Assessing brain-derived neurotrophic factor as a novel clinical marker of endometriosis
Open accessAbstract
OBJECTIVE: To evaluate novel clinical markers of endometriosis including the neurotrophins brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), and neurotrophin 4/5 (NT4/5) and compare them to others previously reported in the literature including cancer antigen 125 (CA-125) and C-reactive protein (CRP). DESIGN: Prospective study. SETTING: University hospital. PATIENT(S): One hundred thirty-eight women were prospectively and consecutively recruited (April 2011-April 2015; cases: undergoing endometriosis surgery, n = 96; controls: benign gynecological surgery, n = 24 combined with healthy women, no history of pelvic pain, not undergoing surgery, n = 18). INTERVENTION(S): Collection of peripheral blood, gynecological and demographic information, eutopic biopsy in women undergoing laparoscopy. MAIN OUTCOME MEASURE(S): Circulating BDNF, NGF, NT4/5, CA-125, and CRP were quantified by ELISA. RESULT(S): Plasma concentrations of BDNF were significantly greater in women with endometriosis (1,091.9 pg/mL [640.4-1,683.1]; n = 68, untreated) than in controls (731.4 pg/mL [352.1-1,176.2]; n = 36), whereas circulating NGF, NT4/5, CA-125, and CRP were not different. When assessed for their ability to differentiate between women with revised Classification of the American Society of Reproductive Medicine stage 1 and 2 or stage 3 and 4 disease and controls, BDNF was the only putative marker able to identify stage 1 and 2 disease, with a sensitivity and specificity of 91.7% and 69.4%, respectively, using an arbitrary cutoff value of 1,000 pg/mL. We also demonstrated that circulating BDNF in women with endometriosis who were receiving ovarian suppression for disease was equivalent to that in the control group. This suggests that BDNF may also offer the opportunity to monitor patient response to treatment. CONCLUSION(S): Plasma BDNF is a potentially useful clinical marker of endometriosis that is superior to NGF, NT4/5, CA-125, and CRP.
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Brain-derived neurotrophic factor (BDNF) is elevated in women with endometriosis compared to the control group.
“Pain is a typical symptom of endometriosis, so the conduction pathways were analyzed and the brain-derived neurotrophic factor (BDNF) was found to be elevated in women with endometriosis compared to the control group [147].”
From Endometriosis: Epidemiology, Classification, Pathogenesis, Treatment and Genetics (Review of Literature) (2021) · cites this paper as [147]
Plasma brain-derived neurotropic factor has been demonstrated as a noninvasive biomarker for detecting stage I-II endometriosis with 91.7% sensitivity and 69.4% specificity.
“Furthermore, Wessels et al. demonstrated the effectiveness of plasma brain-derived neurotropic factor as a noninvasive biomarker for detecting patients with stage I-II endometriosis with 91.7% sensitivity and 69.4% specificity (78).”
From Biomarkers in endometriosis: Challenges and opportunities (2017) · cites this paper as [78]
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Endometriosis and chronic pain syndrome: The role of stress mechanisms
dos Reis, F. M., Vannuccini, S., Logu, F. D., Pisani, I. A., Nassini, R., & Petraglia, F. (2026) · iScience · doi:10.1016/j.isci.2026.117686
- Authors
- Wessels, J. M., Kay, V. R., Leyland, N. A., Agarwal, S. K., & Foster, W. G.
- Affiliations
- McMaster University (CA)
- University of California San Diego (US)
- Corresponding author
- Foster, Warren G.
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 2016-01
- Volume
- 105
- Issue
- 1
- Pages
- 119-128.e5
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W2159823634
- Cited by
- 66
- References
- 27
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 5 · 2023: 6 · 2022: 5 · 2021: 5 · 2020: 11 · 2019: 5 · 2018: 10 · 2017: 8 · 2016: 5
- FWCI
- 8.76
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- Canadian Institutes of Health Research (MOP142230)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
- Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
- Keywords
- endometriosis, brain-derived neurotrophic factor, nerve growth factor, neurotrophin-4/5, CA125, C-reactive protein, plasma biomarkers, endometriosis staging, ovarian suppression, treatment response monitoring, neurotrophins, eutopic endometrium, pelvic pain, endometriosis surgery, sensitivity and specificity
- MeSH terms
- Adult, Endometriosis, Enzyme-Linked Immunosorbent Assay, Female, Humans, Predictive Value of Tests, Prospective Studies, Reproducibility of Results, Biomarkers, Up-Regulation, Case-Control Studies, Brain-Derived Neurotrophic Factor, Young Adult
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