Cited by 53Memory and Neural MechanismsMemory Processes and InfluencesNeuroscience and Neuropharmacology Research

The effect of catecholaminergic depletion within the prelimbic and infralimbic medial prefrontal cortex on recognition memory for recency, location, and objects

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Nelson, Andrew J. D., Cooper, Molly T., Thur, Karen E., Marsden, Charles A., Cassaday, Helen J.·2011·Behavioral Neuroscience

Abstract

There is good evidence that the medial prefrontal cortex (mPFC) is involved in different aspects of recognition memory. However, the mPFC is a heterogeneous structure, and the contribution of the prelimbic (PL) and infralimbic (IL) cortices to recognition memory has not been investigated. Similarly, the role of different neuromodulators within the mPFC in these processes is poorly understood. To this end, we tested animals with 6-hydroxydopamine (6-OHDA) lesions of the PL and IL mPFC on three tests of object recognition memory that required judgments about recency, object location, and object identity. In the recency task, lesions to both PL and IL severely impaired animals' ability to differentiate between old (earlier presented) and recently presented familiar objects. Relative to sham and PL animals, the IL lesion also disrupted performance on the object location task. However, both lesions left novel object recognition intact. These data confirm previous reports that the mPFC is not required for discriminations based on the relative familiarity of individual objects. However, these results demonstrate that catecholamines within the PL cortex are crucial for relative recency judgments and suggest a possible role for neural processing within the IL in the integration of information about object location.

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Authors
Nelson, A. J. D., Cooper, M. T., Thur, K. E., Marsden, C. A., & Cassaday, H. J.
Affiliations
University of Nottingham (GB)
Venue
Behavioral Neuroscience
Published
2011-06
Volume
125
Issue
3
Pages
396-403
ISSN
  • 0735-7044 (ISSN-L)
  • 1939-0084
OpenAlex
W2123962898
Cited by
53
References
50
Citations by year
2026: 2 · 2025: 4 · 2024: 5 · 2023: 2 · 2021: 4 · 2020: 5 · 2019: 3 · 2018: 3 · 2017: 1 · 2016: 2 · 2015: 9 · 2014: 5 · 2013: 3 · 2012: 3
FWCI
2.11
Type
journal article
Language
en
Open access
Locations
  • Behavioral Neuroscience (publishedVersion, other-oa)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Nottingham ePrints (University of Nottingham) (submittedVersion, cc-by)
  • Repository@Nottingham (University of Nottingham) (submittedVersion, cc-by)
  • ORCA Online Research @Cardiff (Cardiff University) (submittedVersion)
Funders
  • Wellcome Trust (082940)
  • British Association for Psychopharmacology
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
medial prefrontal cortex, prelimbic cortex, infralimbic cortex, recognition memory, object recognition memory, object location, catecholamines, 6-hydroxydopamine lesion, novel object recognition, object familiarity
MeSH terms
Animals, Brain, Catecholamines, Discrimination, Psychological, Male, Microinjections, Synaptic Transmission, Space Perception, Time Factors, Oxidopamine, Rats, Wistar, Prefrontal Cortex, Recognition, Psychology, Rats

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