The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
The fucoidans from brown algae of Far-Eastern seas: Anti-tumor activity and structure-function relationship
Abstract
The sulfated polysaccharides from brown algae - the fucoidans - are known to be a topic of numerous studies, due to their beneficial biological activities including anti-tumour activity. In this study the effect of fucoidans isolated from brown algae Saccharina cichorioides, Fucus evanescens, and Undaria pinnatifida on the proliferation, neoplastic transformation, and colony formation of mouse epidermal cells JB6 Cl41, human colon cancer DLD-1, breast cancer T-47D, and melanoma RPMI-7951 cell lines was investigated. The algal fucoidans specifically and markedly suppressed the proliferation of human cancer cells with less cytotoxic effects against normal mouse epidermal cells. The highly sulfated (1→3)-α-l-fucan from S. cichorioides was found to be vitally important in the inhibition of EGF-induced neoplastic transformation of JB6 Cl41 cells. In colony formation assay the fucoidans from different species of brown algae showed selective anti-tumour activity against different types of cancer, which depended on unique structures of the investigated polysaccharides. These results provide evidence for further exploring the use of the fucoidans from S. cichorioides, F. evanescens, and U. pinnatifida as novel chemotherapeutics against different types of cancer.
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“This research is necessary for the solution of problems of standardization of preparations on the basis of fucoidans, which have attracted attention as practically nontoxic natural products [25,26,27] with antitumor, immunomodulatory, and other useful properties [24,28,29,30].”
From Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects (2013) · cites this paper as [29]
In the citing paper
“The inhibition of cell transformation provided evidence on the anti-tumorigenic potential of fucoidans from A. nodosum [57], S. japonica, U. pinnatifida, Alaria sp., and F. evanescens [29,45,58].”
From Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects (2013) · cites this paper as [29]
Citations
Cites
Jemal, A., Bray, F., Ferlay, J., Ward, E., & Forman, D. (2011) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.20107 · Cited by 55,077
Berridge, M. V., & Tan, A. S. (1993) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1993.1311 · Cited by 1,443
Chemical structures and bioactivities of sulfated polysaccharides from marine algae
Jiao, G., Yu, G., Zhang, J., & Ewart, H. S. (2011) · Marine Drugs · doi:10.3390/md9020196 · Cited by 1,054
Cerutti, P. (1994) · The Lancet · doi:10.1016/s0140-6736(94)92832-0 · Cited by 566
A revised structure for fucoidan may explain some of its biological activities.
Patankar, M. S., Oehninger, S., Barnett, T., Williams, R. L., & Clark, G. F. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)80609-7 · Cited by 531
Oversulfation of fucoidan enhances its anti-angiogenic and antitumor activities
Koyanagi, S., Tanigawa, N., Nakagawa, H., Soeda, S., & Shimeno, H. (2003) · Biochemical Pharmacology · doi:10.1016/s0006-2952(02)01478-8 · Cited by 479
Synytsya, A., Kim, W.-J., Kim, S.-M., Pohl, R., Synytsya, A., Kvasnička, F., Čopíková, J., & Il Park, Y. (2010) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2010.01.052 · Cited by 461
Structure of a fucoidan from the brown seaweed Fucus evanescens C.Ag.
