The DOI matches its Crossref record; 159 of the 160 references it cites were found in a registry or an index.
New insights into bacterial bile resistance mechanisms: the role of bile salt hydrolase and its impact on human health
Open accessAbstract
Bile acids (BA), the major components of bile, are biological detergents that facilitate the emulsification and solubilization of dietary lipids and also display potent antimicrobial activity, the bacterial membranes being their main targets. Considering the complicated nature of the stress produced by bile and BA, the microorganism tolerance requires different defence mechanisms including the presence of efflux pumps, bile salt hydrolase (BSH) enzyme, the intrinsic capacity of cells to maintain intracellular homeostasis and modifications in the architecture and composition of the cell membrane. Besides, the expression of proteins involved in carbohydrate and fatty acid metabolism, amino acid and nitrogenous base biosynthesis, and general stress response are commonly affected by the presence of bile. Among the microbial transformations, deconjugation of BA by BSH is the most important. Several studies indicate that BSH activity affects both the host physiology and the microbiota. In fact, it was strongly suggested that BSH could play an important role in the colonization and survival of bacteria in the gut. Also, recent work has shown that BSH and free BA participate in a variety of metabolic processes that include regulation of dietary lipid absorption, cholesterol metabolism, and energy and inflammation homeostasis. In this review we summarize recent advances in the understanding of the mechanisms involved in the tolerance of bacteria to bile, with special emphasis on the contributions of studies applying an omic approach. Besides, the physiological and ecological role of BSH enzyme and its relevance to human health as well as the function of bile acid as metabolic regulator are also discussed.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“The deconjugation ability enhances bacterial survival and colonization of the gastrointestinal tract, modulates lipid metabolism, and shapes the bile acid pool, ultimately influencing host-microbiome signaling [6, 10, 11].”
From Bile Salt Hydrolase Activity in the Food-Derived Strain Levilactobacillus brevis M3R3: Genomic and Functional Characterization (2026) · cites this paper as [10]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“BSH activity is widely distributed among gastrointestinal microbes, including various Lactobacillaceae species [5–8], where the presence of multiple bsh orthologs reflects strain-specific adaptations into the intestinal environment [5, 8–10].”
From Bile Salt Hydrolase Activity in the Food-Derived Strain Levilactobacillus brevis M3R3: Genomic and Functional Characterization (2026) · cites this paper as [10]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“As previously demonstrated, BSs tolerance was largely attributed to BSH-mediated deconjugation of BSs, which enhances cell viability under gastrointestinal conditions [6, 10].”
From Bile Salt Hydrolase Activity in the Food-Derived Strain Levilactobacillus brevis M3R3: Genomic and Functional Characterization (2026) · cites this paper as [10]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“The deconjugation ability enhances bacterial survival and colonization of the gastrointestinal tract, modulates lipid metabolism, and shapes the bile acid pool, ultimately influencing host-microbiome signaling [6, 10, 11].”
From Bile Salt Hydrolase Activity in the Food-Derived Strain Levilactobacillus brevis M3R3: Genomic and Functional Characterization (2026) · cites this paper as [10]
The cited source says what the claim attributes to it.
In the citing paper
“The deconjugation ability enhances bacterial survival and colonization of the gastrointestinal tract, modulates lipid metabolism, and shapes the bile acid pool, ultimately influencing host-microbiome signaling [6, 10, 11].”
From Bile Salt Hydrolase Activity in the Food-Derived Strain Levilactobacillus brevis M3R3: Genomic and Functional Characterization (2026) · cites this paper as [10]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites
Koh, A., De Vadder, F., Kovatcheva-Datchary, P., & Bäckhed, F. (2016) · Cell · doi:10.1016/j.cell.2016.05.041 · Cited by 7,070
Topping, D. L., & Clifton, P. M. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.3.1031 · Cited by 3,091
Sayin, S. I., Wahlström, A., Felin, J., Jäntti, S., Marschall, H.-U., Bamberg, K., Angelin, B., Hyötyläinen, T., Orešič, M., & Bäckhed, F. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.01.003 · Cited by 2,331
Food Animals and Antimicrobials: Impacts on Human Health
Marshall, B. M., & Levy, S. B. (2011) · Clinical Microbiology Reviews · doi:10.1128/cmr.00002-11 · Cited by 2,241
The Enzymes, Regulation, and Genetics of Bile Acid Synthesis
