2007.12.002 · Cited by 494

The chemical biology of clinically tolerated NMDA receptor antagonists

Chen, H. V., & Lipton, S. A. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03991.x · Cited by 474

Nitric Oxide Signaling in Brain Function, Dysfunction, and Dementia

Steinert, J. R., Chernova, T., & Forsythe, I. D. (2010) · The Neuroscientist · doi:10.1177/1073858410366481 · Cited by 469

The amyloid precursor protein has a flexible transmembrane domain and binds cholesterol

Barrett, P. J., Song, Y., Van Horn, W. D., Hustedt, E. J., Schafer, J. M., Hadziselimovic, A., Beel, A. J., & Sanders, C. R. (2012) · Science · doi:10.1126/science.1219988 · Cited by 467

Cerebral ischemia and inflammation

Iadecola, C., & Alexander, M. (2001) · Current Opinion in Neurology · doi:10.1097/00019052-200102000-00014 · Cited by 466

Apoptosis and the Nervous System

Sastry, P. S., & Rao, K. S. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0740001.x · Cited by 463

Cyclooxygenases, lipoxygenases, and epoxygenases in CNS: Their role and involvement in neurological disorders

Phillis, J. W., Horrocks, L. A., & Farooqui, A. A. (2006) · Brain Research Reviews · doi:10.1016/j.brainresrev.2006.02.002 · Cited by 459

Mechanisms of neuronal dysfunction and degeneration in multiple sclerosis

Dutta, R., & Trapp, B. D. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2010.09.005 · Cited by 457

Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin

Okamoto, S.-I., Pouladi, M. A., Talantova, M., Yao, D., Xia, P., Ehrnhoefer, D. E., Zaidi, R., Clemente, A., Kaul, M., Graham, R. K., et al. (2009) · Nature Medicine · doi:10.1038/nm.2056 · Cited by 436

Randomized phase III study 306: Adjunctive perampanel for refractory partial-onset seizures

Krauss, G. L., Serratosa, J. M., Villanueva, V., Endziniene, M., Hong, Z., French, J., Yang, H., Squillacote, D., Edwards, H. B., Zhu, J., et al. (2012) · Neurology · doi:10.1212/wnl.0b013e318254473a · Cited by 431

A molecular switch activated by metabotropic glutamate receptors regulates induction of long-term potentiation

Bortolotto, Z. A., Bashir, Z. I., Davies, C. H., & Collingridge, G. L. (1994) · Nature · doi:10.1038/368740a0 · Cited by 427

NMDA receptors in clinical neurology: excitatory times ahead

Kalia, L. V., Kalia, S. K., & Salter, M. W. (2008) · The Lancet Neurology · doi:10.1016/s1474-4422(08)70165-0 · Cited by 415

Vitamin K 2 Is a Mitochondrial Electron Carrier That Rescues Pink1 Deficiency

Vos, M., Esposito, G., Edirisinghe, J. N., Vilain, S., Haddad, D. M., Slabbaert, J. R., Van Meensel, S., Schaap, O., De Strooper, B., Meganathan, R., et al. (2012) · Science · doi:10.1126/science.1218632 · Cited by 363

Inflammation and neurodegenerative diseases

Griffin, W. S. T. (2006) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/83.2.470s · Cited by 351

Habitual intake of dietary flavonoids and risk of Parkinson disease

Gao, X., Cassidy, A., Schwarzschild, M. A., Rimm, E. B., & Ascherio, A. (2012) · Neurology · doi:10.1212/wnl.0b013e31824f7fc4 · Cited by 332

Taste-active components in some foods: A review of Japanese research

Fuke, S., & Konosu, S. (1991) · Physiology & Behavior · doi:10.1016/0031-9384(91)90195-t · Cited by 318

Neuroglia in neurodegeneration

Heneka, M. T., Rodríguez, J. J., & Verkhratsky, A. (2010) · Brain Research Reviews · doi:10.1016/j.brainresrev.2009.11.004 · Cited by 301

The glutamate story

Watkins, J. C., & Jane, D. E. (2006) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706444 · Cited by 295

The blood-brain barrier and glutamate

Hawkins, R. A. (2009) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.27462bb · Cited by 291

