The fucoidans from brown algae of Far-Eastern seas: Anti-tumor activity and structure-function relationship

Global cancer statistics

Jemal, A., Bray, F., Ferlay, J., Ward, E., & Forman, D. (2011) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.20107 · Cited by 55,077

Characterization of the Cellular Reduction of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT): Subcellular Localization, Substrate Dependence, and Involvement of Mitochondrial Electron Transport in MTT Reduction

Berridge, M. V., & Tan, A. S. (1993) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1993.1311 · Cited by 1,443

Chemical structures and bioactivities of sulfated polysaccharides from marine algae

Jiao, G., Yu, G., Zhang, J., & Ewart, H. S. (2011) · Marine Drugs · doi:10.3390/md9020196 · Cited by 1,054

Oxy-radicals and cancer

Cerutti, P. (1994) · The Lancet · doi:10.1016/s0140-6736(94)92832-0 · Cited by 566

A revised structure for fucoidan may explain some of its biological activities.

Patankar, M. S., Oehninger, S., Barnett, T., Williams, R. L., & Clark, G. F. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)80609-7 · Cited by 531

Oversulfation of fucoidan enhances its anti-angiogenic and antitumor activities

Koyanagi, S., Tanigawa, N., Nakagawa, H., Soeda, S., & Shimeno, H. (2003) · Biochemical Pharmacology · doi:10.1016/s0006-2952(02)01478-8 · Cited by 479

Structure and antitumour activity of fucoidan isolated from sporophyll of Korean brown seaweed Undaria pinnatifida

Synytsya, A., Kim, W.-J., Kim, S.-M., Pohl, R., Synytsya, A., Kvasnička, F., Čopíková, J., & Il Park, Y. (2010) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2010.01.052 · Cited by 461

Structure of a fucoidan from the brown seaweed Fucus evanescens C.Ag.

Bilan, M. I., Grachev, A. A., Ustuzhanina, N. E., Shashkov, A. S., Nifantiev, N. E., & Usov, A. I. (2002) · Carbohydrate Research · doi:10.1016/s0008-6215(02)00053-8 · Cited by 412

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Chizhov, A. O., Dell, A., Morris, H. R., Haslam, S. M., McDowell, R. A., Shashkov, A. S., Nifant’ev, N. E., Khatuntseva, E. A., & Usov, A. I. (1999) · Carbohydrate Research · doi:10.1016/s0008-6215(99)00148-2 · Cited by 326

Structural studies on fucoidans from the brown seaweed Sargassum stenophyllum

Duarte, M. E. R., Cardoso, M. A., Noseda, M. D., & Cerezo, A. S. (2001) · Carbohydrate Research · doi:10.1016/s0008-6215(01)00149-5 · Cited by 319

Recent Advances in Marine Algae Polysaccharides: Isolation, Structure, and Activities

Xu, S., Huang, X., & Cheong, K. (2017) · Marine Drugs · doi:10.3390/md15120388 · Cited by 424

Advanced Technologies for the Extraction of Marine Brown Algal Polysaccharides

Dobrinčić, A., Balbino, S., Zorić, Z., Pedišić, S., Kovačević, D. B., Garofulić, I. E., & Dragović‐Uzelac, V. (2020) · Marine Drugs · doi:10.3390/md18030168 · Cited by 350

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Liu, M., Liu, Y., Cao, M., Liu, G., Chen, Q., Sun, L., & Chen, H. (2017) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2017.05.060 · Cited by 221

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Wang, H.-M. D., Li, X.-C., Lee, D.-J., & Chang, J.-S. (2017) · Bioresource Technology · doi:10.1016/j.biortech.2017.05.198 · Cited by 217

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Lin, Y., Qi, X., Liu, H.-J., Xue, K., Xu, S., & Tian, Z. (2020) · Cancer Cell International · doi:10.1186/s12935-020-01233-8 · Cited by 219

Salt‐Tolerant Superoleophobicity on Alginate Gel Surfaces Inspired by Seaweed (Saccharina japonica)

Cai, Y. Q., Lu, Q., Guo, X., Wang, S., Qiao, J., & Jiang, L. (2015) · Advanced Materials · doi:10.1002/adma.201404479 · Cited by 195

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Sanjeewa, K. K. A., Lee, J.-S., Kim, W.-S., & Jeon, Y. (2017) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2017.09.005 · Cited by 194

