The DOI matches its Crossref record; 159 of the 160 references it cites were found in a registry or an index.
New insights into bacterial bile resistance mechanisms: the role of bile salt hydrolase and its impact on human health
Open accessAbstract
Bile acids (BA), the major components of bile, are biological detergents that facilitate the emulsification and solubilization of dietary lipids and also display potent antimicrobial activity, the bacterial membranes being their main targets. Considering the complicated nature of the stress produced by bile and BA, the microorganism tolerance requires different defence mechanisms including the presence of efflux pumps, bile salt hydrolase (BSH) enzyme, the intrinsic capacity of cells to maintain intracellular homeostasis and modifications in the architecture and composition of the cell membrane. Besides, the expression of proteins involved in carbohydrate and fatty acid metabolism, amino acid and nitrogenous base biosynthesis, and general stress response are commonly affected by the presence of bile. Among the microbial transformations, deconjugation of BA by BSH is the most important. Several studies indicate that BSH activity affects both the host physiology and the microbiota. In fact, it was strongly suggested that BSH could play an important role in the colonization and survival of bacteria in the gut. Also, recent work has shown that BSH and free BA participate in a variety of metabolic processes that include regulation of dietary lipid absorption, cholesterol metabolism, and energy and inflammation homeostasis. In this review we summarize recent advances in the understanding of the mechanisms involved in the tolerance of bacteria to bile, with special emphasis on the contributions of studies applying an omic approach. Besides, the physiological and ecological role of BSH enzyme and its relevance to human health as well as the function of bile acid as metabolic regulator are also discussed.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“The deconjugation ability enhances bacterial survival and colonization of the gastrointestinal tract, modulates lipid metabolism, and shapes the bile acid pool, ultimately influencing host-microbiome signaling [6, 10, 11].”
From Bile Salt Hydrolase Activity in the Food-Derived Strain Levilactobacillus brevis M3R3: Genomic and Functional Characterization (2026) · cites this paper as [10]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“BSH activity is widely distributed among gastrointestinal microbes, including various Lactobacillaceae species [5–8], where the presence of multiple bsh orthologs reflects strain-specific adaptations into the intestinal environment [5, 8–10].”
From Bile Salt Hydrolase Activity in the Food-Derived Strain Levilactobacillus brevis M3R3: Genomic and Functional Characterization (2026) · cites this paper as [10]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“As previously demonstrated, BSs tolerance was largely attributed to BSH-mediated deconjugation of BSs, which enhances cell viability under gastrointestinal conditions [6, 10].”
From Bile Salt Hydrolase Activity in the Food-Derived Strain Levilactobacillus brevis M3R3: Genomic and Functional Characterization (2026) · cites this paper as [10]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“The deconjugation ability enhances bacterial survival and colonization of the gastrointestinal tract, modulates lipid metabolism, and shapes the bile acid pool, ultimately influencing host-microbiome signaling [6, 10, 11].”
From Bile Salt Hydrolase Activity in the Food-Derived Strain Levilactobacillus brevis M3R3: Genomic and Functional Characterization (2026) · cites this paper as [10]
The cited source says what the claim attributes to it.
In the citing paper
“The deconjugation ability enhances bacterial survival and colonization of the gastrointestinal tract, modulates lipid metabolism, and shapes the bile acid pool, ultimately influencing host-microbiome signaling [6, 10, 11].”