Untitled work

(2001) · PubMed Central · Cited by 289

Mitochondrial Dysfunction and Glutamate Excitotoxicity Studied in Primary Neuronal Cultures

Nicholls, D. (2004) · Current Molecular Medicine · doi:10.2174/1566524043479239 · Cited by 272

Role of Nitric Oxide Synthases in Parkinson’s Disease: A Review on the Antioxidant and Anti-inflammatory Activity of Polyphenols

Aquilano, K., Baldelli, S., Rotilio, G., & Ciriolo, M. R. (2008) · Neurochemical Research · doi:10.1007/s11064-008-9697-6 · Cited by 265

Vitamin E and Alzheimer disease: the basis for additional clinical trials

Grundman, M. (2000) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/71.2.630s · Cited by 264

Excitatory amino acids

G. Moloney, M. (1998) · Natural Product Reports · doi:10.1039/a815205y · Cited by 255

Active and passive immunotherapy for neurodegenerative disorders

Brody, D. L., & Holtzman, D. M. (2008) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.31.060407.125529 · Cited by 250

Aging: An important factor for the pathogenesis of neurodegenerative diseases

Farooqui, T., & Farooqui, A. A. (2009) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2008.11.006 · Cited by 245

Preconditioning Doses of NMDA Promote Neuroprotection by Enhancing Neuronal Excitability

Soriano, F. X., Papadia, S., Hofmann, F., Hardingham, N. R., Bading, H., & Hardingham, G. E. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.0455-06.2006 · Cited by 235

Metformin-inclusive sulfonylurea therapy reduces the risk of Parkinson's disease occurring with Type 2 diabetes in a Taiwanese population cohort

Wahlqvist, M. L., Lee, M.-S., Hsu, C.-C., Chuang, S.-Y., Lee, J.-T., & Tsai, H.-N. (2012) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2012.03.010 · Cited by 233

Cyclooxygenase-2 Contributes toN-Methyl-d-aspartate-Mediated Neuronal Cell Death in Primary Cortical Cell Culture

Hewett, S. J., Uliasz, T. F., Vidwans, A. S., & Hewett, J. A. (2000) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)39251-1 · Cited by 227

Kainate receptors in epilepsy and excitotoxicity

Vincent, P., & Mulle, C. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2008.02.066 · Cited by 221

trans-(−)-ε-Viniferin Increases Mitochondrial Sirtuin 3 (SIRT3), Activates AMP-activated Protein Kinase (AMPK), and Protects Cells in Models of Huntington Disease

Fu, J., Jin, J., Cichewicz, R. H., Hageman, S. A., Ellis, T. K., Xiang, L., Peng, Q., Jiang, M., Arbez, N., Hotaling, K., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.382226 · Cited by 210

Structure and mechanism of a glutamate–GABA antiporter

Ma, D., Lu, P., Yan, C., Fan, C., Yin, P., Wang, J., & Shi, Y. (2012) · Nature · doi:10.1038/nature10917 · Cited by 198

Mechanisms underlying NMDA receptor synaptic/extrasynaptic distribution and function

Gladding, C. M., & Raymond, L. A. (2011) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2011.05.001 · Cited by 198

Coupling diverse routes of calcium entry to mitochondrial dysfunction and glutamate excitotoxicity

Stanika, R. I., Pivovarova, N. B., Brantner, C. A., Watts, C. A., Winters, C. A., & Andrews, S. B. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0903546106 · Cited by 193

Columnar Architecture Sculpted by GABA Circuits in Developing Cat Visual Cortex

Hensch, T. K., & Stryker, M. P. (2004) · Science · doi:10.1126/science.1091031 · Cited by 188

NO production results in suspension-induced muscle atrophy through dislocation of neuronal NOS

Suzuki, N., Motohashi, N., Uezumi, A., Fukada, S.-I., Yoshimura, T., Itoyama, Y., Aoki, M., Miyagoe-Suzuki, Y., & Takeda, S. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30654 · Cited by 188

Matrix Metalloproteinases Are Modifiers of Huntingtin Proteolysis and Toxicity in Huntington's Disease

Miller, J. P., Holcomb, J., Al-Ramahi, I., de Haro, M., Gafni, J., Zhang, N., Kim, E., Sanhueza, M., Torcassi, C., Kwak, S., et al. (2010) · Neuron · doi:10.1016/j.neuron.2010.06.021 · Cited by 186