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Fedorov, S., Ermakova, S., Zvyagintseva, T., & Stonik, V. (2013) · Marine Drugs · doi:10.3390/md11124876 · Cited by 189

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Lomartire, S., Marques, J. C., & Gonçalves, A. M. M. (2021) · Marine Drugs · doi:10.3390/md19060341 · Cited by 169

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Barbosa, A. I., Coutinho, A. J., Lima, S. A. C., & Reis, S. (2019) · Marine Drugs · doi:10.3390/md17120654 · Cited by 167

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Gutiérrez, A. G., Juárez-Portilla, C. J., Olivares-Bañuelos, T. N., & Zepeda, R. C. (2017) · Drug Discovery Today · doi:10.1016/j.drudis.2017.10.019 · Cited by 158

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Shang, X.-C., Chu, D., Zhang, J.-X., Zheng, Y.-F., & Li, Y. (2021) · Separation and Purification Technology · doi:10.1016/j.seppur.2020.118169 · Cited by 137

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Kan, Y., Chen, T.-Q., Wu, Y., wu, J., & Wu, J.-Z. (2014) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2014.07.056 · Cited by 131

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Saeed, M., Arain, M. A., Fazlani, S. A., Marghazani, I. B., Umar, M., Soomro, J., Bhutto, Z. A., Soomro, F., Noreldin, A. E., El-Hack, M. E. A., et al. (2021) · Aquaculture Nutrition · doi:10.1111/anu.13233 · Cited by 126

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Hwang, J., Yadav, D., Lee, P. C., & Jin, J. (2021) · Phytotherapy Research · doi:10.1002/ptr.7348 · Cited by 112

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Imbs, T. I., Skriptsova, A. V., & Николаевна, З. Т. (2014) · Journal of Applied Phycology · doi:10.1007/s10811-014-0293-7 · Cited by 107

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Jin, J., Chauhan, P., Arukha, A. P., Chavda, V. K., Dubey, A., & Yadav, D. (2021) · Marine Drugs · doi:10.3390/md19050265 · Cited by 100

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Manlusoc, J. K. T., Hsieh, C.-L., Hsieh, C.-Y., Salac, E. S. N., Lee, Y.-T., & Tsai, P. (2019) · Polymers · doi:10.3390/polym11071163 · Cited by 92

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Imbs, T. I., Ermakova, S. P., Malyarenko (Vishchuk), O. S., Isakov, V. V., & Zvyagintseva, T. N. (2016) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2015.08.062 · Cited by 84

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Ahmed, N., Sheikh, M. A., Ubaid, M., Chauhan, P., Kumar, K., & Choudhary, S. (2024) · Measurement Food · doi:10.1016/j.meafoo.2024.100163 · Cited by 84

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Usoltseva, R. V., Shevchenko, N. M., Malyarenko, O. S., Anastyuk, S. D., Kasprik, A. E., Zvyagintsev, N. V., & Ermakova, S. P. (2019) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2019.05.079 · Cited by 73

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Anastyuk, S. D., Шевченко, Н. М., Usoltseva, R. V., Silchenko, A. S., Zadorozhny, P. A., Dmitrenok, P. S., & Ermakova, S. P. (2016) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2016.11.031 · Cited by 74

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Mak, W., Wang, S. K., Liu, T., Hamid, N., Li, Y., Lu, J., & White, W. L. (2014) · Frontiers in Nutrition · doi:10.3389/fnut.2014.00009 · Cited by 71

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Kumari, A., Garima, G., & Bharadvaja, N. (2023) · 3 Biotech · doi:10.1007/s13205-022-03454-2 · Cited by 66

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Ma, T., Sun, X., Tian, C., Luo, J., Zheng, C., & Zhan, J. (2016) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2016.03.058 · Cited by 64

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Usoltseva, R. V., Шевченко, Н. М., Malyarenko, O. S., Ishina, I. A., Иванникова, С. И., & Ermakova, S. P. (2017) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2017.10.006 · Cited by 64

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Wen, Y., Gao, L., Zhou, H., Ai, C., Huang, X., Wang, M.-F., Zhang, Y., & Zhao, C. (2021) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2021.03.028 · Cited by 64

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Yu, Y., Zhang, Y., Hu, C., Zou, X., Yang, L., Xia, Y., & You, L. (2019) · Food and Chemical Toxicology · doi:10.1016/j.fct.2019.03.042 · Cited by 63