From Bile Salt Hydrolase Activity in the Food-Derived Strain Levilactobacillus brevis M3R3: Genomic and Functional Characterization (2026) · cites this paper as [10]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites
Koh, A., De Vadder, F., Kovatcheva-Datchary, P., & Bäckhed, F. (2016) · Cell · doi:10.1016/j.cell.2016.05.041 · Cited by 7,070
Topping, D. L., & Clifton, P. M. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.3.1031 · Cited by 3,091
Sayin, S. I., Wahlström, A., Felin, J., Jäntti, S., Marschall, H.-U., Bamberg, K., Angelin, B., Hyötyläinen, T., Orešič, M., & Bäckhed, F. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.01.003 · Cited by 2,331
Food Animals and Antimicrobials: Impacts on Human Health
Marshall, B. M., & Levy, S. B. (2011) · Clinical Microbiology Reviews · doi:10.1128/cmr.00002-11 · Cited by 2,241
The Enzymes, Regulation, and Genetics of Bile Acid Synthesis
Russell, D. W. (2003) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.72.121801.161712 · Cited by 2,069
The interaction between bacteria and bile
Begley, M., Gahan, C. G. M., & Hill, C. (2004) · FEMS Microbiology Reviews · doi:10.1016/j.femsre.2004.09.003 · Cited by 1,776
Bile Acid Metabolism and Signaling
Chiang, J. Y. L. (2013) · Comprehensive physiology · doi:10.1002/cphy.c120023 · Cited by 1,662
Multidrug-resistance efflux pumps ? not just for resistance
Piddock, L. J. V. (2006) · Nature Reviews Microbiology · doi:10.1038/nrmicro1464 · Cited by 1,523
Bile acids: regulation of synthesis
Chiang, J. Y. L. (2009) · Journal of Lipid Research · doi:10.1194/jlr.r900010-jlr200 · Cited by 1,515
Molecular Basis for Feedback Regulation of Bile Acid Synthesis by Nuclear Receptors
Lu, T. T., Makishima, M., Repa, J. J., Schoonjans, K., Kerr, T. A., Auwerx, J., & Mangelsdorf, D. J. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00050-2 · Cited by 1,487
Research works printed but not linked: 1
- Reyes-Nava, 2014, Isolation sources of bile salt hydrolase-microorganisms, Herald Journal of Agriculture and Food Science Research, 3, 49
Cited by
Sorted by citations
Diversification of host bile acids by members of the gut microbiota
Winston, J. A., & Theriot, C. M. (2019) · Gut Microbes · doi:10.1080/19490976.2019.1674124 · Cited by 597
Bile acids as modulators of gut microbiota composition and function
Larabi, A. B., Masson, H. L. P., & Bäumler, A. J. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2172671 · Cited by 443
Foley, M. H., O’Flaherty, S., Barrangou, R., & Theriot, C. M. (2019) · PLOS Pathogens · doi:10.1371/journal.ppat.1007581 · Cited by 271
The microbiome modulating activity of bile acids
Tian, Y., Gui, W., Koo, I., Smith, P. B. W., Allman, E. L., Nichols, R. G., Rimal, B., Cai, J., Liu, Q., & Patterson, A. D. (2020) · Gut Microbes · doi:10.1080/19490976.2020.1732268 · Cited by 255
Interactive relationships between intestinal flora and bile acids
Guo, X., Okpara, E. S., Hu, W., Yan, C., Wang, Y., Liang, Q., Chiang, J. Y. L., & Han, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158343 · Cited by 206
Foley, M. H., O’Flaherty, S., Allen, G., Rivera, A. J., Stewart, A. K., Barrangou, R., & Theriot, C. M. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2017709118 · Cited by 205
Zhang, H.-Y., Tian, J., Lian, F., Li, M., Liu, W., Zhong, Z., Liao, J., & Tong, X. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110857 · Cited by 166
Ayyash, M. M., Abdalla, A. K., Alkalbani, N. S., Baig, M. A., Turner, M. S., Liu, S., & Shah, N. P. (2021) · Journal of Dairy Science · doi:10.3168/jds.2021-20398 · Cited by 183