Role of glutamate in neuron-glia metabolic coupling

Magistretti, P. J. (2009) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.27462cc · Cited by 178

Lipoxygenases and their involvement in programmed cell death

Maccarrone, M., Melino, G., & Finazzi-Agro, A. (2001) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4400908 · Cited by 176

Blood‐mediated scavenging of cerebrospinal fluid glutamate

Gottlieb, M., Wang, Y., & Teichberg, V. I. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01972.x · Cited by 170

The mitochondrial permeability transition in neurologic disease

NORENBERG, M., & RAO, K. (2007) · Neurochemistry International · doi:10.1016/j.neuint.2007.02.008 · Cited by 169

The History of the Discovery of the Amino Acids.

Vickery, H. B., & Schmidt, C. L. A. (1931) · Chemical Reviews · doi:10.1021/cr60033a001 · Cited by 166

Nitric oxide NO - biogeneration regulation and relevence to human diseases

Bian, K. (2003) · Frontiers in Bioscience · doi:10.2741/997 · Cited by 164

Gliotoxic Action of Glutamate on Cultured Astrocytes

Chen, C., Liao, S., & Kuo, J. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0751557.x · Cited by 163

Role of activity-dependent regulation of neuronal chloride homeostasis in development

Fiumelli, H., & Woodin, M. A. (2007) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2007.01.002 · Cited by 162

Imaging extrasynaptic glutamate dynamics in the brain

Okubo, Y., Sekiya, H., Namiki, S., Sakamoto, H., Iinuma, S., Yamasaki, M., Watanabe, M., Hirose, K., & Iino, M. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0913154107 · Cited by 161

Suppression of the Intrinsic Apoptosis Pathway by Synaptic Activity

Léveillé, F., Papadia, S., Fricker, M., Bell, K. F. S., Soriano, F. X., Martel, M., Puddifoot, C. A., Habel, M., Wyllie, D. J. A., Ikonomidou, C., et al. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.5115-09.2010 · Cited by 157

Kainate, N-methylaspartate and other excitatory amino acids increase calcium influx into rat brain cortex cells in vitro

Berdichevsky, E., Riveros, N., Sánchez‐Armass, S., & Orrego, F. (1983) · Neuroscience Letters · doi:10.1016/0304-3940(83)90489-5 · Cited by 157

The gourmet ape: evolution and human food preferences

Krebs, J. R. (2009) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.27462b · Cited by 145

Neuronal Store-Operated Calcium Entry Pathway as a Novel Therapeutic Target for Huntington's Disease Treatment

Wu, J., Shih, H.-P., Vigont, V. A., Hrdlicka, L., Diggins, L. T., Singh, C. M., Mahoney, M. B., Chesworth, R., Shapiro, G., Zimina, O. A., et al. (2011) · Chemistry & Biology · doi:10.1016/j.chembiol.2011.04.012 · Cited by 145

Differential neuroprotective effects of 14-3-3 proteins in models of Parkinson's disease

Yacoubian, T. A., Slone, S. R., Harrington, A. J., Hamamichi, S., Schieltz, J. M., Caldwell, K. A., Caldwell, G. A., & Standaert, D. G. (2010) · Cell Death and Disease · doi:10.1038/cddis.2009.4 · Cited by 139

Mitochondria, calcium, and endoplasmic reticulum stress in Parkinson's disease

Calí, T., Ottolini, D., & Brini, M. (2011) · BioFactors · doi:10.1002/biof.159 · Cited by 138

Variations in the neuropathology of familial Alzheimer’s disease

Shepherd, C. E., McCann, H., & Halliday, G. M. (2009) · Acta Neuropathologica · doi:10.1007/s00401-009-0521-4 · Cited by 135

Opposing Roles of Synaptic and Extrasynaptic NMDA Receptor Signaling in Cocultured Striatal and Cortical Neurons

Kaufman, A. M., Milnerwood, A. J., Sepers, M. D., Coquinco, A., She, K., Wang, L., Lee, H., Craig, A. M., Cynader, M. S., & Raymond, L. A. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.4129-11.2012 · Cited by 135

