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Cited by 113Connective tissue disorders researchAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesChild and Adolescent Psychosocial and Emotional Development

The DOI matches its Crossref record; 35 of the 36 references it cites were found in a registry or an index.

Joint hypermobility syndrome is a risk factor trait for anxiety disorders: a 15-year follow-up cohort study

Bulbena, Antoni, Gago, Jordi, Pailhez, Guillem, Sperry, Lili, Fullana, Miquel A., Vilarroya, Oscar·2011·General Hospital Psychiatry
DOI 10.1016/j.genhosppsych.2011.03.004
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Abstract

Objective The objective of the study was to assess whether joint hypermobility syndrome (JHS) is a risk factor for developing anxiety disorders using a 15-year prospective cohort study.Method The initial cohort recruited 158 subjects aged 16 to 20 years from the general population in a Spanish rural town. The cohort was studied at baseline and at a 15-year follow-up. Joint hypermobility syndrome was assessed using Beighton's criteria, and the psychiatric disorders were assessed using the Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Disorders. Subjects with anxiety disorders at baseline were excluded from the follow-up.Results Joint hypermobility syndrome at baseline was found in 29 of 158 subjects (21.1%). Cumulative incidence of panic/agoraphobia disorder at follow-up, as main diagnosis, was significantly higher for the JHS group (41.4%) than for the control group (1.9%), with a relative risk of 22.3 [95% confidence interval (CI) 4.6-108.7, P<.0001] (Number Needed to Treat [NNT] 3, 95% CI 2.9-2.3). Incidence of social phobia and simple phobia was also significantly higher for the JHS group [relative risk (RR)=6.52, 95% CI 1.7-24.2, P<.001 and RR=3.31, 95% CI 1.1-9.6, P=.02, respectively]. Moreover, anxiolytic drug use was nearly fourfold higher among JHS compared to non-JHS subjects.Conclusion Joint hypermobility syndrome was associated with higher risk of developing anxiety disorders. If replicated, these findings may give enhanced value to JHS assessment in clinical and general population studies.

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Research works printed but not linked: 2

  1. Rotés, 1957, La laxitud articular como factor de alteraciones del aparato locomotor, Rev Esp Reumatol, 1, 59
  2. Bulbena, 2004, Anxiety disorder and joint laxity: a definitive link., Neurol Psychiatry Brain Res, 11, 137

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Metadata

Authors
Bulbena, A., Gago, J., Pailhez, G., Sperry, L., Fullana, M. A., & Vilarroya, O.
Affiliations
Universitat Autònoma de Barcelona (ES)
Corresponding author
Pailhez, Guillem
ORCID
Venue
General Hospital Psychiatry
Publisher
Elsevier BV
Published
2011-07
Volume
33
Issue
4
Pages
363-370
ISSN
0163-8343 (ISSN-L)
DOI
10.1016/j.genhosppsych.2011.03.004
OpenAlex
W2002588000
Cited by
113
References
36
Citations by year
2026: 2 · 2025: 5 · 2024: 5 · 2023: 8 · 2022: 8 · 2021: 6 · 2020: 7 · 2019: 7 · 2018: 2 · 2017: 12 · 2016: 6 · 2015: 14 · 2014: 16 · 2013: 8 · 2012: 5
FWCI
6.00
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • General Hospital Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Connective tissue disorders research
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
  • Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
Keywords
joint hypermobility syndrome, anxiety disorders, panic disorder, agoraphobia, social anxiety disorder, specific phobia, Beighton criteria, risk factors
MeSH terms
Adolescent, Adult, Aged, Anxiety Disorders, Female, Follow-Up Studies, Humans, Joint Instability, Male, Middle Aged, Prospective Studies, Surveys and Questionnaires, Risk Factors, Spain, Cohort Studies, Epidemiologic Studies, Young Adult

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