Chen, Q., Liu, M., Zhang, P., Fan, S., Huang, J., Yu, S., Zhang, C., & Li, H. (2019) · Nutrition · doi:10.1016/j.nut.2019.03.001 · Cited by 157
Plasmids Shaped the Recent Emergence of the Major Nosocomial Pathogen Enterococcus faecium
Arredondo-Alonso, S., Top, J., McNally, A., Puranen, S., Pesonen, M., Pensar, J., Marttinen, P., Braat, J. C., Rogers, M. R. C., van Schaik, W., et al. (2020) · mBio · doi:10.1128/mbio.03284-19 · Cited by 144
Bile Salt Hydrolases: At the Crossroads of Microbiota and Human Health
Bourgin, M., Kriaa, A., Mkaouar, H., Mariaule, V., Jablaoui, A., Maguin, E., & Rhimi, M. (2021) · Microorganisms · doi:10.3390/microorganisms9061122 · Cited by 152
Goel, A., Halami, P. M., & Tamang, J. P. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.00040 · Cited by 125
Bustos, A. Y., Taranto, M. P., Gerez, C. L., Agriopoulou, S., Smaoui, S., Varzakas, T. H., & Enshasy, H. A. E. (2024) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-024-10273-9 · Cited by 142
Self-citationda Silva, T. F., Glória, R. D. A., Americo, M. F., Freitas, A. D. S., de Jesus, L. C. L., Barroso, F. A. L., Laguna, J. G., Coelho-Rocha, N. D., Tavares, L. M., le Loir, Y., et al. (2024) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-024-10247-x · Cited by 117
Bile acids affect intestinal barrier function through FXR and TGR5
Song, G., Xie, Y., Yi, L., Cheng, W., Jia, H., Shi, W., Liu, Q., Fang, L., Xue, S., Liu, D., et al. (2025) · Frontiers in Medicine · doi:10.3389/fmed.2025.1607899 · Cited by 111
Agolino, G., Pino, A., Vaccalluzzo, A., Cristofolini, M., Solieri, L., Caggia, C., & Randazzo, C. L. (2024) · Journal of Functional Foods · doi:10.1016/j.jff.2024.106357 · Cited by 99
Hua, Y., Jia, Y., Zhang, X., Yuan, Z., Ji, P., Hu, J., & Wei, Y. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111320 · Cited by 81
Han, B., Li, J., Li, S., Liú, Y., & Zhang, Z. (2022) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2022.130082 · Cited by 71
Metagenomic analysis of bile salt biotransformation in the human gut microbiome
Das, P., Marcišauskas, S., Ji, B., & Nielsen, J. (2019) · BMC Genomics · doi:10.1186/s12864-019-5899-3 · Cited by 74
Imidacloprid disturbed the gut barrier function and interfered with bile acids metabolism in mice
Yang, G., Yuan, X., Jin, C., Wang, D., Wang, Y., Miao, W., & Jin, Y. (2020) · Environmental Pollution · doi:10.1016/j.envpol.2020.115290 · Cited by 69
New insights into microbial bile salt hydrolases: from physiological roles to potential applications
Dong, Z., Yang, S., Tang, C., Li, D., Kan, Y., & Yao, L. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1513541 · Cited by 64
Yu, Z., Shi, Z., Zheng, Z., Han, J., Yang, W., Lu, R., Lin, W., Zheng, Y., Nie, D., & Chen, G. (2020) · Chemosphere · doi:10.1016/j.chemosphere.2020.127959 · Cited by 62
Regulation of bile acid metabolism-related signaling pathways by gut microbiota in diseases
Jia, E., Liu, Z.-Y., Pan, M., Lu, J., & Ge, Q. (2019) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.b1900073 · Cited by 55
Oral delivery of probiotics using single‐cell encapsulation
Han, J., McClements, D. J., Liu, X., & Liu, F. (2024) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.13322 · Cited by 51
The gut microbiota in transplant patients
Chong, P. P., & Koh, A. Y. (2019) · Blood Reviews · doi:10.1016/j.blre.2019.100614 · Cited by 53
Kusada, H., Morinaga, K., & Tamaki, H. (2021) · Microorganisms · doi:10.3390/microorganisms9051011 · Cited by 58