Caspase-Mediated Degradation of AMPA Receptor Subunits: A Mechanism for Preventing Excitotoxic Necrosis and Ensuring Apoptosis

Glazner, G. W., Chan, S. L., Lu, C., & Mattson, M. P. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-10-03641.2000 · Cited by 134

An autophagic mechanism is involved in apoptotic death of rat striatal neurons induced by the non-N-methyl-D-aspartate receptor agonist kainic acid

Wang, Y., Han, R., Zhong-qin, L., Wu, J.-C., Zhang, X., Gu, Z.-L., & Qin, Z.-H. (2008) · Autophagy · doi:10.4161/auto.5369 · Cited by 134

Prostaglandin E2 protects cultured cortical neurons against N-methyl-d-aspartate receptor-mediated glutamate cytotoxicity

Akaike, A., Kaneko, S., Tamura, Y., Nakata, N., Shiomi, H., Ushikabi, F., & Narumiya, S. (1994) · Brain Research · doi:10.1016/0006-8993(94)91268-8 · Cited by 132

Negative regulation of autophagy

Liang, C. (2010) · Cell Death and Differentiation · doi:10.1038/cdd.2010.115 · Cited by 132

Acute administration of phencyclidine induces tonic activation of medial prefrontal cortex neurons in freely moving rats

Suzuki, Y., Jodo, E., Takeuchi, S., Niwa, S., & Kayama, Y. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00298-1 · Cited by 118

Differential expression of N ‐methyl‐ d ‐aspartate receptor NR2 isoforms in Alzheimer's disease

Hynd, M. R., Scott, H. L., & Dodd, P. R. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02548.x · Cited by 116

A molecular signature in blood identifies early Parkinson’s disease

Molochnikov, L., Rabey, J. M., Dobronevsky, E., Bonuccelli, U., Ceravolo, R., Frosini, D., Grünblatt, E., Riederer, P. F., Jacob, C., Aharon‐Peretz, J., et al. (2012) · Molecular Neurodegeneration · doi:10.1186/1750-1326-7-26 · Cited by 116

The powerhouse takes control of the cell: Is the mitochondrial permeability transition a viable therapeutic target against neuronal dysfunction and death?

Stavrovskaya, I. G., & Kristal, B. S. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.11.032 · Cited by 114

Putative role of neuronal 5-lipoxygenase in an aging brain

Manev, H., Uz, T., Sugaya, K., & Qu, T. (2000) · The FASEB Journal · doi:10.1096/fj.14.10.1464 · Cited by 113

The importance of integrating basic and clinical research toward the development of new therapies for Huntington disease

Muñoz-Sanjuán, I., & Bates, G. P. (2011) · Journal of Clinical Investigation · doi:10.1172/jci45364 · Cited by 111

Expression of Concern: Role of LOX/COX pathways in 3‐nitropropionic acid‐induced Huntington's Disease‐like symptoms in rats: protective effect of licofelone

Kumar, P., Kalonia, H., & Kumar, A. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01418.x · Cited by 107

Brain neuroprotection by scavenging blood glutamate

Zlotnik, A. A., Gurevich, B., Tkachov, S., Maoz, I., Shapira, Y., & Teichberg, V. I. (2006) · Experimental Neurology · doi:10.1016/j.expneurol.2006.08.021 · Cited by 106

Effect of dietary monosodium glutamate on trans fat-induced nonalcoholic fatty liver disease

Collison, K. S., Maqbool, Z. M., Saleh, S. M., Inglis, A. L., Makhoul, N. J., Bakheet, R., Al‐Johi, M. A., Al‐Rabiah, R. K., Zaidi, M. Z., & Al-Mohanna, F. A. (2008) · Journal of Lipid Research · doi:10.1194/jlr.m800418-jlr200 · Cited by 99

Glutamate receptors in preclinical research on Alzheimer's disease: Update on recent advances

Hu, N., Ondrejčák, T., & Rowan, M. J. (2011) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2011.04.013 · Cited by 99

Functional neuroimaging of umami taste: what makes umami pleasant?