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Harvey, D. J. (2018) · Mass Spectrometry Reviews · doi:10.1002/mas.21530 · Cited by 61

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Baghel, R. S., Choudhary, B., Pandey, S., Pathak, P. K., Patel, M. K., & Mishra, A. (2023) · Foods · doi:10.3390/foods12193642 · Cited by 62

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Peng, Y., Song, Y., Wang, Q., Hu, Y., He, Y., Ren, D., Wu, L., Liu, S., Cong, H., & Zhou, H. (2018) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2018.12.197 · Cited by 58

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Vishchuk, O. S., Sun, H., Wang, Z., Ermakova, S. P., Xiao, J., Lu, T., Xue, P., Николаевна, З. Т., Xiong, H., Shao, C., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.7708 · Cited by 57

Chemical structure of sulfated polysaccharides from brown seaweed (Turbinaria turbinata)

Hammed, A. M., Jaswir, I., Şimşek, Ş., Amid, A., & Alam, M. Z. (2016) · International Journal of Food Properties · doi:10.1080/10942912.2016.1211144 · Cited by 56

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Centella, M. H., Arévalo-Gallegos, A., Parra‐Saldívar, R., & Iqbal, H. M. N. (2017) · Journal of Cleaner Production · doi:10.1016/j.jclepro.2017.05.086 · Cited by 56

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Usoltseva, R. V., Anastyuk, S. D., Surits, V. V., Шевченко, Н. М., Thinh, P. D., Zadorozhny, P. A., & Ermakova, S. P. (2018) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2018.11.223 · Cited by 56

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Han, Y. H., Wu, J., Liu, T., Hu, Y., Zheng, Q., Wang, B., Lin, H., & Li, X. (2015) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2015.11.049 · Cited by 54

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Ropellato, J., de Carvalho, M. M., Ferreira, L. G., Noseda, M. D., Zuconelli, C. R., Gonçalves, A. G., Ducatti, D. R. B., Kenski, J. C. N., Nasato, P. L., Winnischofer, S. M. B., et al. (2014) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2014.09.089 · Cited by 51

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Rasin, A. B., Silchenko, A. S., Игоревич, К. М., Malyarenko, O. S., Zueva, A. O., Kalinovsky, A. I., Airong, J., Surits, V. V., & Ermakova, S. P. (2020) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2020.116635 · Cited by 49

Recent research advances in polysaccharides from Undaria pinnatifida: Isolation, structures, bioactivities, and applications

Zeng, J., Luan, F., Hu, J., Liu, Y. Z., Zhang, X., Qin, T., Zhang, X., Liu, R., & Zeng, N. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.02.138 · Cited by 50

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Ravi, S., & Devi, K. P. (2019) · Studies in natural products chemistry · doi:10.1016/b978-0-12-817901-7.00005-8 · Cited by 48

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Zahariev, N., Katsarov, P., Lukova, P., & Pilicheva, B. (2023) · Polymers · doi:10.3390/polym15153242 · Cited by 48

High yield ultrasonication extraction method for Undaria pinnatifida sporophyll and its anti-inflammatory properties associated with AP-1 pathway suppression

Song, K., Ha, S. J., Lee, J., Kim, S.-H., Kim, Y. H., Kim, Y.-E., Hong, S.-P., Jung, S. K., & Lee, N. H. (2015) · LWT · doi:10.1016/j.lwt.2015.07.055 · Cited by 47

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Tian, T., Chang, H., He, K., Ni, Y., Li, C., Hou, M., Chen, L., Xu, Z., Chen, B., & Ji, M. (2019) · International Immunopharmacology · doi:10.1016/j.intimp.2019.105823 · Cited by 45

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Hussain, E., Wang, L., Jiang, B., Riaz, S., Butt, G. Y., & Shi, D. (2016) · RSC Advances · doi:10.1039/c5ra23995h · Cited by 46

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Minhas, L. A., Kaleem, M., Farooqi, H. M. U., Kausar, F., Waqar, R., Bhatti, T., Aziz, S., Jung, D. W., & Mumtaz, A. S. (2024) · Algal Research · doi:10.1016/j.algal.2024.103396 · Cited by 45

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Wu, J., Li, H., Wang, X., Zhang, X., Liu, W., Wang, Y., Zhang, Y., Pan, H., Wang, Q., & Han, Y. H. (2018) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2018.10.086 · Cited by 43

