Cited by 361Immune cells in cancerPhagocytosis and Immune RegulationCardiac Fibrosis and Remodeling

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Alternative activation of macrophages: Immune function and cellular biology

Varin, Audrey, Gordon, Siamon·2009·Immunobiology

DOI 10.1016/j.imbio.2008.11.009

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Abstract

Macrophages are the first line of defense of the organism against pathogens and, in response to the microenvironment, become differentially activated. In the presence of IL-4 and IL-13, cytokines that are produced in a Th-2 type response, particularly during allergy and parasitic infections, macrophages become differentially activated. Alternative activated macrophages play an important role in the protection of the host by decreasing inflammation and promoting tissues repair. However, alternative activation of macrophages also downregulates host protection against selected pathogens. This defect is associated with an altered receptor expression pattern and extensive modulation of intracellular membrane trafficking. This review shows how alternative activation of macrophages induces extensive cellular remodelling of phagocytic, endocytic, signaling and secretory pathways which play an important, but unclear role in the pathogenesis of different disease.

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Authors: Varin, A., & Gordon, S.
Affiliations: University of Oxford (GB)
Corresponding author: Gordon, Siamon
ORCID: Varin, Audrey
Gordon, Siamon
Venue: Immunobiology
Publisher: Elsevier BV
Published: 2009-07
Volume: 214
Issue: 7
Pages: 630-641
ISSN: 0171-2985 (ISSN-L)
DOI: 10.1016/j.imbio.2008.11.009
OpenAlex: W2091360431
Cited by: 361
References: 112
Citations by year: 2026: 7 · 2025: 8 · 2024: 7 · 2023: 13 · 2022: 32 · 2021: 15 · 2020: 23 · 2019: 22 · 2018: 20 · 2017: 21 · 2016: 14 · 2015: 27 · 2014: 24 · 2013: 35 · 2012: 43
FWCI: 2.43
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Immunobiology (publishedVersion)
PubMed (publishedVersion)
Funders: Fondation pour la Recherche Médicale
Medical Research Council
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
Keywords: alternative macrophage activation, M2 macrophages, IL-4, IL-13, Th2 immune response, parasitic infection, allergy, inflammation, tissue repair, receptor expression, membrane trafficking, phagocytosis, endocytosis, secretory pathway, host-pathogen interaction
MeSH terms: Animals, Endocytosis, Humans, Hypersensitivity, Immune Tolerance, Macrophage Activation, Membrane Fusion, Parasitic Diseases, Wound Healing, Signal Transduction, Interleukin-4, Th2 Cells

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Alternative activation of macrophages: Immune function and cellular biology

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