Rolls, E. T. (2009) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.27462r · Cited by 99

Functional anatomy of movement disorders

Crossman, A. R. (2000) · Journal of Anatomy · doi:10.1046/j.1469-7580.2000.19640519.x · Cited by 94

Glutathione S-transferase omega genes in Alzheimer and Parkinson disease risk, age-at-diagnosis and brain gene expression: an association study with mechanistic implications

Allen, M., Zou, F., Chai, H. S., Younkin, C. S., Miles, R., Nair, A., Crook, J. E., Pankratz, V. S., Carrasquillo, M. M., Rowley, C. N., et al. (2012) · Molecular Neurodegeneration · doi:10.1186/1750-1326-7-13 · Cited by 94

Regulation of mitochondrial permeability transition pore by PINK1

Gautier, C., Giaime, E., Caballero, E., Núñez, L., Song, Z., Chan, D. C., Villalobos, C., & Shen, J. (2012) · Molecular Neurodegeneration · doi:10.1186/1750-1326-7-22 · Cited by 93

Mitochondrial Nitric Oxide Synthase, Oxidative Stress and Apoptosis

Ghafourifar, P., Bringold, U., Klein, S. D., & Richter, C. (2001) · Neurosignals · doi:10.1159/000046875 · Cited by 89

Excitotoxic death induced by released glutamate in depolarized primary cultures of mouse cerebellar granule cells is dependent on GABAA receptors and niflumic acid‐sensitive chloride channels

Babot, Z., Cristòfol, R. M., & Sunol, C. E. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03848.x · Cited by 86

Synaptic Activity-Mediated Suppression of p53 and Induction of Nuclear Calcium-Regulated Neuroprotective Genes Promote Survival through Inhibition of Mitochondrial Permeability Transition

Lau, D., & Bading, H. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.0802-09.2009 · Cited by 85

Treatment of fluoxetine-induced anorgasmia with amantadine.

Balogh, S. E., Hendricks, S. E., & Kang, J. S. (1992) · PubMed · Cited by 83

Mortalin, Apoptosis, and Neurodegeneration

Londoño, C. A., Osorio, C., Gama, V., & Álzate, Ó. (2012) · Biomolecules · doi:10.3390/biom2010143 · Cited by 79

Rescue from excitotoxicity and axonal degeneration accompanied by age-dependent behavioral and neuroanatomical alterations in caspase-6-deficient mice

Uribe, V., Wong, B. K. Y., Graham, R. K., Cusack, C. L., Skotte, N. H., Pouladi, M. A., Xie, Y., Feinberg, K., Ou, Y., Ouyang, Y., et al. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds005 · Cited by 78

Role of AMPA receptor trafficking in NMDA receptor‐dependent synaptic plasticity in the rat lateral amygdala

Yu, S. Y., Wu, D., Liu, L., Ge, Y., & Wang, Y. T. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05461.x · Cited by 77

Can dietary supplementation of monosodium glutamate improve the health of the elderly?

Yamamoto, S., Tomoe, M., Toyama, K., Kawai, M., & Uneyama, H. (2009) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.27462x · Cited by 77

Neuroprotection, excitotoxicicity and nmda antagonists

Gagliardi, R. J. (2000) · Arquivos de Neuro-Psiquiatria · doi:10.1590/s0004-282x2000000300030 · Cited by 75

Magnesium pre-treatment reduces neuronal apoptosis in newborn rats in hypoxia–ischemia

Türkyılmaz, C., Türkyılmaz, Z., Atalay, Y., Söylemezoğlu, F., & Celasun, B. (2002) · Brain Research · doi:10.1016/s0006-8993(02)03395-4 · Cited by 74

Neuroinflammation : mechanisms and management

Wood, P. L. (2003) · Cited by 73

Polyglutamine-Modulated Striatal Calpain Activity in YAC Transgenic Huntington Disease Mouse Model: Impact on NMDA Receptor Function and Toxicity

Cowan, C. M., Fan, M., Fan, J., Shehadeh, J., Zhang, L. Y. J., Graham, R. K., Hayden, M. R., & Raymond, L. A. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.4619-08.2008 · Cited by 72

Recent Advances in the Design and Development of Novel Negative Allosteric Modulators of mGlu5

Emmitte, K. A. (2011) · ACS Chemical Neuroscience · doi:10.1021/cn2000266 · Cited by 71

Possible GABAergic mechanism in the neuroprotective effect of gabapentin and lamotrigine against 3-nitropropionic acid induced neurotoxicity

Kumar, P., Kalonia, H., & Kumar, A. (2011) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2011.11.030 · Cited by 70

Clinical Features and Pathogenesis of Alzheimer’s Disease: Involvement of Mitochondria and Mitochondrial DNA

Mancuso, M., Orsucci, D., LoGerfo, A., Calsolaro, V., & Siciliano, G. (2010) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-6448-9_4 · Cited by 69

Nitric Oxide–Soluble Guanylyl Cyclase–Cyclic GMP Signaling in the Striatum: New Targets for the Treatment of Parkinson's Disease?