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Bittkau, K. S., Dörschmann, P., Blümel, M., Taşdemir, D., Roider, J. B., Klettner, A., & Alban, S. (2019) · Marine Drugs · doi:10.3390/md17080441 · Cited by 45

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Zhang, A., Li, X., Chen, X., Yang, J., & Sun, P. (2014) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2014.01.013 · Cited by 42

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Mazepa, E., Biscaia, S. M. P., Bellan, D. D. L., Trindade, E. D. S., & Simas, F. F. (2022) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2022.119436 · Cited by 40

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Lowenthal, R. M., & Fitton, J. H. (2014) · Journal of Applied Phycology · doi:10.1007/s10811-014-0444-x · Cited by 40

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Atiq, A., & Parhar, I. S. (2020) · Molecules · doi:10.3390/molecules25214895 · Cited by 40

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Rapinski, M., Cuerrier, A., Harris, C. S., Ivujivik, E. O., Kangiqsujuaq, E. O., & Lemire, M. (2018) · Journal of Ethnobiology · doi:10.2993/0278-0771-38.3.333 · Cited by 35

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Xin, Z., Zhang, M., Cui, H., Ding, X., Zhang, T., Wu, L., Cui, H., Xue, Q., Chen, C., & Gao, J. (2023) · International Journal of Nanomedicine · doi:10.2147/ijn.s423412 · Cited by 33

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Torres, M. D., Flórez-Fernández, N., Simón‐Vázquez, R., Giménez-Abián, J. F., Díaz, J. F., González‐Fernández, Á., & Domı́nguez, H. (2019) · Algal Research · doi:10.1016/j.algal.2019.101748 · Cited by 34

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Wahidi, M. E., Amraoui, B. E., Amraoui, M. E., & Bamhaoud, T. (2015) · Annales Pharmaceutiques Françaises · doi:10.1016/j.pharma.2014.12.005 · Cited by 32

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Malyarenko, O. S., Dyshlovoy, S. A., Kicha, A. A., Ivanchina, N. V., Malyarenko, T. V., Bokemeyer, C., von Gunhild, Stonik, V. A., & Ermakova, S. P. (2017) · Marine Drugs · doi:10.3390/md15070227 · Cited by 31

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Fucoidan Immobilized at the Surface of a Fibrous Mesh Presents Toxic Effects over Melanoma Cells, But Not over Noncancer Skin Cells

Oliveira, C., Soares, A. I., Neves, N. M., Reis, R. L., Marques, A. P., Silva, T. H., & Martins, A. M. (2020) · Biomacromolecules · doi:10.1021/acs.biomac.0c00482 · Cited by 19

Immunostimulatory effects of marine algae extracts on in vitro antigen‐presenting cell activation and in vivo immune cell recruitment

Ho, T. L., Lee, J., Ahn, S. Y., Lee, D., Song, W., Kang, I., & Ko, E. (2023) · Food Science & Nutrition · doi:10.1002/fsn3.3605 · Cited by 18

Optimum Extraction of Polysaccharide fromAreca catechuUsing Response Surface Methodology and its Antioxidant Activity

Hu, M.-B., Peng, W., Liu, Y., Wu, N., Zhao, C., Xie, D., Yan, D., Zhang, X., Tao, X., & Wu, C. (2016) · Journal of Food Processing and Preservation · doi:10.1111/jfpp.12798 · Cited by 18

Cladolosides C4, D1, D2, M, M1, M2, N and Q, new triterpene glycosides with diverse carbohydrate chains from sea cucumber Cladolabes schmeltzii. An uncommon 20,21,22,23,24,25,26,27-okta-nor-lanostane aglycone. The synergism of inhibitory action of non-toxic dose of the glycosides and radioactive irradiation on colony formation of HT-29 cancer cells

Silchenko, A. S., Kalinovsky, A. I., Avilov, S. A., Andryjaschenko, P. V., Dmitrenok, P. S., Yurchenko, E. A., Ermakova, S. P., Malyarenko, O. S., Dolmatov, I. Y., & Kalinin, V. I. (2018) · Carbohydrate Research · doi:10.1016/j.carres.2018.08.003 · Cited by 18

The Effect of Fucoidan from the Brown Alga Fucus evanescence on the Activity of α-N-Acetylgalactosaminidase of Human Colon Carcinoma Cells