Dai, H., Shan, Z., Shi, L., Duan, Y., An, Y., He, C., Lyu, Y., Zhao, Y., Wang, M., Du, Y., et al. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.136876 · Cited by 49
Yang, D., Lyu, W., Hu, Z., Gao, J., Zheng, Z.-Y., Wang, W., Firrman, J., & Ren, D. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.705763 · Cited by 45
Probiotics for the treatment of hyperlipidemia: Focus on gut-liver axis and lipid metabolism
You, M. S., Zhou, L., Wu, F., Zhang, L., Zhu, S.-X., & Zhang, H. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107694 · Cited by 53
Genome analysis reveals probiotic propensities of Paenibacillus polymyxa HK4
Soni, R., Nanjani, S., & Keharia, H. (2020) · Genomics · doi:10.1016/j.ygeno.2020.10.017 · Cited by 43
Shi, Y., Zhai, M., Li, J., & Li, B. (2019) · Journal of Food Science and Technology · doi:10.1007/s13197-019-04089-7 · Cited by 41
Adaptation of the gut pathobiont Enterococcus faecalis to deoxycholate and taurocholate bile acids
Repoila, F., Wessner, F., Guérin, C., Lacoux, C., Tiwari, S., Jaiswal, A. K., Santana, M. P., Kennedy, S., Quinquis, B., Rainteau, D. P., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-12552-3 · Cited by 49
Review of the Relationships Between Human Gut Microbiome, Diet, and Obesity
Patloka, O., Komprda, T., & Franke, G. (2024) · Nutrients · doi:10.3390/nu16233996 · Cited by 50
Functional and Phylogenetic Diversity of BSH and PVA Enzymes
Daly, J. W., Keely, S. J., & Gahan, C. G. M. (2021) · Microorganisms · doi:10.3390/microorganisms9040732 · Cited by 40
Oh, Y. J., Kim, S.-A., Yang, S. H., Kim, D. H., Cheng, Y., Kang, J. I., Lee, S. Y., & Han, N. S. (2022) · PLoS ONE · doi:10.1371/journal.pone.0273986 · Cited by 46
Crosstalk between Gut Microbiota and Bile Acids in Cholestatic Liver Disease
Shi, Q., Yuan, X., Zeng, Y., Wang, J., Zhang, Y., Chen, X., & Li, L. (2023) · Nutrients · doi:10.3390/nu15102411 · Cited by 41
Harnentis, H., Marlida, Y., Nur, Y. S., Wizna, W., Santi, M. A., Septiani, N., Adzitey, F., & Huda, N. (2020) · Veterinary World · doi:10.14202/vetworld.2020.1922-1927 · Cited by 40
Zheng, X., Liang, Q., Zhao, B., Song, X., & Zhang, Y. (2024) · LWT · doi:10.1016/j.lwt.2024.116039 · Cited by 39
Morinaga, K., Kusada, H., & Tamaki, H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231810980 · Cited by 39
Yin, H., Ye, P., Lei, Q., Cheng, Y., Yu, H., Du, J.-J., Pan, H., & Cao, Z. (2020) · Microbial Pathogenesis · doi:10.1016/j.micpath.2020.104163 · Cited by 38
Stress adaptation and cross-protection of Lactobacillus plantarum KLDS 1.0628
Ma, J., Xu, C., Liu, F., Hou, J., Shao, H., & Yu, W. (2021) · CyTA - Journal of Food · doi:10.1080/19476337.2020.1859619 · Cited by 39
Gutiérrez‐Repiso, C., Moreno‐Indias, I., & Tinahones, F. J. (2021) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-021-09676-8 · Cited by 37
Metaflammation’s Role in Systemic Dysfunction in Obesity: A Comprehensive Review
Crasan, I.-M., Tanase, M., Delia, C., Pîrcălăbioru, G. G., Cîmpean, A., & Ionica, E. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262110445 · Cited by 42
Chamignon, C., Guéneau, V., Medina, S., Deschamps, J., Gil‐Izquierdo, Á., Briandet, R., Mousset, P.-Y., Langella, P., Lafay, S., & Bermúdez‐Humarán, L. G. (2020) · Microorganisms · doi:10.3390/microorganisms8071053 · Cited by 39
Metabolic regulation mechanism of fucoidan via intestinal microecology in diseases
Sun, T., Xue, M., Yang, J., Pei, Z., Zhang, N., Qin, K., & Liang, H. W. (2021) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.11202 · Cited by 35
Identifying a Novel Bile Salt Hydrolase from the Keystone Gut Bacterium Christensenella minuta