West, A. R., & Tseng, K. Y. (2011) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2011.00055 · Cited by 69

Allosteric Modulation of Metabotropic Glutamate Receptors

Sheffler, D. J., Gregory, K. J., Rook, J. M., & Conn, P. J. (2011) · Advances in pharmacology · doi:10.1016/b978-0-12-385952-5.00010-5 · Cited by 62

Chronic Nicotine Exposure Enhances Insulin-Induced Mitogenic Signaling via Up-Regulation of α7 Nicotinic Receptors in Isolated Rat Aortic Smooth Muscle Cells

Wada, T., Naito, M., Kenmochi, H., Tsuneki, H., & Sasaoka, T. (2006) · Endocrinology · doi:10.1210/en.2006-0907 · Cited by 58

Pharmaceutical, cellular and genetic therapies for Huntington's disease

Handley, O., Naji, J. J., Dunnett, S. B., & Rosser, A. (2005) · Clinical Science · doi:10.1042/cs20050148 · Cited by 51

Delivered from Distraction: Getting the Most out of Life with Attention Deficit Disorder

Hallowell, E. M., & Ratey, J. J. (2005) · Cited by 48

NMDA receptor activity regulates transcription of antioxidant pathways

Lipton, S. A. (2008) · Nature Neuroscience · doi:10.1038/nn0408-381 · Cited by 46

Inhibition of Striatal Soluble Guanylyl Cyclase-cGMP Signaling Reverses Basal Ganglia Dysfunction and Akinesia in Experimental Parkinsonism

Tseng, K. Y., Caballero, A. C., Dec, A. M., Cass, D. K., Simak, N., Sunu, E., Park, M. J., Blume, S. R., Sammut, S., Park, D. J., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027187 · Cited by 46

Tumour necrosis factor alpha inhibits purinergic calcium signalling in blood–brain barrier endothelial cells

Vandamme, W., Braet, K., Cabooter, L., & Leybaert, L. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.02163.x · Cited by 45

ACh receptors link two signaling pathways to neuroprotection against glutamate‐induced excitotoxicity in isolated RGCs

Asomugha, C. O., Linn, D. M., & Linn, C. L. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06447.x · Cited by 42

The effect of mGluR2 activation on signal transduction pathways and neuronal cell survival

Lee, H.-G., Zhu, X.-W., Casadesus, G., Pallás, M., Camins, A., O'Neill, M., Nakanishi, S., Perry, G., & Smith, M. (2008) · Brain Research · doi:10.1016/j.brainres.2008.10.055 · Cited by 39

Cyclo-Oxygenase Inhibitors and Thromboxane Synthase Inhibitors Differentially Regulate Migration Arrest, Growth Inhibition and Apoptosis in Human Glioma Cells

Kürzel, F., Hagel, C., Zapf, S., Meissner, H., Westphal, M., & Giese, A. (2002) · Acta Neurochirurgica · doi:10.1007/s701-002-8276-9 · Cited by 38

Allosteric modulators of metabotropic glutamate receptors: lessons learnt from mGlu1, mGlu2 and mGlu5 potentiators and antagonists

Johnson, M. P., Nisenbaum, E. S., Large, T. H., Emkey, R., Baez, M., & Kingston, A. E. (2004) · Biochemical Society Transactions · doi:10.1042/bst0320881 · Cited by 36

Progress in the development of new drugs in Alzheimer's disease

Piau, A., Nourhashémi, F., Hein, C., Caillaud, C., & Vellas, B. (2011) · The Journal of nutrition, health and aging · doi:10.1007/s12603-011-0012-x · Cited by 32