Bakunina, I. Y., Chadova, K., Malyarenko, O. S., & Ermakova, S. P. (2018) · Marine Drugs · doi:10.3390/md16050155 · Cited by 17

Recombinant latcripin 11 of Lentinula edodes C91-3 suppresses the proliferation of various cancer cells

Gao, Y., Padhiar, A. A., Wang, J., Zhang, W., Zhong, M., Liu, B., Kang, Z., Wang, X., Li, X., & Huang, M. (2017) · Gene · doi:10.1016/j.gene.2017.10.080 · Cited by 15

Therapeutic potential of fucoidan in the reduction of hepatic pathology in murine schistosomiasis japonica

Bai, X., Li, M., Wang, X., Chang, H., Ni, Y., Li, C., He, K., Wang, H., Yang, Y., Tian, T., et al. (2020) · Parasites & Vectors · doi:10.1186/s13071-020-04332-7 · Cited by 15

Determination of the structure and in vitro anticancer activity of fucan from Saccharina dentigera and its derivatives

Usoltseva, R. V., Шевченко, Н. М., Silchenko, A. S., Anastyuk, S. D., Zvyagintsev, N. V., & Ermakova, S. P. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.02.126 · Cited by 13

In Vitro Anti-HIV-1 Activity of Fucoidans from Brown Algae

Nosik, M. N., Nv, K., Usoltseva, R. V., Surits, V. V., Евгеньевич, К. Д., Shchelkanov, M. Y., Свитич, О. А., & Ermakova, S. P. (2024) · Marine Drugs · doi:10.3390/md22080355 · Cited by 12

The Beneficial Roles of Seaweed in Atopic Dermatitis

Kim, A., Kim, M., Seo, J., Moon, K. M., & Lee, B. (2024) · Marine Drugs · doi:10.3390/md22120566 · Cited by 12

Evaluation of antioxidant properties and cytotoxicity of brown algae (nizamuddinia zanardinii) in uterine (hela) and pancreatic cancer cell lines (paca-2)

Amerifar, M., Arabnozari, H., Shokrzadeh, M., & Habibi, E. (2024) · Human & Experimental Toxicology · doi:10.1177/09603271241227228 · Cited by 12

Structural characterization of sulfated galactofucan from Undaria pinnatifida and its effect on type 2 diabetic mice

Ke, S., Zhang, B., Yu, Y., Wang, S., Jin, W., Wu, J., Chen, J., Zhang, H., Wei, B., & Wang, H. (2022) · Journal of Oceanology and Limnology · doi:10.1007/s00343-021-1307-3 · Cited by 9

The Combined Metabolically Oriented Effect of Fucoidan from the Brown Alga Saccharina cichorioides and Its Carboxymethylated Derivative with 2-Deoxy-D-Glucose on Human Melanoma Cells

Malyarenko, O. S., Usoltseva, R. V., Silchenko, A. S., Zueva, A. O., & Ermakova, S. P. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241512050 · Cited by 9

Fucoidan inhibits Ca2+ responses induced by a wide spectrum of agonists for G‑protein‑coupled receptors

Wu, H., Gao, S., Fu, M., Sakurai, T., & Terakawa, S. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.8035 · Cited by 9

Evaluation of chemical constituents of Stoechospermum marginatum and its potential for antioxidant and antimicrobial activity

Sarangi, N. V., Anandapadmanaban, B. H., Rajkumar, R., & Ashokkumar, V. (2023) · Biomass Conversion and Biorefinery · doi:10.1007/s13399-023-03897-4 · Cited by 9

Advanced Polymeric Membranes as Biomaterials Based on Marine Sources Envisaging the Regeneration of Human Tissues

Carvalho, D. N., Lobo, F. C. M., Rodrigues, L. C., Fernandes, E. M., Williams, D. S., Mearns‐Spragg, A., Sotelo, C. G., Pérez‐Martín, R. I., Reis, R. L., Gelinsky, M., et al. (2023) · Gels · doi:10.3390/gels9030247 · Cited by 8

Combined Radiomodifying Effect of Fucoidan from the Brown Alga Saccharina cichorioides and Pacificusoside D from the Starfish Solaster pacificus in the Model of 3D Melanoma Cells

Malyarenko, O. S., Malyarenko, T. V., Usoltseva, R. V., Kicha, A. A., Ivanchina, N. V., & Ermakova, S. P. (2023) · Biomolecules · doi:10.3390/biom13030419 · Cited by 8