Déjean, G., Tudela, H., Bruno, L., Kissi, D., Rawadi, G., & Claus, S. P. (2021) · Microorganisms · doi:10.3390/microorganisms9061252 · Cited by 35
Yadav, M., Kumar, T., Kanakan, A., Maurya, R., Pandey, R., & Chauhan, N. S. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.932795 · Cited by 31
Kapse, N. G., Pisu, V., Dhakephalkar, T., Margale, P., Shetty, D., Wagh, S. A., Dagar, S. S., & Dhakephalkar, P. K. (2024) · Microorganisms · doi:10.3390/microorganisms12020347 · Cited by 30
Wang, G., Zhai, Z., Ren, F., Li, Z., Zhang, B., & Hao, Y. (2020) · Food Research International · doi:10.1016/j.foodres.2020.109331 · Cited by 28
He, Q., Li, J., Ma, Y., Chen, Q., & Chen, G. (2021) · Microorganisms · doi:10.3390/microorganisms9061224 · Cited by 30
Lei, S., Liu, L., Ding, L., Zhang, Y., & Zeng, H. (2021) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2021.07.031 · Cited by 27
de Felipe, F. L., Rivas, B. D. L., & Múñoz, R. (2021) · Antioxidants · doi:10.3390/antiox11010018 · Cited by 32
Cui, Y., Yin, Y., Li, S., Wu, Z., Xie, Y., Qian, Q., Yang, H., & Li, X. (2022) · Food & Function · doi:10.1039/d1fo04116a · Cited by 29
Bernatek, M., Żukiewicz-Sobczak, W. A., Lachowicz, S., & Piątek, J. (2022) · Nutrients · doi:10.3390/nu14163323 · Cited by 27
Mo, W., Zou, J., Wu, M., Peng, Z., He, W., Li, W., & Wu, X. (2023) · Journal of Functional Foods · doi:10.1016/j.jff.2023.105408 · Cited by 27
Patrone, V., Al-Surrayai, T., Romaniello, F., Fontana, A., Milani, G., Sagheddu, V., Puglisi, E., Callegari, M. L., Al-Mansour, H., Kishk, M., et al. (2020) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-020-09715-x · Cited by 27
Soni, R., Keharia, H., Bose, A., Pandit, N., Doshi, J., Rao, S. V. R., Paul, S. S., & Raju, M. V. L. N. (2021) · Genomics · doi:10.1016/j.ygeno.2021.10.012 · Cited by 27
Naklong, K., Therdtatha, P., Sumonsiri, N., Leksawasdi, N., Techapun, C., Rachtanapun, P., Taesuwan, S., Nunta, R., & Khemacheewakul, J. (2023) · Fermentation · doi:10.3390/fermentation9030296 · Cited by 25
Hu, L., Wang, X., Bao, Z., Xu, Q., Qian, M., & Jin, Y. (2022) · Chemosphere · doi:10.1016/j.chemosphere.2022.136141 · Cited by 25
Gao, S., Chen, W., Zhang, Y., Zhao, X., Chang, K., & Huang, Y. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.123807 · Cited by 25
Bile salt signaling and bile salt-based therapies in cardiometabolic disease
Groenen, C., Nguyen, T.-A., Paulusma, C. C., & van de Graaf, S. F. J. (2024) · Clinical Science · doi:10.1042/cs20230934 · Cited by 25
Boucard, A.-S., Florent, I., Polack, B., Langella, P., & Bermúdez‐Humarán, L. G. (2022) · Microorganisms · doi:10.3390/microorganisms10020273 · Cited by 24
Luo, Z., Li, M., Yang, J., Li, J., Zhang, Y., Liu, F., El-Omar, E. M., Han, L., Bian, J., Gong, L., et al. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.976638 · Cited by 24
Tian, C., Wang, L., Liu, M., Liu, J., Qiu, M., & Chen, Y. (2024) · Microorganisms · doi:10.3390/microorganisms12040795 · Cited by 22
Age-related sarcopenia and altered gut microbiota: A systematic review
Wang, M., Ren, F., Zhou, Y., He, Y., Du, T., & Tan, Y. (2024) · Microbial Pathogenesis · doi:10.1016/j.micpath.2024.106850 · Cited by 24
Fruit and vegetable snacks as carriers of probiotics and bioactive compounds: a review
Bustos, A. Y., Font, G., & Taranto, M. P. (2023) · International Journal of Food Science & Technology · doi:10.1111/ijfs.16400 · Cited by 22
Self-citationShao, J., Mu, Z., Xia, Y., Xiong, Z., Song, X., Yang, Y., Zhang, H., Ai, L., & Wang, G. (2023) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.2c08631 · Cited by 22