Russell, D. W. (2003) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.72.121801.161712 · Cited by 2,069
The interaction between bacteria and bile
Begley, M., Gahan, C. G. M., & Hill, C. (2004) · FEMS Microbiology Reviews · doi:10.1016/j.femsre.2004.09.003 · Cited by 1,776
Bile Acid Metabolism and Signaling
Chiang, J. Y. L. (2013) · Comprehensive physiology · doi:10.1002/cphy.c120023 · Cited by 1,662
Multidrug-resistance efflux pumps ? not just for resistance
Piddock, L. J. V. (2006) · Nature Reviews Microbiology · doi:10.1038/nrmicro1464 · Cited by 1,523
Bile acids: regulation of synthesis
Chiang, J. Y. L. (2009) · Journal of Lipid Research · doi:10.1194/jlr.r900010-jlr200 · Cited by 1,515
Molecular Basis for Feedback Regulation of Bile Acid Synthesis by Nuclear Receptors
Lu, T. T., Makishima, M., Repa, J. J., Schoonjans, K., Kerr, T. A., Auwerx, J., & Mangelsdorf, D. J. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00050-2 · Cited by 1,487
Antibiotic growth promoters in agriculture: history and mode of action
Dibner, J. J., & Richards, J. D. (2005) · Poultry Science · doi:10.1093/ps/84.4.634 · Cited by 1,436
Pleiotropic Roles of Bile Acids in Metabolism
de Aguiar Vallim, T. Q., Tarling, E. J., & Edwards, P. A. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.03.013 · Cited by 1,209
Bile Salt Hydrolase Activity in Probiotics
Begley, M., Hill, C., & Gahan, C. G. M. (2006) · Applied and Environmental Microbiology · doi:10.1128/aem.72.3.1729-1738.2006 · Cited by 1,187
Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor
Inagaki, T., Moschetta, A., Lee, Y.-K., Peng, L., Zhao, G., Downes, M., Yu, R. T., Shelton, J. M., Richardson, J. A., Repa, J. J., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0509592103 · Cited by 1,164
Consequences of bile salt biotransformations by intestinal bacteria
Ridlon, J. M., Harris, S. C., Bhowmik, S., Kang, D.-J., & Hylemon, P. B. (2016) · Gut Microbes · doi:10.1080/19490976.2015.1127483 · Cited by 1,128
Jones, B. V., Begley, M., Hill, C., Gahan, C. G. M., & Marchesi, J. R. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804437105 · Cited by 1,098
Control of Cell Shape in Bacteria
Jones, L. J. F., Carballido‐López, R., & Errington, J. (2001) · Cell · doi:10.1016/s0092-8674(01)00287-2 · Cited by 972
Bile acid signaling in metabolic disease and drug therapy
Li, T., & Chiang, J. Y. L. (2014) · Pharmacological Reviews · doi:10.1124/pr.113.008201 · Cited by 935
Bile Acid Is a Host Factor That Regulates the Composition of the Cecal Microbiota in Rats
Islam, K. B. M. S., Fukiya, S., Hagio, M., Fujii, N., Ishizuka, S., Ooka, T., Ogura, Y., Hayashi, T., & Yokota, A. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.07.046 · Cited by 918
Dietary gut microbial metabolites, short-chain fatty acids, and host metabolic regulation
Kasubuchi, M., Hasegawa, S., Hiramatsu, T., Ichimura, A., & Kimura, I. (2015) · Nutrients · doi:10.3390/nu7042839 · Cited by 904
Systemic gut microbial modulation of bile acid metabolism in host tissue compartments
Swann, J. R., Want, E. J., Geier, F. M., Spagou, K., Wilson, I. D., Sidaway, J. E., Nicholson, J. K., & Holmes, E. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1006734107 · Cited by 726
Li, F., Jiang, C., Krausz, K. W., Li, Y., Albert, I., Hao, H., Fabre, K. M., Mitchell, J. B., Patterson, A. D., & Gonzalez, F. J. (2013) · Nature Communications · doi:10.1038/ncomms3384 · Cited by 705
Regulation of host weight gain and lipid metabolism by bacterial bile acid modification in the gut
Joyce, S. A., MacSharry, J., Casey, P. G., Kinsella, M., Murphy, E. F., Shanahan, F., Hill, C., & Gahan, C. G. M. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1323599111 · Cited by 604
Diversification of host bile acids by members of the gut microbiota
Winston, J. A., & Theriot, C. M. (2019) · Gut Microbes · doi:10.1080/19490976.2019.1674124 · Cited by 597
The role of bile salts in digestion
Maldonado‐Valderrama, J., Wilde, P. J., Macierzanka, A., & Mackie, A. R. (2010) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2010.12.002 · Cited by 573
Vinderola, C. G., & Reinheimer, J. A. (2003) · Food Research International · doi:10.1016/s0963-9969(03)00098-x · Cited by 570
Fanning, S., Hall, L. J., Cronin, M. A., Zomer, A., MacSharry, J. A., Goulding, D., Motherway, M. O., Shanahan, F., Nally, K., Dougan, G., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1115621109 · Cited by 563
Bile resistance mechanisms in Lactobacillus and Bifidobacterium
Ruiz, L., Margolles, A., & Sánchez, B. (2013) · Frontiers in Microbiology · doi:10.3389/fmicb.2013.00396 · Cited by 548
Song, Z., Cai, Y., Lao, X., Wang, X., Lin, X., Cui, Y., Kalavagunta, P. K., Liao, J., Jin, L., Shang, J., et al. (2019) · Microbiome · doi:10.1186/s40168-019-0628-3 · Cited by 505
Interactions between gut bacteria and bile in health and disease
Long, S. L., Gahan, C. G. M., & Joyce, S. A. (2017) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2017.06.002 · Cited by 495