Algal Polysaccharides and Their Biological Properties

Cheong, K., Jesumani, V., Khan, B. M., Liu, Y., & Du, H. (2021) · Wiley eBooks · doi:10.1002/9781119542650.ch10 · Cited by 8

Research hotspots and trends in discovery of anticancer agents from algae: A 20-year bibliometric and visualized analysis based on Web of Science and CiteSpace

Gao, K., Zhang, M., Li, L., Yang, M., Zheng, Q., Liu, Q., Ning, R., Gao, Z., & Deng, X. (2023) · Algal Research · doi:10.1016/j.algal.2023.103244 · Cited by 7

Potential of Fucoidan From Brown Seaweeds (Sargassum sp.) as Innovation Therapy on Breast Cancer

Satyarsa, A. B. S. (2019) · Journal Of Medicine & Health · doi:10.28932/jmh.v2i3.1235 · Cited by 7

Comparison of anti-tumor activities and underlying mechanisms of glucuronomannan oligosaccharides and its sulfated derivatives on the hepatocarcinoma Huh7.5 cells

He, X., Chen, F., Lu, C., Wang, S., Mao, G., Jin, W., & Zhong, W. (2023) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2023.02.049 · Cited by 6

Novel Fermented Marine-Based Products

Rajauria, G., Sharma, S., Emerald, M., & Jaiswal, A. K. (2016) · Food engineering series · doi:10.1007/978-3-319-42457-6_11 · Cited by 6

Characterization of l -fucose isomerase fromPaenibacillus rhizosphaeraeto produce l -fuculose from hydrolyzed fucoidan and commercial fucose

Iqbal, M. W., Riaz, T., Mahmood, S., Zhu, Y., Qi, X., Khan, I. M., Zhang, W., & Mu, W. (2022) · Journal of Applied Microbiology · doi:10.1093/jambio/lxac007 · Cited by 6

Immunomodulatory and Therapeutic Potential of Marine Flora Products in the Treatment of Cancer

Singh, A., & Krishna, S. (2019) · Springer eBooks · doi:10.1007/978-981-13-7607-8_7 · Cited by 6

Magnumosides B 3 , B 4 and C 3 , Mono- and Disulfated Triterpene Tetraosides from the Vietnamese Sea Cucumber Neothyonidium (= Massinium) magnum

Silchenko, A. S., Kalinovsky, A. I., Avilov, S. A., Kalinin, V. I., Andrijaschenko, P. V., Dmitrenok, P. S., Chingizova, E. A., Ermakova, S. P., Malyarenko, O. S., & Николаевна, Д. Т. (2017) · Natural Product Communications · doi:10.1177/1934578x1701201013 · Cited by 5

Antitumor and antimetastatic activity of fucoidan, a sulfated polysaccharide isolated from the Okhotsk Sea Fucus evanescens brown alga

Alekseyenko, T. V., Zhanayeva, S. Y., Venediktova, A. A., Zvyagintseva, T. N., Kuznetsova, T. A., Besednova, N. N., & Korolenko, T. A. (2007) · Bulletin of Experimental Biology and Medicine · doi:10.1007/s10517-007-0226-4 · Cited by 244

Fucoidans: Anticancer Activity and Molecular Mechanisms of Action

Malyarenko, O. S., & Ermakova, S. P. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809816-5.00010-4 · Cited by 21

Fucoidans from Brown Seaweeds Sargassum hornery, Eclonia cava, Costaria costata: Structural Characteristics and Anticancer Activity

Ermakova, S., Sokolova, R., Kim, S.-M., Um, B.-H., Isakov, V., & Zvyagintseva, T. (2011) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-011-9178-2 · Cited by 229

Fucoidan, A Sulfated Polysaccharides from Brown Algae as Therapeutic Target for Cancer

Kalimuthu, S., & Kim, S. (2014) · Springer eBooks · doi:10.1007/978-3-319-07145-9_7 · Cited by 26

Fucoidan From Brown Algae as a Functional Food Ingredient: A Promising Anticancer Agent

Khan, M. U., Khurram, I., Munir, M., Ullah, M. I., Ghanem, H. B., Sharifi‐Rad, J., Setzer, W. N., & Călina, D. C. (2025) · eFood · doi:10.1002/efd2.70085 · Cited by 3