Bilan, M. I., Grachev, A. A., Ustuzhanina, N. E., Shashkov, A. S., Nifantiev, N. E., & Usov, A. I. (2002) · Carbohydrate Research · doi:10.1016/s0008-6215(02)00053-8 · Cited by 412
A study of fucoidan from the brown seaweed Chorda filum
Chizhov, A. O., Dell, A., Morris, H. R., Haslam, S. M., McDowell, R. A., Shashkov, A. S., Nifant’ev, N. E., Khatuntseva, E. A., & Usov, A. I. (1999) · Carbohydrate Research · doi:10.1016/s0008-6215(99)00148-2 · Cited by 326
Structural studies on fucoidans from the brown seaweed Sargassum stenophyllum
Duarte, M. E. R., Cardoso, M. A., Noseda, M. D., & Cerezo, A. S. (2001) · Carbohydrate Research · doi:10.1016/s0008-6215(01)00149-5 · Cited by 319
A disaccharide repeat unit is the major structure in fucoidans from two species of brown algae
Chevolot, L., Mulloy, B., Ratiskol, J., Foucault, A. P., & Colliec‐Jouault, S. (2001) · Carbohydrate Research · doi:10.1016/s0008-6215(00)00314-1 · Cited by 312
Aisa, Y., Miyakawa, Y., Nakazato, T., Shibata, H., Saito, K., Ikeda, Y., & Kizaki, M. (2005) · American Journal of Hematology · doi:10.1002/ajh.20182 · Cited by 307
Tumour promoter induces anchorage independence irreversibly
Colburn, N. H., Former, B. F., Nelson, K. A., & Yuspa, S. H. (1979) · Nature · doi:10.1038/281589a0 · Cited by 284
Fucoidan present in brown algae induces apoptosis of human colon cancer cells
Kim, E. J., Park, S. Y., Lee, J.-Y., & Park, J. H. Y. (2010) · BMC Gastroenterology · doi:10.1186/1471-230x-10-96 · Cited by 275
Vishchuk, O. S., Ermakova, S. P., & Zvyagintseva, T. N. (2011) · Carbohydrate Research · doi:10.1016/j.carres.2011.09.034 · Cited by 267
Self-citationStructure of a fucoidan from the brown seaweed Fucus serratus L.
Bilan, M. I., Grachev, A. A., Shashkov, A. S., Nifantiev, N. E., & Usov, A. I. (2006) · Carbohydrate Research · doi:10.1016/j.carres.2005.11.009 · Cited by 263
A highly regular fraction of a fucoidan from the brown seaweed Fucus distichus L.
Bilan, M. I., Grachev, A. A., Ustuzhanina, N. E., Shashkov, A. S., Nifantiev, N. E., & Usov, A. I. (2004) · Carbohydrate Research · doi:10.1016/j.carres.2003.10.028 · Cited by 259
Relationship between sulfate groups and biological activities of fucans
Haroun-Bouhedja, F., Ellouali, M., Sinquin, C., & Boisson-Vidal, C. (2000) · Thrombosis Research · doi:10.1016/s0049-3848(00)00338-8 · Cited by 256
Yang, C., Chung, D., Shin, I.-S., Lee, H., Kim, J., Lee, Y., & You, S. (2008) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2008.08.006 · Cited by 254
Mechanisms of multistep carcinogenesis and carcinogen risk assessment.
Barrett, J. C. (1993) · Environmental Health Perspectives · doi:10.1289/ehp.931009 · Cited by 231
Ermakova, S., Sokolova, R., Kim, S.-M., Um, B.-H., Isakov, V., & Zvyagintseva, T. (2011) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-011-9178-2 · Cited by 229
Self-citationColon carcinogens: Their metabolism and mode of action
Weisburger, J. H. (1971) · Cancer · doi:10.1002/1097-0142(197107)28:1 · Cited by 227
Николаевна, З. Т., Shevchenko, N. M., Chizhov, A. O., Krupnova, T. N., Sundukova, E. V., & Isakov, V. V. (2003) · Journal of Experimental Marine Biology and Ecology · doi:10.1016/s0022-0981(03)00244-2 · Cited by 221