Active efflux of bile salts by Escherichia coli
Thanassi, D. G., Cheng, L. W., & Nikaido, H. (1997) · Journal of Bacteriology · doi:10.1128/jb.179.8.2512-2518.1997 · Cited by 471
Klaver, F. A. M., & van der Meer, R. (1993) · Applied and Environmental Microbiology · doi:10.1128/aem.59.4.1120-1124.1993 · Cited by 412
Aace Comprehensive Diabetes Management Algorithm 2013
Abrahamson, M. J., Barzilay, J. I., Blonde, L., Bloomgarden, Z. T., Bush, M. A., Dagogo-Jack, S. E., Davidson, M., EINHORN, D. F., Garvey, W. T., Grunberger, G., et al. (2013) · Endocrine Practice · doi:10.4158/endp.19.2.a38267720403k242 · Cited by 393
Danzeisen, J. L., Kim, H. B., Isaacson, R. E., Tu, Z. J., & Johnson, T. J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027949 · Cited by 380
Mechanism of growth inhibition by free bile acids in lactobacilli and bifidobacteria
Kurdi, P., Kawanishi, K., Mizutani, K., & Yokota, A. (2006) · Journal of Bacteriology · doi:10.1128/jb.188.5.1979-1986.2006 · Cited by 364
The environment within: how gut microbiota may influence metabolism and body composition
Vrieze, A., Holleman, F., Zoetendal, E. G., de Vos, W. M., Hoekstra, J. B. L., & Nieuwdorp, M. (2010) · Diabetologia · doi:10.1007/s00125-010-1662-7 · Cited by 358
Dussurget, O., Cabanes, D., Dehoux, P., Lecuit, M., Buchrieser, C., Glaser, P., & Cossart, P. (2002) · Molecular Microbiology · doi:10.1046/j.1365-2958.2002.03080.x · Cited by 356
Degirolamo, C., Rainaldi, S., Bovenga, F., Murzilli, S., & Moschetta, A. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.02.032 · Cited by 356
Turroni, F., Ventura, M., Buttó, L. F., Duranti, S., O’Toole, P. W., Motherway, M. O., & van Sinderen, D. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-013-1318-0 · Cited by 336
Jones, M. L., Martoni, C., Parent, M., & Prakash, S. (2011) · British Journal Of Nutrition · doi:10.1017/s0007114511004703 · Cited by 331
Effect of bile salts on the DNA and membrane integrity of enteric bacteria
Merritt, M. E., & Donaldson, J. R. (2009) · Journal of Medical Microbiology · doi:10.1099/jmm.0.014092-0 · Cited by 290
Bile acids as metabolic regulators
Li, T., & Chiang, J. Y. L. (2015) · Current Opinion in Gastroenterology · doi:10.1097/mog.0000000000000156 · Cited by 282
G protein-coupled receptors for energy metabolites as new therapeutic targets
Blad, C. C., Tang, C., & Offermanns, S. (2012) · Nature Reviews Drug Discovery · doi:10.1038/nrd3777 · Cited by 277
Lilley, K. S., Razzaq, A., & Dupree, P. (2002) · Current Opinion in Chemical Biology · doi:10.1016/s1367-5931(01)00275-7 · Cited by 269
Control of Cholesterol Turnover in the Mouse
Dietschy, J. M., & Turley, S. D. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.r100057200 · Cited by 265
Dumonceaux, T., Hill, J. E., Hemmingsen, S. M., & Kessel, A. G. V. (2006) · Applied and Environmental Microbiology · doi:10.1128/aem.72.4.2815-2823.2006 · Cited by 234
Moser, S. A., & Savage, D. C. (2001) · Applied and Environmental Microbiology · doi:10.1128/aem.67.8.3476-3480.2001 · Cited by 222
Koskenniemi, K., Laakso, K., Koponen, J., Kankainen, M., Greco, D., Auvinen, P., Savijoki, K., Nyman, T. A., Surakka, A., Salusjärvi, T., et al. (2010) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m110.002741 · Cited by 216
The human gut sterolbiome: bile acid-microbiome endocrine aspects and therapeutics
Ridlon, J. M., & Bajaj, J. S. (2015) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2015.01.006 · Cited by 210
Kumar, D. P., Rajagopal, S., Mahavadi, S., Mirshahi, F., Grider, J. R., Murthy, K. S., & Sanyal, A. J. (2012) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.09.104 · Cited by 206
Bile Salts Modulate Expression of the CmeABC Multidrug Efflux Pump inCampylobacter jejuni
Lin, J., Cagliero, C., Guo, B., Barton, Y.-W., Maurel, M. C., Payot, S., & Zhang, Q. (2005) · Journal of Bacteriology · doi:10.1128/jb.187.21.7417-7424.2005 · Cited by 191
Jones, M. L., Tomaro-Duchesneau, C., Martoni, C. J., & Prakash, S. (2013) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.2013.758706 · Cited by 190
Sánchez, B., Champomier‐Vergès, M., Anglade, P., Baraige, F., Reyes‐Gavilán, C. G. D. L., Margollés, A., & Zagorec, M. (2005) · Journal of Bacteriology · doi:10.1128/jb.187.16.5799-5808.2005 · Cited by 185
The influence of the human microbiome and probiotics on cardiovascular health
Ettinger, G., MacDonald, K., Reid, G., & Burton, J. P. (2014) · Gut Microbes · doi:10.4161/19490976.2014.983775 · Cited by 180
Evidence for Hypocholesterolemic Effect of Lactobacillus reuteri in Hypercholesterolemic Mice
Taranto, M. P., Medici, M., Perdigón, G., Holgado, A. P. R., & de Valdez, G. F. (1998) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(98)70123-7 · Cited by 177
Self-citationHamon, E., Horvatovich, P. L., Izquierdo, E., Bringel, F., Marchioni, E., Werner, D., & Ennahar, S. (2011) · BMC Microbiology · doi:10.1186/1471-2180-11-63 · Cited by 174
Interactions between Diet, Bile Acid Metabolism, Gut Microbiota, and Inflammatory Bowel Diseases