Miao, X., Luo, P., Liu, J., Wang, J., & Chen, Y. (2023) · Lipids in Health and Disease · doi:10.1186/s12944-023-01871-7 · Cited by 23
Guo, S.-J., Li, C.-C., Feng, Y.-T., Zhou, Y.-R., Liu, B., Gao, Z.-P., & Guo, C. (2024) · Food Bioscience · doi:10.1016/j.fbio.2024.103847 · Cited by 23
Wang, B., Han, D. W., Hu, X., Chen, J., Liu, Y., & Wu, J. (2024) · Microbiological Research · doi:10.1016/j.micres.2024.127865 · Cited by 24
Nguyen, N., & Nguyen, Q. (2024) · Food Biotechnology · doi:10.1080/08905436.2024.2306505 · Cited by 21
Kang, M. H., Elnar, A. G., & Kim, G.-B. (2025) · Food Science of Animal Resources · doi:10.5851/kosfa.2025.e1 · Cited by 21
Bile acid fitness determinants of a Bacteroides fragilis isolate from a human pouchitis patient
Fiebig, A., Schnizlein, M. K., Pena-Rivera, S., Trigodet, F., Dubey, A. A., Hennessy, M., Basu, A., Pott, S., Dalal, S., Rubin, D., et al. (2023) · mBio · doi:10.1128/mbio.02830-23 · Cited by 20
Sheng, X., Zhan, P., Wang, P., He, W., & Tian, H. (2024) · Food & Function · doi:10.1039/d3fo05235d · Cited by 20
Agolino, G., Cristofolini, M., Vaccalluzzo, A., Tagliazucchi, D., Cattivelli, A., Pino, A., Caggia, C., Solieri, L., & Randazzo, C. L. (2025) · Biomolecules · doi:10.3390/biom15010086 · Cited by 19
Wang, J., Chen, J., Gao, M., Ouyang, Z., Li, Y., Liu, D., Zhu, M., & Sun, H. (2025) · Foods · doi:10.3390/foods14091583 · Cited by 21
Francini, E., Pazmay, G. V. B., Fumarola, S., Procopio, A. D., Olivieri, F., & Marchegiani, F. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26041759 · Cited by 20
Anjum, J., Zaidi, A., Barrett, K. E., & Tariq, M. (2022) · Archives of Microbiology · doi:10.1007/s00203-022-02754-8 · Cited by 23
The Mechanism of Antimicrobial Activity of Conjugated Bile Acids against Lactic Acid Bacilli
Chai, L., Wu, H. J., Wang, X., He, L., & Guo, C. (2023) · Microorganisms · doi:10.3390/microorganisms11071823 · Cited by 18
Mukarromah, T. A., Rustanti, N., Mahati, E., Suparmi, S., & Ayustaningwarno, F. (2025) · Journal of Food Science · doi:10.1111/1750-3841.70301 · Cited by 19
Production of functional beer with the addition of probiotic: Saccharomyces boulardii
Reitenbach, A. F., Iwassa, I. J., & Barros, B. C. B. (2021) · Research Society and Development · doi:10.33448/rsd-v10i2.12211 · Cited by 19
HigBA toxin–antitoxin system of Weissella cibaria is involved in response to the bile salt stress
Cai, T., Zhao, Q., Xiang, W., Zhu, L., Rao, Y., & Tang, J. (2022) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.12042 · Cited by 16
Yang, C., Xu, Z., Huang, Q., Wang, X., Huang, F., & Deng, Q. (2023) · Food Science and Human Wellness · doi:10.1016/j.fshw.2023.03.036 · Cited by 16
Hormonal drugs: Influence on growth, biofilm formation, and adherence of selected gut microbiota
Hammouda, Z. K., Wasfi, R., & Abdeltawab, N. F. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1147585 · Cited by 16
Lun, W., Zhou, J., Bai, Y., Che, Q., Cao, H., Guo, J., & Su, Z. (2023) · Journal of Functional Foods · doi:10.1016/j.jff.2023.105731 · Cited by 15
Impact of imidacloprid exposure on gestational hyperglycemia: A multi-omics analysis
Wen, J., Liu, Q., Geng, S., Shi, X., Wang, J., Yao, X., & Hu, L. (2024) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2024.116561 · Cited by 15
Gut microbiome-derived hydrolases—an underrated target of natural product metabolism
He, J., Liu, X., Zhang, J., Wang, R., Cao, X., & Liu, G. (2024) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2024.1392249 · Cited by 17