Rioux, L.-E., Turgeon, S. L., & Beaulieu, M. (2010) · Phytochemistry · doi:10.1016/j.phytochem.2010.05.021 · Cited by 216
Colburn, N. H., Wendel, E. J., & Abruzzo, G. K. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.11.6912 · Cited by 180
Structural study of fucoidan from Cladosiphon okamuranus tokida
Nagaoka, M., Shibata, H., Kimura-Takagi, I., Hashimoto, S., Kimura, K., Makino, T., Aiyama, R., Ueyama, S., & Yokokura, T. (1999) · Glycoconjugate Journal · doi:10.1023/a:1006945618657 · Cited by 173
Wang, J., Zhang, Q., Zhang, Z., Zhang, H., & Niu, X. (2010) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2010.05.010 · Cited by 159
Skriptsova, A. V., Shevchenko, N. M., Николаевна, З. Т., & Imbs, T. I. (2009) · Journal of Applied Phycology · doi:10.1007/s10811-009-9438-5 · Cited by 152
Apoptosis inducing activity of fucoidan in HCT-15 colon carcinoma cells
Hyun, J.-H., Kim, S.-C., Kang, J.-I., Kim, M.-K., Boo, H.-J., Kwon, J.-M., Koh, Y.-S., Hyun, J.-W., Park, D.-B., Yoo, E.-S., et al. (2009) · Biological & Pharmaceutical Bulletin · doi:10.1248/bpb.32.1760 · Cited by 150
Haneji, K., Matsuda, T., Tomita, M., Kawakami, H., Ohshiro, K., Uchihara, J., Masuda, M., Takasu, N., Tanaka, Y., Ohta, T., et al. (2005) · Nutrition and Cancer · doi:10.1207/s15327914nc5202_9 · Cited by 139
Park, Y., Brinton, L. A., Subar, A. F., Hollenbeck, A. R., & Schatzkin, A. G. (2009) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.27758 · Cited by 137
Nishino, T., Nagumo, T., Kiyohara, H., & Yamada, H. (1991) · Carbohydrate Research · doi:10.1016/0008-6215(91)84147-7 · Cited by 118
Nishino, T., Aizu, Y., & Nagumo, T. (1991) · Thrombosis Research · doi:10.1016/0049-3848(91)90072-5 · Cited by 106
A case–control study on seaweed consumption and the risk of breast cancer
Yang, Y. J., Nam, S. J., Kong, G., & Kim, M. K. (2009) · British Journal Of Nutrition · doi:10.1017/s0007114509993242 · Cited by 103
Polysaccharide and lipid composition of the brown seaweed Laminaria gurjanovae
Шевченко, Н. М., Anastyuk, S. D., Ивановна, Г. Н., Dmitrenok, P. S., Isakov, V. V., & Николаевна, З. Т. (2007) · Russian Journal of Bioorganic Chemistry · doi:10.1134/s1068162007010116 · Cited by 97
Anastyuk, S. D., Shevchenko, N. M., Nazarenko, E. L., Dmitrenok, P. S., & Zvyagintseva, T. N. (2009) · Carbohydrate Research · doi:10.1016/j.carres.2009.01.023 · Cited by 96
Anastyuk, S. D., Шевченко, Н. М., Nazarenko, E. L., Imbs, T. I., Иванович, Г. В., Dmitrenok, P. S., & Николаевна, З. Т. (2010) · Carbohydrate Research · doi:10.1016/j.carres.2010.07.043 · Cited by 92
Cell Transformation Assays as Predictors of Human Carcinogenicity
Combes, R. D., Balls, M., Curren, R., Fischbach, M., Fusenig, N. E., Kirkland, D., Lasne, C., Landolph, J. R., LeBœuf, R. A., Marquardt, H., et al. (1999) · Alternatives to Laboratory Animals · doi:10.1177/026119299902700505 · Cited by 89
Inhibitory Effect of Fucoidan on Huh7 Hepatoma Cells Through Downregulation of CXCL12
Nagamine, T., Hayakawa, K., Kusakabe, T., Takada, H., Nakazato, K., Hisanaga, E., & Iha, M. (2009) · Nutrition and Cancer · doi:10.1080/01635580802567133 · Cited by 88
Lee, N. Y., Ermakova, S. P., Zvyagintseva, T. N., Kang, K. W., Dong, Z., & Choi, H. S. (2008) · Food and Chemical Toxicology · doi:10.1016/j.fct.2008.01.025 · Cited by 75
