Induction of endometriotic nodules in an experimental baboon model mimicking human deep nodular lesions
Open accessAbstract
Objective To establish an experimental model for the study of deep nodular endometriosis.Design Induction of nodular endometriosis in baboons by grafting different uterine specimens to the peritoneal cavity.Setting Research and university facilities.Animal(s) Ten baboons, to develop a model of induced deep nodular endometriosis.Intervention(s) Biopsies of endometrium, and endometrium plus the junctional zone (JZ), full uterine thickness, and myometrium grafted to the peritoneum.Main outcome measure(s) Macroscopic descriptions recorded for observed induced lesions; staining with hematoxylin and eosin for histological evaluation and specific antibodies (CK22, CD10) for immunohistochemical studies; and analysis of surface area and volume of lesions, glandular density, and invasion of surrounding organs.Result(s) The incidence of induced nodular endometriosis was 100%, but the extent depended on the tissue grafted. Lesions induced after grafting specimens containing the JZ were statistically significantly larger than those not containing the JZ. Surrounding organ invasion was reported in more than 40% of lesions after grafting specimens containing the JZ.Conclusion(s) The first experimental model of nodular endometriosis allows investigation of deeper nodular lesions as well as invasion phenomena associated with nodular lesions.
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Currently, the only animal DE model reported is through grafting uterine specimens, especially full uterine thickness, to the peritoneal cavity in baboons.
“Currently, the only animal DE model that has been reported is through grafting uterine specimens, especially in full uterine thickness, to the peritoneal cavity in baboons98.”
From Neuropeptides Substance P and Calcitonin Gene Related Peptide Accelerate the Development and Fibrogenesis of Endometriosis (2019) · cites this paper as [98]
The baboon model with induction of deep endometriosislike lesions by transplantation of endometrium and myometrium is difficult to interpret.
“The baboon model with induction of deep endometriosislike lesions by transplantation of endometrium and myometrium (223) is difficult to interpret.”
From Pathogenesis of deep endometriosis (2017) · cites this paper as [223]
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- Authors
- Donnez, O., Van Langendonckt, A., Defrère, S., Colette, S., Van Kerk, O., Dehoux, J.-P., Squifflet, J., & Donnez, J.
- Affiliations
- UCLouvain (BE)
- Corresponding author
- Donnez, Jacques
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 2013-03
- Volume
- 99
- Issue
- 3
- Pages
- 783-789.e3
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W2007953487
- Cited by
- 42
- References
- 31
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 6 · 2023: 2 · 2022: 4 · 2021: 2 · 2020: 1 · 2019: 4 · 2018: 6 · 2017: 5 · 2016: 3 · 2015: 1 · 2014: 3 · 2013: 3
- FWCI
- 2.62
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- DIAL (Catholic University of Leuven) (submittedVersion)
- Funders
- Pfizer
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
- Keywords
- animal models, baboons, junctional zone, peritoneal implantation, organ invasion, lesion size, CD10
- MeSH terms
- Tissue Adhesions, Animals, Biopsy, Disease Models, Animal, Endometriosis, Female, Myometrium, Peritoneal Cavity, Laparoscopy, Papio anubis
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