López-Palestino, A., Gómez-Vargas, R., Suárez-Quiroz, M. L., González-Ríos, Ó., Hernández‐Estrada, Z. J., Castellanos-Onorio, O. P., Alonso-Villegas, R., Estrada-Beltrán, A. E., & Figueroa-Hernández, C. Y. (2025) · Fermentation · doi:10.3390/fermentation11020095 · Cited by 17
Mokhtari, H. A. E. R., Hassaïne, O., Çeti̇n, B., & Aktaş, H. M. (2025) · Enzyme and Microbial Technology · doi:10.1016/j.enzmictec.2025.110676 · Cited by 16
Listeria monocytogenes gut interactions and listeriosis: Gut modulation and pathogenicity
Oliveira, M., Barbosa, J. B., & Teixeira, P. (2025) · Microbiological Research · doi:10.1016/j.micres.2025.128187 · Cited by 15
Sribounoy, U., Pirarat, N., Solval, K. M., Sathivel, S., & Chotiko, A. (2021) · 3 Biotech · doi:10.1007/s13205-021-02829-1 · Cited by 14
Park, S. M., & Rhee, M. S. (2025) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2025.104984 · Cited by 13
Toupal, S., & Coşansu, S. (2023) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-023-10131-0 · Cited by 13
Zhao, W., Wang, H., Zheng, M., & Ni, Y. (2025) · Microbiome Research Reports · doi:10.20517/mrr.2025.12 · Cited by 13
de Souza, J. V., de Oliveira, A. P. D., Ferrari, I. D. S., Miyasato, I. F., Carrijo, K. D. F., Schwan, R. F., & Dias, F. S. (2020) · Food Bioscience · doi:10.1016/j.fbio.2020.100585 · Cited by 12
Sesín, A. A., Paz, J., Ledesma, A. E., Taranto, M. P., & Bustos, A. Y. (2023) · Brazilian journal of food technology/Brazilian Journal of Food Technology · doi:10.1590/1981-6723.02423 · Cited by 11
Self-citationZhang, Z., Xiong, J., Chen, L., Wang, G., Dong, R., Wang, F., Huang, Y., Meng, X., Li, T., Gu, Q., et al. (2024) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.13552 · Cited by 11
Tian, S., Jiang, Y., Han, Q., Meng, C., Ji, F., Zhou, B., & Ye, M. (2024) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-024-10289-1 · Cited by 11
Peng, S., Moran, M., Luo, P., Liu, J., Wang, J., & Chen, Y. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26030895 · Cited by 12
Li, C., Ji, Q., He, T., Liu, Y., & Ma, Y. (2020) · Biocatalysis and Biotransformation · doi:10.1080/10242422.2020.1804881 · Cited by 11
Metadata
- Authors
- Bustos, A. Y., Font de Valdez, G., Fadda, S., & Taranto, M. P.
- Affiliations
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
- Corresponding author
- Bustos, Ana Y.
- Venue
- Food Research International
- Publisher
- Elsevier BV
- Published
- 2018-10
- Volume
- 112
- Pages
- 250-262
- ISSN
- 0963-9969 (ISSN-L)
- OpenAlex
- W2808975724
- Cited by
- 232
- References
- 160
- Citations by year
- 2026: 31 · 2025: 41 · 2024: 40 · 2023: 28 · 2022: 39 · 2021: 25 · 2020: 18 · 2019: 10
- FWCI
- 1.30
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Food Research International (publishedVersion)
- PubMed (publishedVersion)
- CONICET Digital (CONICET) (submittedVersion, cc-by-nc-sa)
- Funders
- Consejo Nacional de Investigaciones Científicas y Tecnológicas (PIP2015-530)
- Agencia Nacional de Promoción Científica y Tecnológica (PICT2015-1705)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Keywords
- bile salt hydrolase, bile acid resistance, bile acids, bacterial stress response, efflux pumps, bile acid deconjugation, gut microbiota, host-microbe interactions, cholesterol metabolism, fat absorption, inflammation, omics approaches
- MeSH terms
- Gastrointestinal Microbiome, Amidohydrolases, Animals, Bacteria, Bacterial Proteins, Bile Acids and Salts, Humans, Microbial Viability, Lipid Metabolism, Host-Pathogen Interactions
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