Devkota, S., & Chang, E. B. (2015) · Digestive Diseases · doi:10.1159/000371687 · Cited by 167
Leverrier, P., Dimova, D., Pichereau, V., Auffray, Y., Boyaval, P., & Jan, G. (2003) · Applied and Environmental Microbiology · doi:10.1128/aem.69.7.3809-3818.2003 · Cited by 167
Beysen, C., Murphy, E. J., Deines, K., Chan, M., Tsang, E., Glass, A., Turner, S., Protasio, J., Riiff, T. J., & Hellerstein, M. K. (2011) · Diabetologia · doi:10.1007/s00125-011-2382-3 · Cited by 164
The World Heart Federation's vision for worldwide cardiovascular disease prevention
Yusuf, S., Wood, D., Ralston, J., & Reddy, K. S. (2015) · The Lancet · doi:10.1016/s0140-6736(15)60265-3 · Cited by 160
Bacterial Shape: Two-Dimensional Questions and Possibilities
Young, K. D. (2010) · Annual Review of Microbiology · doi:10.1146/annurev.micro.112408.134102 · Cited by 149
Tsai, C., Lin, P.-P., Hsieh, Y.-M., Zhang, Z., Wu, H.-C., & Huang, C.-C. (2014) · The Scientific World JOURNAL · doi:10.1155/2014/690752 · Cited by 149
Whitehead, K. J., Versalovic, J. A., Roos, S., & Britton, R. A. (2008) · Applied and Environmental Microbiology · doi:10.1128/aem.02259-07 · Cited by 148
Purification and characterization of bile salt hydrolase from Bacteroides fragilis subsp. fragilis
Stellwag, E. J., & Hylemon, P. B. (1976) · Biochimica et Biophysica Acta (BBA) - Enzymology · doi:10.1016/0005-2744(76)90068-1 · Cited by 145
Kumar, R. S., Brannigan, J. A., Prabhune, A. A., Pundle, A. V., Dodson, G. G., Dodson, E. J., & Suresh, C. G. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m604172200 · Cited by 143
Bron, P. A., Marco, M. L., Hoffer, S. M., Mullekom, E. V., de Vos, W. M., & Kleerebezem, M. (2004) · Journal of Bacteriology · doi:10.1128/jb.186.23.7829-7835.2004 · Cited by 139
Joyce, S. A., Shanahan, F., Hill, C., & Gahan, C. G. (2014) · Gut Microbes · doi:10.4161/19490976.2014.969986 · Cited by 139
Bile salts and cholesterol induce changes in the lipid cell membrane of Lactobacillus reuteri
Taranto, M. P., Fernández-Murga, M. L., Lorca, G. L., & de Valdez, G. F. (2003) · Journal of Applied Microbiology · doi:10.1046/j.1365-2672.2003.01962.x · Cited by 138
Self-citationRuíz, L., Ruas‐Madiedo, P., Gueimonde, M., Reyes‐Gavilán, C. G. D. L., Margollés, A., & Sánchez, B. (2011) · Genes & Nutrition · doi:10.1007/s12263-010-0207-5 · Cited by 134
Guban, J., Korver, D. R., Allison, G. E., & Tannock, G. W. (2006) · Poultry Science · doi:10.1093/ps/85.12.2186 · Cited by 133
Response of Intestinal Microbiota to Antibiotic Growth Promoters in Chickens
Lin, J., Hunkapiller, A. A., Layton, A. C., Chang, Y., & Robbins, K. R. (2013) · Foodborne Pathogens and Disease · doi:10.1089/fpd.2012.1348 · Cited by 131
Effect of Lactobacillus reuteri on the Prevention of Hypercholesterolemia in Mice
Taranto, M. P., Medici, M., Perdigón, G., Holgado, A. P. R., & de Valdez, G. F. (2000) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(00)74895-8 · Cited by 128
Self-citationPumbwe, L., Skilbeck, C. A., Nakano, V., Ávila-Campos, M. J., Piazza, R. M. F., & Wexler, H. M. (2007) · Microbial Pathogenesis · doi:10.1016/j.micpath.2007.04.002 · Cited by 128
Effect of bile on the lipid composition and surface properties of bifidobacteria
Gómez‐Zavaglia, A., Kociubinski, G., Pérez, P. F., Disalvo, E. A., & Antoni, G. D. (2002) · Journal of Applied Microbiology · doi:10.1046/j.1365-2672.2002.01747.x · Cited by 127
Survival of the Fittest: How Bacterial Pathogens Utilize Bile To Enhance Infection
Sistrunk, J. R., Nickerson, K. P., Chanin, R. B., Rasko, D. A., & Faherty, C. S. (2016) · Clinical Microbiology Reviews · doi:10.1128/cmr.00031-16 · Cited by 127
Importance of microbial defence systems to bile salts and mechanisms of serum cholesterol reduction
Horáčková, Š., Plocková, M., & Demnerová, K. (2017) · Biotechnology Advances · doi:10.1016/j.biotechadv.2017.12.005 · Cited by 124
Sánchez, B., Champomier‐Vergès, M., Stuer‐Lauridsen, B., Ruas‐Madiedo, P., Anglade, P., Baraige, F., Reyes‐Gavilán, C. G. D. L., Johansen, E., Zagorec, M., & Margollés, A. (2007) · Applied and Environmental Microbiology · doi:10.1128/aem.00637-07 · Cited by 122
Deconjugation of bile salts by Lactobacillus acidophilus isolates
Ahn, Y. T., Kim, G. B., Lim, K. S., Baek, Y. J., & Kim, H. U. (2003) · International Dairy Journal · doi:10.1016/s0958-6946(02)00174-7 · Cited by 120
Probiotics and the BSH-related cholesterol lowering mechanism: a Jekyll and Hyde scenario
Choi, S.-B., Lew, L.-C., Yeo, S.-K., Nair Parvathy, S., & Liong, M.-T. (2015) · Critical Reviews in Biotechnology · doi:10.3109/07388551.2014.889077 · Cited by 119
Franz, C. M. A. P., Specht, I., Haberer, P., & Holzapfel, W. H. (2001) · Journal of Food Protection · doi:10.4315/0362-028x-64.5.725 · Cited by 118
Avcı, G. A., & Aslım, B. (2009) · Anaerobe · doi:10.1016/j.anaerobe.2009.06.006 · Cited by 118
Purification and characterization of bile salt hydrolase from Clostridium perfringens.