Possible nitric oxide modulation in protective effect of FK-506 against 3-nitropropionic acid-induced behavioral, oxidative, neurochemical, and mitochondrial alterations in rat brain

Kumar, P., Kalonia, H., & Kumar, A. (2010) · Drug and Chemical Toxicology · doi:10.3109/01480541003642050 · Cited by 30

Neuroprotection Abilities of Cytosolic Phospholipase A2 Inhibitors in Kainic acid-induced Neurodegeneration

Farooqui, A. A., Ong, W., & Horrocks, L. A. (2004) · Cardiovascular & Haematological Disorders - Drug Targets · doi:10.2174/1568006043481239 · Cited by 29

Pharmacological approaches to nitric oxide signalling during neural development of locusts and other model insects

Bicker, G. (2006) · Archives of Insect Biochemistry and Physiology · doi:10.1002/arch.20161 · Cited by 27

Nitric oxide (NO), citrulline–NO cycle enzymes, glutamine synthetase, and oxidative status in kainic acid–mediated excitotoxicity in rat brain

Swamy, M., Sirajudeen, K. N. S., & Chandran, G. (2009) · Drug and Chemical Toxicology · doi:10.1080/01480540903130641 · Cited by 27

A sensitive method to assay the xanthine oxidase activity in primary cultures of cerebellar granule cells

Atlante, A., Valenti, D., Gagliardi, S., & Passarella, S. (2000) · Brain Research Protocols · doi:10.1016/s1385-299x(00)00030-1 · Cited by 20

The Efficacy of Sodium Channel Blockers to Prevent Phencyclidine-Induced Cognitive Dysfunction in the Rat: Potential for Novel Treatments for Schizophrenia

Large, C. H., Bison, S., Sartori, I., Read, K. D., Gozzi, A., Quarta, D., Antolini, M., Hollands, E. C., Gill, C. H., Gunthorpe, M. J., et al. (2011) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.110.178475 · Cited by 20

The identification and functional implications of human-specific “fixed” amino acid substitutions in the glutamate receptor family

Goto, H., Watanabe, K., Araragi, N., Kageyama, R., Tanaka, K., Kuroki, Y., Toyoda, A., Hattori, M., Sakaki, Y., Fujiyama, A., et al. (2009) · BMC Evolutionary Biology · doi:10.1186/1471-2148-9-224 · Cited by 16

[Neuroprotective effect of sodium channel blockers in ischemia: the pathomechanism of early ischemic dysfunction].

Ádám‐Vizi, V. (2000) · PubMed · Cited by 13

Amyotrophic lateral sclerosis and riluzole use during pregnancy: A case report

Scalco, R., Vieira, M. C., Filho, E. V. D. C., Lago, E. G., da Silva, I. G., & Becker, J. (2012) · Amyotrophic Lateral Sclerosis · doi:10.3109/17482968.2012.673171 · Cited by 12

Microglia: Roles of Microglia in Chronic Neurodegenerative Diseases

Wood, P. L. (2003) · Humana Press eBooks · doi:10.1007/978-1-59259-297-5_1 · Cited by 6

Ferroptosis: Death by Lipid Peroxidation

Yang, W. S., & Stockwell, B. R. (2016) · Trends in Cell Biology · doi:10.1016/j.tcb.2015.10.014 · Cited by 3,088

Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles

Galluzzi, L., Bravo-San Pedro, J. M., Levine, B., Green, D. R., & Kroemer, G. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2017.22 · Cited by 842

Inflammasomes in the CNS

Walsh, J. G., Muruve, D. A., & Power, C. (2014) · Nature Reviews Neuroscience · doi:10.1038/nrn3638 · Cited by 637

Progressive multiple sclerosis: from pathophysiology to therapeutic strategies

Faissner, S., Plemel, J. R., Gold, R., & Yong, V. W. (2019) · Nature Reviews Drug Discovery · doi:10.1038/s41573-019-0035-2 · Cited by 459

microRNA dysregulation in neurodegenerative diseases: A systematic review

Juźwik, C. A., S. Drake, S., Zhang, Y., Paradis-Isler, N., Sylvester, A., Amar-Zifkin, A., Douglas, C., Morquette, B., Moore, C. S., & Fournier, A. E. (2019) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2019.101664 · Cited by 426