Self-citationIsolation and Characterization of a Fucoidan-Degrading Marine Bacterial Strain and Its Fucoidanase
Sakai, T., Kawai, T., & Kato, I. (2004) · Marine Biotechnology · doi:10.1007/s10126-003-0033-5 · Cited by 69
Vishchuk, O. S., Tarbeeva, D. V., Ermakova, S. P., & Zvyagintseva, T. N. (2012) · Chemistry & Biodiversity · doi:10.1002/cbdv.201100266 · Cited by 56
Self-citationAntitumor properties of nonstarch polysaccharides: Fucoidans and chitosans
Khotimchenko, Y. S. (2010) · Russian Journal of Marine Biology · doi:10.1134/s1063074010050019 · Cited by 30
Oligosaccharides as anti-angiogenic agents
Cole, C. L., & Jayson, G. C. (2008) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.8.3.351 · Cited by 23
Research works printed but not linked: 1
- Vishchuk, 2009, Antitumor activity of fucoidans from brown algae, Pacific Medical Journal, 3, 92
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Xu, S., Huang, X., & Cheong, K. (2017) · Marine Drugs · doi:10.3390/md15120388 · Cited by 424
Advanced Technologies for the Extraction of Marine Brown Algal Polysaccharides
Dobrinčić, A., Balbino, S., Zorić, Z., Pedišić, S., Kovačević, D. B., Garofulić, I. E., & Dragović‐Uzelac, V. (2020) · Marine Drugs · doi:10.3390/md18030168 · Cited by 350
Antibacterial activity and mechanisms of depolymerized fucoidans isolated from Laminaria japonica
Liu, M., Liu, Y., Cao, M., Liu, G., Chen, Q., Sun, L., & Chen, H. (2017) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2017.05.060 · Cited by 221
Potential biomedical applications of marine algae
Wang, H.-M. D., Li, X.-C., Lee, D.-J., & Chang, J.-S. (2017) · Bioresource Technology · doi:10.1016/j.biortech.2017.05.198 · Cited by 217
The anti-cancer effects of fucoidan: a review of both in vivo and in vitro investigations
Lin, Y., Qi, X., Liu, H.-J., Xue, K., Xu, S., & Tian, Z. (2020) · Cancer Cell International · doi:10.1186/s12935-020-01233-8 · Cited by 219
Metadata
- Authors
- Vishchuk, O. S., Ermakova, S. P., & Zvyagintseva, T. N.
- Affiliations
- Russian Academy of Sciences (RU)
- Venue
- Food Chemistry
- Publisher
- Elsevier BV
- Published
- 2013-11
- Volume
- 141
- Issue
- 2
- Pages
- 1211-1217
- ISSN
- 0308-8146 (ISSN-L)
- OpenAlex
- W2066719859
- Cited by
- 117
- References
- 44
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 10 · 2023: 14 · 2022: 7 · 2021: 7 · 2020: 10 · 2019: 18 · 2018: 8 · 2017: 13 · 2016: 9 · 2015: 5 · 2014: 8 · 2013: 1
- FWCI
- 11.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Food Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Russian Foundation for Basic Research
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
- Physical Sciences › Earth and Planetary Sciences › Oceanography › Marine and coastal plant biology
- Keywords
- fucoidan, sulfated polysaccharides, brown algae, anticancer activity, structure-function relationship, Fucus evanescens, Undaria pinnatifida, colon cancer, breast cancer, melanoma, cell proliferation inhibition, colony formation, chemotherapeutics, Far Eastern seas
- MeSH terms
- Phaeophyceae, Animals, Antineoplastic Agents, Humans, Neoplasms, Polysaccharides, Structure-Activity Relationship, Cell Proliferation, Mice
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