Gopal-Srivastava, R., & Hylemon, P. B. (1988) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38464-9 · Cited by 117
Wu, R., Zhang, W., Sun, T., Wu, J., Yue, X., Meng, H., & Zhang, H. (2011) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2011.04.003 · Cited by 109
Bile Affects the Synthesis of Exopolysaccharides by Bifidobacterium animalis
Ruas-Madiedo, P., Gueimonde, M., Arigoni, F., de los Reyes-Gavilán, C. G., & Margolles, A. (2009) · Applied and Environmental Microbiology · doi:10.1128/aem.00908-08 · Cited by 103
Noriega, L., Cuevas, I., Margollés, A., & Reyes‐Gavilán, C. G. D. L. (2005) · International Dairy Journal · doi:10.1016/j.idairyj.2005.09.008 · Cited by 101
Wang, Z., Zeng, X., Mo, Y., Smith, K., Guo, Y., & Lin, J. (2012) · Applied and Environmental Microbiology · doi:10.1128/aem.02519-12 · Cited by 99
Molecular features of bile salt hydrolases and relevance in human health
Chand, D., Avinash, V. S., Yadav, Y., Pundle, A. V., Suresh, C. G., & Ramasamy, S. (2016) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2016.09.024 · Cited by 98
Damodharan, K., Lee, Y. S., Palaniyandi, S. A., Yang, S. H., & Suh, J. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.00768 · Cited by 97
Prouty, A. M., van Velkinburgh, J. C., & Gunn, J. S. (2002) · Journal of Bacteriology · doi:10.1128/jb.184.5.1270-1276.2002 · Cited by 95
The cell-envelope proteome of Bifidobacterium longum in an in vitro bile environment
Ruíz, L., Couté, Y., Sánchez, B., Reyes‐Gavilán, C. G. D. L., Sanchez, J., & Margollés, A. (2009) · Microbiology · doi:10.1099/mic.0.024273-0 · Cited by 93
Lv, L., Ren, Y., Shi, H., Shi, D., Fang, D., Jiang, H., Wu, W., Guo, F., Jiang, X., Gu, S., et al. (2016) · Journal of Proteomics · doi:10.1016/j.jprot.2016.08.021 · Cited by 93
Role of Transporter Proteins in Bile Tolerance ofLactobacillus acidophilus
Pfeiler, E. A., & Klaenhammer, T. R. (2009) · Applied and Environmental Microbiology · doi:10.1128/aem.00495-09 · Cited by 92
Analysis of Host-Inducing Proteome Changes in Bifidobacterium longum NCC2705 Grown in Vivo
Yuan, J., Wang, B., Sun, Z., Bo, X., Yuan, X., He, X., Zhao, H., Du, X., Wang, F., Jiang, Z., et al. (2007) · Journal of Proteome Research · doi:10.1021/pr0704940 · Cited by 92
Grill, J.-P., Cayuela, C., Antoine, J., & Schneider, F. (2000) · Journal of Applied Microbiology · doi:10.1046/j.1365-2672.2000.01147.x · Cited by 88
Martoni, C. J., Labbé, A., Ganopolsky, J. G., Prakash, S., & Jones, M. L. (2015) · Gut Microbes · doi:10.1080/19490976.2015.1005474 · Cited by 87
Proteomic and transcriptomic analysis of the response to bile stress of Lactobacillus casei BL23
Alcántara, C., & Zúñiga, M. (2012) · Microbiology · doi:10.1099/mic.0.055657-0 · Cited by 87
Tauroconjugation of cholic acid stimulates 7 alpha-dehydroxylation by fecal bacteria
Eldere, J. V., Celis, P., Pauw, G. D., Lesaffre, E., & Eyssen, H. (1996) · Applied and Environmental Microbiology · doi:10.1128/aem.62.2.656-661.1996 · Cited by 86
Ooi, L.-G., Ahmad, R., Yuen, K. H., & Liong, M. (2010) · Journal of Dairy Science · doi:10.3168/jds.2010-3311 · Cited by 85
An, H., Douillard, F. P., Wang, G., Zhai, Z., Yang, J., Song, S., Cui, J., Ren, F., Luo, Y., Zhang, B., et al. (2014) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m114.039156 · Cited by 84
Role of Bile Acid Sequestrants in the Treatment of Type 2 Diabetes
Handelsman, Y. (2011) · Diabetes Care · doi:10.2337/dc11-s237 · Cited by 84
Kawamoto, K., Horibe, I., & Uchida, K. (1989) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a122962 · Cited by 83
Delpino, M. V., Marchesini, M. I., Estein, S. M., Comerci, D. J., Cassataro, J., Fossati, C. A., & Baldi, P. C. (2006) · Infection and Immunity · doi:10.1128/iai.00952-06 · Cited by 82
Bile-Inducible Efflux Transporter from Bifidobacterium longum NCC2705, Conferring Bile Resistance
Gueimonde, M., Garrigues, C., van Sinderen, D., Reyes‐Gavilán, C. G. D. L., & Margollés, A. (2009) · Applied and Environmental Microbiology · doi:10.1128/aem.00172-09 · Cited by 81
