Dopamine D1 receptor stimulation modulates the formation and retrieval of novel object recognition memory: role of the prelimbic cortex

Pezze, Marie A.; Marshall, Hayley J.; Fone, Kevin C.F.; Cassaday, Helen J.

doi:10.1016/j.euroneuro.2015.07.018

Cited by 51Memory and Neural MechanismsNeurotransmitter Receptor Influence on BehaviorMemory Processes and Influences

Dopamine D1 receptor stimulation modulates the formation and retrieval of novel object recognition memory: role of the prelimbic cortex

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Pezze, Marie A., Marshall, Hayley J., Fone, Kevin C.F., Cassaday, Helen J.·2015·European Neuropsychopharmacology

DOI 10.1016/j.euroneuro.2015.07.018PMC PMC4661036

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Abstract

Previous studies have shown that dopamine D1 receptor antagonists impair novel object recognition memory but the effects of dopamine D1 receptor stimulation remain to be determined. This study investigated the effects of the selective dopamine D1 receptor agonist SKF81297 on acquisition and retrieval in the novel object recognition task in male Wistar rats. SKF81297 (0.4 and 0.8 mg/kg s.c.) given 15 min before the sampling phase impaired novel object recognition evaluated 10 min or 24 h later. The same treatments also reduced novel object recognition memory tested 24 h after the sampling phase and when given 15 min before the choice session. These data indicate that D1 receptor stimulation modulates both the encoding and retrieval of object recognition memory. Microinfusion of SKF81297 (0.025 or 0.05 μg/side) into the prelimbic sub-region of the medial prefrontal cortex (mPFC) in this case 10 min before the sampling phase also impaired novel object recognition memory, suggesting that the mPFC is one important site mediating the effects of D1 receptor stimulation on visual recognition memory.

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Pre-sample infusions of SKF81297 into the PFC impair short-term (1 hour) NOP.
“Pre-sample infusions of SKF81297 into the PFC impaired short-term (1 hour) NOP (Pezze et al., 2015).”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Pezze et al., 2015
NOP memory tested even minutes later was impaired by pre-sample infusions of substances into the PFC.
“Furthermore, pharmacological studies have found that NOP memory tested even minutes later was impaired by pre-sample infusions of substances into the PFC (Christoffersen et al., 2008; Pezze et al., 2015; Watson et al., 2012).”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Pezze et al., 2015

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Authors: Pezze, M. A., Marshall, H. J., Fone, K. C. F., & Cassaday, H. J.
Affiliations: University of Nottingham (GB)
Corresponding author: Pezze, Marie A.
ORCID: Marshall, Hayley J.
Fone, Kevin C.F.
Cassaday, Helen J.
Venue: European Neuropsychopharmacology
Publisher: Elsevier BV
Published: 2015-11
Volume: 25
Issue: 11
Pages: 2145-2156
ISSN: 0924-977X (ISSN-L)
DOI: 10.1016/j.euroneuro.2015.07.018
PMC: PMC4661036
OpenAlex: W1895515176
Cited by: 51
References: 50
Citations by year: 2026: 1 · 2025: 1 · 2024: 3 · 2023: 3 · 2022: 5 · 2021: 9 · 2020: 5 · 2019: 8 · 2018: 6 · 2017: 5 · 2016: 4 · 2015: 1
FWCI: 3.21
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by/4.0/ (vor)
Locations: European Neuropsychopharmacology (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Repository@Nottingham (University of Nottingham) (publishedVersion, other-oa)
Repository@Nottingham (University of Nottingham) (submittedVersion, cc-by)
Nottingham ePrints (University of Nottingham) (submittedVersion, cc-by-nc-nd)
Funders: BBSRC, UK (BB/K004980/1)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
Keywords: dopamine D1 receptor, SKF 81297, novel object recognition memory, memory encoding, memory retrieval, prelimbic cortex, medial prefrontal cortex, visual recognition memory
MeSH terms: Animals, Benzazepines, Dose-Response Relationship, Drug, Male, Microinjections, Motor Activity, Neuropsychological Tests, Time Factors, Rats, Wistar, Prefrontal Cortex, Receptors, Dopamine D1, Nootropic Agents, Recognition, Psychology

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Dopamine D1 receptor stimulation modulates the formation and retrieval of novel object recognition memory: role of the prelimbic cortex

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