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The neurobiology of attention deficit/hyperactivity disorder
Open accessAbstract
ADHD is a brain based disorder with structural and functional abnormalities in widespread but specific areas of the brain. The most significant and consistent structural imaging findings include smaller total brain volumes, and reduced volumes in the right frontal lobe, right parietal cortex, caudate nucleus, cerebellar hemispheres, and posterior-inferior lobules of the cerebellar vermis. ADHD involves hypofunction of catecholaminergic circuits, particularly those that project to the prefrontal cortex. A minimum of 18 genes have been reported to be associated with the disorder; among them the DRD4 7-repeat allele has been found associated with a thinner prefrontal and posterior parietal cortex. Epigenetic factors acting during critical periods of prenatal and postnatal development may interact with genetic determinants. Methylphenidate, as well as the catecholaminergic nonstimulant atomoxetine, are effective in improving ADHD symptoms.
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Metadata
- Authors
- Curatolo, P., Paloscia, C., D'Agati, E., Moavero, R., & Pasini, A.
- Affiliations
- University of Rome Tor Vergata (IT)
- Corresponding author
- Curatolo, Paolo
- Venue
- European Journal of Paediatric Neurology
- Publisher
- Elsevier BV
- Published
- 2009-07
- Volume
- 13
- Issue
- 4
- Pages
- 299-304
- ISSN
- 1090-3798 (ISSN-L)
- OpenAlex
- W2136277713
- Cited by
- 136
- References
- 75
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 7 · 2023: 7 · 2022: 5 · 2021: 7 · 2020: 9 · 2019: 4 · 2018: 1 · 2017: 6 · 2016: 9 · 2015: 12 · 2014: 12 · 2013: 6 · 2012: 10
- FWCI
- 1.29
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- Locations
- European Journal of Paediatric Neurology (publishedVersion)
- PubMed (publishedVersion)
- Cineca Institutional Research Information System (Tor Vergata University) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- attention deficit hyperactivity disorder, neurobiology, structural brain abnormalities, brain atrophy, prefrontal cortex, genetic susceptibility, epigenetics, methylphenidate, atomoxetine, non-stimulant medication
- MeSH terms
- Attention Deficit Disorder with Hyperactivity, Diagnostic Imaging, Environment, Humans, Neurobiology, Risk Factors, History, 20th Century, History, 21st Century
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