Inside the adaptation process of Lactobacillus delbrueckii subsp. lactis to bile
Burns, P., Sánchez, B., Vinderola, G., Ruas‐Madiedo, P., Ruíz, L., Margollés, A., Reinheimer, J. A., & Reyes‐Gavilán, C. G. D. L. (2010) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2010.06.013 · Cited by 79
Diet1 Functions in the FGF15/19 Enterohepatic Signaling Axis to Modulate Bile Acid and Lipid Levels
Vergnes, L., Lee, J. M., Chin, R. G., Auwerx, J. H., & Reue, K. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.04.007 · Cited by 79
Taranto, M. P., Pérez‐Martínez, G., & de Valdez, G. F. (2006) · Research in Microbiology · doi:10.1016/j.resmic.2006.04.002 · Cited by 76
Self-citationAllain, T., Chaouch, S., Thomas, M., Vallée, I., Buret, A. G., Langella, P., Grellier, P., Polack, B., Bermúdez‐Humarán, L. G., & Florent, I. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.02707 · Cited by 76
Sonne, D. P., Hansen, M., & Knop, F. K. (2014) · European Journal of Endocrinology · doi:10.1530/eje-14-0154 · Cited by 75
Molecular mechanisms of probiotic action: a proteomic perspective
Siciliano, R. A., & Mazzeo, M. F. (2012) · Current Opinion in Microbiology · doi:10.1016/j.mib.2012.03.006 · Cited by 74
Chae, J. P., Valeriano, V. D., Kim, G., & Kang, D. K. (2012) · Journal of Applied Microbiology · doi:10.1111/jam.12027 · Cited by 74
Park, Y. H., Kim, J. G., Shin, Y. W., Kim, H. S., Kim, Y., Chun, T., Kim, S. H., & Whang, K. Y. (2008) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.70581 · Cited by 72
Characterisation of a Bifidobacterium strain with acquired resistance to cholate—A preliminary study
Margollés, A., Garcı́a, L., Sánchez, B., Gueimonde, M., & Reyes‐Gavilán, C. G. D. L. (2003) · International Journal of Food Microbiology · doi:10.1016/s0168-1605(02)00261-1 · Cited by 71
Wu, R., Sun, Z., Wu, J., Meng, H., & Zhang, H. (2010) · Journal of Dairy Science · doi:10.3168/jds.2009-2967 · Cited by 68
Yokota, A., Veenstra, M., Kurdi, P., van Veen, H. W., & Konings, W. N. (2000) · Journal of Bacteriology · doi:10.1128/jb.182.18.5196-5201.2000 · Cited by 67
Lee, K.-B., Lee, H., & Choi, Y. (2008) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2008.07.1788 · Cited by 66
Chand, D., Panigrahi, P., Varshney, N. K., Ramasamy, S., & Suresh, C. G. (2018) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2018.01.003 · Cited by 64
Cloning and analysis of bile salt hydrolase genes from Lactobacillus plantarum CGMCC No. 8198
Gu, X.-C., Luo, X., Wang, C.-X., Ma, D.-Y., Wang, Y., He, Y., Li, W., Zhou, H., & Zhang, T. (2013) · Biotechnology Letters · doi:10.1007/s10529-013-1434-9 · Cited by 62
Bile salts hydrolase plays a key role on cholesterol removal by Lactobacillus reuteri
Taranto, M. P., Sesma, F. J. M., Holgado, A. P. D. R., & de Valdez, G. F. (1997) · Biotechnology Letters · doi:10.1023/a:1018373217429 · Cited by 58
Self-citationŠušković, J., Kos, B., Matošić, S., & Besendorfer, V. (2000) · World Journal of Microbiology and Biotechnology · doi:10.1023/a:1008909505651 · Cited by 58
Discovery of Bile Salt Hydrolase Inhibitors Using an Efficient High-Throughput Screening System
Smith, K., Zeng, X., & Lin, J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0085344 · Cited by 57
Ruíz, L., Zomer, A., Motherway, M. O., van Sinderen, D., & Margollés, A. (2011) · Applied and Environmental Microbiology · doi:10.1128/aem.06060-11 · Cited by 57
Proteomics of stress response in Bifidobacterium
Sánchez, B. (2008) · Frontiers in bioscience · doi:10.2741/3198 · Cited by 57
Tackling probiotic and gut microbiota functionality through proteomics
Ruíz, L., Hidalgo-Cantabrana, C., Blanco‐Míguez, A., Lourenço, A. M. G., Sánchez, B., & Margollés, A. (2016) · Journal of Proteomics · doi:10.1016/j.jprot.2016.03.023 · Cited by 56
Bile Acid Sequestrants: Glucose-Lowering Mechanisms and Efficacy in Type 2 Diabetes
Hansen, M., Sonne, D. P., & Knop, F. K. (2014) · Current Diabetes Reports · doi:10.1007/s11892-014-0482-4 · Cited by 55
Bile Salt Hydrolase Activities: A Novel Target to Screen Anti-Giardia Lactobacilli?
