The effect of catecholaminergic depletion within the prelimbic and infralimbic medial prefrontal cortex on recognition memory for recency, location, and objects
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There is good evidence that the medial prefrontal cortex (mPFC) is involved in different aspects of recognition memory. However, the mPFC is a heterogeneous structure, and the contribution of the prelimbic (PL) and infralimbic (IL) cortices to recognition memory has not been investigated. Similarly, the role of different neuromodulators within the mPFC in these processes is poorly understood. To this end, we tested animals with 6-hydroxydopamine (6-OHDA) lesions of the PL and IL mPFC on three tests of object recognition memory that required judgments about recency, object location, and object identity. In the recency task, lesions to both PL and IL severely impaired animals' ability to differentiate between old (earlier presented) and recently presented familiar objects. Relative to sham and PL animals, the IL lesion also disrupted performance on the object location task. However, both lesions left novel object recognition intact. These data confirm previous reports that the mPFC is not required for discriminations based on the relative familiarity of individual objects. However, these results demonstrate that catecholamines within the PL cortex are crucial for relative recency judgments and suggest a possible role for neural processing within the IL in the integration of information about object location.
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Catecholamine depletion in the mPFC induced by 6-OHDA disrupts TOM, but neither NOP nor OPP.
“The catecholaminergic systems in the PFC are involved in the processing of TOM, given that catecholamine depletion in the mPFC induced by 6-hydroxydopamine (6-OHDA) disrupted this memory, but neither memory for NOP nor that for OPP (Nelson et al., 2011).”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Nelson et al., 2011
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- Authors
- Nelson, A. J. D., Cooper, M. T., Thur, K. E., Marsden, C. A., & Cassaday, H. J.
- Affiliations
- University of Nottingham (GB)
- Venue
- Behavioral Neuroscience
- Published
- 2011-06
- Volume
- 125
- Issue
- 3
- Pages
- 396-403
- ISSN
- 0735-7044 (ISSN-L)
- 1939-0084
- PMC
- PMC3129330
- OpenAlex
- W2123962898
- Cited by
- 53
- References
- 50
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 5 · 2023: 2 · 2021: 4 · 2020: 5 · 2019: 3 · 2018: 3 · 2017: 1 · 2016: 2 · 2015: 9 · 2014: 5 · 2013: 3 · 2012: 3
- FWCI
- 2.11
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Behavioral Neuroscience (publishedVersion, other-oa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Nottingham ePrints (University of Nottingham) (submittedVersion, cc-by)
- Repository@Nottingham (University of Nottingham) (submittedVersion, cc-by)
- ORCA Online Research @Cardiff (Cardiff University) (submittedVersion)
- Funders
- Wellcome Trust (082940)
- British Association for Psychopharmacology
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- medial prefrontal cortex, prelimbic cortex, infralimbic cortex, recognition memory, object recognition memory, object location, catecholamines, 6-hydroxydopamine lesion, novel object recognition, object familiarity
- MeSH terms
- Animals, Brain, Catecholamines, Discrimination, Psychological, Male, Microinjections, Synaptic Transmission, Space Perception, Time Factors, Oxidopamine, Rats, Wistar, Prefrontal Cortex, Recognition, Psychology, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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