Allain, T., Chaouch, S., Thomas, M., Travers, M., Valle, I., Langella, P., Grellier, P., Polack, B., Florent, I., & Bermúdez‐Humarán, L. G. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.00089 · Cited by 55
Bustos, A. Y., Saavedra, L., de Valdez, G. F., Raya, R. R., & Taranto, M. P. (2012) · Biotechnology Letters · doi:10.1007/s10529-012-0932-5 · Cited by 53
Self-citation11β-Hydroxysteroid dehydrogenase 1: Regeneration of active glucocorticoids is only part of the story
Odermatt, A., & Klusoňová, P. (2014) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2014.08.011 · Cited by 53
Duary, R. K., Batish, V. K., & Grover, S. (2011) · Molecular Biology Reports · doi:10.1007/s11033-011-1006-9 · Cited by 52
Kim, G., & Lee, B. H. (2005) · Asian-Australasian Journal of Animal Sciences · doi:10.5713/ajas.2005.1505 · Cited by 48
The Bifidobacterium longum NCIMB 702259 T ctr Gene Codes for a Novel Cholate Transporter
Price, C. E., Reid, S. J., Driessen, A. J. M., & Abratt, V. R. (2006) · Applied and Environmental Microbiology · doi:10.1128/aem.72.1.923-926.2006 · Cited by 46
Kaur, G., Ali, S. A., Kumar, S., Mohanty, A. K., & Behare, P. V. (2017) · Journal of Proteomics · doi:10.1016/j.jprot.2017.08.008 · Cited by 45
Bøhle, L. A., Færgestad, E. M., Veiseth-Kent, E., Steinmoen, H., Nes, I. F., Eijsink, V. G. H., & Mathiesen, G. (2010) · Proteome Science · doi:10.1186/1477-5956-8-37 · Cited by 44
Sánchez, B., Noriega, L., Ruas‐Madiedo, P., Reyes‐Gavilán, C. G. D. L., & Margollés, A. (2004) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2004.tb09564.x · Cited by 44
Mouse organic solute transporter alpha deficiency alters FGF15 expression and bile acid metabolism
Lan, T., Rao, A., Haywood, J., Kock, N. D., & Dawson, P. A. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2012.03.025 · Cited by 42
Chen, S., Hsu, J., Chou, Y., & Wang, H. (2018) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.8904 · Cited by 42
Dean, M., Cervellati, C., Casanova, E., Squerzanti, M., Lanzara, V., Medici, A., de Laureto, P. P., & Bergamini, C. M. (2002) · Applied and Environmental Microbiology · doi:10.1128/aem.68.6.3126-3128.2002 · Cited by 41
Margollés, A., Flórez, A. B., Moreno-Muñoz, J. A., van Sinderen, D., & Reyes‐Gavilán, C. G. D. L. (2006) · Microbiology · doi:10.1099/mic.0.29097-0 · Cited by 39
Bustos, A. Y., de Valdez, G. F., Raya, R. R., de Almeida, A. M., Fadda, S., & Taranto, M. P. (2015) · Food Research International · doi:10.1016/j.foodres.2015.10.001 · Cited by 39
Self-citationJayashree, S., Pooja, S., Muthuirulan, P., Rajendhran, J., & Gunasekaran, P. (2014) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-014-1118-5 · Cited by 39
Genetic Diversity of Bile Salt Hydrolases Among Human Intestinal Bifidobacteria
Jarocki, P., & Targoński, Z. (2013) · Current Microbiology · doi:10.1007/s00284-013-0362-1 · Cited by 38
de Valdez, G. F., Martos, G., Taranto, M. P., Lorca, G. L., Oliver, G. D., & Holgado, A. P. D. R. (1997) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(97)76137-x · Cited by 36
Self-citationA bile‐inducible membrane protein mediates bifidobacterial bile resistance
Ruíz, L., Motherway, M. O., Zomer, A., Reyes‐Gavilán, C. G. D. L., Margollés, A., & van Sinderen, D. (2012) · Microbial Biotechnology · doi:10.1111/j.1751-7915.2011.00329.x · Cited by 32
Lan, T., Haywood, J., & Dawson, P. A. (2013) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2013.05.017 · Cited by 32
Gónzalez-Vázquez, R., Azaola‐Espinosa, A., Mayorga-Reyes, L., Reyes-Nava, L. A., Shah, N. P., & Rivera‐Espinoza, Y. (2015) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-015-9202-x · Cited by 32
Effect of bile components on the surface properties of bifidobacteria
Kociubinski, G., Gómez‐Zavaglia, A., Pérez, P. F., Disalvo, E. A., & Antoni, G. L. D. (2002) · Journal of Dairy Research · doi:10.1017/s0022029901005313 · Cited by 29
Burns, P., Reinheimer, J. A., & Vinderola, G. (2011) · Research in Microbiology · doi:10.1016/j.resmic.2011.07.005 · Cited by 28
Effect of bile on the $\beta$-galactosidase activity of dairy propionibacteria
Zárate, G., González, S., Chaia, A. P., & Oliver, G. (2000) · Le Lait · doi:10.1051/lait:2000125 · Cited by 26
Panigrahi, P., Sule, M., Sharma, R., Ramasamy, S., & Suresh, C. G. (2014) · Microbiology · doi:10.1099/mic.0.077586-0 · Cited by 25
Characterization of the smallest dimeric bile salt hydrolase from a thermophile Brevibacillus sp.
Sridevi, N., Srivastava, S., Khan, B. M., & Prabhune, A. A. (2009) · Extremophiles · doi:10.1007/s00792-008-0224-0 · Cited by 23
Efflux of bile acids in Lactobacillus reuteri is mediated by ATP
Bustos, A. Y., Raya, R. R., de Valdez, G. F., & Taranto, M. P. (2011) · Biotechnology Letters · doi:10.1007/s10529-011-0696-3 · Cited by 23
Self-citationRegulation of bile acid homeostasis by the intestinal Diet1–FGF15/19 axis
Reue, K., Lee, J. M., & Vergnes, L. (2014) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000060 · Cited by 23
Elkins, C. A., & Savage, D. C. (2003) · Microbial Physiology · doi:10.1159/000076738 · Cited by 16
Genome Sequence of the Antarctic Psychrophile Bacterium Planococcus antarcticus DSM 14505
Margollés, A., Gueimonde, M., & Sánchez, B. (2012) · Journal of Bacteriology · doi:10.1128/jb.00888-12 · Cited by 16
Bile Acids in Gastroenterology
Takikawa, H., & Tazuma, S. (2017) · Springer eBooks · doi:10.1007/978-4-431-56062-3 · Cited by 15
Malpeli, A., Taranto, M. P., Cravero, R., Tavella, M., Fasano, M. V., Vicentin, D., Ferrari, G., Magrini, G., Hebert, E. M., de Valdez, G. F., et al. (2015) · Food and Nutrition Sciences · doi:10.4236/fns.2015.617163 · Cited by 13
Self-citationBustos, A. Y., Raya, R. R., Bru, E., de Valdez, G. F., & Taranto, M. P. (2011) · Biotechnology Letters · doi:10.1007/s10529-011-0564-1 · Cited by 9
Self-citationMukherji, R., & Prabhune, A. A. (2015) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-015-1563-9 · Cited by 8
Centro de Referencia para Lactobacilos (CERELA-CONICET) - Chacabuco 145 (T4000ILC) San Miguel de Tucumán, A., Bustos, A. Y., Font de Valdez, G., & Facultad de Bioquímica, Q. Y. F. (2016) · International Journal of Genomics Proteomics Metabolomics & Bioinformatics · doi:10.19070/2577-4336-160001 · Cited by 5
Intestinal Digestion and Absorption
Honda, A., Ikegami, T., & Matsuzaki, Y. (2017) · Springer eBooks · doi:10.1007/978-4-431-56062-3_3 · Cited by 4
Research works printed but not linked: 1
- Reyes-Nava, 2014, Isolation sources of bile salt hydrolase-microorganisms, Herald Journal of Agriculture and Food Science Research, 3, 49
Cited by
Sorted by citations
Diversification of host bile acids by members of the gut microbiota
Winston, J. A., & Theriot, C. M. (2019) · Gut Microbes · doi:10.1080/19490976.2019.1674124 · Cited by 597
Bile acids as modulators of gut microbiota composition and function
Larabi, A. B., Masson, H. L. P., & Bäumler, A. J. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2172671 · Cited by 443
Foley, M. H., O’Flaherty, S., Barrangou, R., & Theriot, C. M. (2019) · PLOS Pathogens · doi:10.1371/journal.ppat.1007581 · Cited by 271
The microbiome modulating activity of bile acids
Tian, Y., Gui, W., Koo, I., Smith, P. B. W., Allman, E. L., Nichols, R. G., Rimal, B., Cai, J., Liu, Q., & Patterson, A. D. (2020) · Gut Microbes · doi:10.1080/19490976.2020.1732268 · Cited by 255
Interactive relationships between intestinal flora and bile acids
Guo, X., Okpara, E. S., Hu, W., Yan, C., Wang, Y., Liang, Q., Chiang, J. Y. L., & Han, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158343 · Cited by 206
Metadata
- Authors
- Bustos, A. Y., Font de Valdez, G., Fadda, S., & Taranto, M. P.
- Affiliations
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
- Corresponding author
- Bustos, Ana Y.
- Venue
- Food Research International
- Publisher
- Elsevier BV
- Published
- 2018-10
- Volume
- 112
- Pages
- 250-262
- ISSN
- 0963-9969 (ISSN-L)
- OpenAlex
- W2808975724
- Cited by
- 232
- References
- 160
- Citations by year
- 2026: 31 · 2025: 41 · 2024: 40 · 2023: 28 · 2022: 39 · 2021: 25 · 2020: 18 · 2019: 10
- FWCI
- 1.30
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Food Research International (publishedVersion)
- PubMed (publishedVersion)
- CONICET Digital (CONICET) (submittedVersion, cc-by-nc-sa)
- Funders
- Consejo Nacional de Investigaciones Científicas y Tecnológicas (PIP2015-530)
- Agencia Nacional de Promoción Científica y Tecnológica (PICT2015-1705)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Keywords
- bile salt hydrolase, bile acid resistance, bile acids, bacterial stress response, efflux pumps, bile acid deconjugation, gut microbiota, host-microbe interactions, cholesterol metabolism, fat absorption, inflammation, omics approaches
- MeSH terms
- Gastrointestinal Microbiome, Amidohydrolases, Animals, Bacteria, Bacterial Proteins, Bile Acids and Salts, Humans, Microbial Viability, Lipid Metabolism, Host-Pathogen Interactions
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
